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生态瞬时评估应用于自杀研究的可行性评价

中国临床心理学杂志 2024年第1期32卷 46-50,31页

作者：朱佳鑫牛璐侯筱菲曾梦陈腾伟李同赫陶好娟马亚荣林康广周亮中南大学湘雅公共卫生学院社会医学与卫生事业管理系长沙410078 天津市安定医院天津300000 中南大学湘雅二医院精神科国家精神心理疾病临床研究中心长沙410011 广州医科大学附属脑科医院广州510000

目的:探究在中国文化背景下,运用智能手机结合可穿戴式设备的生态瞬时评估方法(ecological momentary assessment,ema)进行自杀想法动态监测研究的可行性。方法:在国内三所医院门诊中招募32名心境障碍且目前有自杀意念的成人患者作为研... 详细信息

目的:探究在中国文化背景下,运用智能手机结合可穿戴式设备的生态瞬时评估方法(ecological momentary assessment,ema)进行自杀想法动态监测研究的可行性。方法:在国内三所医院门诊中招募32名心境障碍且目前有自杀意念的成人患者作为研究对象,通过智能手机完成28天每日5~8次自杀想法及相关因素调查,并佩戴智能手环以客观收集睡眠和运动情况。结果:调查对象平均完成23.0±8.0天调查(范围7~28天),其中68.8%完成28天调查。共发送调查3780次,应答2557次(应答依从性为67.6%)。每位患者平均应答79.9±47.1次,平均佩戴手环19.5±10.3天。结论:结果初步支持在国内背景下运用主客观相结合的ema动态监测自杀想法的可行性,未来可进一步探索自杀想法变化特征和短期预测因素。

关键词：生态瞬时评估法自杀想法动态监测可行性心境障碍

p18^(INK4C)缺失通过激活LMO2加快Notch-1诱导的急性T淋巴细胞白血病进展

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中国科学：生命科学 2017年第12期47卷 1386-1396页

作者：董芳拜海涛王晓芳张森张珊珊马士卉 Hideo ema 程涛郝莎中国医学科学院&北京协和医学院血液病医院(血液学研究所) 实验血液学国家重点实验室天津300020 中国医学科学院干细胞医学中心天津300020 北京协和医学院干细胞与再生医学系天津300020

p18^(INK4C)(CDKN2C)属于细胞周期蛋白激酶抑制剂家族成员,通过阻断细胞周期蛋白激酶4/6使细胞周期处于G1早期.研究提示,p18缺失影响T细胞的正常发育并可能参与急性T淋巴细胞白血病(T-ALL)的发生,但p18缺失导致T-ALL发生和进展的机制并... 详细信息

p18^(INK4C)(CDKN2C)属于细胞周期蛋白激酶抑制剂家族成员,通过阻断细胞周期蛋白激酶4/6使细胞周期处于G1早期.研究提示,p18缺失影响T细胞的正常发育并可能参与急性T淋巴细胞白血病(T-ALL)的发生,但p18缺失导致T-ALL发生和进展的机制并不清楚.本文利用Notch-1胞内段(ICN-1)过表达诱导的T-ALL模型来研究p18影响T-ALL的发生和进展的可能机制.结果发现,p18-/-骨髓细胞过表达ICN-1可诱发T-ALL,白血病细胞表型为更加原始的CD4/CD8双阴性细胞,且这些细胞主要阻滞在DN3阶段;T-ALL细胞连续移植结果显示,p18缺失能够显著加速T-ALL的进展,且p18-/-T-ALL细胞更多地处于细胞周期的G0期,即静息状态;基因表达结果发现,与T-ALL发生直接相关的原癌基因Lmo2及共结合分子如Sfpi1,Nfe2及Ldb1等以及N-myc的表达水平在p18-/-组显著高于对照组.以上结果提示,p18缺失后可能通过激活Lmo2及N-myc等的表达从而加速T-ALL的进展.本研究对p18缺失如何加速T-ALL的发展进行了阐释,对临床伴随有p18缺失或者LMO2异常激活型突变T-ALL病人的预后提供了理论依据,具有一定的临床指导价值.

关键词：细胞周期蛋白激酶抑制剂 p18INK4C 急性T淋巴细胞白血病 LMO2

阳离子型絮凝剂片段在高岭石表面的吸附机理研究

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有色金属（选矿部分） 2024年第3期 128-134页

作者：刘连平刘崇峻李伟涛张立峰吴桂叶卢通马艳红刘慧南王涛国家能源集团乌海能源有限责任公司内蒙古乌海016000 矿冶科技集团有限公司矿物加工科学与技术国家重点实验室北京100160 北矿化学科技(沧州)有限公司河北沧州061100 青海省地质调查局西宁810000

采用密度泛函理论(DFT)研究了3种不同结构的阳离子聚丙烯酰胺片段(Ea.ema.EAA)在高岭石表面的吸附机理。通过Mulliken布局分析、电子密度差以及吸附原子态密度对吸附体系的成键性质和相互作用类型进行了分析。结果表明,三种阳离子聚... 详细信息

