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Association between intercellular adhesion molecule-1 to depression and blood-brain barrier penetration in cerebellar vascular disease

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World Journal of Psychiatry 2024年第11期14卷 1661-1670页

作者： Ju-Luo Chen Rui Wang Pei-qi ma You-Meng Wang qi-qiang Tang Cheeloo College of Medicine Shandong UniversityJinan 250012Shandong ProvinceChina The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Neurology Fuyang People’s HospitalFuyang 236000Anhui ProvinceChina

BACKGROUND Cerebral small vessel disease(CSVD)is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease.A clear understanding of the underlying causes of CSVD remains *** To explore the association between intercellular adhesion molecule-1(ICAM-1)and blood-brain barrier(BBB)penetration in *** This study included patients admitted to Fuyang People’s Hospital and Fuyang Community(Anhui,China)between December 2021 and march *** study population comprised 142 patients,including 80 in the CSVD group and 62 in the control *** was present in 53 out of 80 patients with *** magnetic resonance imaging(MRI)and dynamic contrast-enhanced MRI were applied in patients to determine the brain volume,cortical thickness,and cortical area of each brain ***,neuropsychological tests including the Hamilton depression scale,mini-mental state examination,and Montreal cognitive assessment basic scores were *** The multivariable analysis showed that age[P=0.011;odds ratio(OR)=0.930,95%confidence interval(CI):0.880-0.983]and ICAM-1 levels(P=0.023;OR=1.007,95%CI:1.001-1.013)were associated with *** regions of interest(ROIs;ROI3 and ROI4)in the white matter showed significant(both Pmatter showed signi-ficant difference(P=0.046;95%CI:0.007-0.680)between the two ***-1 was significantly correlated(all Pmay be associated with cortical thickness in the brain,predominantly in the white matter,and a significant increase in BBB permeability,proposing the involvement of ICAM-1 in BBB destruction.

关键词： Cerebral small vessel disease Intercellular adhesion molecule-1 Blood-brain barrier penetration Cortical thickness White matter

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RNA interference in Colorado potato beetle(Leptinotarsa decemlineata): A potential strategy for pest control

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Journal of Integrative Agriculture 2020年第2期19卷 428-437页

作者： ma Mei-qi HE Wan-wan XU Shi-jing XU Le-tian ZHANG Jiang State Key Laboratory of Biocatalysis and Enzyme Engineering College of Life SciencesHubei University

Colorado potato beetle(CPB),Leptinotarsa decemlineata,is a notorious destructive pest that mainly feeds on the leaves of potato and several other solanaceous *** is widely recognized for its adaptation to a remarkable variety of host plants and diverse climates,and its high resistance to insecticides and Bacillus thuringiensis *** interference(RNAi)is a sequence-specific,endogenous gene silencing mechanism evoked by small RNA molecules that is used as a robust tool for virus and pest *** has been extensively tested for CPB management by employing various target genes and delivery *** article reviews the screening of RNAi target genes,efficient RNAi delivery systems,and factors affecting RNAi efficiency in CPB,which may help understand the mechanisms of RNAi and its application in CPB control strategy.

关键词： Colorado potato beetle double-stranded RNA pest control RNA interference RNAi delivery system

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GhAP1-D3 positively regulates flowering time and early maturity with no yield and fiber quality penalties in upland cotton

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Journal of Integrative Plant Biology 2023年第4期65卷 985-1002页

作者： Caixiang Wang Juanjuan Liu Xiaoyu Xie Ji Wang qi ma Pengyun Chen Delong Yang Xiongfeng ma Fushun Hao Junji Su State Key Laboratory of Aridland Crop Science College of Life Science and TechnologyGansu Agricultural UniversityLanzhou 730070China State Key Laboratory of Cotton Biology College of Life ScienceHenan UniversityKaifeng 475004China Cotton Research Institute Xinjiang Academy of Agricultural and Reclamation ScienceShihezi 832000China State Key Laboratory of Cotton Biology Institute of Cotton Research of Chinese Academy of Agricultural SciencesAnyang 455000China

