检索结果-南通市图书馆

Salmonella-mediated blood-brain barrier penetration,tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

引用

Acta Pharmaceutica Sinica B 2023年第2期13卷 819-833页

作者： Ze Mi Qing Yao Yan Qi Jinhai zheng Jiahao Liu zhenguo Liu Hongpei Tan Xiaoqian ma Wenhu Zhou Pengfei Rong Department of Radiology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Department of Pathology Shihezi University School of Medicine and the First Affiliated Hospital to Shihezi University School of MedicineShihezi 832003China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410082China School of Biomedical Sciences Hunan UniversityChangsha 410082China Department of Pathology Cangzhou Central Hospital&the Affiliated to Hebei Medical UniversityCangzhou 062650China

Chemotherapy is an important adjuvant treatment of glioma,while the efficacy is far from satisfactory,due not only to the biological barriers of blood-brain barrier(BBB)and blood-tumor barrier(BTB)but also to the intrinsic resistance of glioma cells via multiple survival mechanisms such as upregulation of P-glycoprotein(P-gp).To address these limitations,we report a bacteria-based drug delivery strategy for BBB/BTB transportation,glioma targeting,and *** selectively colonized into hypoxic tumor region and modulated tumor microenvironment,including macrophages repolarization and neutrophils ***,tumor migration of neutrophils was employed as hitchhiking delivery of doxorubicin(DOX)-loaded bacterial outer membrane vesicles(OMVs/DOX).By virtue of the surface pathogen-associated molecular patterns derived from native bacteria,OMVs/DOX could be selectively recognized by neutrophils,thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting ***,the P-gp expression on tumor cells was silenced by bacteria typeⅢsecretion effector to sensitize the efficacy of DOX,resulting in complete tumor eradication with 100%survival of all treated *** addition,the colonized bacteria were finally cleared by anti-bacterial activity of DOX to minimize the potential infection risk,and cardiotoxicity of DOX was also avoided,achieving excellent *** work provides an efficient trans-BBB/BTB drug delivery strategy via cell hitchhiking for enhanced glioma therapy.

关键词： Glioma Neutrophil hitchhiking Blood-brain barrier Chemo-sensitization Outer membrane vesicles Doxorubicin P-glycoprotein Salmonella

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polymerizing Ladder-type Heteroheptacene-Cored Small-Molecule Acceptors for Efficient All-Polymer Solar Cells

引用

Chinese Journal of Polymer Science 2023年第7期41卷 1018-1026页

作者： Peng Wang Yu-Hang Zhu Hong-Xin Tao Yun-Long ma Dong-Dong Cai Qi-Sheng Tu Ruo-Chuan Liao Qing-Dong zheng State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China State Key Laboratory of Coordination Chemistry College of Engineering and Applied SciencesNanjing UniversityNanjing210023China

One important subject in the field of all-polymer solar cells (all-PSCs) is the exploration of electron-deficient building blocks with optimized physicochemical properties to promote the performance of polymer acceptors. Here, two ladder-type heteroheptacene-containing small-molecule acceptors with branched 2-octyldodecyl or 2-hexyldecyl side-chains are synthesized and polymerized with the thiophene co-monomer to afford polymer acceptors (PW-OD and PW-HD) with strong near-infrared absorption. Experimental results reveal that the alkyl chain length has a large impact on the molecular packing behavior of the resulting polymers, which in turn affects their light-absorbing and charge transport properties, and thus the photovoltaic performance of the final devices. When blended with the polymer donor PM6, PW-HD-based all-PSCs deliver a higher power conversion efficiency (PCE) of 9.12% compared to the PCE of 6.47% for the PW-OD-based all-PSCs, mainly due to its more ordered inter-chain packing and more favorable blend morphology. This work provides a promising building block for the development of high-performance narrow-bandgap polymer acceptors and highlights the importance of side-chain substitution in optimizing the photovoltaic performance of polymer acceptors.

