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极坐标系下黏性流动的拟谱方法

浙江大学学报（工学版） 2006年第1期40卷 103-106页

作者：麻剑锋沈新荣章本照浙江大学力学系浙江杭州310027

针对拟谱方法在极坐标下遇到的坐标奇异以及压力边界条件难处理等问题,提出了一种新的基于极坐标系下的拟谱方法.该方法在一致网格上直接求解非定常原始变量形式的N-S方程,采用算子分裂法来解耦速度和压力,在径向采用Chebyshev-Radau配... 详细信息

针对拟谱方法在极坐标下遇到的坐标奇异以及压力边界条件难处理等问题,提出了一种新的基于极坐标系下的拟谱方法.该方法在一致网格上直接求解非定常原始变量形式的N-S方程,采用算子分裂法来解耦速度和压力,在径向采用Chebyshev-Radau配置点,在角方向采用标准的Fourier配置点.同时对压力的谱导数矩阵进行了变换,使边界上的压力点不出现在计算方程中.把该方法应用于圆截面的曲线管道的层流流动中,数值实验结果表明,该方法成功解决了极坐标系中的坐标奇异问题;对压力谱导数矩阵的变换,避免了对压力提非物理的边界条件,保证了解的精度,同时也消除了虚假压力模式.

关键词：拟谱方法配置点曲线管道极坐标系

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旋转环形偏心圆截面弯管内流动特性分析

浙江大学学报（工学版） 2005年第11期39卷 1829-1832页

作者：麻剑锋沈新荣章本照陈华军浙江大学力学系浙江杭州310027

采用贴体坐标系下的SIMPLE方法来求解旋转环形偏心圆截面弯管内流体流动的速度场.分析了偏心距和旋转对于二次流以及轴向速度分布的影响,同时给出了平均摩擦系数和壁面摩擦力的分布.结果表明,二次流和轴向速度的最大值总是趋向位于内、... 详细信息

采用贴体坐标系下的SIMPLE方法来求解旋转环形偏心圆截面弯管内流体流动的速度场.分析了偏心距和旋转对于二次流以及轴向速度分布的影响,同时给出了平均摩擦系数和壁面摩擦力的分布.结果表明,二次流和轴向速度的最大值总是趋向位于内、外壁面距离较大的一侧.在计算参数保持一致的条件下,在所研究的3种偏心距(0,0.2,-0.2)中,当偏心距为0.2时平均摩擦系数最小.当旋转从负到正连续变化时,平均摩擦系数和二次流强度存在临界点,临界点的数值依赖于偏心距.

关键词：旋转环形偏心弯管贴体坐标二次流动

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-xin Hao Lu feng Hugh RAJones jian Li Jing Xu Li-Yong Liu Teng-Fei Song jian-feng Wang Hua-Lin Chen Yan-Jie Xue Huang shen Yong-Heng zhao zhao-Xiang Qi jian-rong Shi Yuan Tian Zheng Wang Xia Wang Jin-Liang Hou Jin-ming Bai Ji Yang Xu Zhou Yong-Qiang Yao Jia Yin Ali Esamdin Guang-xin Pu Peng Wei Chun-Hai Bai Guo-Jie feng Lu ma Xuan zhang Yu Liu Chong Pei Zhi-Xia shen Yun-Ying jiang jian-feng Tian Xian-Qun Zeng Zhi-Gang Hou Xu Yang Jun-Bo zhang Shi-Long Liao Dong-Wei Fan Yun-Fei Xu jian-Ping Xiong Tai-sheng Yan Xi zhang Chang-Hua Li Yi-Han Tao Si-Cheng Yu Zhi-Song Cao Hong-Shuai Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 march 10 to 2019 march *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

Site testing campaign for the Large Optical/infrared Telescope of China:overview

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Research in Astronomy and Astrophysics 2020年第6期20卷 81-95页

