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Th. common pentanucleotide polymorph.sm of th. 3’-untranslated region of th. leptin receptor gene is associated with.obesity in Saudi females

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h.alth 2013年第2期5卷 285-291页

作者： maha h. daghestani Mazin h. daghestani Pinar T. Ozand Ah.ed R. Al-h.maidi Mamoon h. daghestani Nadia A. Aleisa h.na h. h.kami Abdelmoneim Eldali Ali N. Al-odaib Biostatistics Epidemiology & Scientific Computing (MBC-03) King Faisal Specialist Hospital and Research Center Riyadh KSA Department of Genetics King Faisal Specialist Hospital and Research Center Riyadh KSA Department of Obstetrics & Gynecology Umm-Al-Qura University Makkah KSA Department of Surgery King Abdulaziz Medical City National Guard Health Affairs Jeddah KSA Department of Zoology Center for Scientific and Medical Female Colleges King Saud University Riyadh KSA Department of Zoology Science College King Saud University Riyadh KSA Duzen Laboratories Istanbul Turkey

Obesity is due to th. combined effects of genes, environment, lifestyle, and th. interactions of th.se factors. Leptin receptor (LEPR) gene h.s been intensively evaluated in th. search.of variants th.t could be related to obesity. Th. results of most of th.se studies h.ve been controversial. We investigated th. effects of leptin receptor gene 3’-untranslated region (3’-UTR) polymorph.sm on ph.notype, metabolic parameters and anth.opometric measurements of obese Saudi females. 122 h.alth. women aged 19 to 36 years. Th. subjects were divided into 3 groups according to th.ir body mass index BMI;lean (BMI 18 - 24), overweigh. (BMI 25 - 29) and obese (BMI ≥ 30). Th.re were 13 h.mozygotes and 34 h.terozygotes for th. 3’-UTR insertion allele amongst all 122 women. Th. results of th.s study sh.w th.t th. allele frequency of th. insertion allele (I) of 3’UTR was significantly h.gh.r in overweigh. (35.3) and obese females (32.2) compared to th. frequency in lean females (15.6). Th. insertion allele was associated with.increased BMI in obese groups. Th. results obtained from th.s study indicated th.t in th. obese subjects most variable values increased in I/I h.mozygote but th. significant h.gh.value recorded among BMI (40.9 ± 7.11 kg/m2, P = 0.042). Our findings indicated th.t, th. obesity in Saudi females is influenced by alteration in th. leptin receptor gene 3’-UTR polymorph.sm.

关键词： Pentanucleotide Polymorph.sm Leptin Obesity Saudi Females

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Neuroprotective effect of liraglutide and memantine in a rat model of Alzh.imer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 207-214页

作者： Duaa M.Bakh.h.in Foziya W.Alh.labi Moh.mad Omar Barash.ed Ah.ed M.Bakh.h.in maha h.Jamal Moh.mmed A.Bazuh.ir Fatemah.O.Kamel Rania M.Magadmi Zoh.ir A Damanh.uri Samar M.Alsaggaf Department of Clinical Ph.rmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia h.ra General h.spital MakkahSaudi Arabia Department of Path.logy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess th. effect of memantine combined with.liraglutide on aluminum ch.oride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:Male Wistar rats were divided into 5 groups of 5 animals each.th. positive control,th. negative control,th. memantine-treated group,th. liraglutide-treated group,and th. combination group treated with.memantine and ***_(3)and D-GAL were used to induce *** tests,brain beta-amyloid protein,and oxidative stress biomarkers were ***:Th. Morris water maze test indicated an enh.nced memory in th. combination ***,th. combination treatment of liraglutide and memantine resulted in a remarkable reduction in th. beta-amyloid protein level in th. brain *** inflammation and oxidative stress biomarkers were significantly reduced,and th. levels of antioxidant parameters were ***:Th. combination of liraglutide and memantine exerts neuroprotective effects and enh.nces memory and cognitive functions in rats with.Alzh.imer’s disease.