关键词： All-polymer solar cells Polymer acceptors Ladder-type heteroheptacene Power conversion efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

脾氨肽口服溶液对季节性过敏性鼻炎预防与治疗的应用研究

引用

中华预防医学杂志 2024年第8期58卷 1219-1229页

作者：石海云郑凯莉樊长娥蔡惠娇马婷婷宁慧宇王洪田张俊晶王学艳首都医科大学附属北京世纪坛医院变态反应中心北京100038 首都医科大学附属北京世纪坛医院变态反应科北京100038 呼和浩特市第一医院变态反应中心呼和浩特010030

目的开展内蒙古呼和浩特地区季节性过敏性鼻炎防治的研究,探讨脾氨肽口服溶液对季节性过敏性鼻炎的预防与治疗作用,以及其相关机制。方法于2023年4—5月首都医科大学附属北京世纪坛医院变态反应科牵头,呼和浩特市第一医院协助开展的内... 详细信息

目的开展内蒙古呼和浩特地区季节性过敏性鼻炎防治的研究,探讨脾氨肽口服溶液对季节性过敏性鼻炎的预防与治疗作用,以及其相关机制。方法于2023年4—5月首都医科大学附属北京世纪坛医院变态反应科牵头,呼和浩特市第一医院协助开展的内蒙古呼和浩特地区过敏性疾病流行病学调查项目的流调人群中,选取392例季节性过敏性鼻炎患者,按3∶1随机分为脾氨肽治疗组(296例)和对照组(96例),并在2023年6月1—14日完成入组。治疗组在花粉播散期前4~6周(±7 d)开始应用脾氨肽口服溶液治疗12周,对照组应用脾氨肽口服溶液模拟剂,治疗组和对照组在花粉播散期间均按需使用口服抗组胺药物和/或鼻用糖皮质激素治疗。通过对比两组人群的症状评分、药物评分和生活质量评分评估疗效,并检测血清中多种细胞因子的表达水平。采用独立样本t检验/Kruskal-Wallis检验、χ^(2)检验/Fisher精确检验比较症状评分、生活质量评分、药物评分和实验室检查。结果与对照组相比,脾氨肽治疗12周可显著改善鼻塞[M(Q_(1),Q_(3)):2(1,2)vs.2(1,3),H值=6.308,P<0.05]、鼻痒[M(Q_(1),Q_(3)):2(1,2)vs.2(1,3),H值=4.966,P<0.05]、喷嚏[M(Q_(1),Q_(3)):2(1,2)vs.2(1,3),H值=5.245,P<0.05]、流涕[M(Q_(1),Q_(3)):2(1,2)vs.2(1,3),H值=5.41,P<0.05]、流泪[M(Q_(1),Q_(3)):1(0,2)vs.1(0,3),H值=4.664,P<0.05]症状。治疗12周时对照组和试验组鼻部症状及眼部症状评分与基线相比均升高(P<0.05),试验组鼻塞[M(Q_(1),Q_(3)):1(0,1)vs.1(0,2),H值=4.042,P<0.05]、眼痒/异物感/眼红[M(Q_(1),Q_(3)):1(0,2)vs.1(0,2),H值=5.302,P<0.05]症状评分及总评分[M(Q_(1),Q_(3)):4(-1,9)vs.5(0,12.5),H值=3.958,P<0.05]升高的幅度低于对照组。脾氨肽治疗组治疗6周抗组胺药物评分低于对照组(H值=4.232,P<0.05);治疗12周时,抗组胺药物评分[M(Q_(1),Q_(3)):10(0,24)vs.19(2,36.5),H值=6.67,P<0.05]及药物总评分[M(Q_(1),Q_(3)):28.5(5,77.5)vs.46(6,155.5),H值=3.995,P<0.05]均低于对照组。在脾氨肽治疗6周(0.7±1.77vs.0.85±1.67,H值=10.08,P<0.05)和12周(0.81±1.63vs.0.94±1.73,H值=5.196,P<0.05)时,治疗组血清IL-17A水平均低于对照组。结论脾氨肽口服溶液早期干预治疗可能改善患者季节性过敏性鼻炎的鼻部症状和眼部症状,减少发作期用药,改善患者的生活质量,其可能通过降低患者血清中IL-17A的表达水平从而发挥免疫调节作用。

关键词：季节性过敏性鼻炎免疫调节预防治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

气象遥感图像去噪预处理方法研究

引用

气象科技 2024年第3期52卷 309-317页

作者：赵丽斌刘浩马国忠郭潆茹贺铮王悦黑龙江省人工影响天气办公室哈尔滨150000 黑龙江省气象数据中心哈尔滨150000 黑龙江省人民政府人工降雨办公室哈尔滨150000