Flowering time(FTi)is a major factor determining how quickly cotton plants reach *** maturity greatly affects lint yield and fiber quality and is crucial for mechanical harvesting of cotton in northwestern ***,few quantitative trait loci(QTLs)or genes regulating early maturity have been reported in cotton,and the underlying regulatory mechanisms are largely *** this study,we characterized 152,68,and 101 loci that were significantly associated with the three key early maturity traits—FTi,flower and boll period(FBP)and whole growth period(WGP),respectively,via four genome-wide association study methods in upland cotton(Gossypium hirsutum).We focused on one major early maturity-related genomic region containing three single nucleotide polymorphisms on chromosome D03,and determined that GhAP1-D3,a gene homologous to Arabidopsis thaliana APETALA1(AP1),is the causal locus in this *** plants overexpressing GhAP1-D3 showed significantly early flowering and early maturity without penalties for yield and fiber quality compared to wild-type(WT)*** contrast,the mutant lines of GhAP1-D3 generated by genome editing displayed markedly later flowering than the ***1-D3 interacted with GhSOC1(SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1),a pivotal regulator of FTi,both in vitro and in *** in GhAP1-D3 transcript levels clearly affected the expression of multiple key flowering regulatory ***,DNA hypomethylation and high levels of H3K9ac affected strong expression of GhAP1-D3 in early-maturing cotton *** propose that epigenetic modifications modulate GhAP1-D3 expression to positively regulate FTi in cotton through interaction of the encoded GhAP1 with GhSOC1 and affecting the transcription of multiple flowering-related *** findings may also lay a foundation for breeding early-maturing cotton varieties in the future.

关键词： upland cotton early maturity genome‐wide association studies QTL AP1 flowering time

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ZnO Surface Passivation with Glucose Enables Simultaneously Improving Efficiency and Stability of Inverted Polymer:Non-fullerene Solar Cells

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Chinese Journal of Polymer Science 2022年第12期40卷 1594-1603,I0007页

作者： Bo-Wen Liu Ze-Rui Li Ling-Peng Yan Jing-Bo Guo Qun Luo Chang-qi ma School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China i-Lab&Printable Electronics Research Center Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

The power conversion efficiency(PCE)of polymer solar cells(PSCs)has exceeded 19%due to the rapid progress of photoactive organic materials,including conjugated polymer donors and the matched non-fullerene acceptors(NFAs).Due to the high density of oxygen vacancies and the consequent photocatalytic reactivity of ZnO,structure inverted polymer solar cells with the ZnO electron transport layer(ETL)usually suffer poor device *** this work,the eco-friendly glucose(Glu)is found to simultaneously improve the efficiency and stability of polymer:NFA solar *** the optimal conditions,we achieved improved PCEs from 14.77%to 15.86%for the PM6:Y6 solar *** a PCE improvement was attributed to the improvement in J_(SC) and FF,which is ascribed to the smoother and more hydrophobic surface of the ZnO/Glu surface,thereby enhancing the charge extraction efficiency and inhibiting charge ***,UV-Vis absorption spectra analysis revealed that glucose modification could significantly inhibit the photodegradation of Y6,resulting in a significant improvement in the stability of the device with 92%of its initial PCE after aging for 1250 *** application of natural interface materials in this work brings hope for the commercial application of organic solar cells and provides new ideas for developing new interface materials.

关键词： Polymer solar cells Glucose Surface passivation Charge injection Stability improvement

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Photocatalytic activity of perovskite SrTiO_(3)catalysts doped with variable rare earth ions

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Rare Metals 2021年第5期40卷 1077-1085页

作者： Yue-Xin Song Wen-qi ma Jing-Jing Chen Jiao Xu Zhi-Yong mao Da-Jian Wang Tianjin Key Laboratory for Photoelectric materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China Key Laboratory of Display materials and Photoelectric Devices Ministry of EducationTianjin University of TechnologyTianjin 300384China

In this work,15 types of rare earth(Re)ions,including Y^(3+),La^(3+),Ce^(3+),Pr^(3+),Nd^(3+),Sm^(3+),Eu^(3+),Gd^(3+),Tb^(3+),Dy^(3+),Ho^(3+),Er^(3+),Tm^(3+),Yb^(3+)and Lu^(3+)doped perovskite SrTiO_(3)powders were synthesized by solgel *** influence of Re ions doping on the crystal structure,morphology and optical property as well as the photocatalytic activity for the photodegradation of rhodamine B(RhB)was investigated in detail when the synthesized Re ions doped SrTiO_(3)powders were served as *** presented results revealed that the crystal structure is invariable,whereas the morphology and the optical bandgap are variable for the resultant SrTiO_(3)powders when different Re ions were incorporated into the SrTiO_(3)*** relatedness between the morphology,optical property and photocatalytic activity of the synthesized SrTiO_(3)catalysts doped with variable Re ions were analyzed deeply,providing an insight into the influence factors on the photocatalytic activity of catalysts.

