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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： m.rta chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari m.rta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali mohamed margherita Piccolella mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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The Story of the Century

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英语学习 1995年第8期 34-35页

作者： m.rta Tikkanen

玛尔塔·蒂坎恩是芬兰本世纪七十至八十年代女权主义运动中著名作家和诗人。她的散文诗《本世纪的故事》严肃地反映了妇女婚姻家庭矛盾,诗中那位妇女发出"Love me less,respect me more"的心声,不难读出作者及那个时代的芬兰女性已渐鲜... 详细信息

玛尔塔·蒂坎恩是芬兰本世纪七十至八十年代女权主义运动中著名作家和诗人。她的散文诗《本世纪的故事》严肃地反映了妇女婚姻家庭矛盾,诗中那位妇女发出"Love me less,respect me more"的心声,不难读出作者及那个时代的芬兰女性已渐鲜明的自我意识。

关键词：女权主义家庭矛盾散文诗 The Story of the Century 玛尔塔自我意识

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Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity

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World Journal of Diabetes 2016年第20期7卷 572-598页

作者： Ananthi Anandhakrishnan m.rta Korbonits Centre for Endocrinology William Harvey Research InstituteBarts and the London School of Medicine and DentistryQueen Mary University of London

Though the pathophysiology of clinical obesity is un-doubtedly multifaceted, several lines of clinical evidence implicate an important functional role for glucagon-like peptide 1(GLP-1) signalling. Clinical studies assessing GLP-1 responses in normal weight and obese subjects suggest that weight gain may induce functional deficits in GLP-1 signalling that facilitates maintenance of the obesity phenotype. In addition, genetic studies implicate a possible role for altered GLP-1 signalling as a risk factor towards the development of obesity. As reductions in functional GLP-1 signalling seem to play a role in clinical obesity, the pharmacological replenishment seems a promising target for the medical management of obesity in clinical practice. GLP-1 analogue liraglutide at a high dose(3 mg/d) has shown promising results in achieving and maintaining greater weight loss in obese individuals compared to placebo control, and currently licensed antiobesity medications. Generally well tolerated, provided that longer-term data in clinical practice supports the currently available evidence of superior short- and longterm weight loss efficacy, GLP-1 analogues provide promise towards achieving the successful, sustainable medical management of obesity that remains as yet, an unmet clinical need.

关键词： Obesity pathophysiology Glucagon-like peptide 1 analogues Glucagon-like peptide 1 Clinical obesity

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New serological markers in pediatric patients with inflammatory bowel disease

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World Journal of Gastroenterology 2014年第17期20卷 4873-4882页

作者： m.rta Kovács Katalin Eszter müller mária Papp Péter László Lakatos mihály Cs?ndes Gábor Veres Department of Pediatrics Petz Aladár County and Teaching Hospital9023 Gy?rHungary 1~(st) Department of Pediatrics Semmelweis University1083 BudapestHungary 2~(nd) Department of medicine University of Debrecen4032 DebrecenHungary 1~(st) Department of medicine Semmelweis University1083 BudapestHungary Department of Gastroenterology Petz Aladár County and Teaching Hospital9023 Gy?rHungary

The spectrum of serological markers associated with inflammatory bowel disease (IBD) is rapidly growing. Due to frequently delayed or missed diagnoses, the application of non-invasive diagnostic tests for IBD, as well as differentiation between ulcerative colitis (UC) and Crohn’s disease (CD), would be useful in the pediatric population. In addition, the combination of pancreatic autoantibodies and antibodies against Saccharomyces cerevisiae antibodies/perinuclear cytoplasmic antibody (pANCA) improved the sensitivity of serological markers in pediatric patients with CD and UC. Some studies suggested that age-associated differences in the patterns of antibodies may be present, particularly in the youngest children. In CD, most patients develop stricturing or perforating complications, and a significant number of patients undergo surgery during the disease course. Based on recent knowledge, serum antibodies are qualitatively and quantitatively associated with complicated CD behavior and CD-related surgery. Pediatric UC is characterized by extensive colitis and a high rate of colectomy. In patients with UC, high levels of anti-CBir1 and pANCA are associated with the development of pouchitis after ileal pouch-anal anastomosis. Thus, serologic markers for IBD can be applied to stratify IBD patients into more homogeneous subgroups with respect to disease progression. In conclusion, identification of patients at an increased risk of rapid disease progression is of great interest, as the application of early and more aggressive pharmaceutical intervention could have the potential to alter the natural history of IBD, and reduce complications and hospitalizations.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Pediatric, Serologic markers, Antimicrobial antibodies, Anti-glycan antibodies, Pancreatic antibodies, Inflammatory bowel disease

