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Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells

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Protein & Cell 2022年第2期13卷 102-119页

作者： Hongling Zhang Yuanyuan Li yongjian ma Chongping Lai Qian Yu Guangyong Shi Jinsong Li State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Animal Core Facility Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

The use of two inhibitors of Mek1/2 and Gsk3β(2i)promotes the generation of mouse diploid and haploid embryonic stem cells(ESCs)from the inner cell mass of biparental and uniparental blastocysts,***,a system enabling long-term maintenance of imprints in ESCs has proven ***,we report that the use of a two-step a2i(alternative two inhibitors of Src and Gsk3β,TSa2i)derivation/culture protocol results in the establishment of androgenetic haploid ESCs(AG-haESCs)with stable DNA methylation at paternal DMRs(differentially DNA methylated regions)up to passage 60 that can efficiently support generating mice upon oocyte *** also show coexistence of H3K9me3 marks and ZFP57 bindings with intact DMR ***,we demonstrate that TSa2itreated AG-haESCs are a heterogeneous cell population regarding paternal DMR ***,AGhaESCs with late passages display increased paternal-DMR methylations and improved developmental potential compared to early-passage cells,in part through the enhanced proliferation of H19-DMR hypermethylated ***,we establish AG-haESCs that can longterm maintain paternal imprints.

关键词： paternal imprints androgenetic haploid ESCs DMRs semi-cloned mice alternative 2i

Czech Republic: A Typical and Flexible European Economy for Trade with China

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China's Foreign Trade 2006年第13期 32-33页

作者： Sun yongjian ma Wei

During the early time of July, martin Tlapa, Deputy Minister of Industry and Trade, Czech Republic visited China. During his visit, arranged by Czech Embassy, China's Foreign Trade had an exclusive interview with him.... 详细信息

关键词：捷克欧洲国家中国对外经贸知识产权保护跨国公司

Within the Current IPR Framework, How to Protect Intangible Cultural Heritages?——Interview with Yang Hongju, Director of Dept. of Legal Affairs, SIPO

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China's Foreign Trade 2006年第13期 10-12页

作者： Sun yongjian ma Wei

＂We are seeking more protection for the intangible cultural heritages within the current IRP framework, such as patents, trade marks, copyrights, commercial secret, anti-trust competition, each of them can be available for the protection of the intangible cultural heritages.＂ Yang Hongju, Director of Department of Legal Affairs, State Intellectual Property Office, People＇s Republic of China（SIPO） illustrated her comments very frankly when interviewed by China＇s Foreign Trade.

关键词：中国知识产权保护文化遗产中医无形资产

A comprehensive review of recent progress on enhancement-modeβ-Ga_(2)O_(3)FETs:Growth,devices and properties

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Journal of Semiconductors 2023年第6期44卷 7-23页

作者： Botong Li Xiaodong Zhang Li Zhang yongjian ma Wenbo Tang Tiwei Chen Yu Hu Xin Zhou Chunxu Bian Chunhong Zeng Tao Ju Zhongming Zeng Baoshun Zhang School of Nano Technology and Nano Bionics University of Science and Technology of ChinaHefei 230026China Nano Fabrication Facility Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

Power electronic devices are of great importance in modern *** decades of development,Si power devices have approached their material limits with only incremental improvements and large conversion *** the demand for electronic components with high efficiency dramatically increasing,new materials are needed for power device *** gallium oxide,an ultra-wide bandgap semiconductor,has been considered as a promising candidate,and variousβ-Ga_(2)O_(3)power devices with high breakdown voltages have been ***,the realization of enhancement-mode(E-mode)β-Ga_(2)O_(3)field-effect transistors(FETs)is still challenging,which is a critical problem for a myriad of power electronic ***,researchers have made some progress on E-modeβ-Ga_(2)O_(3)FETs via various methods,and several novel structures have been *** article gives a review of the material growth,devices and properties of these E-modeβ-Ga_(2)O_(3)*** key challenges and future directions in E-modeβ-Ga_(2)O_(3)FETs are also discussed.

