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Primary prevention of colorectal cancer:myth or reality?

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World Journal of Gastroenterology 2014年第41期20卷 15060-15069页

作者： marcela Crosara teixeira maria Ignez Braghiroli Jorge Sabbaga Paulo m Hoff Division of medical Oncology Instituto do Cancer do Estado de S?o PauloHospital Sírio Libanês

Colorectal cancer incidence has been rising strongly in parallel with economic *** the past few decades,much has been learned about the lifestyle,dietary and medication risk factors for this *** respect to lifestyle,compelling evidence indicates that prevention of weight gain and maintenance of a reasonable level of physical activity can positively influence in lowering the *** there is controversy about the role of specific nutritional factors,consideration of dietary pattern as a whole appears useful for formulating *** quite often recommended,the role for many supplements,including omega-3,vitamin D,folate,and vitamin B6,remains *** calcium and vitamin D supplementation appear to add a modest benefit,particularly in those with a low daily *** regard to chemoprevention,medications such as aspirin and nonsteroidal antiinflammatory drugs,and postmenopausal hormonal replacement for women might be associated with substantial reductions in colorectal cancer risk,though their utility is affected by their side effect ***,the role of agents such as statins,bisphosphonates and antioxidants have yet to be ***,primary prevention strategies focusing on modifying environmental,lifestyle risk factors,and chemopreventive drugs are options that have already been tested,and may impact on colon cancer incidence.

关键词： Primary prevention Colorectal cancer Physical activity Diet Chemoprevention

Recipes for the derivation of Water Quality Parameters Using the High-Spatial-Resolution Data from Sensors on Board Sentinel-2A,Sentinel-2B,Landsat-5,Landsat-7,Landsat-8,and Landsat-9 Satellites

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Journal of Remote Sensing

Journal of Remote Sensing 2023年第1期3卷 213-230页

作者： Juliana Tavora Binbin Jiang Thomas Kiffney Guillaume Bourdin Patrick Clifton Gray Lino Sander de Carvalho Gabriel Hesketh Kristin m.Schild luiz Faria de Sousa Damian CBrady Emmanuel Boss Faculty of Geo-Information Science and Earth Observation(ITC) University of TwentePO Box 2177500 AE EnschedeThe Netherlands State Key Laboratory of marine Geology Tongji UniversityShanghaiChina School of marine Sciences University of MaineOronoMEUSA Nicholas School of the Environment Duke University Marine LabBeaufortNCUSA departamento de meteorologia Universidade Federal do Rio de JaneiroRio de JaneiroBrazil department of marine Sciences University of Southern MississippiOcean SpringMSUSA School of Earth and Climate Sciences University of MaineOronoMEUSA Climate Change Institute University of MaineOronoMEUSA

Satellites have provided high-resolution(<100 m)water color(i.e.,remote sensing reflectance)and thermal emission imagery of aquatic environments since the early 1980s;however,global operational water quality products ... 详细信息

Satellites have provided high-resolution(m)water color(i.e.,remote sensing reflectance)and thermal emission imagery of aquatic environments since the early 1980s;however,global operational water quality products based on these data are not readily available(e.g.,temperature,chlorophyll-a,turbidity,and suspended particle matter).Currently,because of the postprocessing required,only users with expressive experience can exploit these data,limiting their ***,we provide paths(recipes)for the nonspecialist to access and derive water quality products,along with examples of applications,from sensors on board Landsat-5,Landsat-7,Landsat-8,Landsat-9,Sentinel-2A,and *** emphasize that the only assured metric for success in product derivation and the assigning of uncertainties to them is via validation with in situ *** hope that this contribution will motivate nonspecialists to use publicly available high-resolution satellite data to study new processes and monitor a variety of novel environments that have received little attention to date.

关键词： environments Sentinel Spatial

Evaluation of the Biotechnological Potential of Isolated Bacteria of the Soil in the degradation of Residues of Skin Swine

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Advances in microbiology 2014年第9期4卷 493-497页

作者： Andréia Dalla Rosa Nelson G. Golynski m.rio L. teixeira Curso de medicina Veterinaria Instituto Federal Catarinense—Campus Concordia Concordia Brazil

The degradation of industrial residues is of great importance for the maintenance of the environment. Therefore, the objective of this study is to verify the proteases production for bacteria of the gender isolated Bacillus of soil. The samples of skin residue were collected in industries of the area west of Santa Catarina, using residue of skin rude swine and residue of skin processed swine. The verification of the biotechnological potential consisted of the use of these residues in middle of culture and inoculation of the respective species of bacteria. The results were more expressive in the samples of skin processed swine, where it showed a degradation average around 43.55% (p/p). While, in the samples of residue of skin rude swine, an average of degradation of 20.60% (p/p) happened. In this way, the residue of skin processed swine is more sensitive than the catalytic activity of the bacterial enzymes.