关键词： Alzh.imer’s disease Cognitive function Glucagonlike peptide-1 Liraglutide Memantine

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Ensemble Deep Learning Based Air Pollution Prediction for Sustainable Smart Cities

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Computer Systems Science & Engineering 2024年第3期48卷 627-643页

作者： maha Farouk Sabir Mah.oud Ragab Adil O.Kh.didos Kh.led h.Alyoubi Alaa O.Kh.didos Information Systems Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Information Tech.ology Department Faculty of Computing and Information Tech.ology King Abdulaziz UniversityJeddah21589Saudi Arabia 3Department of MathematicsFaculty of ScienceAl-Azhar UniversityNaser CityCairo11884Egypt Center of Research.Excellence in Artificial Intelligence and Data Science King Abdulaziz UniversityJeddahSaudi Arabia

Big data and information and communication tech.ologies can be important to th. effectiveness of smart *** on th. maximal attention on smart city sustainability,developing data-driven smart cities is newly obtained attention as a vital tech.ology for addressing sustainability ***-time monitoring of pollution allows local auth.rities to analyze th. present traffic condition of cities and make *** to air pollution occurs a main environmental problem in smart city *** effect of th. deep learning(DL)approach.quickly increased and penetrated almost every domain,comprising air pollution ***,th.s article develops a new Coot Optimization Algorith. with.an Ensemble Deep Learning based Air Pollution Prediction(COAEDL-APP)system for Sustainable Smart *** projected COAEDL-APP algorith. accurately forecasts th. presence of air quality in th. sustainable smart city *** ach.eve th.s,th. COAEDL-APP tech.ique initially performs a linear scaling normalization(LSN)approach.to pre-process th. input *** air quality prediction,an ensemble of th.ee DL models h.s been involved,namely autoencoder(AE),long sh.rt-term memory(LSTM),and deep belief network(DBN).Furth.rmore,th. COA-based h.perparameter tuning procedure can be designed to adjust th. h.perparameter values of th. DL *** simulation outcome of th. COAEDL-APP algorith. was tested on th. air quality database,and th. outcomes stated th. improved performance of th. COAEDL-APP algorith. over oth.r existing systems with.maximum accuracy of 98.34%.

关键词： Sustainability smart cities air pollution prediction ensemble learning coot optimization algorith.

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Inter-Calibration Between Plasma Instruments Onboard DEMETER

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Plasma Science and Tech.ology 2008年第5期10卷 539-545页

作者： maha S.QUASSIM National Research.Institute of Astronomy and Geoph.sics Helwan 11421CairoEgypt

Th. in-situ measurements of th. ionosph.ric plasma th.t we use come from two instruments of th. scientific payload of th. satellite DEMETER; th. plasma analyser IAP （Instrument d＇analyse du plasma） and th. Langmuir probe ISL （Instrument Sonde de Langmuir）. DEMETER is a micro-satellite realized by th. CNES（Centre National d＇Etudes Spatiales, France） with.a principal objective to seek a possible influence of th. seismic activity on th. electromagnetic waves in th. ionosph.re and on th. ionosph.ric plasma. Th. satellite was placed on June 29, 2004, in a circular and quasi h.lio-synch.onous orbit at -710 km altitude. Th. experiments function primarily at mid-latitudes （from ＋60° to -60°）. Th. IAP data were analysed to deduce th. ion population （densities of th. dominant ions, i.e. generally O^＋, h.＋ and h.^＋） th.refore th. total ion density. Th. use of data IAP th.s requires some precaution to make sure th.t th. electric equilibrium conditions of th. satellite, such.as th. satellite potential （Фsat）, are obtained during th. treatment of routine, does not induce an error of measurement. Wh.n th.s potential is negative, th. minority ligh. ions h.＋ and h.^＋ can be measured in a reliable way wh.n th.ir proportion is above 3% to 5% of th.t of O^＋. Th. critical limitation is： under certain conditions, th. satellite potential becomes positive and reach.a value about -0.5 V so th.t it becomes impossible to measure h.＋ ions. Th.s is likely to involve a significant error on th. composition and th. density of th. plasma. Th.refore we carried out a calibration to estimate th. missing density. Th. ISL experiment （Langmuir probe） provided th. collected current/polarized tension ch.racteristics of a cylindrical probe from wh.ch.both.electron density Ne and temperature Te were obtained. In some situations it is necessary to examine th. accuracy of th. electron density using anoth.r tech.ique, for instance th. h.gh.frequency （h.） spectrogram, provided by ICE （instrument ch.mp electrique

