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Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika m.Joshi Theresa Currier Thomas Nafisa m.Jadavji College of Osteopathic medicine Midwestern UniversityGlendaleCAUSA Department of Biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that B-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin B12 vitamin B2 vitamin B3

Profile of SARS-CoV-2 Infected Patients Hospitalized at the Epidemic Treatment Center (ETC) in Saint-Louis, Senegal during the First Two Waves

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Advances in Infectious Diseases 2024年第2期14卷 322-337页

作者： Alassane Dièye Papa Latyr Junior Diouf Bourama Diémé moustapha Diedhiou Diatou Dia-Gueye Amadou Diop Dia Samba Niang Ibrahima Louis martin Dieng Ameth Dieng Seynabou Lô Ndéye m.ry Dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Emergency Department of Regional Hospital Center Saint-Louis Senegal Department of Infectious and Tropical Diseases of Fann Dakar Senegal

Introduction: The SARS-CoV-2 infection is a major public health emergency. Several risk factors are involved in the occurrence of respiratory distress that can lead to death despite resuscitation measures. Objectives: The aim of this study was to describe the epidemiological, clinical, paraclinical, therapeutic, and evolution profile of patients infected with SARS-CoV-2 hospitalized at the CTE of Saint-Louis (Senegal) during the first two waves. Patients and methods: We conducted a retrospective, cross-sectional, descriptive, and analytical study that included all patients hospitalized at the ETC of Saint-Louis (Senegal) with SARS-CoV-2 infection from march 2020 to April 2021. Results: A total of 358 cases were collected, 256 (71.5%) during the first wave and 102 (28.5%) during the second wave. The mean age was 49.5 years (19.5). There was a male predominance (58.4%), with a sex ratio of 1.4. Hypertension was the main comorbidity, with 87 cases (24.3%). The most common functional signs were cough in 194 cases (54.2%), dyspnea in 143 cases (40%) and ageusia in 134 cases (37.4%). Thoracic CT scans were performed on 20 patients (5.6%), with severe involvement (50% - 75%) observed in 50% of cases. Hydroxychloroquine-azithromycin was prescribed to 351 patients (98%). Overall, 338 (94.4%) recovered and 17 (4.7%) died. In multivariate analysis, factors associated with death were male sex [OR = 2.645;95% CI: 1.530 - 4.785;p = 0.011], age 60 years [OR = 1.039;95% CI: 0.564 - 1.914;p = 0.002], the presence of comorbidities [OR = 2.171;95% CI: 0.564 - 3.429;p = 0.033], SpO2 (ambient air) 95% [OR = 2.061;95% CI: 0.616 - 3.827;p = 0.03], acute respiratory distress syndrome (ARDS) [OR = 0.635;95% CI: 0.316 - 1.275;p = 0.001], severe form [OR = 1.664;95% CI: 0.298 - 2.478;p = 0.016], occurrence of complications [OR = 0.521;95% CI: 0.287 - 0.944;p = 0.032], high creatinine levels [OR = 2.061;95% CI: 1.616 - 3.827;p = 0.026], and lymphopenia [OR = 0.485;95% CI: 0.370 - 0.636;p = 0.0

关键词： SARS-CoV-2 Saint-Louis Senegal

COVID-19/Tuberculosis Co-Infection at the Epidemic Treatment Center (ETC) of Saint-Louis (Senegal): About 9 Cases

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Advances in Infectious Diseases 2024年第1期14卷 56-66页

作者： Alassane Dièye moustapha Diedhiou Papa Latyr Junior Diouf mba Bambo Diakhaby Demba makalou Samba Niang Diatou Dia-Gueye Amadou Diop Dia Ibrahima Louis martin Dieng Seynabou Lô Ndéye m.ry Dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Department of medicine Saint-Louis Regional Hospital Saint-Louis Senegal Infectious and Tropical Diseases Clinic of Fann Dakar Senegal