关键词： Bacteria Bacillus Skin Swine degradation Bioremediation

Genesis of the Gentio metagranitoid: Post-Collisional High-K Plutonism within the mineiro Belt, S?o Francisco Craton, Brazil

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Journal of Earth Science 2021年第6期32卷 1374-1396页

作者： marize m.da Silva Ciro A.Ávila Felipe m.Tavares Natali S.Barbosa Wilson teixeira Programa de Pós-graduação em Geologia Universidade Federal do Rio de Janeiro21.949-900Rio de JaneiroRJBrazil museu Nacional Universidade Federal do Rio de Janeiro20940-040Rio de JaneiroRJBrazil Serviço Geológico do Brasil Divisão de Geologia Econômica22290-255Rio de JaneiroBrazil Instituto de Geociências Universidade Federal da Bahia40170-110SalvadorBABrazil

The Gentio metagranitoid presents equigranular and porphyritic facies, modal composition ranging from tonalite to monzogranite with calculated T_(Zr)6 wt.%). Zircon analyses by LA-ICP-mS and SHRImP yielded a concordia... 详细信息

The Gentio metagranitoid presents equigranular and porphyritic facies, modal composition ranging from tonalite to monzogranite with calculated T_(Zr)most samples. Its mineralogy is dominated by quartz and feldspar(77% to 95%), biotite is the only mafic mineral present(2% to 18%) and, titanite, zircon, apatite, allanite are important accessory phases. These rocks range from metaluminous to weakly peraluminous, and have large variation in major and trace elements, and high alkali contents(>6 wt.%). Zircon analyses by LA-ICP-mS and SHRImP yielded a concordia age of 2 119±10 ma for the porphyritic facies and an upper intercept age of 2 111±15 ma for the equigranular facies. The whole-rock Sm-Nd T_(Dm) ages vary from 2.4 to 2.8 Ga with ε_(Nd)(2.1) values between -0.7 and-5.3, indicating crustal derivation from distinct and/or heterogeneous protoliths. Field observations indicate that the Gentio metagranitoid was formed through different pulses of magma. Individual batches were subject to little or even no fractionation process after its emplacement. Although the Gentio metagranitoid crosscuts metamafic and metaultramafic rocks akin to an oceanic arc setting, this pluton is likely originated by partial melting of a more evolved quartz-feldspathic crustal igneous rock in a post-collisional environment, after the accretion of the arcs from the mineiro belt and rocks of the mantiqueira Complex.

关键词： high-K granites mineiro belt post-collisional Sao Francisco Craton U-Pb geochronology

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The assessment of climatic,environmental,and socioeconomic aspects of the Brazilian Cerrado

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Ecological Processes 2023年第1期12卷 274-285页

作者： Washington luiz Félix Correia Filho JoséFrancisco de Oliveira-Júnior Dimas de Barros Santiago Hazem Ghassan Abdo Hussein Almohamad Ahmed Abdullah Al Dughairi Carlos Antonio da Silva Junior Postgraduate Program in Environmentrics(PPGAmb) Institute of MathematicsStatisticsand Physics(IMEF)Federal University of Rio Grande(FURG)Rio GrandeRio Grande do Sul 96203-900Brazil Institute of Atmospheric Sciences(ICAT) Federal University of Alagoas(UFAL)MaceióAlagoas 57072-260Brazil Postgraduate Program in Biosystems Engineering(PGEB) Federal Fluminense University(UFF)NiteróiRio de Janeiro 24220-900Brazil Postgraduate Program in meteorology Unidade Acadêmica de Ciências Atmosféricas(UACA)Federal University of Campina Grande(UFCG)Campina GrandeParaíba 58429-140Brazil Geography department Faculty of Arts and HumanitiesTartous UniversityTartousSyria Geography department Faculty of Arts and HumanitiesDamascus UniversityDamascusSyria Geography department Faculty of Arts and HumanitiesTishreen UniversityLat-takiaSyria department of Geography College of Arabic Language and Social StudiesQassim UniversityBuraydah 51452Saudi Arabia departamento de Geografia State University of Mato Grosso(UNEMAT)SinopMato Grosso 78555-000Brazil

