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Journal of Huazhong University of Science and Technology(medical Sciences) 2002年第4期22卷 302-304页

作者：韩少杰郑智任大宏 DepartmentofEmergencymedicine DepartmentofPathology

Chronic treatment with Salvia miltiorrhiza preventing left ventricular hypertrophy (L VH) and its possible mechanism- inhibiting the action of cardiac aldosterone in spontaneously hypertensive rats (shr) were *** Wistar- kyoto (WKY ) rats and shrs were *** of shrs was treated with Salvia miltiorrhiza for 12 *** blood pres- sure (SBP) and left ventricular mass index were *** of heart tissue were stained with HE method and Van Gieson *** volume fraction was determined in the leftven- tricle by automatically quantitative m *** aldosterone concentration was measured by radioimm *** results indicated thatcom pared with WKY rats,shrs exhibited high- er SBP,left ventricular collagen volume fraction,and aldosterone concentration (all Pm ent with Salvia miltiorrhiza,SBP,left ventricular collagen volum e fraction,and aldosterone concentration in shr were decreased as compared with control group (Pment with Salvia miltiorrhiza could preventleftven- tricular hypertrophy in shr,significantly inhibit collagen compositions in left *** m echanism was probably related with the inhibition of the cardiac aldosterone action.

关键词： Salvia miltiorrhiza spontaneously hypertensive rats leftventricular hypertrophy al- dosterone

Some novel integration techniques to explore the conformable m-fractional Schrödinger-Hirota equation

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Journal of Ocean Engineering and Science 2022年第4期7卷 337-344页

作者： Asim Zafar m.Raheel m.Asif Kamyar Hosseini mohammad mirzazadeh Lanre Akinyemi Department of mathematics COMSATS University IslamabadVehari CampusPakistan Department of mathematics and Statistics ISP MultanPakistan Department of mathematics Rasht BranchIslamic Azad UniversityRashtIran Department of Engineering Sciences Faculty of Technology and EngineeringEast of GuilanUniversity of GuilanVajargah P.C.44891-63157RudsarIran Department of mathematics Lafayette CollegeEastonPAUSA

The current study deals with exact soliton solutions for Schrödinger-Hirota(SH)equation via two modi-fied integration *** methods are known as the improved(G/G)-expansion method and the Kudryashov *** model is a generalized version of the nonlinear Schrödinger(NLS)equation with higher order dispersion and cubic *** can be considered as a more accurate approximation than the NLS equation in explaining wave propagation in the ocean and optical fibers.A novel deriva-tive operator named as the conformable truncated m-fractional is used to study the above mentioned *** obtained results can be used in describing the Schrödinger-Hirota equation in some better *** the obtained results are verified through symbolic computational ***,the ob-tained results show that the suggested approaches have broaden capacity to secure some new soliton type solutions for the fractional differential equations in an effective *** the end,the results are also explained through their graphical representations.

关键词： shrödinger-Hirota equation Truncated m-fractional derivative Soliton solutions

自发性高血压大鼠主动脉对前列腺素H_2反应的增加先于前列腺素H合酶1表达的变化(英文)

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中国药理学报 1999年第12期20卷 1087-1092页

作者： Tong GE Paul m VANHOUTTE Chantal m BOULANGER Center for Experimental Therapeutics Baylor College of Medicine Houston TX 77030 USAIRIS 6 Place des Pleiades 92415 Courbevoie cdex FranceCenter for Experimental Therapeutics Baylor College of Medicine Houston TX 77030 USA

AIm: To determine the expression of PGH synthase-1and the sensitivity of vascular smooth muscle to PGH_2in the aorta from the shr at an age when noendothelium-dependent contractions to acetylcholine areobserved under control conditions. mETHODS: Allexperiments were performed in parallel on aortas from20-wk-old shr and Wistar-Kyoto normotensive rats(WKY). Rings, with or without endothelium, weresuspended in conventional organ chambers for therecording of changes in isometric force. Theexpression of PGH Synthase-1 was evaluated by

关键词：乙酰胆碱前列腺素过氧化物合酶 PCH

Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 287-295页

作者： Yucinda YY Khor Siew-Keah Lee Dharmani Devi m Wei Chih Ling Department of Pre-clinical Sciences M.Kandiah Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSelangorMalaysia Department of Pharmacology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia

