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Head-to-head comparison of PSma PET/CT and mpMRI for detecting biochemical recurrence of prostate cancer: A systematic review and meta-analysis

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Current Urology 2024年第3期18卷 177-184页

作者： Xinru Zhang zhe ma Department of Ultrasound The First Affiliated Hospital of Shandong First Medical UniversityJinanChina

Objectives This study aimed to evaluate the performance of prostate-specific membrane antigen positron emission tomography/computed tomography(PSma PET/CT)in comparison to multiparametric magnetic resonance imaging(mpMRI)for detecting biochemical recurrence of prostate cancer(PCa).materials and methods We conducted a comprehensive search for articles published in PubMed,Web of Science,Embase,and the Cochrane Library,spanning the inception of the database until October 26,2022,which included head-to-head comparisons of PSma PET/CT and mpMRI for assessing the biochemical recurrence of *** A total of 5 studies including 228 patients were *** overall positivity rates of PSma PET/CT and mpMRI for detecting biochemical recurrence of PCa after final treatment were 0.68(95%confidence interval[CI],0.52–0.89)and 0.56(95%CI,0.36–0.88),*** positivity rates of PSma PET/CT and mpMRI for detecting local recurrence,lymph node metastasis,and bone metastases were 0.37(95%CI,0.30–0.47)and 0.38(95%CI,0.22–0.67),0.44(95%CI,0.35–0.56)and 0.25(95%CI,0.17–0.35),and 0.19(95%CI,0.11–0.31)and 0.12(95%CI,0.05–0.25),*** with mpMRI,PSma PET/CT exhibited a higher positivity rate for detecting biochemical recurrence and lymph node metastases,and no significant difference in the positivity rate of local recurrence was observed between these 2 imaging *** Compared with mpMRI,PSma PET/CT appears to have a higher positivity rate for detecting biochemical recurrence of *** both imaging methods showed similar positivity rates of detecting local recurrence,PSma PET/CT outperformed PSma PET/CT in detecting lymph node involvement and overall recurrence.

关键词： Prostate-specific membrane antigen Positron emission tomography/computed tomography Multiparametric magnetic resonance imaging Prostate cancer Biochemical recurrence Positive rate

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Synthesis,Characterization of Polyethylene Ionomers and Their Antibacterial Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1077-1084页

作者： Jia-Jia Wu Fei Wang Peng-Qi Wan Li Pan Chun-Sheng Xiao zhe ma Yue-Sheng Li Tianjin Key Lab Composite&Functional materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Key Lab Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Owing to its high production volume and wide range of application s,polyethylene has gained a great deal of attention,but its low surface energy and non-polar nature have limited its application in some important *** this study,ethylene/11-iodo-1-undecene copolymers were prepared and used as the intermediates to afford a series of imidazolium-based ionomers bearing methanesulfonate(CH_(3)SO_(3)^(-)),trifluoromethanesulfonate(CF_(3)SO_(3)^(-)),or bis(trifluoromethane)sulfonimide(Tf_(2)N^(-))*** tensile test results showed that the stress-at-break(7.8-25.6 MPa)and the elongation-at-break(445%-847%)of the ionomers could be adjusted by changing the counterion species and the ionic group *** importantly,the ionomers exhibited marvelous antibacterial activities against Staphylococcus aureus(***)and Escherichia coli(***).The ionomers bearing Tf_(2)N^(-)exhibited antibacterial activities>99%against both *** and *** when ionic content reached 9.1%.The imidazolium-based ionomers prepared in this work demonstrated excellent comprehensive properties,especially highefficient and broad-spectrum antibacterial ability,exhibiting the potential fo r the application as the antibacterial materials in packaging,medical,and other fields.