采用密度泛函理论(DFT)研究了3种不同结构的阳离子聚丙烯酰胺片段(Ea.ema.EAA)在高岭石表面的吸附机理。通过Mulliken布局分析、电子密度差以及吸附原子态密度对吸附体系的成键性质和相互作用类型进行了分析。结果表明,三种阳离子聚丙烯酰胺片段在高岭石(001)Si一O端面吸附能均要大于其在高岭石(001)Al一O端面的吸附能,主要吸附在高岭石(001)Si—O端面,三种阳离子聚丙烯酰胺片段在高岭石表面的吸附能大小顺序为EA>EAa.ema.经过Mulliken电荷和态密度分析,三种阳离子聚丙烯酰胺片段在高岭石(001)Si一O端面吸附主要为氢键。

关键词：阳离子聚丙烯酰胺片段高岭石表面氢键吸附机理 DFT

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A reappraisal of the relationship between metatarsus adductus and hallux valgus

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Chinese Medical Journal 2014年第11期127卷 2067-2072页

作者： Chen Li Wang Chen Wang Xu Huang Jiazhang Zhang Chao Zhang Yijun ma Xin Department of Orthopedics Huashan Hospital Fudan University Shanghai 200040 China

Background A causal link between the metatarsus adductus and hallux valgus is not *** aim of this study was to investigate the configurations of the metatarsus adductus deformity by radiological measurements and reappraise the relationship between hallux valgus and metatarsus *** The first step was evaluation of the relationship between metatarsus adductus and hallux valgus on 143 dorsoplantar weight-bearing radiographs diagnosed as hallux valgus which was also known as *** including the hallux valgus angle （HVA）,the intermetatarsal angle （Ima）,the Kilmartin angle （KA）,the tibial sesamoid position （TSP）,and metatarsus adductus angle were *** metatarsus adductus angle is defined by Sgarlato＇s angle （Sma） and Engel＇s angle （ema） *** The metatarsus adductus angle positively correlates with the HVA （r=0.590,P=0.000） and KA （r=0.601,P=0.000）,yet negatively correlates with the grade of TSP,（r=-0.348,P=0.000）.Contradiction of diagnosis existed in 22 （22/100） subjects diagnosed as metatarsus adductus by Sma yet normal by *** this group,the correlation between HVA and metatarsus adductus angle was negative （r=-0.472,P=0.027）.Conclusions ema and Sma defined metatarsus adductus by different deformity *** adductus configurations in that the apex of the deformity lay in either the base of metatarsals or *** respectively correlate positively or negatively to the HVA.

关键词： metatarsus adductus hallux valgus sesamoid bones radiological measurements

Dependence of electromagnetic wave absorption properties on the topography of Ni anchoring on reduced graphene oxide

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Chinese Chemical Letters 2021年第2期32卷 870-874页

作者： Luyang Liang Zhaoyang Li Zhongyi Bai Yuezhan Feng Xiaoqin Guo Jianmin ma Chuntai Liu Key Laboratory of Advancedεmaterials Processing Mold Ministry of EducationNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China Henan Key Laboratory of Aeronautical materials and Application Technology School of Material Science and EngineeringZhengzhou University of AeronauticsZhengzhou 450046China Key Laboratory for Micro-/Nano-Optoelectronic Devices Ministry of EducationSchool of Physics and ElectronicsHunan UniversityChangsha 410022China

Specific topographic Ni anchoring on reduced graphene oxide(rGO) composites show an astronomical potential as effective wave absorbers due to the synergistic electromagnetic loss ***,Ni/rGO composites with different topography were successfully prepared via hydrothermal in-situ reduction *** structure and morphology characteristics revealed that particle-like,chain-like,coin-like and flower-like Ni were closely anchored onto rGO,*** electromagnetic wave absorption(ema) performance revealed that chain-like Ni/rGO exhibited the optimal reflection loss of-43.7 dB with a thickness of 1.8 mm as well as the EAB of 6.1 GHz at 2.0 mm among all samples due to the good impedance match and the synergistic dielectric and magnetic ***,one conclusion can be drawn that excellent magnetic coupling effect and impedance matching were the main reasons for significantly improving the ema *** the systematic dependence of morphology on ema,this work provides a perspective for designing high-performance absorbing materials.

关键词： Ni/rGO Morphology structure magnetic coupling effect Synergistic effect Electromagnetic wave absorption

聚乙醇酸材料的加工改性及其水下降解特性的研究进展

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中国塑料 2022年第9期36卷 74-84页

作者：马超马兰荣魏辽尹慧博林祥北京科技大学化学与生物工程学院北京100083 中国石化石油工程技术研究院有限公司北京102206

从具有广阔应用前景的聚乙醇酸(PGA)材料的物性、加工改性及应用等方面概括了PGA的基本改性原理、改性方法以及加工过程中需要注意的问题;从增韧、增强、增塑、增容等角度,阐述了不同助剂,如增容剂、扩链剂及增塑剂等对PGA材料的改性机... 详细信息