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Unexpected ecotone dynamics of a sand dune vegetation complex following water table decline

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Journal of Plant Ecology 2016年第1期9卷 40-50页

作者： Csaba Tölgyesi m.rta Zalatnai LászlóErdős Zoltán Bátori Nicole Rosemary Hupp LászlóKörmöczi Department of Ecology University of SzegedSzeged H-6726Hungary Wildlife Biology Program College of Forestry and ConservationUniversity of Montana32 Campus DriveMissoulaMontanaMT 59812USA

Aims Central Hungarian inland dune ranges harbor heterogeneous grassland vegetation with an extensive network of ecotones,arranged perpendicular to topography-driven hydrologic *** area suffers from severe aridification due to climate change and local anthropogenic factors,which have led to a dramatic decline of the water *** a result,groundwater is no longer reachable for lowlying plant communities;thus,we expect they are bound to undergo profound *** study investigates how the plant communities respond to this changing environment over time by monitoring ecotones,since they are frequently the hotspots of ecosystem *** monitored five ecotones along permanent belt transects for 15 years to characterize their dynamic response,and to identify the internal structural changes of the plant communities the ecotones *** Ecotones were delineated with the split moving window *** dynamics of two ecotone parameters,location and contrast,were analyzed with linear regression models incorporating two independent variables:study year as a measure of time since the loss of groundwater,and precipitation as a possible driver of interannual *** internal changes of the patches separated by the ecotones were analyzed using plant functional *** Findings Precipitation had no detectable effect on the ecotone descriptors,but study year influenced ecotones in an unusual *** position of the ecotones appeared to be very stable in time;their dynamics are stationary,not directional as we *** contrasts had clear tendencies;two ecotones disappeared,one new one was formed and two ecotones showed no *** internal changes of the patches over time were dramatic,showing a shift toward more xeric and more open plant assemblages in most stretches of the ***,the dynamic response of the vegetation was not patch expansion ***,but fusion ***,which profoundly restructured the vegetati

关键词： groundwater decline plant functional group sand dune vegetation split moving window stationary ecotone

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Effects of chronic and subtoxic chlorobenzenes on adrenocorticotrophic hormone release

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Journal of Environmental Sciences 2015年第8期27卷 165-170页

作者： Zsolt molnár Regina Pálf?ldi Anna László marianna Radács Krisztián Sepp Péter Hausinger László Tiszlavicz Zsuzsanna Valkusz m.rta Gálfi Institute of Applied Science Department of Environmental Biology and Education Gyula Juhász Faculty of Education University of Szeged Department of Pulmonology Faculty of Medicine University of Szeged Department of medical Physics and Informatics Faculty of Medicine University of Szeged Endocrine Unit of First Department of Internal medicine Faculty of Medicine University of Szeged Invasive Cardiology Department Second Department of Internal Medicine and Cardiology Faculty of Medicine University of Szeged Department of Pathology Faculty of Medicine University of Szeged

many environmental chemicals and pesticides have been found to alter neuroendocrine communication in exposed biological objects. The environmental loads have primary and secondary effects that can alter the homeostatic regulation potential. Since it is difficult to avoid human exposition, a potentially important area of research to develop in vivo and in vitro experimental models. In this context, the primary aim of this study was to demonstrate the effects of chlorobenzenes on adrenocorticotrophic hormone（ACTH） release. In our experimental study, male Wistar rats were exposed to 0.1, 1.0 and 10 μg/b.w.（body weight） kg of 1,2,4-trichlorobenzene and hexachlorobenzene（Cl B） mix via gastric tube for 30, 60 or 90 days. At the endpoints of the experiment blood samples were taken and animals were decapitated. Primary,monolayer adenohypophysis cell cultures were prepared by enzymatic and mechanical digestion. The ACTH hormone content in serum and supernatant media was measured by immuno-chemiluminescence assay. The mg2＋-dependent ATPase activity was determined by modified method of martin and Dotty. Significant differences were detected in the hormone release between the control and treated groups. The hormone release was enhanced characteristically in exposed groups depending upon the dose and duration of exposure. The mg2＋-ATPase activity enhanced after chronic and subtoxic Cl B exposition. Light microscopy revealed that the adenohypophysis seemed to be more abundant. Results indicate that Wistar rats exposed to subtoxic Cl B have direct and indirect effects on hypothalamus–hypophysis–adrenal axis.

