检索结果-南通市图书馆

Effect of Mn addition on microstructure and mechanical properties of GX40CrNiSi25-12 austenitic heat resistant steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Foundry 2024年第3期21卷 205-212页

作者： Guan-yu Jiang Meng-wu Wu xiao-guang Yang Hui Wang Yu-yuan Zhu Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina Wescast Industries(China)Co. Ltd.Wuhan 430100China

Three types of steels were designed on the basis of GX40CrNiSi25-12 austenitic heat resistant steel by adding different Mn contents(2wt.%,6wt.%,and 12wt.%).Thermodynamic calculation,microstructure characterization and mechanical property tests were conducted to investigate the effect of Mn addition on the microstructure and mechanical properties of the austenitic heat resistant *** show that the matrix structure in all the three types of steels at room temperature is completely *** NbC and M_(23)C_(6)precipitate at grain boundaries of austenite *** the increase of Mn content,the number of carbides increases and their distribution becomes more *** the Mn content increases from 1.99%to 12.06%,the ultimate tensile strength,yield strength and elongation increase by 14.6%,8.0%and 46.3%,*** improvement of the mechanical properties of austenitic steels can be explained by utilizing classic theories of alloy strengthening,including solid solution strengthening,precipitation strengthening,and grain *** increase in alloy strength can be attributed to solid solution strengthening and precipitation strengthening caused by the addition of *** improvement of the plasticity of austenitic steels can be explained from two aspects:grain refinement and homogenization of precipitated phases.

关键词： austenitic heat resistant steel manganese microstructure mechanical properties

Investigating the Mechanism of Qu Du Qiang Fei 1 Hao Fang Formula against Coronavirus Disease 2019 Based on Network Pharmacology Method

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2024年第1期10卷 93-103页

作者： yuan-Hua Wang He-Yang Zhou Jin-Yun ma Gui-Qing Ding Hua Yu Yong-Sheng Jin xiao-Dong Cheng Institute of Clinical Immunology Yue-Yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Pharmacy Naval Medical UniversityShanghaiChina

Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain *** objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 *** and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking ***:In total,288 effective QDQF1 ingredients were *** identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related *** key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network *** functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling *** central targets(CCL2,CXCL8,IL1B,IL6,maPK1,maPK3,maPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment ***,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to ***:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.

关键词： Coronavirus disease 2019 molecular docking molecular mechanism network pharmacology Qu Du Qiang Fei 1 Hao Fang formula

Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing Qian Jun-Feng Li Wan-yuan Xiong xiao-Rong mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue xiao Yan-wei ma Jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and ***:HaCaT cells were treated with *** proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration *** mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,***_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with *** expression of circ_0084443 was detected by ***:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

Systematic bibliometric analysis of research hotspots and trends on the application of premium IOLs in the past 2 decades

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第4期17卷 736-747页

作者： Liang-Pin Li Li-Yun yuan De-Shen mao Xia Hua xiao-Yong yuan Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China School of Medicine Nankai UniversityTianjin 300071China Anhui Medical University Hefei 230032Anhui ProvinceChina Tianjin Aier Eye Hospital Tianjin UniversityTianjin 300190China

AIM:To analysis of research hotspots and trends on the application of premium intraocular lens(PIOLs)in the past 2 ***:The literature search was performed on the Web of Science and included PIOLs studies published between January 2000 and December *** retrieved literature was collated and analyzed by R-tool’s Bibliometrix package,CitNetExplorer,CiteSpace and other ***:A total of 1801 articles about PIOLs were obtained,most of which were published in Spain and the United *** organization that published the most articles was the University of Valencia in ***ó JL,and Montés-Micó R,from Spain were the most influential authors in this *** Journal of Cataract and Refractive Surgery and Journal of Refractive Surgery were the core journals for this field;the top 10 cited articles mainly focus on postoperative satisfaction with multifocal intraocular lens(IOLs)and postoperative results of toric *** the keyword analysis,we found that trifocal IOLs,astigmatism and extended depth of focus(EDoF)IOLs are the most discussed topics at present,and the importance of astigmatism and the clinical application of the new generation of PIOLs are the emerging research ***:Bibliometric analysis can effectively help to identify multilevel concerns in PIOLs research and the prevailing research trends in the realm of PIOLs encompass the adoption of EDoF IOLs,trifocal IOLs,and their respective Toric models.