Introduction: COVID-19 is a global public health emergency that can cause acute respiratory distress syndrome. In countries where tuberculosis (TB) is endemic, coinfection of COVID-19 and TB is often encountered, which increases the risk of developing severe forms of COVID-19. Objectives: The aim of this study was to determine the prevalence of COVID-19/TB coinfection at the Epidemic treatment center (ETC) in Saint-Louis (Senegal) and to describe the epidemiological, clinical, paraclinical, and outcome profile of co-infected patients. Patients and methods: This is a retrospective, cross-sectional, descriptive cohort study based on the records of COVID-19/ TB co-infected patients who were hospitalized at the ETC in Saint-Louis (Senegal) over an 18-month period from march 2020 to September 2021. Results: Out of a total of 454 hospitalizations, we collected records of 9 patients co-infected with COVID-19/TB, resulting in a prevalence of 2%. The study included patients with a median age of 34 years (range: 10-86 years), with a male predominance (7 cases) and a sex ratio of 3.5. The majority of patients (88.9%) had severe forms of COVID-19. Dyspnea and cough were reported in all patients (100%). Pulmonary TB was the most frequent localization, with 9 cases. The diagnosis of COVID-19 was confirmed by nasopharyngeal PCR in all patients (100%). Bacilloscopy was positive in 3 out of 5 cases. One patient tested positive for GeneXpert? mTB/RIF without rifampicin resistance. All patients were prescribed the hydroxychloroquine-azithromycin combination and anti-tuberculosis treatment. Out of the nine patients, four recovered (44.4%) and five died (55.5%). Conclusion: COVID-19/TB coinfection had a low prevalence in our cohort, but was associated with a high mortality due to the frequent occurrence of severe forms of the disease.

关键词： COVID-19 Tuberculosis Saint-Louis Senegal

Alternating-current losses in two-layer superconducting cables consisting of second-generation superconductors coated by U-shaped ferromagnetic materials

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Chinese Physics B 2013年第12期22卷 509-513页

作者： Ahmet Cicek Fedai Inanir Fedor Gm.ry Department of Physics Faculty of Arts and Sciences Mehmet Akif Ersoy University Department of Physics Faculty of Arts and Sciences Recep Tayyip Erdog an University Institute of Electrical Engineering Slovak Academy of Sciences Du'bravska' Cesta 9 842 39 Bratislava Slovakia

Alternating-current losses in a two-layer superconducting cable, each layer being composed of 15 closely-spaced rectangular wires made up of second-generation superconductors when the ends of wires are coated by either a non-magnetic or strong ferromagnetic material having a U profile is numerically investigated. Computations are carried out through the finite-element method. The alternating-current losses do not increase significantly if the relative permeability of the coating is increased three orders of magnitude, provided that the current amplitude is less than half of the critical current in a superconducting wire. However, the losses are much higher for ferromagnetic coating if the amplitude of the applied current oscillating at 50 Hz is close to the critical current. The ferromagnetic coating is seen to accumulate the magnetic field lines normally on its surfaces, while the field lines are parallel to the long axes of the wires, leading to more significant flux penetration in the coated regions. This facilitates a uniform low-loss current flow in the uncoated regions of the wires. In contrast, coating with a non-magnetic material gives rise to a considerably smaller current flow in the uncoated regions, whereas the low-loss flow is maintained in the coated regions. moreover, the current flows in opposite directions in the coated and uncoated regions, where the direction in each region is converse for the two materials.

关键词： second-generation superconductor two-layer cable ferromagnetic coating U profile alternating-current losses

Thermomechanical Processing and Superplasticity of AZ91 magnesium Alloy

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Journal of materials Science & Technology 2004年第3期20卷 295-297页

作者： RongshiCHEN J.J.Blandin m.Suéry QudongWANG EnhouHAN StateKeyLabforCorrosionandProtection InstituteofMetalResearchChineseAcademyofSciencesShenyang110016China InstitutNationalPolytechniquedeGrenoble(INPG)GéniePhysiqueetmécaniquedesmatériaux(GPm2) UMRCNRS5010ENSPGBP4638402Saint-Martind'HéresCedexFrance SchoolofmaterialsScience&Engineering NationalResearchCenterofLightAlloyNetFormingEngineeringShanghaiJiaoTongUniversityShanghai200030China

The effect of extrusion on grain refinement has been studied in the AZ91 cast ingots. It is found that grain sizesmaller than 10μm can be obtained by the extrusion processing. Vickers hardness measurements were also carriedout to evaluate the effect of these processes on the room temperature mechanical properties. The experimentalresults of high temperature tensile tests revealed that the stress was inversely proportional to the square of the grainsize and that the activation energy for superplastic flow was higher than that for grain boundary diffusion.

关键词： magnesium alloy Thermo-mechanical treatment Superplasticity mechanical properties

Cirrhotic ascites review: Pathophysiology, diagnosis and management

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World Journal of Hepatology 2013年第5期5卷 251-263页

作者： Christopher m moore David H Van thiel Section of Hepatology Department of MedicineRush University Medical CenterChicagoIL 60612United States

Ascites is a pathologic accumulation of peritoneal fluidcommonly observed in decompensated cirrhotic states. Its causes are multi-factorial, but principally involve significant volume and hormonal dysregulation in the setting of portal hypertension. The diagnosis of ascites is considered in cirrhotic patients given a constellation of clinical and laboratory findings, and ultimately confirmed, with insight into etiology, by imaging and paracentesis procedures. Treatment for ascites is multimodal including dietary sodium restriction, pharmacologic therapies, diagnostic and therapeutic paracentesis, and in certain cases transjugular intra-hepatic portosystemic shunt. Ascites is associated with numerous complications including spontaneous bacterial peritonitis, hepato-hydrothorax and hepatorenal syndrome. Given the complex nature of ascites and associatedcomplications, it is not surprising that it heralds increased morbidity and mortality in cirrhotic patients and increased cost-utilization upon the health-care system. This review will detail the pathophysiology of cirrhotic ascites, common complications derived from it, and pertinent treatment modalities.

