检索结果-南通市图书馆

Effects of methyl palmitate and lutein on LPS-induced acute lung injury in rats

World Journal of Respirology 2013年第2期3卷 20-28页

作者： El-Sayed M Ammar maha h sharawy Asem A Shalaby Dina S El-Agamy Department of Pharmacology and Toxicology Faculty of PharmacyMansoura University Mansoura 35516 Egypt Department of Pathology Faculty of Medicine Mansoura University Mansoura 35516 Egypt

AIM: To investigate the effects of methyl palmitate and lutein on lipopolysaccharide(LPS)-induced acute lung injury(ALI) in rats and explore the possible mechanisms. METhODS: Male Sprague-Dawley rats were divided into 4 groups:(1) control;(2) LPS;(3) Methyl palmitate; and(4) Lutein groups. Methyl palmitate(300 mg/kg, ip) was administered 3 times per week on alternating days while lutein(100 mg/kg, oral) was given once daily. After 1 wk of vehicle/methyl palmitate/lutein treatment, ALI was induced by a single dose of LPS(7.5 mg/kg, iv). After 24 h of LPS injection, animals were sacrificed then biochemical parameters and histopathology were assessed. RESULTS: Treatment with methyl palmitate attenuated ALI, as it significantly decreased the lung wet/dry weight(W/D) ratio, the accumulation of the inflammatory cells in the bronchoalveolar lavage fluid(BALF) andhistopathological damage. however, methyl palmitate failed to decrease lactate dehydrogenase(LDh) activity in BALF. On the other hand, lutein treatment produced significant anti-inflammatory effects as revealed by significant decrease in accumulation of inflammatory cells in lung, LDh level in BALF and histopathological damage. Methyl palmitate and lutein significantly increased superoxide dismutase(SOD) and reduced glutathione(GSh) activities with significant decrease in the lung malondialdehyde(MDA) content. Importantly, methyl palmitate and lutein decreased the level of the inflammatory cytokine tumor necrosis factor-α(TNF-α) in the lung. Lutein also reduced LPS-mediated overproduction of pulmonary nitrite/nitrate(NO-2/NO-3), which was not affected by methyl palmitate pretreatment. CONCLUSION: These results demonstrate the potent protective effects of both methyl palmitate and lutein against LPS-induced ALI in rats. These effects can be attributed to potent antioxidant activities of these agents, which suppress inflammatory cell infiltration and regulated cytokine effects.

关键词： Acute lung injury Lipopolysaccharide Methyl palmitate Lutein Rats

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease

引用

Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 207-214页

作者： Duaa M.Bakhshwin Foziya W.Alhalabi Mohamad Omar Barasheed Ahmed M.Bakhshwin maha h.Jamal Mohammed A.Bazuhair Fatemah O.Kamel Rania M.Magadmi Zoheir A Damanhouri Samar M.Alsaggaf Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia hera General hospital MakkahSaudi Arabia Department of Pathology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess the effect of memantine combined with liraglutide on aluminum chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:Male Wistar rats were divided into 5 groups of 5 animals each:the positive control,the negative control,the memantine-treated group,the liraglutide-treated group,and the combination group treated with memantine and ***_(3)and D-GAL were used to induce *** tests,brain beta-amyloid protein,and oxidative stress biomarkers were ***:The Morris water maze test indicated an enhanced memory in the combination ***,the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain *** inflammation and oxidative stress biomarkers were significantly reduced,and the levels of antioxidant parameters were ***:The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer’s disease.

关键词： Alzheimer’s disease Cognitive function Glucagonlike peptide-1 Liraglutide Memantine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ensemble Deep Learning Based Air Pollution Prediction for Sustainable Smart Cities

引用

Computer Systems Science & Engineering 2024年第3期48卷 627-643页

作者： maha Farouk Sabir Mahmoud Ragab Adil O.Khadidos Khaled h.Alyoubi Alaa O.Khadidos Information Systems Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Information Technology Department Faculty of Computing and Information Technology King Abdulaziz UniversityJeddah21589Saudi Arabia 3Department of MathematicsFaculty of ScienceAl-Azhar UniversityNaser CityCairo11884Egypt Center of Research Excellence in Artificial Intelligence and Data Science King Abdulaziz UniversityJeddahSaudi Arabia