关键词： Polyethylene Ionomer Polymerization catalysis Imidazolium Antibacterial material

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Genomic alterations in oral multiple primary cancers

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International Journal of Oral Science 2024年第1期16卷 145-153页

作者： Wen Wang Qian Wang Shiying Sun Pengfei Zhang Yuyu Li Weimin Lin Qiwen Li Xiao Zhang zhe ma Haiyan Lu Hebei Key Laboratory of Stomatology Hebei Clinical Research Center for Oral DiseasesHebei Medical UniversityShijiazhuangChina Department of Orthodontics School and Hospital of StomatologyHebei Medical UniversityShijiazhuangChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Preventive Dentistry School and Hospital of StomatologyHebei Medical UniversityShijiazhuangHebeiChina

Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n=202) and oral MPCs (n=34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis. Whole-exome sequencing was employed to identify potential unique gene mutations in oral MPCs patients. Additionally, CNA and phylogenetic tree analyses were used to gain preliminary insights into the molecular characteristics of different primary tumors within individual patients. Our findings revealed that, in contrast to oral SPC, females predominated the oral MPCs (70.59%), while smoking and alcohol use were not frequent in ***, long-term survival outcomes were poorer in oral MPCs. From a CNA perspective, no significant differences were observed between oral MPCs patients and those with recurrence and lymph node metastasis. In addition to commonly mutated genes such as CASP8, TP53 and MUC16, in oral MPCs we also detected relatively rare mutations, such as HS3ST6 and RFPL4A. Furthermore, this study also demonstrated that most MPCs patients exhibited similarities in certain genomic regions within individuals, and distinct differences of the similarity degree were observed between synchronous and metachronous oral MPCs.

关键词： alterations metastasis oral

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Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer

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当代医学科学（英文） 2024年第4期44卷 833-840页

作者： Jun-he CHEN Cheng-ming WEI Qian-yu LIN Zi WANG Fu-ming ZHANG Mei-na SHI Wen-jian LAN Chang-gang SUN Wan-jun LIN Wen-zhe ma State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and TechnologyMacau 999078China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Traditional Chinese Medicine Weifang Medical UniversityWeifang 261053China

Objective:Colorectal cancer(CRC),a prevalent malignancy worldwide,has prompted extensive research into anticanccr *** Chinese medicinal materials offer promising avenues for cancer management due to their diverse pharmacological *** study investigated the effects of Notopterygium incisum,a traditional Chinese medicine named Qianghuo(QH),on CRC cells and the underlying ***:The sulforhodamine B assay and colony formation assay were employed to assess the effect of QH extract on the proliferation of CRC cell lines HCT116 and *** iodide(PI)staining was utilized to detect cell cycle progression,and PE Annexin V staining to detect *** blotting was conducted to examine the levels of apoptotic proteins,including B-cell lymphoma 2-interacting mediator of cell death(BIM),B-cell lymphoma 2(Bcl-2),Bcl-2-associated X protein(BAX)and cleaved caspase-3,as well as BIM stability after treatment with the protein synthesis inhibitor *** expression of BAX was suppressed using lentivirus-mediated shRNA to validate the involvement of the BIM/BAX axis in QH-induced *** in vivo effects of QH extract on tumor growth were observed using a xenograft ***,APCMin+mice were used to study the effects of QH extract on primary intestinal ***:QH extract exhibited significant in vitro anti-CRC activities evidenced by the inhibition of cell proliferation,perturbation of cell cycle progression,and induction of ***,QH extract significantly increased the stability of BIM proteins,which undergo rapid degradation under unstressed *** of BAX,the downstream effector of BIM,significantly rescued QH-induced ***,the in vitro effect of QH extract was recapitulated in *** extract significantly inhibited the tumor growth of HCT116 xenografts in nude mice and decreased the number of intestinal polyps in the APCMin+***:QH extract promot

关键词： Notopterygium incisum B-cell lymphoma 2-interacting mediator of cell death apoptosis colorectal cancer

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玻璃纤维板阵列增多层吸波复合结构

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Journal of Central South University 2024年第2期31卷 384-398页

作者：麻晢乂培黎嘉乐姜超 Powder Metallurgy Research Institute Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

本文将电路模拟吸波阵列与玻璃纤维介质板(FEPL)阵列结合,采用真空热压成型工艺制备了一种具有超宽带强吸波性能的多层复合结构。整个FEPL阵列复合结构的表面密度约为2.4 kg/m^(2),厚度约为10.0 mm。仿真和测量结果均表明,FEPL阵列可以... 详细信息