作者： Lu feng Jin-xin Hao Zi-Huang Cao Jin-Min Bai Ji Yang Xu Zhou Yong-Qiang Yao Jin-Liang Hou Yong-Heng zhao Yu Liu Teng-Fei Song Li-Yong Liu Jia Yin Hua-Lin Chen Chong Pei Ali Esamdin Lu ma Chun-Hai Bai Peng Wei Jing Xu Guang-xin Pu Guo-Jie feng Xuan zhang Liang ming Abudusaimaitijiang Yisikandee jian-rong Shi jian Li Yuan Tian Zheng Wang Xia Wang Xiao-Jun jiang jian-feng Wang jian-feng Tian Yan-Jie Xue jian-sheng Chen Jing-Yao Hu Zhi-Xia shen Yun-Ying jiang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Yunnan Observatories Chinese Academy of SciencesKunming 650216China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China University of Chinese Academy of Sciences Beijing 100049China

The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter optical/infrared telescope which is proposed to be built in the western part of China in the next *** on satellite remote sensing data,along with geographical,logistical and political considerations,three candidate sites were chosen for ground-based astronomical performance *** sites include:Ali in Tibet,Daocheng in Sichuan and Muztagh-ata in *** until now,all three sites have continuously collected data for two *** this paper,we will introduce this site testing campaign,and present its monitoring results obtained during the period between march 2017 and march 2019.

关键词： techniques telescope-site testing

Long-term analysis of clear nights using satellite data considering astronomical sites in western China

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Research in Astronomy and Astrophysics 2020年第6期20卷 96-108页

作者： Zi-Huang Cao Li-Yong Liu Yong-Heng zhao Lu feng Hugh RAJones Huang shen Jin-xin Hao Yan-Jie Xue Yong-Qiang Yao Jing Xu Ali Esamdin zhao-Xiang Qi jian-rong Shi jian Li Yuan Tian Zheng Wang Tai-sheng Yan Xia Wang jian-Ping Xiong Si-Cheng Yu Jun-Bo zhang Zhi-Xia shen Yun-Ying jiang Jia Yin Guang-xin Pu Peng Wei Chun-Hai Bai Guo-Jie feng Lu ma Teng-Fei Song jian-feng Wang jian-feng Tian Xian-Qun Zeng Zhi-Gang Hou Shi-Long Liao Zhi-Song Cao Dong-Wei Fan Yun-Fei Xu Chang-Hua Li Yi-Han Tao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism.Communication University of China Beijing 100024China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in *** cloud-free night percentage is the primary meteorological consideration for evaluating candidate *** data from GMS and NOAA satellites and the MODIS instrument were utilized in this research,covering the period from 1996 to *** data analysis benefits from overlapping results from different independent teams as well as a uniform analysis of selected sites using GMS+NOAA *** significant ground-based monitoring is needed to validate these findings,we identify three different geographical regions with a high percentage of cloud-free conditions(~83%on average),which is slightly lower than at mauna Kea and Cerro Armazones(~85%on average)and were chosen for the large international projects TMT and ELT *** study finds evidence that cloud distributions and the seasonal changes affected by the prevailing westerly winds and summer monsoons reduce the cloud cover in areas influenced by the *** is consistent with the expectations from climate change models and is suggestive that most of the identified sites will have reduced cloud cover in the future.

关键词： methods statistical-site testing-atmospheric effects-MODIS

The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants

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National Science Review 2021年第8期8卷 141-143页