关键词： Chlorobenzenes Subtoxic Adrenocorticotrophic hormone release mg2+ -dependent ATPase

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Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe

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World Journal of Gastroenterology 2015年第6期21卷 1728-1737页

作者： Fanni Rencz m.rta Péntek martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński mihai m Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos Department of Health Economics Corvinus University of Budapest Semmelweis University Doctoral School of Clinical medicine IBD Clinical and Research Centre ISCARE a.s.1~(st) Faculty of Medicine Charles University Department of Gastroenterology The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology and Medical Center for Postgraduate Education Gastroenterology Unit Department of Internal Medicine V University Hospital Bratislava Public Health Department Health Sciences Faculty Medical University in ?ód? and National Health Fund Department of Gastroenterology and Hepatology Carol Davila University Department of Gastroenterology Medical Academy Lithuanian University of Health Sciences 1~(st) Department of medicine Semmelweis University

Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and *** data on the epidemiology and disease burden of IBD in CEE countries was systematically ***,we provide an estimation on prevalence of IBD as well as biological treatment *** all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of *** heterogeneity(up to 96-fold)was found in access to biologicals across the CEE ***,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to *** of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not *** assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for *** conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health *** in reimbursement policy could contribute to better access to biologicals in some countries.

关键词： Inflammatory bowel diseases Ulcerative colitis Bio

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Abscisic Acid Connects Phytohormone Signaling with RNA metabolic Pathways and Promotes an Antiviral Response that Is Evaded by a Self- Controlled RNA Virus

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Plant Communications 2020年第5期1卷 111-128页

作者： Fabio Pasin Hongying Shan Beatriz García maren müller David San León m.rta Ludman David H.Fresno Károly Fátyol Sergi munné-Bosch Guillermo Rodrigo Juan Antonio García Centro Nacional de Biotecnología(CNB-CSIC) 28049 MadridSpain Agricultural Biotechnology Research Center Academia Sinica11529 TaipeiTaiwan Departamento de Biologı´a Evolutiva Ecologı´a y Ciencias AmbientalesFacultad de Biologı´aUniversidad de Barcelona08028 BarcelonaSpain Agricultural Biotechnology Institute National Agricultural Research and Innovation Centre2100 Godoll}oHungary Institute for Integrative Systems Biology(I2SysBio) CSIC-University of Valencia46980 PaternaSpain Present address:College of Horticulture and Gardening Tianjin Agricultural University300384 TianjinChina

A complex network of cellular receptors,RNA targeting pathways,and small-molecule signaling provides robust plant immunity and tolerance to *** maximize their fitness,viruses must evolve control mechanisms to balance host immune evasion and plant-damaging *** genus Potyvirus comprises plant viruses characterized by RNA genomes that encode large polyproteins led by the P1 protease.A P1 autoinhibitory domain controls polyprotein processing,the release of a downstream functional RNAsilencing suppressor,and viral ***,we show that P1Pro,a plum pox virus clone that lacks the P1 autoinhibitory domain,triggers complex reprogramming of the host transcriptome and high levels of abscisic acid(ABA)accumulation.A meta-analysis highlighted ABA connections with host pathways known to control RNA stability,turnover,maturation,and *** changes triggered by P1Pro infection or ABA showed similarities in host RNA abundance and *** and hormone treatment assays showed that ABA promotes plant resistance to potyviral ***,quantitative mathematical modeling of viral replication in the presence of defense pathways supported self-control of polyprotein processing kinetics as a viral mechanism that attenuates the magnitude of the host antiviral ***,our findings indicate that ABA is an active player in plant antiviral immunity,which is nonetheless evaded by a self-controlled RNA virus.