本文将电路模拟吸波阵列与玻璃纤维介质板(FEPL)阵列结合,采用真空热压成型工艺制备了一种具有超宽带强吸波性能的多层复合结构。整个FEPL阵列复合结构的表面密度约为2.4 kg/m^(2),厚度约为10.0 mm。仿真和测量结果均表明,FEPL阵列可以明显改善吸波结构的斜入射角的稳定性,提高电磁吸收率,拓宽吸收带宽。在斜入射角40°~60°范围内,FEPL阵列显著提高了吸波复合结构的吸收性能,同时将相对带宽(FBW)拓宽了约9.1%;此外,它还将复合吸波结构正入射角的平均反射系数从−14.4 dB降低到了−25.7 dB,降低了约11.3 dB。本文所提出的玻璃纤维板阵列增多层吸波复合结构性能优异,制备工艺简单,适合实际工程应用。

关键词：超宽带微波吸收复合材料玻璃纤维板阵列电路模拟吸波体

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论作为分离财产的企业财产:“家企隔离”的理论基础

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中国政法大学学报 2024年第4期 71-87页

作者：马哲澳门大学法学院中国澳门

《促进民营经济发展壮大的意见》中提出,要“依法推动实现企业法人财产与出资人个人或家族财产分离,明晰企业产权结构”。为实现这一“家企隔离”目标,需首先反思企业财产作为独立财产的法律性质,这是隔离债务承担财产的理论基础。本文... 详细信息

《促进民营经济发展壮大的意见》中提出,要“依法推动实现企业法人财产与出资人个人或家族财产分离,明晰企业产权结构”。为实现这一“家企隔离”目标,需首先反思企业财产作为独立财产的法律性质,这是隔离债务承担财产的理论基础。本文认为,无论投资者是否选择法人形式,企业财产都具有独立性,只是不同情况下的独立程度有别而已。当涉及企业法人时,原则上投资人或代理人毋须为法人所负债务负责,这在我国立法上已经获得确认,唯其实践效果仍需提升;另一方面,应对未设立企业法人的情况做出立法上的回应,如果企业财产仍然充足,也不应执行企业主的个人和家庭财产(反之亦然)。由此鼓励企业家的创新和创业精神,促进民营经济高质发展。

关键词：企业财产分离财产责任财产资产分割民营经济

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Büchi自动机确定化分析工具

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软件学报 2024年第9期35卷 4310-4323页

作者：马润哲田聪王文胜段振华西安电子科技大学计算机科学与技术学院陕西西安710071

无限字自动机的确定化是理论计算机研究重要的一部分,在形式化验证,时序逻辑,模型检测等方面有重要应用.自Büchi自动机提出半个世纪以来,其自动机的确定化算法始终是其中的基础.有别于当初只是在理论上对其大小上下界的探索,利用日新... 详细信息

无限字自动机的确定化是理论计算机研究重要的一部分,在形式化验证,时序逻辑,模型检测等方面有重要应用.自Büchi自动机提出半个世纪以来,其自动机的确定化算法始终是其中的基础.有别于当初只是在理论上对其大小上下界的探索,利用日新月异的高性能计算机技术不失为一种有效的辅助手段.为了深入研究非确定性Büchi自动机确定化算法的实现过程,希望重点研究确定化过程中的索引能否继续被优化的问题,实现确定化研究工具NB2DR.可以对非确定性Büchi自动机进行高效的确定化,并通过工具提供的分析其确定化过程来达到对其确定化算法改进的目的.通过对生成的确定性无限字自动机的索引的深入分析来探索相关索引的理论.该工具还实现了可以根据需要的Büchi自动机的大小与字母表参数,生成确定化的Rabin自动机族,亦可以反向根据需要的指定索引的大小来生成全部Büchi自动机族,测试生成无限字自动机的等价性等功能.