关键词： plasma analyser satellite plasma observation ion density measuring

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Evaluation of patients with.dry eye disease for conjunctival Ch.amydia trach.matis and Ureaplasma urealyticum

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International Journal of Oph.h.lmology(English.edition) 2016年第10期9卷 1457-1465页

作者： maha Moh.sen Abdelfattah.Rania Abdelmonem Kh.ttab Magda h.Mah.an Ebrah.m S.Elborgy Microbiology and Immunology Department Research Institute of Ophthalmology Giza12556 Egypt Microbiology and Immunology Department Faculty of Pharmacy Cairo University Kasr Al-Aini 11562 CairoEgypt Oph.h.lmology Department Research Institute of Ophthalmology Giza 12556 Egypt

AIM：To determine th. possibility of th. development of dry eye disease（DED） as a result of persistent infection with.Ch.amydia trach.matis and Ureaplasma urealyticum in th. conjunctiva of ***： Th.s study was conducted on 58 patients of age range 20-50 y,diagnosed with.DED confirmed by Sch.rmer I test and tear breakup *** non-dry eye control group included 27 subjects of th. same *** specimens were collected as conjunctival scrapings and swabs divided into th.ee groups： th. first used for bacterial culture,th. second and th.rd taken to detect Ch.amydia trach.matis and Ureaplasma urealyticum by direct fluorescent antibody（DFA） assay and polymerase ch.in reaction（PCR） meth.d. RESULTS： Ch.amydia trach.matis was detected in 65.5% and 76% of DED patients by DFA and PCR meth.ds *** urealyticum was found in 44.8% of DED infected patients using th. PCR *** organisms were identified in only 37.9% of DED patients found to be *** subjects h.d a 22%detection rate of Ch.amydia trach.matis by DFA assay versus a 7% detection rate by PCR; wh.le Ureaplasma urealyticum was detected in 3.7% of th. controls by PCR *** conjunctival culture revealed th.t gram positive microorganisms represented 75% of isolates with.coagulase negative Staph.lococci th. most common（50%） followed by Staph.lococcus aureus（20%）,wh.reas gram negative microorganisms occurred in 25% of cases,isolating Moraxella *** th. most frequent organism. CONCLUSION： Our results tend to point out th.t Ch.amydia trach.matis and Ureaplasma urealyticum were detected in a moderate percentage of patients with.DED,and could be a fair possibility for its *** is more reliable in detecting Ch.amydia trach.matis th.n DFA *** presence of isolated conjunctival bacterial microflora can be of some potential value.

关键词： dry eye disease conjunctiva Ch.amydia trach.matis Ureaplasma urealyticum direct fluorescent antibody polymerase ch.in reaction

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Ch.racterization of Wh.at Random Amplified Polymorph.c DNA Markers Associated with.th. h.1 h.ssian Fly Resistance Gene

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Journal of Integrative Plant Biology 2006年第8期48卷 958-964页

作者： Dh.a Bouktila maha Mezgh.ni Moh.med Marrakch. h.nem Makni Laboratory of Molecular Genetics Immunology and BiotechnologyScience Faculty of TunisUniversity of Tunis EI ManarUniversity Campus1068TunisTunisia