关键词： Ascites Cirrhosis Hepato-hydrothorax Hepatorenal syndrome Spontaneous bacterial peritonitis

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IryCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Influence of extrusion temperature on microstructure and mechanical properties of mg-4Y-4Sm-0.5Zr alloy

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Transactions of Nonferrous metals Society of China 2010年第7期20卷 1311-1315页

作者：李大全王渠东丁文江 J.J.BLANDIN m.SUéry National Engineering Research Center for Nonferrous metals Composites General Research Institute for Nonferrous Metals National Engineering Research Center of Light Alloys Net Forming State Key Laboratory of Metal Matrix CompositesSchool of Materials Science and EngineeringShanghai Jiao Tong University Universitéde Grenoble Grenoble INPScience et Ingénieriedes Matériaux et Procédés(SIMAP) CNRS UMR 5266UJFBP 4638402 Saint-Martin d'Héres CedexFrance

The solution-treated mg-4Y-4Sm-0.5Zr alloy was extruded at temperatures from 325℃ to 500℃.Dynamic recrystallization(DRX) completely occurs when the alloy is extruded at 350℃and *** grains of the extruded alloy are obviously refined by the occurrence of *** average grain size of the extruded alloy increases with increasing the extrusion temperature,leading to a slight decrease of the ultimate tensile strength(UTS) and the yield strength(YS) .On the contrary,the UTS and YS of the extruded and aged alloy increase with increasing the extrusion *** of UTS of 400 mPa,YS larger than 300 mPa and elongation(EL) of 7%are achieved after extrusion at 400℃ and ageing at 200℃ for 16 *** grain refinement and precipitation are efficient strengthening mechanisms for the mg-4Y-4Sm-0.5Zr alloy.

关键词： mg-Y-Sm-Zr alloy extrusion heat treatment ageing mechanical properties

Patterns of grassland invasions by trees: insights from demographic and genetic spatial analyses

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Journal of Plant Ecology 2015年第5期8卷 468-479页

作者： martin Dovčiak Richard Hrivnák Karol Ujházy Dušan Göm.ry State University of New York College of Environmental Science and Forestry(SUNY ESF)1 Forestry DriveSyracuseNY 13210USA Institute of Botany Slovak Academy of SciencesDúbravskácesta 9Bratislava 84523Slovakia Technical University in Zvolen Faculty of ForestryT.G.Masaryka 24Zvolen 96053Slovakia

Aims Woody invasions into grasslands have increased globally due to changing land use,climate and introduced woody species,but spatial processes generating and sustaining these invasions are not well *** gain insight into the patterns of spread of tree populations within grasslands,and to propose a full spatial analytical toolbox for studying native and non-native woody spe-cies spread when long-term data are not available,we tested if 50 years of grassland invasion in Western Carpathians by Norway spruce(Picea abies Karst.)proceeded by one of the two tradi-tionally competing hypotheses of species spread:(i)by frontier expansion,or(ii)by advanced groups established ahead of the population *** also tested whether the pattern of invasion changed over *** We analyzed the spatial demographic and genetic patterns of a Norway spruce population invading a Western Carpathian grass-land using ripley’s L(t)and genetic kinship coefficients(Fij).We mapped and genotyped spruce trees across the invasion front(from the invasion leading edge to fully colonized grassland near the source population)using three demographic classes(adults,juve-niles and seedlings)to approximate the temporal aspects of the *** studied how the spatial patterns of invasion by indi-vidual demographic classes and their genetic kinship varied among adjacent plots established at different distances from the source population(ranging from 0 to 160 m,in 40-m distance increments).Important Findings Juveniles were positively genetically related to adults on fine scales(m),suggesting that adults within the grassland acted as a seed source and accelerated early ***,adults did not act as nucleation centers for the formation of advanced juvenile ***,geneti-cally unrelated juveniles formed groups independently of *** groups were small and separate at the leading edge but they increased in size and graded into a continuous zone near the source popul

关键词： genetic spatial structure mountain meadows point pattern analysis population structure secondary succession