针对静止轨道遥感卫星上多通道扫描型载荷成像、传输与存储过程中,存在数据质量下降等问题,本文在经典三维块匹配算法(Block matching 3D,BM3D)基础上,提出一种基于多层级小波分解的并行执行策略。首先,使用小波变换对原始气象遥感图像... 详细信息

针对静止轨道遥感卫星上多通道扫描型载荷成像、传输与存储过程中,存在数据质量下降等问题,本文在经典三维块匹配算法(Block matching 3D,BM3D)基础上,提出一种基于多层级小波分解的并行执行策略。首先,使用小波变换对原始气象遥感图像分解,得到4个图像分量;其次,将所得图像分量进一步进行3级分解,并选择其中的10个图像分量;最后,每个分量并行执行BM3D滤波器去噪,并重构10个分量的输出图像。与传统BM3D去噪算法相比,改进BM3D算法的计算量可有效降低20%以上。通过与中值滤波、均值滤波、NL-Bayes、BM3D四种降噪算法进行实验对比,所提算法的峰值信噪比平均增益在0.39~4.45 dB之间,特别是在高斯白噪声和脉冲噪声的混合噪声去噪方面要显著优于选取的四种对比算法。

关键词：气象遥感特征识别图像去噪 Morlet小波变换 BM3D算法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

钛焊管连续辊弯成型工艺研究

引用

钢管 2024年第3期53卷 72-78页

作者：郑帮智冯兆龙孙思博肖勇杨杰马嘉钒钛资源综合利用国家重点实验室四川攀枝花617000 成都先进金属材料产业技术研究院股份有限公司四川成都610300 四川攀钢嘉德精工科技有限公司四川眉山620020

研究聚焦于Ф168 mm钛焊管的连续辊弯成型工艺,通过数值仿真和实验验证,深入分析了成型速度和成型间距对成型抗力、应力应变的影响。结果表明,在成型速度≤5 m/min、成型间距缩至700 mm时,钛焊管辊弯成型抗力显著降低,成型应力、应变维... 详细信息

研究聚焦于Ф168 mm钛焊管的连续辊弯成型工艺,通过数值仿真和实验验证,深入分析了成型速度和成型间距对成型抗力、应力应变的影响。结果表明,在成型速度≤5 m/min、成型间距缩至700 mm时,钛焊管辊弯成型抗力显著降低,成型应力、应变维持在低水平,实现了成型稳定性的显著改善。此外,针对成型过程中的变形情况进行了详细分析,指出边缘拉压作用易导致失稳,产生边浪、鼓包等缺陷。最后,通过数值模拟和试验对比,验证了数值模型的可行性,为钛焊管实际生产提供了指导。

关键词：钛焊管辊弯成型数值仿真工艺

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

汉唐建筑风格在武威东站建筑设计中的传承应用

引用

铁路技术创新 2024年第3期 156-162页

作者：唐文国杨永成郑庆丰叶文亮马林锋中国铁路兰州局集团有限公司甘肃兰州730000 杭州中联筑境建筑设计有限公司浙江杭州310000

铁路客站融入地域建筑文化既有助于提升城市文化形象,还能为铁路客站赋予独特的艺术价值和文化内涵。以武威东站站房设计为例,通过梳理武威地域文化特色,分析汉唐建筑风格特点,提出将汉唐建筑风格融入铁路客站设计的策略与方法,并从传... 详细信息

铁路客站融入地域建筑文化既有助于提升城市文化形象,还能为铁路客站赋予独特的艺术价值和文化内涵。以武威东站站房设计为例,通过梳理武威地域文化特色,分析汉唐建筑风格特点,提出将汉唐建筑风格融入铁路客站设计的策略与方法,并从传统建筑形式的转译、建构一体化设计手法、室内外一体化设计、传统建筑元素的应用等角度进行阐述,充分展现武威东站站房设计中的汉唐建筑风格。

关键词：武威东站汉唐建筑风格铁路客站建筑设计

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance

引用

Neural Regeneration Research 2020年第6期15卷 1094-1101页

作者： Fang Xing Xin Fang Xiang-Dan Gong Xin Zhao Ying Du zheng-Liang ma Xiao-Ping Gu Tian-Jiao Xia Department of Anesthesiology Affiliated Drum Tower Hospital of Medical Department of Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina

Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive *** treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pattern *** this study,we examined whether light and sound interventions could reduce sleep-wake pattern disturbances and memory deficits in a sleep rhythm disturbance *** established a model of sleep rhythm disturbance in C57 BL/6 J mice via a sleep deprivation method involving manual cage tapping,cage jostling,and nest *** used a Mini Mitter radio transmitter device to monitor motor activity in the mice and fear conditioning tests to assess cognitive *** results indicated that an intervention in which the mice were exposed to blue light(40-Hz flickering frequency)for 1 hour during their subjective daytime significantly improved the 24-hour-acrophase shift and reduced the degree of memory deficit induced by sleep ***,interventions in which the mice were exposed to a 40-Hz blue light at offset time or subjective night time points,as well as 2 Hz-blue light at 3 intervention time points(subjective day time,subjective night time,and offset time points),had no positive effects on circadian rhythm shift or memory ***,a 2000-Hz sound intervention during subjective day time attenuated the24-hour-acrophase shift and memory decline,while 440-Hz and 4000-Hz sounds had no effect on circadian ***,these results demonstrate that photoacoustic treatment effectively corrected abnormal sleep-wake patterns and cognitive dysfunction associated with sleep-deprivation-induced disturbances in sleep-wake *** animal experiments were approved by the Experimental Animal Ethics Committee of Drum Tower Hospital Affiliated to the Medical College of Nanjing University,China(approval No.20171102)on N

关键词： circadian rhythm cognitive impairment fear conditioning light intervention photoacoustic treatment rhythm disturbance rhythm shift sleep deprivation sleep-wake rhythm sound intervention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tidal water exchanges can shape the phytoplankton community structure and reduce the risk of harmful cyanobacterial blooms in a semi-closed lake

引用

Journal of Oceanology and Limnology 2022年第5期40卷 1868-1880页

作者： Wenxu zheng Renhui LI Wenli QIN Binbin CHEN Min WANG Wanchun GUAN Xiaoling ZHANG Qiao YANG Min ZHAO Zengling ma Zhejiang Provincial Key Laboratory for Subtropical Water Environment and marine Biological Resources Protection Wenzhou UniversityWenzhou 325035China National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution Wenzhou UniversityWenzhou 325035China Department of marine Biotechnology School of Laboratory Medicine and Life ScienceWenzhou Medical UniversityWenzhou 325035China marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China School of Petrochemical Engineering and Environment Zhejiang Ocean UniversityZhoushan 316022China

For estuaries,inland lakes play a vital role in the ecological balance under the impact of tide *** effect of tides-induced water exchange on phytoplankton community in a semi-closed lake was studied and compared with that of an adjacent closed lake in the Oujiang River mouth in Zhejiang,East China Sea,from June 29,2020 to June 14,*** show that the dominant species,abundance,dominance,and diversity of the phytoplankton species between the two lakes were significantly *** the closed lake,cyanobacteria were the dominant species during the study *** the semi-closed lake,the diversification of the dominant species was greater,and some species of diatoms and green algae became *** average phytoplankton abundance in the closed lake was 6 times of that in the semi-closed *** average dominance of cyanobacteria in the closed lake was 0.96,and those in the semi-closed lake and the Oujiang River were 0.51 and 0.22,*** blooms occurred throughout the study time in the closed lake but not in the semi-closed ***,the species diversity richness of the phytoplankton in the semi-closed lake was higher than that of the closed one,and the phytoplankton community between the closed lake and semi-closed lake could be divided into distinctly different groups based on non-metic multidimensional scaling analysis(NMDS)and analysis of similarities(ANOSIM)*** salinity of the water was significantly greater and the transparency significantly smaller in the semi-closed lake than those in the closed ***,water exchange driven by local tidal movement increased salinity and decreased transparency of water,which consequently shaped the community structures of different phytoplankton and reduced the risk of a cyanobacterial bloom outbreak in the semi-closed lake.

