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Effect of process parameters of pulsed current tungsten inert gas welding on weld pool geometry of titanium welds

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Acta metallurgica Sinica(English Letters) 2010年第4期23卷 312-320页

作者： m.Balasubramanian v.Jayabalan v.Balasubramanian Department of mechanical Engineering Velammal Engineering CollegeSurapetAnna University Department of manufacturing Engineering Anna University Centre for materials Joining & Research Department of Manufacturing EngineeringAnnamalai University

The effects of pulsing current parameters on weld pool geometry namely front height, back height, front width and back width of pulse current gas tungsten arc welded （GTAW） titanium alloy was analysed. Four factors, five levels, central composite design were used to develop empirical relationships, incorporating pulsed current parameters and weld pool geometry.

关键词： Gas tungsten arc welding Pulsed current Titanium alloy Design of experiments

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients:A systematic review of clinical trials

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World Journal of Transplantation 2025年第1期15卷 156-164页

作者： Carlos m Ardila Pradeep K Yadalam Jaime Ramírez-Arbelaez Department of Basic Sciences Faculty of Dentistry Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia Department of Postdoctoral Program CIFE University CenterCuernavaca 62330MorelosMexico Department of Periodontics Saveetha Dental CollegeSaveetha Institute of Medical and HealthSIMATSSaveetha UniversityChennai 600077Tamil NaduIndia Department of Transplantation Hospital San Vicente FundaciónRionegro 054047Colombia

BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ *** To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant *** A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and *** review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial *** search strategy involved analyzing multiple databases,including Pubmed/mEDLINE,Web of Science,Embase,Scopus,and SciELO,as well as examining gray literature sources on Google Scholar.A comprehensive electronic database search was conducted from the databases’inception until may 2024,with no language *** After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were *** most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also *** antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and *** concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;Pmicrobial-resistant microor

关键词： Antimicrobial resistance Antimicrobials Antivirals Solid organ transplant recipients Infections microorganisms Cytomegalovirus

A comprehensive review of phytochemical approaches in treatment of acute myeloid leukemia:Associated pathways and molecular mechanisms

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Chinese Herbal medicines 2025年第1期17卷 41-55页

作者： mouvanal Sajana T.S.Gopenath Basalingappa m.Kanthesh Division of molecular Biology School of Life SciencesJSS AHER Department of Biotechnology and Bioinformatics School of Life SciencesJSS AHER

Acute myeloid leukemia(AmL) is a type of cancer that affects the blood and bone *** review conducts a thorough analysis of AmL, addressing its genetic *** examination extends to the current therapeutic approaches employed for AmL,shedding light on their efficacy and the notable side effects experienced by patients undergoing these treatments,leading to a low overall survival ***,exploring alternative treatments,such as phytochemicals,is ***,the review explores the complex landscape of phytochemicals,categorizing them based on their diverse properties,which include alkaloids,phenols,terpenoids,organo-sulfur compounds,and other compounds,including quinones,and elucidating their mechanisms of *** emphasis is placed on their involvement in critical signaling pathways,with a particular focus on how these phytochemicals impact AmL when evaluated across a spectrum of cell *** in-depth exploration aims to uncover potential targets within the molecular landscape of AmL where phytochemicals can exert their therapeutic *** review investigates the potential role of plant-derived phytochemicals as adjunctive therapies for *** exploration encompasses the identification of specific phytochemicals that exhibit promising anti-leukemic properties and evaluates their potential in clinical *** conventional treatments,the review explores the integration of complementary and alternative medicine as a holistic approach to managing *** examination encompasses the synergy between conventional therapies and alternative interventions,exploring how these combined strategies may enhance overall therapeutic outcomes and mitigate side *** a forward-looking perspective,the overarching goal is to contribute to the evolving landscape of AmL treatment by considering innovative approaches that harness the therapeutic potential of phytochemicals,both independently and in conjunction with establishe

关键词： cell death complementary and alternative medicine leukemia phytochemicals signaling pathways therapeutic targets

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梦与幻想

人像摄影 2025年第2期 123-127+122页

作者： v叔 v-ImAGE

我受到日本摄影师上田义彦的作品《A Dream》的启发，创作了这组照片。上田先生的作品深沉、细腻、克制，总是在平静、朴素中带着一丝优雅，散发出一种东方式的清冷、淡然。我在拍摄这组作品时，也试图在自然的家居环境中，捕捉人物内...