关键词： abscisic acid antiviral immune evasion mathematical modeling viral polyprotein processing Potyvirus RNA metabolism

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Characterization of Newly Developed Wheat/Barley Introgression Lines in Respect of Aluminium Tolerance

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American Journal of Plant Sciences 2012年第10期3卷 1462-1469页

作者： Eva Darko Beáta Barnabás m.rta molnár-Láng Cell Biology Department of Agricultural Institute Centre for Agricultural Research Hungarian Academy of Sciences Martonvásár Hungary Department of Plant Genetic Resources and Organic Breeding of Agricultural Institute Centre for Agricultural Research Hungarian Academy of Sciences Martonvásár Hungary

The Al tolerance of newly developed wheat/barley disomic addition, substitution and translocation lines carry chromosomes of three different barley cultivars was evaluated by comparing the root growth in solution containing 75 μm AlCl3 at pH 4.0 to that of known Al-tolerant and sensitive wheat genotypes. The wheat Asakaze komugi, barley manas cultivars and their hybrid derivatives were found to have high levels of Al tolerance. The wheat line mv9kr1, barley cultivar Igri and progenies of the hybrids were sensitive to Al. In most cases, the Al tolerance of the wheat/barley introgression lines derived from Al-sensitive wheat mv9kr1 and barley Betzes with moderate Al tolerance was similar to that of the wheat parents, but the 2DS.2DL-1HS translocation line of mv9kr1/Betzes exhibited more intensive root growth, while accumulating less Al than the parental lines. This indicates that either the lack of the distal part of chromosome 2DL or the presence of the distal part of 1HS improved the Al tolerance level.

关键词： Aluminium Tolerance Barley Introgression Line Wheat

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Access to biologicals in Crohn's disease in ten European countries

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World Journal of Gastroenterology 2017年第34期23卷 6294-6305页

作者： m.rta Péntek Peter L Lakatos Talitha Oorsprong László Gulácsi milena Pavlova Wim Groot Fanni Rencz Valentin Brodszky Petra Baji Crohn’s Disease Research Group department of health economics corvinus university of budapest mcgill university muhcmontreal general hospital 1st department of internal medicine semmelweis university department of health services research caphrimaastricht university medical centrefaculty of healthmedicine and life sciencesmaastricht university top institute evidence based education research (tier) teachers academymaastricht university 不详

AIm To analyze access(availability, affordability and acceptability) to biologicals for Crohn's disease(CD) in ten European countries and to explore the associations between these dimensions, the uptake of biologicals and economic *** A questionnaire-based survey combined with desk research was carried out in may 2016. Gastroenterologists from the Czech Republic, France, Germany, Hungary, Latvia, Poland, Romania, Slovakia, Spain and Sweden were invited to participate and provide data on the availability of biologicals/biosimilars, reimbursement criteria, clinical practice and prices, and use of biologicals. An availability score was developed to evaluate the restrictiveness of eligibility and administrative criteria applied in the countries. Affordability was defined as the annual cost of treatment as a share of gross domestic product(GDP) per capita. Correlations with the uptake of biologicals, dimensions of access and GDP per capita were *** At the time of the survey, infliximab and adalimumab were reimbursed in all ten countries, and vedolizumab was reimbursed in five countries(France, Germany, Latvia, Slovakia, Sweden). Reimbursement criteria were the least strict in Sweden and Germany, and the strictest in Hungary, Poland and Slovakia. Between countries, the annual cost of different biological treatments differed 1.6-3.3-fold. Treatments were the most affordable in Sweden(13%-37% of the GDP per capita) and the least affordable in the Central and Eastern European countries, especially in Hungary(87%-124%) and Romania(141%-277%). Biosimilars made treatments more affordable by driving down the annual costs. The number of patients with CD on biologicals per 100000 population was strongly correlated with GDP per capita(0.91), although substantial differences were found in the uptake among countries with similar economic development. Correlation between the number of patients with CD on biologicals per 100000 population and the availabi

关键词： Crohn’s disease Biological therapy Access Inequality Europe

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