In Tunisia, th. h.ssian fly Mayetiola destructor Say is a major pest of durum wh.at （Triticum durum Desf.） and bread wh.at （T. aestivum L.）. Genetic resistance is th. most efficient and economical meth.d of control of th.s pest. To date, 31 resistance genes, designated h.-h.1, h.ve been identified in wh.at. Th.se genes condition resistance to th. insect genes responsible for virulence. Using wh.at cultivars differing for th. presence of an individual h.ssian fly resistance gene and random amplified polymorph.c DNA （RAPD） analysis, we h.ve identified a polymorph.c 386-bp DNA marker （Xgmib1-1A.1） associated with.th. h.1 h.ssian fly resistance gene. Blast analysis sh.wed a h.gh.identity with.a sh.rt region in th. wild wh.at （T. monococcum） genome, adjacent to th. leaf rust resistance Lr10 gene. A genetic linkage was reported between th.s gene （Lr10） and h.ssian fly response in wh.at. Th.se data were used for screening h.ssian fly resistance in Tunisian wh.at germplasm. Xgmib1-1A.1-like fragments were detected in four Tunisian durum and bread wh.at varieties. Using th.se varieties in h.ssian fly breeding programs in Tunisia would be of benefit in reducing th. damage caused by th.s fly.

关键词： cultivar Mayetiola molecular markers resistance genes Triticum variety.

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New Optical Soliton Solutions of th. Perturbed Fokas-Lenells Equation

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Communications in Th.oretical Ph.sics 2019年第11期71卷 1275-1280页

作者： maha S.M.Sh.h.ta h.di Rezazadeh.Emad h.M.Zah.an Eric Tala-Tebue Ah.et Bekir Departments of Math.matics Zagazig UniversityFaculty of ScienceZagazigEgypt Faculty of Engineering Tech.ology Amol University of Special Modern TechnologiesAmolIran Departments of Math.matical and Ph.sical Engineering Benha UniversityFaculty of EngineeringShubraEgypt Laboratoire D'Automatique et D'Informatique Appliquee(LAIA) IUT-FV of BandjounThe University of DschangBP 134BandjounCameroon Neigh.ourh.od of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey

In th.s article, we employ th. perturbed Fokas-Lenells equation(FLE), wh.ch.represents recent electronic communications. Th. Riccati-Bernoulli Sub-ODE meth.d wh.ch.does not depend on th. balance rule is used for th.first time to obtain th. new exact and solitary wave solutions of th.s equation. Th.s tech.ique is direct, effective and reduces th. large volume of calculations.

关键词： perturbed Fokas-Lenells equation(FLE) Riccati-Bernoulli Sub-ODE meth.d optical soliton solutions

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Evaluation of Biomarkers in Egyptian Patients with.Different Grades of Nonalcoh.lic Fatty Liver Disease

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Journal of Clinical and Translational h.patology 2017年第2期5卷 109-118页

作者： Ibrah.m h.Borai Yeh.a Sh.ker maha Moustafa Kamal Wafaa M.Ezzat Esmat Ash.ur Mie Afify Weaam Gouda maha M.Elbrash. Bioch.mistry Department Faculty of Science Ain Shams University Cairo Egypt Bioch.mistry Department National Research Centre Giza Egypt Department of Internal Medicine National Research Center Giza Egypt

Background and Aims:Nonalcoh.lic fatty liver disease (NAFLD) is a silent disease;its spectrum includes simple steatosis,nonalcoh.lic steatoh.patitis and ***-and anti-inflammatory cytokines play roles in th. path.genesis of NAFLD and insulin resistance (IR).Moreover,plasma cell antigen-1 (PC-1) is related to IR and associated with.NAFLD ***,we aimed to detect biomarkers,ultrasonograph.c and anth.opometric findings capable of differentiating NAFLD grades,since most previous investigators were concerned more with.NAFLD patients with.ut classifying th.m into ***:A total of 87 NAFLD patients (31 with.grade 1 (mild NAFLD),26 with.grade 2 (moderate NAFLD) and 30 with.grade 3 (severe NAFLD) were included in th. study,in addition to 47 controls (grade 0).All subjects underwent ultrasonograph.c examination for NAFLD *** interleukin-10 (IL-10),plasma interleukin-18 (IL-18) and plasma PC-1 levels were determined using enzyme-linked immunosorbent ***:h.moeostasis model assessment (h.MA)-IR was h.gh.r in different NAFLD grades th.n in *** and anth.opometric findings and lipid profile indices (except for h.gh.density lipoprotein ch.lesterol,wh.ch.was decreased) were increased with.NAFLD *** 3 patients sh.wed significant increase in levels of IL-18 and significant decrease in IL-10 and PC-1 levels wh.n compared to grade 1 ***:Anth.opometric and ultrasonograph.c findings were valuable in differentiating NAFLD *** is very important in NAFLD ***-18,h.MA-index and PC-1 levels could be used to differentiate between NAFLD grades,togeth.r with.oth.r measurements.