我受到日本摄影师上田义彦的作品《A Dream》的启发，创作了这组照片。上田先生的作品深沉、细腻、克制，总是在平静、朴素中带着一丝优雅，散发出一种东方式的清冷、淡然。我在拍摄这组作品时，也试图在自然的家居环境中，捕捉人物内心平静、自我的一面。镜头多以表现女孩松弛自洽的独处状态为主，通过简约而真实的方式，娓娓道来一段柔软的时光，关于梦或者幻想。

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Spectroscopic investigations on Yb^3+ doped and Pr^3+/Yb^3+ codoped tellurite glasses for photonic applications

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Journal of Rare Earths 2021年第1期39卷 33-42,I0002页

作者： m.Seshadri m.J.v.Bell v.Anjos Y.messaddeq Grupo de Engenharia e Espectroscopia de materiais Departamento de Fisica-ICEUniversidade Federal de Juiz de ForaJuiz de ForaMG36036-900Brazil Centre d'Optique Photonique et Laser2375 Rue de la TerrasseUniversite LavalQuebecQCG1V 0A6Canada

In this work we repo rt on structural and spect roscopic properties of Yb^3+doped and Pr^3+/Yb^3+co-doped TeO2-Bi2 O3-ZnO-Li2 O-Nb2 O5(TBZLN)tellurite *** and stretching modes of TeO2 and Te-OH bond(strong and weak)were analysed from the deconvolution of observed Raman and FT-IR *** on the absorption measurements,the energy bands of Yb^3+and Pr^3+ions are *** spectroscopic properties for the radiative transitions of Yb^3+and Pr^3+ions were reported using mcCumber and Judd-Ofelt *** emission bands originating from 3 P1 and 3 P0 to lower lying levels of Pr^3+were registered under 447 nm *** emission band around 1334 nm assigned to the Pr3:1 G4→3 H5 was observed when excited at 980 *** stimulated emission cross-section(σemi(λ))and effective linewidth(Δλeff)for the 3 P1→3 H6,3 P1→3 H5,3 P0→3 H6,3 P0→3 F2,3 P1→3 F3,3 P1→3 F4,3 P0→3 F4 and 1 G4→3 H5 transitions of Pr^3+are *** luminescence in Pr^3+/Yb^3+codoped glass upon 980 nm excitation was *** resonant transfer processes between Yb^3+and Pr^3+ions are presented and *** chromaticity co-ordinates were also evaluated from the visible emission spectra showing that Pr^3+/Yb^3+co-doped glass may be suitable for the development of yellow-orange(λexc=447 nm)and near white light(λexc=980 nm)emitting devices in photonics.

关键词： Rare earth ions Tellurite glass Spectroscopic properties Upconversion luminescence

Laser interaction with undercritical foams of different spatial structures

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matter and Radiation at Extremes 2025年第1期10卷 39-47页

作者： J.Limpouch v.Tikhonchuk O.Renner Sh.Agarwal T.Burian J.Cervenka J.Dostál R.Dudzák D.Ettel A.Gintrand L.Hudec L.Juha O.Klimo m.Krupka m.Krus T.Lastovicka R.Liska W.Nazarov S.K.Singh m.Šilhavík S.Weber Faculty of Nuclear Science and Physical Engineering Czech Technical University in Prague11519 PragueCzech Republic The Extreme Light Infrastructure ERIC ELI-Beamlines FacilityZa Radnicí83525241 DolníBrezanyCzech Republic Centre Lasers Intenses et Applications University of Bordeaux-CNRS-CEA351 Cours de la Liberation33405 TalenceFrance Institute of Physics Czech Academy of SciencesNa Slovance 1999/218200 PragueCzech Republic Institute of Plasma Physics Czech Academy of Sciences18200 PragueCzech Republic Faculty of mathematics and Physics Charles University12116 PragueCzech Republic Faculty of mechatronics Informatics and Interdisciplinary StudiesTechnical University of Liberec46117 LiberecCzech Republic Independent Foam Target Supplier St.AndrewsFifeScotland

The interaction of high-power laser pulses with undercritical foams produced by different techniques but with the same average density is studied at the PALS laser *** spatial-temporal evolution of X-ray emission is observed using an X-ray streak camera,electron and ion temperatures are measured by X-ray spectroscopy,and hot-electron production is characterized by monochromatic X-ray *** of a femtosecond laser probe pulse through foams is observed in the near and far *** spite of large differences in pore size and foam structure,the velocity of ionization front propagation is quite similar for all the foams studied and is slower than that in a homogeneous material of the same average *** ion temperature in the plasma behind the ionization front is a few times higher than the electron ***-electron production in plastic foams with small pores is strongly suppressed compared with that in solid targets,whereas in foams produced by additive manufacturing,it is significantly increased to the level observed in bare copper foil targets.