作者： ben Hu Ran Liu Xiaolu Tang Yuchen Pan ming Wang Yongqing Tong Guangming Ye Gaigai shen Ruochen Ying Aisi Fu Di Li Wanxu zhao Jing Peng Jie Guo Dong Men xinmin Yao Yirong Wang Hong zhang Zhihui feng Junping Yu Liangjun Chen Zixin Deng Xuemei Lu Ya-Ping zhang Yirong Li bende Liu Lilei Yu Yan Li jian Lu Tiangang Liu Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education and School of Pharmaceutical Sciences Wuhan University CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic Biology Shenzhen Institute of Advanced Technology Chinese Academy of Sciences State Key Laboratory of Protein and Plant Gene Research Center for Bioinformatics School of Life Sciences Peking University Department of Cardiology Renmin Hospital of Wuhan University Department of Clinical Laboratory Renmin Hospital of Wuhan University Department of Clinical Laboratory Medicine Zhongnan Hospital of Wuhan University CAS Key Laboratory of Special Pathogens and Biosafety Centre for Biosafety Mega-Sciences Wuhan Institute of Virology Chinese Academy of Sciences State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Department of Emergency Medicine First People’s Hospital of Jiangxia

Coronavirus disease 2019(COVID-19),the disease caused by infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has developed into a global pandemic that continues to pose an enormous threat to pu... 详细信息

关键词： coronavirus SARS-CoV-2 COVID-19 clinical severity genetic variant

双清合剂治疗卫气同病证流行性感冒有效性和安全性多中心随机对照非劣效性试验

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中国中西医结合杂志 2024年第9期44卷 1036-1043页

作者：林江涛孙增涛封继宏吴建华陆光兵郭瑞斌麻晓李月荣申云红王光恩马晓斌黄滔郭安张常喜赵小兵孙绪武江柏华甄会陈红平丁俊平中日友好医院呼吸与危重症医学科北京100029 天津中医药大学热病与呼吸疾病研究所天津300250 天津中医药大学第二附属医院呼吸与危重症医学科天津300250 山西省汾阳医院呼吸与危重症医学科山西032200 眉山市中医医院呼吸与危重症医学科四川620000 阳煤集团总医院呼吸与危重症医学科四川620000 漯河市中医院急诊科河南462000 济南市章丘区人民医院感染性疾病科济南250200 长治市第二人民医院感染疾病科山西046000 邯郸市中医院呼吸科河北056001 山东省立医院呼吸与危重症医学科济南250000 眉山市人民医院发热门诊四川620000 天津中医药大学研究生院天津300250 宁夏回族自治区中医医院肺病科银川750000 枣庄妇幼保健院呼吸科山东277000 牡丹江市中医医院呼吸科黑龙江157000 黑龙江省中医医院肺病科哈尔滨150036 中国中药协会呼吸病药物研究专业委员会北京100061 北京药海宁康医药科技有限公司北京100101 哈尔滨康赛思医药科技开发有限公司哈尔滨150001

目的观察双清合剂治疗卫气同病证流行性感冒的有效性及安全性。方法采用多中心、随机、双盲、双模拟平行对照、非劣效性试验设计,将240例卫气同病证流行性感冒患者采用分层区组随机化方法,使用SAS软件按1:1随机分为试验组和对照组,每组... 详细信息

目的观察双清合剂治疗卫气同病证流行性感冒的有效性及安全性。方法采用多中心、随机、双盲、双模拟平行对照、非劣效性试验设计,将240例卫气同病证流行性感冒患者采用分层区组随机化方法,使用SAS软件按1:1随机分为试验组和对照组,每组120例。试验组服用双清合剂和磷酸奥司他韦胶囊模拟剂,对照组服用磷酸奥司他韦胶囊和双清合剂模拟剂,两组疗程均为5日。分别于治疗前、治疗3日、治疗5日时进行访视,评价其主要临床症状缓解时间、完全退热时间、退热起效时间、对乙酰氨基酚使用量、中医证候积分、中医证候疗效、重要临床症状缓解时间、重症/危重流感发生率及安全性。结果试验期间,共脱落/剔除16例(试验组8例、对照组8例),最终纳入符合方案集224例,其中试验组112例,对照组112例。与对照组比较,试验组可缩短头痛缓解时间[28.00(17.75,42.99)h vs.41.00(18.75,59.00)h]、减少肌肉或关节酸痛缓解时间[37.83(12.88,52.77)h vs.38.07(13.50,69.25)h](P0.05)。两组患者不良反应发生率,试验组为4.17%和对照组为1.67%,差异无统计学意义(χ^(2)=1.36,P>0.05)。结论双清合剂可有效缓解卫气同病证流行性感冒的头痛、肌肉或关节酸痛症状,效果优于磷酸奥司他韦胶囊;在改善发热、咳嗽、汗出、面赤、咳黄痰临床症状,减少对乙酰氨基酚使用量,降低中医证候积分方面与磷酸奥司他韦胶囊疗效相当;安全性与磷酸奥司他韦胶囊相当。(中国临床试验注册中心注册***2400087831)。