关键词： estuary harmful cyanobacterial blooms phytoplankton community water exchange tidal movement environmental parameters

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mesozoic mafic magmatism in North China:Implications for thinning and destruction of cratonic lithosphere

引用

Science China Earth Sciences 2018年第4期61卷 353-385页

作者： Yongfei zheng zheng XU Zifu ZHAO Liqun DAI CAS Key Laboratory of Crust-mantle materials and Environments School of Earth and Space ScienceUniversity of Science and Technology of China

The North China Craton(NCC) has been thinned from >200 km to <100 km in its eastern part. The ancient subcontinental lithospheric mantle(SCLM) has been replaced by the juvenile SCLM in the Meoszoic. During this period... 详细信息

The North China Craton(NCC) has been thinned from >200 km to mantle(SCLM) has been replaced by the juvenile SCLM in the Meoszoic. During this period, the NCC was destructed as indicated by extensive magmatism in the Early Cretaceous. While there is a consensus on the thinning and destruction of cratonic lithosphere in North China, it has been hotly debated about the mechanism of cartonic *** study attempts to provide a resolution to current debates in the view of Mesozoic mafic magmatism in North China. We made a compilation of geochemical data available for Mesozoic mafic igneous rocks in the NCC. The results indicate that these mafic igneous rocks can be categorized into two series,manifesting a dramatic change in the nature of mantle sources at ~121 ma. mafic igneous rocks emplaced at this age start to show both oceanic island basalts(OIB)-like trace element distribution patterns and depleted to weakly enriched Sr-Nd isotope compositions. In contrast,mafic igneous rocks emplaced before and after this age exhibit both island arc basalts(IAB)-like trace element distribution patterrs and enriched Sr-Nd isotope *** difference indicates a geochemical mutation in the SCLM of North China at^121 ma. Although mafic magmatism also took place in the Late Triassic, it was related to exhumation of the deeply subducted South China continental crust because the subduction of Paleo-Pacific slab was not operated at that time. Paleo-Pacific slab started to subduct beneath the eastern margin of Eruasian continent since the Jurrasic. The subducting slab and its overlying SCLM wedge were coupled in the Jurassic, and slab dehydration resulted in hydration and weakening of the cratonic mantle. The mantle sources of ancient IAB-like mafic igneous rocks are a kind of ultramafic metasomatites that were generated by reaction of the cratonic mantle wedge peridotite notonly with aqueous solutions

关键词： Cratonic destruction mafic magmas IAB-like series OIB-like series Lithospheric thinning Slab subduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

多尺寸维度挡砂单元筛管冲蚀损伤实验

引用

长江大学学报（自然科学版） 2024年第3期21卷 69-75页

作者：曹砚锋郑强马龙邱浩文敏范志利闫新江中海油研究总院有限责任公司北京100028 中国石油东部井控应急救援响应中心天津300280

基于不同流速作用下,金属网布筛管冲蚀破坏机理的不确定性,建立了中海油首套可控流速、可控砂比的冲蚀实验平台,开展了从金属单丝、金属网布到全尺寸筛管的不同尺寸维度试件的冲蚀实验,并基于大量的室内冲蚀实验数据分析,研究了不同冲... 详细信息

基于不同流速作用下,金属网布筛管冲蚀破坏机理的不确定性,建立了中海油首套可控流速、可控砂比的冲蚀实验平台,开展了从金属单丝、金属网布到全尺寸筛管的不同尺寸维度试件的冲蚀实验,并基于大量的室内冲蚀实验数据分析,研究了不同冲蚀流速对筛管冲蚀破坏的影响机理,形成了不同流速下多维度的筛管冲蚀规律。研究结果表明,流速对筛管冲蚀破坏影响较大,在低冲蚀流速(≤7 m/s)下筛管冲蚀破坏不明显;在中冲蚀流速(7~15 m/s)下筛管冲蚀破坏受颗粒砂堵塞引起的局部“冲蚀热点”影响,冲蚀破坏明显;在高冲蚀流速(≥15 m/s)下筛管冲蚀破坏表现为射流切割效应,破坏时间短,破坏强度大。在此基础上,形成了海上防砂筛管的防冲蚀推荐做法,以指导海上油田筛管优选。该研究结果有助于提前分析生产工况下筛管破坏可能性,并为避免冲蚀的筛管结构优化提供理论参考。

关键词：出砂冲蚀优质筛管冲蚀率冲蚀模型

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：