关键词： SrTiO_(3) Rare earth ions Doping Photocatalytic activity

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A proteomic analysis of rice seedlings responding to 1,2,4-trichlorobenzene stress

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Journal of Environmental Sciences 2008年第3期20卷 309-319页

作者： GE Cailin WAN Dingzhen WANG Zegang DING Yan WANG Yulong SHANG qi ma Fai LUO Shishi Jiangsu Provencial Key Laboratory of Crop Genetics and Physiology Yangzhou University Yangzhou 225009 China

The proteomic analysis of rice （Oryza sativa L.） roots and leaves responding tol,2,4-trichlorobenzene （TCB） stress was carded out by two dimensional gel electrophoresis, mass spectrometric （MS）, and protein database analysis. The results showed that 5 mg/L TCB stress had a significant effect on global proteome in rice roots and leaves. The analysis of the category and function of TCB stress inducible proteins showed that different kinds of responses were produced in rice roots and leaves, when rice seedlings were exposed to 5 mg/L TCB stress. Most responses are essential for rice defending the damage of TCB stress. These responses include detoxication of toxic substances, expression of pathogenesis-related proteins, synthesis of cell wall substances and secondary compounds, regulation of protein and amino acid metabolism, activation of methionine salvage pathway, and also include osmotic regulation and phytohormone metabolism. Comparing the TCB stress inducible proteins between the two cultivars, the β-glucosidase and pathogenesis-related protein family 10 proteins were particularly induced by TCB stress in the roots of rice cultivar （Oryza sativa L.） Aizaizhan, and the glutathione S-transferase and aci-reductone dioxygenase 4 were induced in the roots of rice cultivar Shanyou 63. This may be one of the important mechanisms for Shanyou 63 having higher tolerance to TCB stress than Aizaizhan.

关键词： Oryza sativa 1,2,4-tfichlorobenzene (TCB) proteome stress response

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The Spatial and Electronic Effects of Substituent Groups on the Thermal Curing of Bio-Based Benzoxazines

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Journal of Renewable materials 2021年第12期9卷 2093-2117页

作者： Rumeng Li Guozhu Zhan qi ma Yunhe Yang Xiaoyun Liu Yitong Zhang qixin Zhuang Laboratory of Specially Functional Polymeric materials and Related Technology(ECUST) Ministry of EducationEast China University of Science and TechnologyShanghai200237China The 806th Institute of the Eighth Academy of CASC Huzhou313000China

To explore the influence of substituent groups on thermally induced curing,eight new bio-based benzoxazines containing different substituent groups with different electron negativity and volumes were *** thermal curing of these bio-based benzoxazines was studied in *** with the curing reaction kinetics,simulation and calculation of Highest Occupied Molecular and Lowest Unoccupied Molecular values,the spatial and electronic effects of different substituent groups on the curing of benzoxazine was *** was found that when the substituent was located at the position directly connected to the N atom,the steric hindrance effect of the group was *** the substituent group was located on the benzene ring connected to the O atom,both the electronic effect and the spatial effect influenced the curing of *** an electron-withdrawing group was connected ortho position to the O atom,the curing reaction was promoted due to the decreased electron cloud density of O-on the oxazine ring,making the C-O bond easier to *** an electron-donating group was connected to the meta position of the O atom it also promoted the curing reaction,possibly because it increased the electron cloud density of the+CH2 reaction site and thereby facilitated electrophilic substitution via attack of+CH2 on the cross linking reaction *** work provides a deeper understanding of how spatial and electronic effects of substituents affect the curing of benzoxazine.