Background The Cerrado is the most biodiverse savanna and maintains other *** of its significance,this paper evaluated the Brazilian Cerrado’s climatic,environmental,and socioeconomic aspects using remote sensing data and spatial statistics(correlation analysis and principal components analysis—PCA).Following the measures of sample adequacy(mSA)and Kaiser–meyer–Olkin(KmO)tests,seventeen variables were *** The mSA revealed that the dataset had a good quality(0.76),and nine variables were selected:elevation,evapotranspiration,active fires,Human development Index(HDI),land use and land cover(LULC;shrubland and cropland/rainfed),rainfall(spring and autumn),and *** correlation matrix indicated a positive(negative)association between HDI and autumn rainfall(HDI and active fires)with a value of 0.77(-0.55).The PCA results determined which three principal components(PC)were adequate for extracting spatial patterns,accounting for 68.02%of the total variance with respective values of 38.59%,16.89%,and 12.5%.Due to economic development and agribusiness,Cerrado’s northern(central,western,and southern)areas had negative(positive)score HDI values,as shown in ***(rainfall—spring and fall)and environmental(cropland/rainfed and shrubland)aspects dominated the PC2,with negative scores in northern and western portions due to the transition zone between Amazon and Cerrado biomes caused by rainfall *** the other hand,environmental aspects(LULC-shrubland and elevation)influenced the PC3;areas with high altitudes(>500 m)received a higher *** Agricultural expansion substantially affected LULC,leading to deforestation-caused suppression of native vegetation.

关键词： Environment Agribusiness Active fire Human development Index Land use and land cover

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Is there a window of opportunity to optimize trastuzumab cardiac monitoring?

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World Journal of Cardiology 2022年第7期14卷 403-410页

作者： Bruno Henrique Rala de Paula maria Eduarda teixeira Ferro Costa Carlos Augusto moreira de Sousa JoséBines Sarah Cannon Research Institute London W1G 6ADUnited Kingdom department of Cardiology Hospital do Câncer III-Instituto Nacional de CâncerRio de Janeiro 20560-121Brazil departamento de Tecnologias da Informação e Educação em Saúde(DTIES) da Faculdade de Ciências Médicas(FCM)na Universidade do Estado do Rio de Janeiro(UERJ)Rio de Janeiro 20550-170Brazil department of medical Oncology Instituto Nacional de CâncerRio de Janeiro 20560-121Brazil

BACKGROUND It remains unclear whether the current arbitrary screening recommendations of trastuzumab-related cardiotoxicity provides an adequate balance between preventing heart damage and curtailing a curative *** To determine the incidence rate and consequences of trastuzumab-induced cardiotoxicity as adjuvant treatment in a real-world *** We present a retrospective analysis of cardiac function measured by echocardiogram at baseline and every 3 mo during trastuzumab *** was defined as a drop in left ventricular ejection fraction(LVEF)≥10%from baseline and/or any dropdecember 2014,407 patients were ***(93.6%)were treated with an anthracycline followed by a taxane-based regimen and trastuzumab for 12 *** patients(9.8%)had *** of them were symptomatic,and 28(72.5%)completely recovered *** happened early as shown by LVEF measured on echocardiogram 2 to 4 as compared to 5 to 7(odds ratio=2.47,95%confidence interval:1.09,5.63,P=0.024).There were 54 deaths(13.3%)during the 70-mo follow-up period;1(0.2%)was attributed to late cardiotoxicity(4 years after treatment).The absence of symptomatic cardiotoxicity during trastuzumab treatment and moreover the early occurrence on the treatment period may translate into a strategy to evaluate less *** We observed a 10%rate of asymptomatic cardiotoxicity,which mirrors the results from the large adjuvant *** being transient,an LVEF drop led to frequent treatment delays and *** remains unclear whether LVEF decline is predictive of late cardiotoxicity,and treatment efficacy is compromised.