Objective:To investigate the effect of epigallocatechin-3-gallate(EGCG)on endothelial dysfunction in spontaneously hypertensive rats(shr).methods:Wistar-Kyoto(WKY)rats and shr were divided into four groups;WKY control,shr control and shr treated with EGCG(50 mg/kg/day)or losartan(10 mg/kg/day).The treatment was given daily for 4 weeks by oral gavage and the blood pressure was monitored by tail-cuff method every 3 *** endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of *** vascular levels of reactive oxygen species,nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate were also ***,the expression of angiotensinⅡtype 1(AT_(1))receptor protein was ***:The systolic blood pressure was significantly decreased in shr treated with *** impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated shr *** also significantly increased the levels of nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate,while decreasing the level of reactive oxygen species and the protein expression of AT_(1)receptor in ***:EGCG attenuates endothelial dysfunction in shr by decreasing oxidative stress and increasing vascular nitric oxide bioavailability,which may be modulated partly by inhibition of vascular AT_(1)*** increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.

关键词： Epigallocatechin-3-gallate Vascular protection Antihypertension Tetrahydrobiopterin Cyclic guanosine monophosphate Angiotensin typeⅠreceptor Spontaneously hypertensive rats

shr-SCR regulates cortical cell division and nodulation

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molecular Plant 2021年第2期14卷 198-198页

作者： m.Arif Ashraf Jaimie m.Van Norman Department of Biology University of Massachusetts AmherstAmherstMAUSA Department of Botany and Plant Sciences and Center for Plant Cell Biology University of CaliforniaRiversideRiversideCA 92521USA

Legume plants,such as the model systems,medicago truncatula and Lotus japonica,and crop plants like soybean(Glycine max)and common bean(Phaseolus vulgaris),are able to utilize atmospheric nitrogen due to their symbiosis with nitrogen-fixing soil bacteria,rhizobia(Roy et al.,2020).Interestingly,this symbiosis is limited to only a few plant species,and the mechanisms behind the distinct ability of legume roots to facilitate this symbiosis remained obscure for a long *** hint as to how this occurs is that cortex cells in the legume root ground tissue are able to divide and form a unique structure called the nodule that supports rhizobia colonization.

关键词： vulgaris nodulation utilize

Altered Endothelial modulation of Vasoconstriction to Alphal Adrenoceptor Autoantibodies in Spontaneously Hypertensive Rats:a Potential mechanism for Primary Hypertension Development

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Altered Endothelial Modulation of Vasoconstriction to Alphal...

Endothelium-dependent Contractions in Hypertension:When Prostacyclin Becomes Ugly

第八届海峡两岸心血管科学研讨会

作者： Li YAN~1,Yun-hui DU~2,Zhong-mei HE~3,Hui-rong LIU~(2,3),Ji-min CAO~1 (1.Department of Physiology and Pathophysiology,Institute of Basic medical Sciences Chinese Academy of medical Sciences,School of Basic medical Sciences Peking Union medical College,Beijing 100005,China 2.Department of Pathophysiology,School of Basic medical Sciences, Capital medical University,Beijing 100069,China. 3.Department of Physiology, Shanxi medical University,Taiyuan 030001,China)

Objective Primary or secondary activation of immune mechanisms has been implicated in the pathogenesis of ***,hypertensive patients have been found to have high levels of the autoantibody against the second extracellular loop of alphal - adrenoceptor(α- AR autoantibody,α- AA), which exertα - AR agonist - like vasoconstrictive ***,whether the vasoconstrictive effect ofα - AA is enhanced in hypertension with concomitantly decreased endothelial function is *** The present study utilized isolated aortic rings from spontaneously hypertensive rats(shrs) and control normotensive Wistar - Kyoto(WKY) rats to perform vascular reactivity *** nitrotyrosine content was measured by *** Aortic contractile responses to phenylephrine(1 nm - 100 mm) andα - AA (1 nm - 100 mm) were greater in shrs than in *** endothelium denudation and non - selective NOS inhibitor L- NAmE(100μm) further increased phenylephrine - andα- AA - induced vasoconstriction in both shrs and ***,the selective iNOS inhibitor 1400W(10 mm) enhancedα - AA -induced aortic constriction in control,but not *** aortic nitrotyrosine content was significantly increased compared to *** These results demonstrate that decreased endothelial vasodilatory function and decreased NO bioavailability contribute to the increased shr arterial contractile responsiveness toα - AA,suggestive of a potential mechanism for hypertension development in patients harboring highα -AA levels.

关键词： alphal-adrenoceptor Inos α1-AA

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Endothelium-dependent Contractions in Hypertension:When Pros...