关键词： Benzoxazine spatial effects electronic effects bio-based

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Causes of maize density loss in farmers’ fields in Northeast China

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Journal of Integrative Agriculture 2019年第8期18卷 1680-1689页

作者： ZHAO Ying-jie XING Sen ZHANG qing-song ZHANG Fu-suo ma Wen-qi Key Laboratory of Plant-Soil Interactions Ministry of Education Beijing 100193 P.R.China College of Resources and Environmental Sciences China Agricultural University Beijing 100193 P.R.China College of Resources and Environmental Science Hebei Agricultural University Baoding 071001 P.R.China

Increasing plant density is an effective and important way to reduce maize yield gaps in Northeast China. However, the fact is that a significant plant density gap exists between optimum plant density and actual plant density in farmers’ *** quantify the density gap between planned planting density and final harvest plant density(HPD), we studied 60 farmers’ fields on three types of soil for three crop seasons from 2015 to 2017 by measuring their plant-plant distance, actual seedlings density(ASD), final HPD and yield. We also explored the potential causes of density loss by digging the places where the seedlings were missing for two consecutive years in 2016–2017. Results show that the three-year average HPD in farmers’ fields was 59 699 plants ha^–1, which was significantly lower than the planned density, including both the machine setting density(MSD;67 962 plants ha^–1) and theoretical plant density(TPD;67 467 plants ha^–1). No significant difference was found in HPD between years and soil types. However, for MSD and TPD, the average value in 2015 was significantly higher than that in 2016 and 2017. No significant difference between soil types was observed. Furthermore,the results from 2016 till 2017 indicated that a lack of seeds in the soil, a failure to germinate due to low-quality seeds,and a lack of seedlings breaking out of the soil due to environmental problems explained approximately 60.88, 10.33 and 28.80% of density loss, respectively. According to our survey, 63% of farmers did not know their own TPD and HPD, and 54% of farmers did not know the density loss. Therefore, we argue that farmers’ limited knowledge of density and density loss is an urgent problem that needs to be solved in maize production. These observations will be useful for determining best management practices for maize production and for providing helpful suggestions for machine improvement.

关键词： plant density maize production density loss density gap farmers’ fields

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Spinless Bosons in a 1D Harmonic Trap with Repulsive Delta Function Interparticle Interaction Ⅱ： Numerical Solutions

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Chinese Physics Letters 2010年第2期27卷 40-42页

作者：马中骐杨振宁 Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 Center for Advanced Study Tsinghua University Beijing 100084 Institute of Theoretical Physics The Chinese University of Hong Kong Hong Kong

Following the general theory developed in paper I [Chin. Phys. Lett. 26 （2009） 120506] we present here the numerical results for an N spinless boson system in a 1D harmonic trap with repulsive delta function interpa... 详细信息

关键词： Quantum gases liquids and solids Computational physics Statistical physics and nonlinear systems

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Self-assembled nanostructures of a series of linear oligothiophene derivatives adsorbed on surfaces

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Chinese Chemical Letters 2023年第2期34卷 630-635页

作者： Xuan Peng Ting Meng Lilei Wang Linxiu Cheng Wenchao Zhai Ke Deng Chang-qi ma qingdao Zeng CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China Center of materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Printable Electronics Research Center Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

many previous studies have shown that the molecular structures of oligothiophene derivatives including molecular skeleton and alkyl chains have a significant effect on their self-assemblies on the *** this work, a series of linear oligothiophene derivatives(DCV-n T-Hex, n = 3~11) modified with terminal dicyanovinyls and alkyl chains were adopted to further investigate the different assembly behaviors at liquid-solid interface by scanning tunneling microscopy(STM). Interestingly, via the hydrogen bonding and van der Waals interactions, DCV-3T-Hex formed zigzag and flower structures while DCV-n T-Hex(n = 4~11) formed lamellar structures. Density functional theory(DFT) calculations show that for the most energetically favorable configurations of DCV-n T-Hex, the different distribution of alkyl chains affected intermolecular interactions, and ultimately led to the different assembled structures. The zigzag and flower structures of DCV-3T-Hex had preferential thermodynamic stability compared to other structures of DCV-n T-Hex(n = 4~11). In addition, self-assembled nanostructures of DCV-n T-Hex molecules with even numbers(n = 4, 6, 8, 10) were overall more stable than those with odd numbers(n = 5, 7, 9,11), and the stability of the self-assembled structure was weakened with the extension of the molecular backbone, individually. The orientation of molecular alkyl chains was found to greatly affect the intermolecular interactions and thus leading to various self-assembly structures of DCV-n T-Hex(n = 3~11).

关键词： Oligothiophene derivatives Scanning tunneling microscopy Supramolecular self-assembly Van der Waals force DFT calculations

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