从具有广阔应用前景的聚乙醇酸(PGA)材料的物性、加工改性及应用等方面概括了PGA的基本改性原理、改性方法以及加工过程中需要注意的问题;从增韧、增强、增塑、增容等角度,阐述了不同助剂,如增容剂、扩链剂及增塑剂等对PGA材料的改性机理,比较了不同增韧材料与PGA材料相容性及界面互溶增强技术;最终总结了PGA加工性能及使用性能的调控规律。

关键词：聚乙醇酸改性降解应用

Simultaneous removal of ammonia and N-nitrosamine precursors from high ammonia water by zeolite and powdered activated carbon

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Journal of Environmental Sciences 2018年第2期30卷 82-91页

作者： Runmiao Xue Ariel Donovan Haiting Zhang Yinfa ma Craig Adams John Yang Bin Hua Enos Inniss Todd Eichholz Honglan Shi Department of Chemistry and Environmental Research Center Missouri University of Science and Technology RoIIa MO 65409 USA Center for Single Nanoparticle Single Cell and Single Molecule Monitoring (CS3M) Missouri University of Science and Technology RollaMO 6S409 USA Department of Civil Engineering Saint Louis University St. Louis MO 63103 USA Department of Agriculture and Environmental Sciences Lincoln University of Missouri Jefferson City MO 65101 USA Department of Civil & Environmental Engineering University of Missouri-Columbia Columbia MO 65211 USA Missouri Department of Natural Resources Jefferson City MO 65102 USA

When adding sufficient chlorine to achieve breakpoint chlorination to source water containing high concentration of ammonia during drinking water treatment, high concentrations of disinfection by-products（DBPs） may form. If N-nitrosamine precursors are present, highly toxic N-nitrosamines, primarily N-nitrosodimethylamine（NDma）, may also form. Removing their precursors before disinfection should be a more effective way to minimize these DBPs formation. In this study, zeolites and activated carbon were examined for ammonia and N-nitrosamine precursor removal when incorporated into drinking water treatment *** test results indicate that Mordenite zeolite can remove ammonia and five of seven N-nitrosamine precursors efficiently by single step adsorption test. The practical applicability was evaluated by simulation of typical drinking water treatment processes using six-gang stirring system. The Mordenite zeolite was applied at the steps of lime softening, alum coagulation, and alum coagulation with powdered activated carbon（PAC） sorption. While the lime softening process resulted in poor zeolite performance, alum coagulation did not impact ammonia and N-nitrosamine precursor removal. During alum coagulation, more than67% ammonia and 70%–100% N-nitrosamine precursors were removed by Mordenite zeolite（except 3-（dimethylaminomethyl）indole（DmaI） and 4-dimethylaminoantipyrine（DmaP））. PAC effectively removed DmaI and DmaP when added during alum coagulation. A combination of the zeolite and PAC selected efficiently removed ammonia and all tested seven N-nitrosamine precursors（dimethylamine（Dma）, ethylmethylamine（ema）, diethylamine（DEA）, dipropylamine（DPA）, trimethylamine（Tma）, DmaP, and DmaI） during the alum coagulation process.

关键词： Disinfection by-products Drinking water treatment Ammonia removal by zeolite N-nitrosodimethylamine(NDma) N-nitrosamines N-nitrosamine precursor removal by zeolite and powdered activated carbon

欧盟发布克唑替尼儿童用药患者视觉异常风险的致医生函

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中国药物警戒 2023年第6期20卷 720-720页

作者：欧洲药品管理局ema网站

欧洲药品管理局(ema)近期发布上市许可持有人(Pfizer Europe ma EEIG)就克唑替尼(crizotinib,商品名:赛可瑞/XALKORI)儿童用药患者视觉异常风险的致医生函(DHPC),警示克唑替尼可造成严重的视觉丧失,儿童患者使用克唑替尼需监测视觉情况... 详细信息

欧洲药品管理局(ema)近期发布上市许可持有人(Pfizer Europe ma EEIG)就克唑替尼(crizotinib,商品名:赛可瑞/XALKORI)儿童用药患者视觉异常风险的致医生函(DHPC),警示克唑替尼可造成严重的视觉丧失,儿童患者使用克唑替尼需监测视觉情况。主要内容如下:概要视觉异常是克唑替尼的已知风险。在克唑替尼临床试验中。

关键词：克唑替尼视觉异常儿童用药 Pfizer 欧洲药品管理局临床试验儿童患者上市许可持有人

sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/ema as a supplementary diagnostic indicator

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Cancer Biology & Medicine 2021年第2期18卷 477-489页

作者： Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu Department of Breast Cancer Pathology and Research Laboratory Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationBreast Cancer Innovation Team of the Ministry of EducationState Key Laboratory of Breast Cancer ResearchTianjin 300060China

Objective: Mucin 1(MUC1/ema) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/ema and sLe^(x) and to assess their diagnostic and prognostic value in patients with ***: The expression of sLe^(x) and MUC1/ema in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence ***: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/ema in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/ema, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/ema-expression patterns, and 8 patients had sLe^(x)-/ema+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/ema and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS ***: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/ema as a complementary diagnostic indicator to avoid missed IMPC diagnosis.

关键词： Invasive micropapillary carcinoma polarity reversal diagnostic indicator ema sLe^(x)