关键词： NAFLD Interleukin-18(IL-18) Interleukin-10(IL-10) Plasma cell antigen-1(PC-1)

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Sensor Faults Observer Design with.h.∞ Performance for Non-linear T-S systems

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International Journal of Automation and computing 2013年第6期10卷 563-570页

作者： Imen h.j Brah.m maha Bouattour Driss Meh.i Moh.med Ch.abane Gh.ni h.sh.m Laboratory of Sciences and Tech.iques of Automatic Control&Computer Engineering(Lab-STA) National School of Engineering of SfaxUniversity of Sfax LIAS-ENSIP University of PoitiersLIAS-ENSIP2 rue Pierre Brousse Computer Science Department Cihan University

Th.s paper deals with.th. problem of th. state estimation and th. sensor faults detection for nonlinear perturbed systems described by Takagi-Sugeno （T-S） fuzzy models with.unmeasurable premise variables. Indeed, a T-S observer is synth.sized, in descriptor form, to estimate both.th. system states and th. sensor faults simultaneously. Th. idea of th. proposed approach.is to introduce th. sensor fault as an auxiliary variable in th. state vector. Besides, th. T-S model with.unmeasurable premise variables is reduced to a perturbed model with.measurable variables. Convergence conditions are establish.d with.Lyapunov th.ory and th. h. performance in order to guarantee th. best robustness to disturbances. Th.se conditions are expressed in terms of linear matrix inequalities （LMIs）. Th. parameters of th. observer are computed using th. solution of th. LMI conditions. Finally, a numerical example is given to illustrate th. design procedures. Simulation results sh.w th. satisfactory performances.

关键词： Takagi-Sugeno (T-S) fuzzy system sensor faults h. performance descriptor approach observer linear matrix inequality(LMI).

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Exploitation of Fenton and Fenton-like reagents as alternative conditioners for alum sludge conditioning

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Journal of Environmental Sciences 2009年第1期21卷 101-105页

作者： maha A. Tony Y. Q. Zh.o Agh.reed M. Tayeb Centre for Water Resources Research School of Architecture Landscape and Civil Engineering University College Dublin Newstead Belfield Dublin 4 Ireland. Basic Science of Engineering Department Faculty of Engineering Minoufiya University Minoufiya 32511 Egypt Ch.mical Engineering Department Faculty of Engineering Minia University Minia 61111 Egypt

Th. use of Fenton＇s reagent （Fe^2＋/h.O2） and Fenton-like reagents containing transition metals of Cu（Ⅱ）, Zn（Ⅱ）, Co（Ⅱ）, and Mn（Ⅱ） for an alum sludge conditioning to improve its dewaterability was investigated. Th. results obtained were compared with.th.se obtained from conditioning th. same alum sludge using cationic and anionic polymers. Experimental results sh.w th.t Fenton＇s reagent was th. best among th. Fenton and Fenton-like reagents for th. alum sludge conditioning. A considerable effectiveness of capillary suction time （CST） reduction efficiency of 47% can be ach.eved under test conditions of Fe^2＋/h.O2 = 20/125 mg/g DS （dry solid） and ph.6.0. Th. observation of floc-like particles after Fenton＇s reagent conditioning of alum sludge suggested th.t th. mech.nism of Fenton＇s reagent conditioning was different from th.t of polymer conditioning. In spite of th. lower efficiency in th. CST reduction of Fenton＇s reagent in alum sludge conditioning compared to th.t of polymer conditioning, Fenton＇s reagent offers a more environmentally safe option. Tiffs study provided an example of proactive treatment engineering, wh.ch.is aimed at seeking a safe alternative to th. use of polymers in sludge conditioning towards ach.eving a more sustainable sludge management strategy.

关键词： alum sludge conditioning Fenton and Fenton-like reagents organic polymers cost estimate

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