Primary prevention of colorectal cancer:Myth or reality?

作     者：Marcela Crosara Teixeira Maria Ignez Braghiroli Jorge Sabbaga Paulo M Hoff 

作者机构：Division of Medical OncologyInstituto do Cancer do Estado de S?o PauloHospital Sírio Libanês 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第41期

页      面：15060-15069页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Primary prevention Colorectal cancer Physical activity Diet Chemoprevention 

摘      要：Colorectal cancer incidence has been rising strongly in parallel with economic *** the past few decades,much has been learned about the lifestyle,dietary and medication risk factors for this *** respect to lifestyle,compelling evidence indicates that prevention of weight gain and maintenance of a reasonable level of physical activity can positively influence in lowering the *** there is controversy about the role of specific nutritional factors,consideration of dietary pattern as a whole appears useful for formulating *** quite often recommended,the role for many supplements,including omega-3,vitamin D,folate,and vitamin B6,remains *** calcium and vitamin D supplementation appear to add a modest benefit,particularly in those with a low daily *** regard to chemoprevention,medications such as aspirin and nonsteroidal antiinflammatory drugs,and postmenopausal hormonal replacement for women might be associated with substantial reductions in colorectal cancer risk,though their utility is affected by their side effect ***,the role of agents such as statins,bisphosphonates and antioxidants have yet to be ***,primary prevention strategies focusing on modifying environmental,lifestyle risk factors,and chemopreventive drugs are options that have already been tested,and may impact on colon cancer incidence.