Big data and information and communication technologies can be important to the effectiveness of smart *** on the maximal attention on smart city sustainability,developing data-driven smart cities is newly obtained attention as a vital technology for addressing sustainability ***-time monitoring of pollution allows local authorities to analyze the present traffic condition of cities and make *** to air pollution occurs a main environmental problem in smart city *** effect of the deep learning(DL)approach quickly increased and penetrated almost every domain,comprising air pollution ***,this article develops a new Coot Optimization Algorithm with an Ensemble Deep Learning based Air Pollution Prediction(COAEDL-APP)system for Sustainable Smart *** projected COAEDL-APP algorithm accurately forecasts the presence of air quality in the sustainable smart city *** achieve this,the COAEDL-APP technique initially performs a linear scaling normalization(LSN)approach to pre-process the input *** air quality prediction,an ensemble of three DL models has been involved,namely autoencoder(AE),long short-term memory(LSTM),and deep belief network(DBN).Furthermore,the COA-based hyperparameter tuning procedure can be designed to adjust the hyperparameter values of the DL *** simulation outcome of the COAEDL-APP algorithm was tested on the air quality database,and the outcomes stated the improved performance of the COAEDL-APP algorithm over other existing systems with maximum accuracy of 98.34%.

关键词： Sustainability smart cities air pollution prediction ensemble learning coot optimization algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inter-Calibration Between Plasma Instruments Onboard DEMETER

引用

Plasma Science and Technology 2008年第5期10卷 539-545页

作者： maha S.QUASSIM National Research Institute of Astronomy and Geophysics Helwan 11421CairoEgypt

The in-situ measurements of the ionospheric plasma that we use come from two instruments of the scientific payload of the satellite DEMETER; the plasma analyser IAP （Instrument d＇analyse du plasma） and the Langmuir probe ISL （Instrument Sonde de Langmuir）. DEMETER is a micro-satellite realized by the CNES（Centre National d＇Etudes Spatiales, France） with a principal objective to seek a possible influence of the seismic activity on the electromagnetic waves in the ionosphere and on the ionospheric plasma. The satellite was placed on June 29, 2004, in a circular and quasi helio-synchronous orbit at -710 km altitude. The experiments function primarily at mid-latitudes （from ＋60° to -60°）. The IAP data were analysed to deduce the ion population （densities of the dominant ions, i.e. generally O^＋, h^＋ and he^＋） therefore the total ion density. The use of data IAP thus requires some precaution to make sure that the electric equilibrium conditions of the satellite, such as the satellite potential （Фsat）, are obtained during the treatment of routine, does not induce an error of measurement. When this potential is negative, the minority light ions h^＋ and he^＋ can be measured in a reliable way when their proportion is above 3% to 5% of that of O^＋. The critical limitation is： under certain conditions, the satellite potential becomes positive and reach a value about -0.5 V so that it becomes impossible to measure h^＋ ions. This is likely to involve a significant error on the composition and the density of the plasma. Therefore we carried out a calibration to estimate the missing density. The ISL experiment （Langmuir probe） provided the collected current/polarized tension characteristics of a cylindrical probe from which both electron density Ne and temperature Te were obtained. In some situations it is necessary to examine the accuracy of the electron density using another technique, for instance the high frequency （hF） spectrogram, provided by ICE （instrument champ electrique

关键词： plasma analyser satellite plasma observation ion density measuring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Radiolabeling, docking studies, in silico ADME and biological evaluation of serotonin with 125I for 5-hTRs imaging

引用

Nuclear Science and Techniques 2020年第8期31卷 64-71页

作者： Dina M.El-sharawy Marwa S.El Refaye h.hussien Asmaa M.AboulMagd Labeled Compounds Department Hot Lab.CenterEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt Radioactive Isotopes and Generators Department Hot Lab.CenterEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt Cyclotron Project Nuclear Research CenterCairoEgypt Pharmaceutical Chemistry Department Faculty of PharmacyNahda UniversityBeni SuefEgypt Pharmaceutics and Clinical Pharmacy Department Faculty of PharmacyNahda UniversityBeni SuefEgypt

Serotonin is one of the significant signaling molecules used by several neural systems in the gut and brain. This study aimed to develop a novel and potent tracer for targeting, detecting, and imaging serotonin receptors(5-hTRs), which is a promising tool in the determination of the receptor’s function and relationship with the diseases related to serotonin and its receptor dysfunction. Serotonin was effectively labeled via a direct electrophilic substitutional reaction using an oxidizing agent such as iodogen with 125I in a neutral medium, and 125I-serotonin was achieved with a maximum labeling yield of 91 ± 0.63% with in vitro stability up to 24 h. Molecular modeling was conducted to signify 125I-serotonin structure and confirm that the radiolabeling process did not affect serotonin binding ability to its receptors. Biodistribution studies show that the maximum gastro intestinal tract uptake of 125I-serotonin was 17.8 ± 0.93% ID/organ after 30 min postinjection and the tracer’s ability to pass the blood–brain barrier. Thus, 125I-serotonin is a promising single photon emission computed tomography tracer in the detection of 5 hTRs.