关键词： enhancement mode FETs β-Ga_(2)O_(3)

Homoepitaxial growth of (100) Si-doped β-Ga_(2)O_(3) films via MOCVD

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Journal of Semiconductors 2023年第6期44卷 39-45页

作者： Wenbo Tang Xueli Han Xiaodong Zhang Botong Li yongjian ma Li Zhang Tiwei Chen Xin Zhou Chunxu Bian Yu Hu Duanyang Chen Hongji Qi Zhongming Zeng Baoshun Zhang School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China Nanofabrication facility Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Research Center of Laser Crystal Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Hangzhou Institute of Optics and Fine Mechanics Hangzhou 311421China

Homoepitaxial growth of Si-doped β-Ga_(2)O_(3) films on semi-insulating(100) β-Ga_(2)O_(3) substrates by metalorganic chemical vapor deposition(MOCVD) is studied in this work. By appropriately optimizing the growth conditions, an increasing diffusion length of Ga adatoms is realized, suppressing 3D island growth patterns prevalent in(100) β-Ga_(2)O_(3) films and optimizing the surface morphology with [010] oriented stripe features. The slightly Si-doped β-Ga_(2)O_(3) film shows smooth and flat surface morphology with a root-mean-square roughness of 1.3 nm. Rocking curves of the(400) diffraction peak also demonstrate the high crystal quality of the Si-doped films. According to the capacitance–voltage characteristics, the effective net doping concentrations of the films are 5.41 × 10~(15) – 1.74 × 10~(20) cm~(-3). Hall measurements demonstrate a high electron mobility value of 51cm~2/(V·s), corresponding to a carrier concentration of 7.19 × 10~(18) cm~(-3) and a high activation efficiency of up to 61.5%. Transmission line model(TLM) measurement shows excellent Ohmic contacts and a low specific contact resistance of 1.29 × 10~(-4) Ω·cm~2 for the Si-doped film, which is comparable to the Si-implanted film with a concentration of 5.0 × 10~(19) cm~(-3), confirming the effective Si doing in the MOCVD epitaxy.

关键词： homoepitaxial growth MOCVD Si-doping films high activation efficiency Ohmic contacts

CHARACTERISTICS OF ALKALINE VOLCANIC ROCKS OF PLIOCENE IN THE WESTERN PART OF HONGHE FAULT ZONE

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地学前缘 2000年第S1期7卷 270-271页

作者： Wang Guozhi,Huang yongjian,ma Renze,Wang Chengshan [WT5,5”BX](Chengdu University of Technology,Chengdu 610059,China)

A set of pull\|apart basins were formed along the Weixi—Qiaohou right\|lateral slip shear zone of the western part of Honghe fault zone during the period from Miocene to Quaternary.A rock suite of alkaline basalt\|trachyte\|leucite phonolite is distributed in the Pliocene basin developed in the middle and northern parts of the fault. The location of these rocks and the features of the basin indicate the close relationship between the rock suite and the strike\|slipping.. The sedimentological and chronological evidences prove that Dianxi plateau uplifted quickly in the Pliocene. We can get the information about the plutonic process of the uplift of the plateau from this alkaline rock association. There are mainly olivine\|pyroxene\|trachyandesite and biotite\|trachyte in the rock association. The rocks are often of porphyritic texture and block or semi\|directional flowage structure while the matrix is of trachytic or microcrystalline texture. The phanerocrysts are diopsidic augite, rimpylite, biotite and perthite (olivine sometimes can be seen). The matrix are made up of alkaline feldspar microcrystalline (30%～50%), short\|grained diopside (10%～15%), light\|colored volcanic glass (0～15%) and some magnetite, while feldspar microcrystalline in some rocks are arranged directionally. And there are sharp\|edged or round pyroxenite enclaves and hemicrystalline of short grained sinaite, biotite sinaite and felsic breccia in the trachyte, with good demarcation line. The pyroxenite enclaves in the trachyte are of different size, and the size of the biggest ones are 10cm or so with the characteristic of plastic yield flowing. Sinaite hemicrystalline may come from the older intrusions of Pliocene and Eocene epoch.