关键词：流行性感冒卫气同病双清合剂随机对照试验中西医结合

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极坐标系下泊松方程的拟谱方法

空气动力学学报 2006年第2期24卷 243-245,255页

作者：麻剑锋沈新荣章本照陈华军浙江大学力学系流体工程研究所浙江杭州310027

极坐标系下的泊松方程,由于坐标原点的奇异性,给谱方法的实施带来了很大的困难。本文提出了一种新的拟谱方法,在径向上求解区域为[-1,1],采用标准的Gauss-Lobatto配置点;而在角方向上配置点均匀分布在[0,π]内。通过对配置点及空间导数... 详细信息

极坐标系下的泊松方程,由于坐标原点的奇异性,给谱方法的实施带来了很大的困难。本文提出了一种新的拟谱方法,在径向上求解区域为[-1,1],采用标准的Gauss-Lobatto配置点;而在角方向上配置点均匀分布在[0,π]内。通过对配置点及空间导数矩阵的处理,成功解决了坐标奇异问题。同时也避免了配置点在原点附近的集中,极大改善了矩阵条件数,减小了舍入误差,从而提高了解的精度。数值实验表明,该方法具有很高的精度。

关键词：拟谱方法配置点泊松方程

Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing maPK hyperactivation

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3925-3939页

作者： Guan-Nan Li Xue-Jiao zhao Zhen Wang Meng-Shi Luo shen-Nan Shi Dan-Mei Yan Hua-Yi Li Jia-Hao Liu Yang Yang Jia-Hong Tan Ze-Yu zhang Ru-Qi Chen Hui-Ling Lai Xiao-Yuan Huang jian-feng Zhou Ding ma Yong Fang Qing-Lei Gao Cancer Biology Research Center(Key Laboratory of the Ministry of Education) Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanHubeiChina National Clinical Research Center for Obstetrics and Gynecology Department of Gynecological OncologyTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanHubeiChina Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanHubeiChina Department of Gynecology the Sixth Affiliated HospitalSun Yat-Sen University510000 GuangzhouGuangdongChina

Finely tuned mitogen-activated protein kinase(maPK)signaling is important for cancer cell *** that push cells out of the maPK fitness zone result in cell ***,in a screen of the North China Pharmaceutical Group Corporation’s pure compound library of microbial origin,we identified elaiophylin as an autophagy ***,we demonstrated a new role for elaiophylin in inducing excessive endoplasmic reticulum(ER)stress,ER-derived cytoplasmic vacuolization,and consequent paraptosis by hyperactivating the maPK pathway in multiple cancer ***-wide CRISPR/Cas9 knockout library screening identified SHP2,an upstream intermediary of the maPK pathway,as a critical target in elaiophylin-induced *** cellular thermal shift assay(CETSA)and surface plasmon resonance(SPR)assay further confirmed the direct binding between the SHP2 and *** of the SHP2/SOS1/maPK pathway through SHP2 knockdown or pharmacological inhibitors distinctly attenuated elaiophylin-induced paraptosis and autophagy ***,elaiophylin markedly increased the alreadyelevated maPK levels and preferentially killed drug-resistant cells with enhanced basal maPK *** overcame drug resistance by triggering paraptosis in multiple tumor-bearing mouse models resistant to platinum,taxane,or PARPi,suggesting that elaiophylin might offer a reasonable therapeutic strategy for refractory ovarian cancer.

关键词： cancer activation elevated