关键词： Serotonin Electrophilic substitution Molecular modeling 5hTRs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of patients with dry eye disease for conjunctival Chlamydia trachomatis and Ureaplasma urealyticum

引用

International Journal of Ophthalmology(English edition) 2016年第10期9卷 1457-1465页

作者： maha Mohssen Abdelfattah Rania Abdelmonem Khattab Magda h.Mahran Ebrahim S.Elborgy Microbiology and Immunology Department Research Institute of Ophthalmology Giza12556 Egypt Microbiology and Immunology Department Faculty of Pharmacy Cairo University Kasr Al-Aini 11562 CairoEgypt Ophthalmology Department Research Institute of Ophthalmology Giza 12556 Egypt

AIM：To determine the possibility of the development of dry eye disease（DED） as a result of persistent infection with Chlamydia trachomatis and Ureaplasma urealyticum in the conjunctiva of ***： This study was conducted on 58 patients of age range 20-50 y,diagnosed with DED confirmed by Schirmer I test and tear breakup *** non-dry eye control group included 27 subjects of the same *** specimens were collected as conjunctival scrapings and swabs divided into three groups： the first used for bacterial culture,the second and third taken to detect Chlamydia trachomatis and Ureaplasma urealyticum by direct fluorescent antibody（DFA） assay and polymerase chain reaction（PCR） method. RESULTS： Chlamydia trachomatis was detected in 65.5% and 76% of DED patients by DFA and PCR methods *** urealyticum was found in 44.8% of DED infected patients using the PCR *** organisms were identified in only 37.9% of DED patients found to be *** subjects had a 22%detection rate of Chlamydia trachomatis by DFA assay versus a 7% detection rate by PCR; while Ureaplasma urealyticum was detected in 3.7% of the controls by PCR *** conjunctival culture revealed that gram positive microorganisms represented 75% of isolates with coagulase negative Staphylococci the most common（50%） followed by Staphylococcus aureus（20%）,whereas gram negative microorganisms occurred in 25% of cases,isolating Moraxella *** the most frequent organism. CONCLUSION： Our results tend to point out that Chlamydia trachomatis and Ureaplasma urealyticum were detected in a moderate percentage of patients with DED,and could be a fair possibility for its *** is more reliable in detecting Chlamydia trachomatis than DFA *** presence of isolated conjunctival bacterial microflora can be of some potential value.

关键词： dry eye disease conjunctiva Chlamydia trachomatis Ureaplasma urealyticum direct fluorescent antibody polymerase chain reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of Wheat Random Amplified Polymorphic DNA Markers Associated with the h11 hessian Fly Resistance Gene

引用

Journal of Integrative Plant Biology 2006年第8期48卷 958-964页

作者： Dhia Bouktila maha Mezghani Mohamed Marrakchi hanem Makni Laboratory of Molecular Genetics Immunology and BiotechnologyScience Faculty of TunisUniversity of Tunis EI ManarUniversity Campus1068TunisTunisia

In Tunisia, the hessian fly Mayetiola destructor Say is a major pest of durum wheat （Triticum durum Desf.） and bread wheat （T. aestivum L.）. Genetic resistance is the most efficient and economical method of control of this pest. To date, 31 resistance genes, designated h1-h31, have been identified in wheat. These genes condition resistance to the insect genes responsible for virulence. Using wheat cultivars differing for the presence of an individual hessian fly resistance gene and random amplified polymorphic DNA （RAPD） analysis, we have identified a polymorphic 386-bp DNA marker （Xgmib1-1A.1） associated with the h11 hessian fly resistance gene. Blast analysis showed a high identity with a short region in the wild wheat （T. monococcum） genome, adjacent to the leaf rust resistance Lr10 gene. A genetic linkage was reported between this gene （Lr10） and hessian fly response in wheat. These data were used for screening hessian fly resistance in Tunisian wheat germplasm. Xgmib1-1A.1-like fragments were detected in four Tunisian durum and bread wheat varieties. Using these varieties in hessian fly breeding programs in Tunisia would be of benefit in reducing the damage caused by this fly.