自发性高血压大鼠主动脉对前列腺素H2反应的增加先于前列腺素H合酶1表达的变化（英文）

第八届海峡两岸心血管科学研讨会

作者： Paul m.VANHOUTTE Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong Department of BIN Fusion Technology Chonbuk National UniversityJeonjuKorea

＜正＞Endothelial cells modulate vascular tone by causing vasodilatation resulting from the release of nitric oxide（NO） and the generation of hyperpolarizing signals（EDHF）,but also can release endothelium - derived contracting factors（EDCF）,prostanoids derived from the metabolism of arachidonic *** over-production of EDCF contributes to the endothelial dysfunction which accompanies spontaneous[essential]hypertension. EDCF-release can be triggered by,agonists suh as acetylcholine,adenine nucleotides and calcium -ionophores which augment the intracellular calcium concentration in the endothelial *** increase in cytosolic calcium ions initiates the activation of the calcium-dependent phospholipase A2,cyclooxygenases and prostanoid *** arteries of spontaneously hypertensive rats（shr） both cyclooxygenase-1 and prostacyclin synthase are over-expressed Their exaggerated activity leads to an abnormal production of prostanoids, mainly prostacyclin,which subsequently activate thromboxane - prostanoid（TP） receptors on the vascular smooth muscle cells which have lost the ability to relax in response to *** observation that inhibitors of cyclooxygenase nearly normalize the vasodilatation to acetylcholine in the forearm of essential hypertensive patients illustrates the role of EDCF in the endothelial dysfunction of hypertension.

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Acta Pharmacologica Sinica 1999年第12期 3-5页

作者： Tong GE,Paul m VANHOUTTE,Chantal m BOULANGER Center for Experimental Therapeutics Baylor College of medicine Houston TX 77030 USA IRIS 6 Place des Pleiades 92415 Courbevoie cdex France Center for Experimental Therapeutics Baylor College of medicine Houston TX 77030 USA

AIm: To determine the expression of PGH synthase-1and the sensitivity of vascular smooth muscle to PGH2in the aorta from the shr at an age when noendothelium-dependent contractions to acetylcholine areobserved under control conditions. mETHODS: Allexperiments were performed in parallel on aortas from20-wk-old shr and Wistar-Kyoto normotensive rats（WKY）. Rings, with or without endothelium, weresuspended in conventional organ chambers for therecording of changes in isometric force. Theexpression of PGH Synthase-1 was evaluated by reverse

关键词：乙酰胆碱前列腺素内过氧化物合酶近交shr大鼠近交WKY大鼠内皮依赖性收缩聚合酶链反应蛋白质印迹硝基精氨酸

Enrichment Discrimination Behavior in Spontaneously Hypertensive Rats

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Journal of Behavioral and Brain Science 2012年第4期2卷 479-484页

作者： Ramiz m. Salimov Georgy I. Kovalev Laboratory of Radioisotope Researches Zakusov Institute of Pharmacology Russian Academy of Medical SciencesMoscow Russia

Objectives: 1) To reveal, among spontaneously hypertensive rats, subpopulations that diverge in attention to objects enriching an empty cross-maze;2) To evaluate effect of clinically efficient drug for treatment of attention deficiency atomoxetine on the attention to environmental cues in attentionally-low rats. method: A novel paradigm that provides measure of attention towards enriching objects independent of general locomotor activity and spatial orientation is employed. The apparatus consists of 4-arm radial maze, two arms of which contain objects (enriched compartments). Animals exploring the objects typically stay longer in enriched parts of maze than in empty arms and have a higher score of enrichment discrimination ratio. Results: Frequency distribution of the enrichment discrimination ratio had clear bimodal shape that differed significantly from normal distribution suggesting the existence of subpopulations of attentionally-low and -high individuals. The attentionally-low phenotype did not show inferiority in spatial orientation as compared with attentionally-high phenotype. The phenotypes did not differ from each other in measures of locomo- tor activity and blood pressure. Atomoxetine (3 mg/kg, orally, once daily for 4 days) enhanced enrichment discrimina- tion in animals of attentionally-low phenotype. Single administration of the drug was ineffective. Conclusion: Popula- tion of spontaneously hypertensive rat includes two phenotypes of attentionally-low and -high individuals. Subchronic atomoxetine ameliorates attention to environmental cues in attentionally-low rats. The enrichment discrimination test could be useful in studies of neurobiology of attention deficit condition and for screening of novel drug candidates.

关键词： Attention Deficit Enrichment Discrimination Spontaneously Hypertensive Rat Atomoxetine