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Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease

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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira Saeed Linlin ma Griffith Institute for Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment and Science Griffith University NathanBrisbaneQLDAustralia

Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.

关键词： homeostasis clinical subsequent

Harnessing therapeutic potential of induced pluripotent stem cell–derived endothelial cells for remyelination in the central nervous system

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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： Dan ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged myelin sheaths(remyelination) often fails in MS, leading to neuronal loss and irreversible functional deficits.

关键词： myelin protective diseases

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基于熵权聚类的国内空铁综合枢纽分类方法

交通运输研究 2021年第3期7卷 82-89页

作者：严琛朱金福马睿馨彭安娜南京航空航天大学民航学院江苏南京211106

为探究城市社会经济发展水平与所属空铁枢纽类别之间的关系,以332个城市节点为研究对象,建立城市空铁综合枢纽类别的评价指标体系。分别采用熵值法加权的K-means聚类算法以及模糊C均值聚类算法对样本点枢纽类别进行划分,得出5种具有典... 详细信息

为探究城市社会经济发展水平与所属空铁枢纽类别之间的关系,以332个城市节点为研究对象,建立城市空铁综合枢纽类别的评价指标体系。分别采用熵值法加权的K-means聚类算法以及模糊C均值聚类算法对样本点枢纽类别进行划分,得出5种具有典型特征的枢纽类别划分结果。从区域和城市的角度进行对比分析,结果显示:K-means算法的分类较为严格,模糊C均值算法的分类更能识别出潜在枢纽;两种分类结果均呈现出国内东南沿海地区城市空铁综合枢纽等级较高、密度较大,而中西部地区城市空铁综合枢纽等级较低、较为分散的特点;单个城市节点虽受制于其社会经济发展水平、地理环境等,总体上其所属枢纽类别仍较为准确。两种分类方法分别在现实性和前瞻性的角度上合理。

关键词：城市交通空铁综合枢纽熵权 K-means聚类模糊聚类

Synthesis of novel 15-membered macrolide dimers

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Chinese Chemical Letters 2009年第8期20卷 931-934页

作者： Shu Tao ma rui xin ma rui Qing Xian Bo Jiao School of Pharmaceutical Sciences Shandong University Jinan 250012 China Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China Shandong Institute for Drug Control Jinan 250000 China

A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against erythromycin-resistant S. pneumoniae encoded by erm gene. ？2009 Shu Tao ma. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

关键词： macrolide Azithromycin derivatives D/mers Synthesis

magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang ma Qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng Dong He Qiang Sun Xuhang ma Francesco Lamberti Zhubing He Department of materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DmacPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide magnetron sputter Defect Stability Perovskite solar cell

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

Towards direct superlubricity and superlow wear via amino modification of polyhydroxy alcohol solutions

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Friction 2024年第9期12卷 1980-1990页

作者： Qiang ma Chengpeng YAN rui YAN xin XU Haifeng WANG State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi'an 710072China Chongqing Innovation Center Northwestern Polytechnical UniversityChongqing 401135China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China

Friction remains as the primary mode of energy dissipation and components wear,and achieving superlubricity shows high promise in energy conservation and lifetime wear *** results in this work demonstrate that direct superlubricity combined with superlow wear can be realized for steel/Si_(3)N_(4)contacts on engineering scale when polyhydroxy alcohol solution was selectively modified by amino *** direct superlubricity occurs because 3-amino-1,2-propanediol molecules at the friction interface could be induced to rotate and adsorb vertically on the friction surface,forming in-situ thick and dense molecular films to passivate the asperity ***,amino modification is also conducive to improving the lubrication state from boundary to mixed lubrication regime by strengthening the intermolecular hydrogen bonding interaction,presenting enhanced load-bearing capability and reduced direct solid asperity ***,direct superlow average friction of 0.01 combined with superlow wear are achieved *** design principle of direct superlubricity and superlow wear in this work indeed offers an effective strategy to fundamentally improve energy efficiency and provide lifetime wear protection for moving mechanical assemblies.