关键词： cultivar Mayetiola molecular markers resistance genes Triticum variety.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New Optical Soliton Solutions of the Perturbed Fokas-Lenells Equation

引用

Communications in Theoretical Physics 2019年第11期71卷 1275-1280页

作者： maha S.M.Shehata hadi Rezazadeh Emad h.M.Zahran Eric Tala-Tebue Ahmet Bekir Departments of Mathematics Zagazig UniversityFaculty of ScienceZagazigEgypt Faculty of Engineering Technology Amol University of Special Modern TechnologiesAmolIran Departments of Mathematical and Physical Engineering Benha UniversityFaculty of EngineeringShubraEgypt Laboratoire D'Automatique et D'Informatique Appliquee(LAIA) IUT-FV of BandjounThe University of DschangBP 134BandjounCameroon Neighbourhood of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey

In this article, we employ the perturbed Fokas-Lenells equation(FLE), which represents recent electronic communications. The Riccati-Bernoulli Sub-ODE method which does not depend on the balance rule is used for thefirst time to obtain the new exact and solitary wave solutions of this equation. This technique is direct, effective and reduces the large volume of calculations.

关键词： perturbed Fokas-Lenells equation(FLE) Riccati-Bernoulli Sub-ODE method optical soliton solutions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sensor Faults Observer Design with h_∞ Performance for Non-linear T-S systems

引用

International Journal of Automation and computing 2013年第6期10卷 563-570页

作者： Imen haj Brahim maha Bouattour Driss Mehdi Mohamed Chaabane Ghani hashim Laboratory of Sciences and Techniques of Automatic Control&Computer Engineering(Lab-STA) National School of Engineering of SfaxUniversity of Sfax LIAS-ENSIP University of PoitiersLIAS-ENSIP2 rue Pierre Brousse Computer Science Department Cihan University

This paper deals with the problem of the state estimation and the sensor faults detection for nonlinear perturbed systems described by Takagi-Sugeno （T-S） fuzzy models with unmeasurable premise variables. Indeed, a T-S observer is synthesized, in descriptor form, to estimate both the system states and the sensor faults simultaneously. The idea of the proposed approach is to introduce the sensor fault as an auxiliary variable in the state vector. Besides, the T-S model with unmeasurable premise variables is reduced to a perturbed model with measurable variables. Convergence conditions are established with Lyapunov theory and the h∞ performance in order to guarantee the best robustness to disturbances. These conditions are expressed in terms of linear matrix inequalities （LMIs）. The parameters of the observer are computed using the solution of the LMI conditions. Finally, a numerical example is given to illustrate the design procedures. Simulation results show the satisfactory performances.

关键词： Takagi-Sugeno (T-S) fuzzy system sensor faults h∞ performance descriptor approach observer linear matrix inequality(LMI).

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease

引用

Journal of Clinical and Translational hepatology 2017年第2期5卷 109-118页

作者： Ibrahim h.Borai Yehia Shaker maha Moustafa Kamal Wafaa M.Ezzat Esmat Ashour Mie Afify Weaam Gouda maha M.Elbrashy Biochemistry Department Faculty of Science Ain Shams University Cairo Egypt Biochemistry Department National Research Centre Giza Egypt Department of Internal Medicine National Research Center Giza Egypt

Background and Aims:Nonalcoholic fatty liver disease (NAFLD) is a silent disease;its spectrum includes simple steatosis,nonalcoholic steatohepatitis and ***-and anti-inflammatory cytokines play roles in the pathogenesis of NAFLD and insulin resistance (IR).Moreover,plasma cell antigen-1 (PC-1) is related to IR and associated with NAFLD ***,we aimed to detect biomarkers,ultrasonographic and anthropometric findings capable of differentiating NAFLD grades,since most previous investigators were concerned more with NAFLD patients without classifying them into ***:A total of 87 NAFLD patients (31 with grade 1 (mild NAFLD),26 with grade 2 (moderate NAFLD) and 30 with grade 3 (severe NAFLD) were included in the study,in addition to 47 controls (grade 0).All subjects underwent ultrasonographic examination for NAFLD *** interleukin-10 (IL-10),plasma interleukin-18 (IL-18) and plasma PC-1 levels were determined using enzyme-linked immunosorbent ***:homoeostasis model assessment (hOMA)-IR was higher in different NAFLD grades than in *** and anthropometric findings and lipid profile indices (except for high-density lipoprotein cholesterol,which was decreased) were increased with NAFLD *** 3 patients showed significant increase in levels of IL-18 and significant decrease in IL-10 and PC-1 levels when compared to grade 1 ***:Anthropometric and ultrasonographic findings were valuable in differentiating NAFLD *** is very important in NAFLD ***-18,hOMA-index and PC-1 levels could be used to differentiate between NAFLD grades,together with other measurements.

关键词： NAFLD Interleukin-18(IL-18) Interleukin-10(IL-10) Plasma cell antigen-1(PC-1)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：