关键词： Büchi自动机 Rabin自动机无限字自动机确定化

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CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

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International Journal of Oral Science 2024年第1期16卷 134-144页

作者： Xuan Zhou Xinjia Cai Fengyang Jing Xuefen Li Jianyun Zhang Heyu Zhang Tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina

Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force ***, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages. Compression upregulated CD97 expression and inhibited osteoclast differentiation;while knockdown of CD97 partially rescued osteoclast differentiation. It suggests that CD97 may be an important mechanosensitive receptor during osteoclast differentiation. RNA sequencing analysis showed that the Rap1a/ERK signalling pathway mediates the effects of CD97 on osteoclast differentiation under compression. Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating tooth movement. In conclusion,our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pathway under orthodontic compressive force.

关键词： CD97 osteoclast inhibited

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双层超表面互补增强宽频广角复合吸波体

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电子学报 2024年第8期52卷 2668-2678页

作者：麻晢乂培姜超刘妍琼黎嘉乐中南大学粉末冶金研究院湖南长沙410083 粉末冶金国家重点实验室湖南长沙410083

本文提出了一种基于双层超表面的多层复合吸波体的设计方法,设计的吸波体包含两层核心超表面功能层、顶层吸收增强蒙皮和数层支撑介质层,两层超表面Ⅰ和Ⅱ的结构单元分别为加载贴片电阻的异形金属片和加载贴片电阻的六边形金属环,蒙皮... 详细信息

本文提出了一种基于双层超表面的多层复合吸波体的设计方法,设计的吸波体包含两层核心超表面功能层、顶层吸收增强蒙皮和数层支撑介质层,两层超表面Ⅰ和Ⅱ的结构单元分别为加载贴片电阻的异形金属片和加载贴片电阻的六边形金属环,蒙皮为玻璃纤维层压板,支撑介质为PMI泡沫.仿真结果表明,反射系数低于-10 dB的吸波频带覆盖范围为2.80~23.64 GHz,低于-20 dB的吸波频带覆盖范围为3.56~22.56 GHz.测试结果表明,反射系数低于-10 dB的频带为2.36~23.87 GHz;-20 dB吸波频带为3.17~23.16 GHz.仿真和测试所得反射系数曲线具有良好的一致性,验证了该设计方法的有效性.仿真和测试结果表明,50°斜入射的-10 dB反射系数频带与垂直入射时基本保持一致,起始和终止频率的偏移量小于0.8 GHz;进一步地,斜入射角为60°时,反射系数低于-10 dB的相对带宽最大可达141.8%,表明本研究所设计的复合吸波体具有宽角域入射稳定特性.此外,本文研究了该复合吸波体宽频广角强吸收的相关机理以及主要结构参数对吸波性能的影响,结果表明顶层蒙皮在超宽带范围内可提升吸波率0.2(1.0代表100%吸波),两层超表面吸波频带的互补增强设计能够明显改善其斜入射角度稳定性.

关键词：吸波体超表面多层结构超宽带斜入射

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新世纪儿童科幻小说男性向创作的缺憾

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兰州文理学院学报（社会科学版） 2024年第1期40卷 71-77页

作者：马皓哲西北师范大学文学院甘肃兰州730070

儿童科幻小说近年来发展势头看好。基于儿童科幻小说发展大背景,在女性主义视域下对男性向创作的缺憾进行分析研究。从创作者、主角到受众,讨论儿童科幻小说创作的男性权力话语。新世纪儿童科幻小说女性作家群人数稀少但是有较强的独特... 详细信息

儿童科幻小说近年来发展势头看好。基于儿童科幻小说发展大背景,在女性主义视域下对男性向创作的缺憾进行分析研究。从创作者、主角到受众,讨论儿童科幻小说创作的男性权力话语。新世纪儿童科幻小说女性作家群人数稀少但是有较强的独特性,属于作家群中的独特分支,男性作者在其潜意识的表达中呈现出对女性的忽视。总体而言女性在儿童科幻小说中形象单一、数量偏少,儿童科幻小说的作家群与形象群仍然存在着一片尚未开发完全的女性高地。

关键词：儿童文学科幻文学女性主义新世纪权力话语

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