关键词： Cardiac toxicity Ventricular Dysfunction Heart failure Trastuzumab Breast cancer

Influence of fire on woody vegetation of savanna and forest formations in the Cerrado biome

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Journal of Forestry Research 2023年第5期34卷 1207-1216页

作者： Aline das Gracas Costa Fillipe Tamiozzo Pereira Torres Gumercindo Souza Lima Fabiano Rodrigues de melo Carlos moreira miquelino Eleto Torres Bruno Leao Said Schettini Vicente Paulo Santana Neto Andréluiz Lopes de Faria department of Forest Engineering Federal University of VicosaUFVVicosaMG 36570-900Brazil department of Geography Federal University of VicosaUFVVicosaMG 36570-900Brazil

Wildfires have environmental,economic,and social impacts,and can shape the landscape and benefit ecosystems such as the *** study evaluated the diversity,similarity,and floristic and structural differences of woody savanna and forest formations of the Cerrado,when affected and not affected by ***-eight 25-400m2 plots were randomly allocated and divided into Burnt Cerrado and Unburnt Cerrado,Burnt Forest,and Unburnt Forest,and divided into three levels of inclusion according to diameter class(smaller than 2 cm,2-5 cm and larger than5 cm).Species were identified,DBH and height measured,and phyto sociological parameters such as volume,diversity,and floristic similarity *** Cerrado had lower diversity,density,and dominance at all inclusion levels compared to the Unburnt Cerrado,and showed similarities between treatments at the inclusion *** Forest had smaller differences in diversity,density,and dominance than Unburnt *** formation was similar at level 1 of inclusion and in the total ***,it was dissimilar at lower *** lower density and diversity of species at the lowest levels of inclusion was associated with mortality from fire.

关键词： Biodiversity Brazil Burning Floristic Phytosociology

Structure and genetic diversity of natural populations of Guadua weberbaueri in the southwestern Amazon,Brazil

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Journal of Forestry Research 2021年第2期32卷 755-763页

作者： Glória da Silva Almeida Leal Fabrício Assis Leal Hugo teixeira Gomes Anderson marcos de Souza Sabina Cerruto Ribeiro Jonny Everson Scherwinski-Pereira Centro multidisciplinar Universidade Federal do AcreCruzeiro do SulAcreBrazil Universidade de Brasília BrasíliaDistrito FederalBrazil Centro de Ciências Biológicas e da Natureza Universidade Federal do AcreRio BrancoAcreBrazil Centro de Pesquisa e Aplicação de Bambu e Fibras Naturais Universidade de Brasília–CPAB/UnBBrasíliaDistrito FederalBrazil Embrapa Recursos Genéticos e Biotecnologia Av.W5 Norte(final)PqEBBrasíliaDistrito Federal 70770-917Brazil

The Brazilian state of Acre has an extensive natural reserve of bamboo,making it one of the largest in loco gene *** aim of this study was to characterize the structure and genetic diversity of Guadua weberbaueri *** two populations,one native(FAPB)and the other anthropized(FAPBA),using ISSR *** results show that the FAPB population exhibited higher values for all estimates of population ***,the FAPBA population also showed high heterozygosity,corroborated by estimated gene flow(Nm=3.9)between the *** study of the association between Nei’s genetic distances and the geographic distances between the populations were significantly correlated(r=0.45,p=0.01),corroborated by the dendrogram revealing two distinct groups corresponding to the collection sites,without mixing classes between populations in the same *** for the coancestry coefficient,pairs of individuals in the first distance class were positive and significant,indicating that plants that are geographically closer share common alleles with a frequency greater than by chance,which means that there is a tendency that geographically closer individuals are *** presented similar genetic structure when the geographical distance between them was up to 56 m for FAPB and up to 156 m for *** was concluded that anthropized environments exhibit less genetic diversity than native environments,inferring risks for species conservation if appropriate and planned management techniques are not adopted.

关键词： Guadua Bamboo Genetic diversity Amazon rainforest Anthropized and native populations Underutilization plants

Responses of the Host Plant Tissues to Gall Induction in Aspidosperma spruceanum mü***.(Apocynaceae)

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American Journal of Plant Sciences 2011年第6期2卷 823-834页

作者： Anete teixeira Formiga Geraldo luiz Goncalves Soares Rosy mary dos Santos Isaias departamento de Botanica Campus da PampulhaInstituto de Ciencias BiologicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil departamento de Botanica Campus do ValeInstituto de BiocienciasUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

The ontogenetic characterization of the leaf galls induced in the internervural region and in the second and third order veins of A. spruceanum müell Arg. (Apocynaceae) aims to evaluate the distinct levels of cell reaction during the process of gall formation, and the relation between external gall morphology and the oviposition sites. The ground system had the most remarkable alterations, namely, the non differentiation of palisade parenchyma in both leaf sides, the hyperplasia of the spongy parenchyma and the neoformation of fibersclereids, a cell type not observed in non galled leaves. Changes of the feeding sites inside the larval chamber reveal distinct levels of cell competence to respond to the insects stimuli and explain the variations in the shape of the larval chamber.

关键词： Aspidosperma Cell Competence Gall development Leaf Anatomy