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Effect of metallic nanoparticles on amyloid fibrils and their influence to neural cell toxicity

Nano Research 2020年第4期13卷 1081-1089页

作者： marianna Barbalinardo Andrea antosova marta Gambucci Zuzana Bednarikova Cristiano Albonetti Francesco Valle Paola Sassi Loredana Latterini(ISI) Zuzana Gazova Eva Bystrenova C.N.R.-I.S.m.N via gobetti101bologna 40129italy Institute of experimental physics department of biophysicsslovak academy of sciencewatsonova 4704001kosiceslovakia department of chemistry biology and biotechnologyuniversity of perugiaperugia 06123italy consorzio interuniversitario per lo sviluppo dei sistemi a grande interfase(csgi) ismn-cnrbologna 40129italy department of medical and clinical biochemistry faculty of medicinesafarik universitykosice 04001slovakia

The modification of amyloid fibrils cytotoxicity through exogenous nanomaterials is crucial to understand the processes controlling the role of protein aggregation in the related *** influence of nanoparticles on amyloid stability yields great interest due to the small size and high surface area-to-volume ratio of *** physico-chemical parameters play a role in the interaction of proteins and nanoparticles in solution,thus influencing the disaggregation of preformed *** have examined the influence of two kinds of metallic nanoparticles on lysozyme amyloid fibrils using a multi-technique approach and focalized their impact on cytotoxicity on human neuroblastoma cells(SH-SY5Y).In particular,fluorescence,infrared and circular dichroism spectroscopies,optical and atomic force microscopy experiments have been carried out;the results are analyzed to rationalize the effects of these complexes on neural cell *** is remarkable,that the fibrils in the presence of AuNPs,unlike fibrils alone or with AgNPs,do not generate a significant cytotoxic effect even at high concentration and an amyloid degradation effect is visible.

关键词： lysozyme amyloid fibrils nanoparticles spectroscopy toxicity

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Imetit Dihydrobromide and Thioperamide medication in Cough Hypersensitivity model—The Role of H₃ Receptors

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Open Journal of molecular and Integrative Physiology 2016年第1期6卷 1-9页

作者： Tomas Buday Eva Kovacova Silvia Gavliakova Natalia Kavalcikova-Bogdanova m.rtina antosova Jana Plevkova Department of Pathophysiology Biomedicine Centre Jessenius Faculty of Medicine Comenius University Martin Slovak Republic Department of Physiology Biomedicine Centre Jessenius Faculty of Medicine Comenius University Martin Slovak Republic Simulation Educational Center Jessenius Faculty of Medicine Comenius University Martin Slovak Republic

Chronic cough is a troublesome problem and it is frequently associated with diseases such as gastroesophageal reflux, asthma and upper airway diseases—so called diagnostic triade. The magnitude and severity of cough is strongly associated with the ongoing nasal inflammation in subjects with rhinosinusitis and treatment of nasal inflammation leads to the down regulation of pathologically up-regulated cough. Histamine plays a key role in the inflammation of the upper airways of different aetiologies;therefore histamine receptors seem to be promising targets. The aim of our study was to ascertain the effect of H3R agonist imetit and H3R antagonist thioperamide on cough and symptoms of allergic rhinitis (AR) in an animal model of upper airway cough syndrome in ovalbumin sensitized guinea pigs. OVA sensitized guinea pigs (n = 10) were repeatedly challenged with i.n. allergen-OVA to induce allergic rhinitis and to enhance cough reflex according to the validated model of experimental allergic rhinitis. Animals were pre-treated by i.p. administration of imetit (1 mg/kg and 2 mg/kg of body weight) and thioperamide 30 min. prior i.n. OVA administration. Rhinitis evaluation was based on the occurrence of typical symptoms. The effect on cough was assessed from the response to inhalation of citric acid (0.4 m, 10 min), final cough count and cough latency were analysed from the airflow traces, cough motor pattern and the cough sound. AR up-regulated the cough response from 9 ± 2 to 16 ± 1 cough per provocation, med ± IQR, p metit (1 mg/kg) suppressed nasal symptoms and decreased number of cough from 16 ± 1 to 12 ± 1;however the data did not reach significance. Imetit (2 mg/kg) significantly suppressed the nasal symptoms, and number of coughs from 16 ± 1 to 6 ± 2, med ± IQR, p mide (5 mg/kg of body weight) did not have expected effects on tested parameters. H3R agonist imetit, unlike H3R antagonist thiopera

关键词： Chronic Cough Allergic Rhinitis Histamine Antitussive Imetit Thioperamide H3 Receptor

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