关键词： premium intraocular lens bibliometric H-index cataract surgery global trends

Evaluating effectiveness and safety of combined percutaneous transhepatic gallbladder drainage and laparoscopic cholecystectomy in acute cholecystitis patients:Meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1407-1419页

作者： Yu Li Wei-Ke xiao xiao-Jun Li Hui-yuan Dong Department of General Surgery No.942 Hospital of PLAYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Acute cholecystitis(AC)is a common disease in general *** cholecystectomy(LC)is widely recognized as the"gold standard"surgical procedure for treating *** low-risk patients without complications,LC is the recommended treatment plan,but there is still controversy regarding the treatment strategy for moderate AC patients,which relies more on the surgeon's experience and the medical platform of the visiting *** transhepatic gallbladder puncture drainage(PTGBD)can effectively alleviate gallbladder inflammation,reduce gallbladder wall edema and adhesion around the gallbladder,and create a"time window"for elective *** To compare the clinical efficacy and safety of LC or PTGBD combined with LC for treating AC patients,providing a theoretical basis for choosing reasonable surgical methods for AC *** In this study,we conducted a clinical investigation regarding the combined use of PTGBD tubes for the treatment of gastric cancer patients with *** performed searches in the following databases:PubMed,Web of Science,EMBASE,Cochrane Library,China National Knowledge Infrastructure,and Wanfang *** search encompassed literature published from the inception of these databases to the ***,relevant data were extracted,and a meta-analysis was conducted using Revman 5.3 *** A comprehensive analysis was conducted,encompassing 24 studies involving a total of 2564 *** patients were categorized into two groups:1371 in the LC group and 1193 in the PTGBD+LC *** outcomes of the meta-analysis revealed noteworthy disparities between the PTGBD+LC group and the LC group in multiple dimensions:(1)Operative time:Mean difference(MD)=17.51,95%CI:9.53-25.49,P<0.01;(2)Conversion to open surgery rate:Odds ratio(OR)=2.95,95%CI:1.90-4.58,P<0.01;(3)Intraoperative bleeding loss:MD=32.27,95%CI:23.03-41.50,P<0.01;(4)Postoperative hospital stay:MD=1.44,95%CI:0.14-2.73,P=0.03;(5)Overall posto

关键词： Acute cholecystitis Laparoscopic cholecystectomy Percutaneous transhepatic gallbladder drainage Metaanalysis Efficacy

Bubble dynamics properties of B-particles in a quasi-2D gas-solid fluidized bed:Computational particle fluid dynamics numerical simulation and post-processed by digital image analysis technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第3期86卷 223-238页

作者： Zemin yuan Zhong Huang Guotao Qin Guanjia Zhao Suxia ma Hairui Yang Guangxi Yue Key Laboratory of Clean and Efficient Combustion and Utilization in the Circulating Fluidized Bed Taiyuan University ofTechnologyTaiyuan030024China Department of Energy and Power Engineering Tsinghua UniversityBeijing100084.China