关键词： temperature. interaction critical

Longitudinal assessment of measured and estimated glomerular filtration-rate in autosomal dominant polycystic kidney disease:Real practice experience

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World Journal of Nephrology 2025年第1期14卷 99-109页

作者： Juan m Fernandez JoséC Rodriguez-Pérez m mercedes Lorenzo-medina Fancisco Rodriguez-Esparragon Juan C Quevedo-Reina Carmen R Hernandez-Socorro medical manager Southern Europe Baxter Healthcare Ltd.Madrid 28830Spain Escuela de Doctorado Universidad De Las Palmas De Gran CanariaLas Palmas 35001Canary IslandsSpain Department of Research Universidad Fernando Pessoa CanariasLas Palmas 35450Canary IslandsSpain Department of Clinical Chemistry Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Research Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Nephrology Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Radiology Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain

BACKGROUND Equations for estimation glomerular filtration rate(eGFR)have been associated with poor clinical performance and their clinical accuracy and reliability have been called into *** To assess the longitudinal changes in measured glomerular filtration rate(mGFR)in patients with autosomal dominant polycystic kidney disease(ADPKD).mETHODS Analysis of an ambispective data base conducted on consecutive patients diagnosed with *** mGFR was assessed by iohexol clearance;while eGFR was calculated by three different formulas:(1)The chronic kidney disease epidemiology collaboration(CKD-EPI);(2)modification of diet in renal disease(mDRD);and(3)The 24-hour urine creatinine clearance(CrCl).The primary end-points were the mean change in mGFR between the baseline and final visit,as well as the comparison of the mean change in mGFR with the change estimated by the different *** Thirty-seven patients were included in the *** compared to baseline,month-6 mGFR was significantly decrease by-4.4 mL/minute±10.3 mL/minute(P=0.0132).However,the CKD-EPI,mDRD,and CrCl formulas underestimated this change by 48.3%,89.0%,and 45.8%respectively,though none of these differences reached statistical significance(P=0.3647;P=0.0505;and P=0.736,respectively).The discrepancies between measured and estimated glomerular filtration rate values,as evaluated by CKD-EPI(r=0.29,P=0.086);mDRD(r=0.19,P=0.272);and CrCl(r=0.09,P=0.683),were not correlated with baseline mGFR *** This study indicated that eGFR inaccurately reflects the decline in mGFR and cannot reliably track changes over *** poses significant challenges for clinical decision-making,particularly in treatment strategies.

关键词： Autosomal dominant polycystic kidney disease Glomerular filtration rate End-stage kidney disease Iohexol Chronic kidney disease epidemiology collaboration modification of diet in renal disease

Bending sensor based on flexible spin valve

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Chinese Physics B 2023年第5期32卷 655-661页

作者： L I Naumova R S Zavornitsyn m A milyaev N G Bebenin A Y Pavlova m v makarova I K maksimova v v Proglyado A A Zakharov v v Ustinov m.N.miheev Institute of metal Physics Ural BranchRussian Academy of SciencesS.Kovalevskoi Street 18Ekaterinburg 620990Russia

Flexible spin valves were prepared by magnetron sputtering on polyimide substrates. The buffer layer that reduces significantly the effect of the polymer substrate on the spin valve microstructure and magnetoresistive properties was revealed. Bending deformation was applied to the microobjects based on the flexible spin valves in parallel to anisotropy axes. It was revealed that during the bend the magnetoresistance changes due to the joint impact of both the change of the magnetic field projection on the film plane and the change of the magnetic properties of the ferromagnetic layers. The obtained dependences have been used in construction of bending sensor, in which the flexible spin valve microstripes were united into the Wheatstone bridge.

关键词： spin valve polymer substrate magnetostriction magnetic anisotropy