关键词： direct superlubricity amino modification molecular layer superlow wear

厄贝沙坦与美托洛尔的联合方案对男性高血压患者性功能的影响

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中华心血管病杂志 2011年第7期39卷 636-641页

作者：杨陇权余静马瑞新刘培君郭雪娅李秀丽常鹏胡浩赵锋白锋兰州大学第二医院心血管内科 730030

目的探讨非洛地平联合厄贝沙坦或美托洛尔两种降压方案对男性高血压病患者性功能的影响.方法 123例高血压病患者随机分为两组：非洛地平（5 mg/d）＋厄贝沙坦（150 mg/d）组（F＋I组,64例）;非洛地平（5 mg/d）＋琥珀酸美托洛尔（47.5 ... 详细信息

目的探讨非洛地平联合厄贝沙坦或美托洛尔两种降压方案对男性高血压病患者性功能的影响.方法 123例高血压病患者随机分为两组：非洛地平（5 mg/d）＋厄贝沙坦（150 mg/d）组（F＋I组,64例）;非洛地平（5 mg/d）＋琥珀酸美托洛尔（47.5 mg/d）组（F＋M组,59例）.监测患者血压变化;治疗第0、24周用国际男性性功能问卷（IIEF）评价患者的性功能,同时用放射性免疫法测血清睾酮和性激素结合蛋白、硫代巴比妥酸法测丙二醛、ELISA 法测8-羟基脱氧鸟苷和4-羟基壬烯酸.结果 F＋I组治疗后性欲积分值增高（P〈0.05）,轻度勃起功能障碍患者的勃起功能评分增加;勃起功能障碍患者8-羟基脱氧鸟苷治疗前、后分别为（146.02±60.54）ng/L比（139.89±62.03）ng/L,丙二醛治疗前、后分别为（6.59±1.75）μmol/L比（6.01±1.65）μmol/L,治疗前后比较差异有统计学意义（P〈0.05）.两组治疗前后血压达标率、有效率、勃起功能障碍的发生率、睾酮、性激素结合蛋白、4-羟基壬烯酸差异均无统计学意义（P〉0.05）.结论相对于F＋M组,F＋I组可能更有益于男性高血压病患者性功能,但这种获益是否与该组治疗后患者氧化应激状态的改变有关。

关键词：高血压性功能障碍药物疗法

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渔用配合饲料中左旋肉碱含量的测定

河北渔业 2020年第5期 38-41,61页

作者：马瑞欣李同庆张志华河北省水产技术推广总站河北省水产品质量检验监测站河北石家庄050035

建立了亲水作用色谱-串联质谱法(HILIC-MS/MS)检测渔用配合饲料中左旋肉碱含量的方法。样品用超纯水超声提取,提取液稀释后经HILIC色谱柱分离,以乙腈和乙酸铵(含0.15%甲酸)溶液为流动相梯度洗脱,三重四级杆串联质谱多反应监测(MRM)方式... 详细信息

建立了亲水作用色谱-串联质谱法(HILIC-MS/MS)检测渔用配合饲料中左旋肉碱含量的方法。样品用超纯水超声提取,提取液稀释后经HILIC色谱柱分离,以乙腈和乙酸铵(含0.15%甲酸)溶液为流动相梯度洗脱,三重四级杆串联质谱多反应监测(MRM)方式扫描,外标法定量。结果表明,左旋肉碱在0.2~100 ng/mL范围线性良好(r>0.999);检出限0.5μg/kg,定量限1.5μg/kg。在20、50和100 mg/kg添加水平下,回收率为75.2%~111%,相对标准偏差RSD为3.4%~9.9%(n=6)。该方法前处理简单、快速,定性定量准确,适合于渔用配合饲料中左旋肉碱的准确定性定量。

关键词：亲水作用色谱-串联质谱左旋肉碱渔用配合饲料