关键词： Honghe fault zone Pliocene trachyte strike\|slip uplift

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有源电力滤波器闭环控制算法研究

电工技术学报 2006年第2期21卷 73-78页

作者：马永健徐政沈沉清华大学深圳研究生院电力系统国家重点实验室深圳研究室深圳518055 清华大学电力系统国家重点实验室北京100084

有源滤波器是电力系统谐波补偿的新型解决方案。现有的有源滤波器多采用开环控制算法,谐波补偿性能受参数不确定和干扰的影响较大。在讨论了延时稳定性等并联型有源电力滤波器闭环控制算法设计的关键技术基础上,扩展了RDFT(Real Discret... 详细信息

有源滤波器是电力系统谐波补偿的新型解决方案。现有的有源滤波器多采用开环控制算法,谐波补偿性能受参数不确定和干扰的影响较大。在讨论了延时稳定性等并联型有源电力滤波器闭环控制算法设计的关键技术基础上,扩展了RDFT(Real Discrete Fourier Transform)组合选频滤波器并证明了其数学性质,提出了基于此算法与重复控制原理的闭环无差控制算法。PSCAD/EMTDC仿真实验表明,该算法可以实现对多个指定频率的谐波进行稳态无差的补偿。

关键词：有源滤波器闭环控制重复控制零稳态误差补偿选频滤波器

中国实体经济宏观杠杆率收敛性的国际比较与泡沫检验研究

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国际金融研究 2020年第5期 14-23页

作者：马永健西安交通大学管理学院湖北经济学院金融学院湖北金融发展与金融安全研究中心

本文基于国际清算银行实体经济宏观杠杆率数据,采用包含傅里叶级数的非线性面板SPSM单位根检验方法与GSADF泡沫检验模型,研究了中国实体经济及各部门宏观杠杆率的收敛性和泡沫特征。结果表明,中国实体经济宏观杠杆率已经超过发展中国家... 详细信息

本文基于国际清算银行实体经济宏观杠杆率数据,采用包含傅里叶级数的非线性面板SPSM单位根检验方法与GSADF泡沫检验模型,研究了中国实体经济及各部门宏观杠杆率的收敛性和泡沫特征。结果表明,中国实体经济宏观杠杆率已经超过发展中国家和地区的均值并接近发达国家和地区水平,中国实体经济、居民部门、政府部门、非金融企业部门和私人非金融部门宏观杠杆率均存在显著的泡沫特征。实体经济、非金融企业部门和私人非金融部门宏观杠杆率已经走出泡沫区间,且长期来看存在收敛性;居民部门和政府部门宏观杠杆率仍处于泡沫之中,且表现为发散。围绕实证研究结论,本文提出建立以宏观杠杆率为重点,结合《巴塞尔协议Ⅲ》信贷缺口、货币供应量等指标的金融风险监测预警体系,动态测度国民经济各部门宏观杠杆率收敛性与泡沫特征等属性的政策建议。

关键词：宏观杠杆率实体经济序列面板选择方法 GSADF检验

气相色谱-质谱法同时测定氟乙酰胺及毒鼠强方法研究

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卫生研究 2000年第6期29卷 369-369,378页

作者：马永建冯芳陈蓓江苏省卫生防疫站南京210009 中国药科大学药分教研室

运用气相色谱 -质谱法 (GC- MS)同时测定氟乙酰胺及毒鼠强 ,对其分离条件、提取方法、定性定量方式进行了研究。氟乙酰胺及毒鼠强的线性范围分别为 5～ 40和 0 .5～ 2 0 .0 μg/ ml,2种化合物在不同的样品中 (固体、液体、油样 )的回收... 详细信息

运用气相色谱 -质谱法 (GC- MS)同时测定氟乙酰胺及毒鼠强 ,对其分离条件、提取方法、定性定量方式进行了研究。氟乙酰胺及毒鼠强的线性范围分别为 5～ 40和 0 .5～ 2 0 .0 μg/ ml,2种化合物在不同的样品中 (固体、液体、油样 )的回收率分别为 5 2 .2 5 %～ 94.30 %和 6 1.85 %～ 92 .5 0 %。该法快速、灵敏。

关键词：气相色谱-质谱法氟乙酰胺毒鼠强