Bubble dynamics properties play a crucial and significant role in the design and optimization of gas-solid fluidized *** this study,the bubble dynamics properties of four B-particles were investigated in a quasi-two-dimensional(quasi-2D)fluidized bed,including bubble equivalent diameter,bubble size distribution,average bubble density,bubble aspect ratio,bubble hold-up,bed expansion ratio,bubble radial position,and bubble *** studies were performed by computational particle fluid dynamics(CPFD)numerical simulation and post-processed with digital image analysis(DIA)technique,at superficial gas velocities ranging from 2u_(mf) to 7u_(mf).The simulated results shown that the CPFD simulation combining with DIA technique post-processing could be used as a reliable method for simulating bubble dynamics properties in quasi-2D gas-solid fluidized ***,it seemed not desirable for the simulation of bubble motion near the air distributor at higher superficial gas velocity from the simulated average bubble density *** superficial gas velocity significantly affected the bubble equivalent diameter and evolution,while it had little influence on bubble size distribution and bubble aspect ratio distribution for the same *** time-averaged bubble hold-up and bed expansion ratio increased with the increase of superficial gas *** core-annular flow structures could be found in the fluidized bed for all *** average bubble rising velocity increased with the increasing bubble equivalent *** bubble lateral movement,the smaller bubbles might be more susceptible,and superficial gas velocity had a little influence on the absolute lateral velocity of *** simulated results presented a valuable and novel approach for studying bubble dynamics *** comprehensive understanding of bubble dynamics behaviors in quasi-2D gas-solid fluidized beds would provide support in the design,operation,and optimization of gas-solid

关键词： Bubble dynamics properties CPFD simulation Quasi-2D gas-solid fluidized bed Digital image analysis

A Comprehensive Study of a Low-Grade Heat-Driven Cooling and Power System Based on Heat Current Method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第4期33卷 1523-1541页

作者： ZHAO Tian XU Ronghong XIN Yonglin HE Kelun ma Huan yuan Mengdi CHEN Qun School of Energy Storage Science and Engineering North China University of TechnologyBeijing100144China Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing100084China

Combined cooling and power(CCP)system driven by low-grade heat is promising for improving energy *** work proposes a CCP system that integrates a regenerative organic Rankine cycle(RORC)and an absorption chiller on both driving and cooling fluid *** system is modeled by using the heat current method to fully consider nonlinear heat transfer and heat-work conversion constraints and resolve its behavior *** off-design system simulation is performed next,showing that the fluid inlet temperatures and flow rates of cooling water as well as RORC working fluid strongly affect system *** off-design operation even becomes infeasible when parameters deviate from nominal values largely due to limited heat transfer capability of components,highlighting the importance of considering heat transfer constraints via heat current *** optimization aiming to minimize the total thermal conductance is also *** efficiency increases by 7.9%and decreases by 12.4%after optimization,with the hot fluid inlet temperature increase from 373.15 to 403.15 K and mass flow rate ranges from 10 to 30 kg/s,emphasizing the necessity of balancing system cost and performance.

关键词： combined cooling and power system organic Rankine cycle absorption chiller cascade heat utilization heat current method off-design analysis

Existence of long-range magnetic order in Heisenberg spin nanoribbons with edge modification

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第7期76卷 134-144页

作者： Da-cheng ma Ling-yi Cui Chu-xiao Sun xiao-dan Chi Zheng-Nan XianYu An Du College of Science Northeastern UniversityShenyang 110819China Department of Basic Science Dalian Naval AcademyDalian 116018China Department of Physics College of SciencesShenyang University of Chemical TechnologyShenyang 110142China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityChina Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of EducationChina

Long-range magnetic order appears on a side decorated Heisenberg spin nanoribbon at nonzero temperature,although no spontaneous magnetization exists in a one-or two-dimensional isotropic Heisenberg model at any nonzero temperature according to the Mermin-Wagner *** use of the spin Green's function method,we calculated the magnetizations of Heisenberg nanoribbons decorated by side spins with single-ion anisotropy and found that the system exhibits a nonzero transition temperature,whether the decorated edge spins of the system link together or separate from each *** the width of the nanoribbon achieves infinite limit,the transition temperatures of the system tend to the same finite constant eventually whether one edge or both edges are decorated by side spins in the *** results reveal that the magnetism of a low-dimensional spin system is different from that of a threedimensional spin *** the single-ion anisotropy of edge spins in a Heisenberg spin nanoribbon can be modulated by an electric field experimentally,various useful long-range magnetic orders of the system can be *** work can provide a detailed theoretical basis for designing and fabricating next-generation low-dimensional magnetic random-access memory.

关键词： Nanoribbon magnetic anisotropy long-range magnetic order Heisenberg model transition temperature