检索结果-南通市图书馆

Biomarkers of hypoxic-ischemic encephalopathy:a systematic review

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第6期19卷 505-548页

作者： Ines Caramelo margarida Coelho miguel Rosado Carla m.P.Cardoso Alexandra Dinis Carlos B.Duarte m.rio graos Bruno manadas CNC-Center for Neuroscience and Cell Biology University of Coimbra3004‑504 CoimbraPortugal PhD Programme in Experimental Biology and Biomedicine Institute for Interdisciplinary Research(IIIUC)University of CoimbraCasa Costa Alemão3030‑789 CoimbraPortugal Chemistry Department Faculty of Sciences and TechnologyUniversity of Coimbra3004‑535 CoimbraPortugal Stemlab SA 3060‑197 CantanhedePortugal Pediatric Intensive Care Unit Hospital PediátricoCentro Hospitalar E Universitário de Coimbra3000‑075 CoimbraPortugal Department of Life Sciences University of Coimbra3001‑401 CoimbraPortugal Biocant Technology Transfer Association3060‑197 CantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)3030‑789 CoimbraPortugal

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement ***,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROSPERO ID:CRD42021272610).Data sources Searches were performed in Pubmed,Web of Science,and Science Direct databases until November *** original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were *** was assessed by the Newcastle–Ottawa *** search and data extraction were verified by two authors *** From 373 papers,30 met the inclusion *** from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal *** addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic ***,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to *** Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy ***,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.

关键词： Biomarker Hypoxic-ischemic encephalopathy Neonatal brain injury Newborn Neuron-specific enolase S100-calcium-binding protein-B

Comparison of Classical models for Evaluating the Heat Requirements of Olive(Olea europeae L.) in Portugal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2006年第6期48卷 664-671页

作者： Helena Ribeiro m.rio Cunha Ilda Abreu Autonomous Section of Agricultural Sciences Faculty of Sciences University of Porto4485-661 VairaoPortugal Department of Botany Faculty of SciencesUniversity of Porto1191-4150 PortoPortugal Institute of Agricultural Sciences and Technology 4485-661 VairaoPortugal Department of Botany Faculty of Sciences University of Porto1191-4150 PortoPortugal Institute for molecular and Cell Biology 823-4150 PortoPortugal

The aim of the present study was to compare the accuracy and reproducibility of six statistical models for the calculation of olive （Olea europeae L.） heat requirements to trigger the onset of flowering in three Portuguese regions： Reguengos de monsaraz, Valenga do Douro, and Braga. Other alms were to ascertain the date on which the heat-accumulation period started and the threshold temperatures above which the development of reproductive structures starts in olives. The starting and peak dates for the regional O. europeae flowering season were estimated by monitoring airborne pollen from 1998 to 2004 using ＂Cour＂- type samplers. The threshold temperature values calculated for the three regions were very similar （9.0 ℃ for Valenca do Douro, 9.2 ℃ for Reguengos de monsaraz, and 9.7 ℃ for Braga）. The accumulated daily mean temperature model had less interannual and inter-regional variation, showing best predictive results for 2004, with absolute differences between the observed and predicted dates of 4 d in Reguengos de monsaraz and 2 d In Valenca do Douro and Braga for the onset of flowering date and of 2 d In Reguengos de monsaraz, 7 d in Valenca do Douro, and 4 d in Braga for peak flowering dates. This model was the most accurate, reproducible, and operational to calculate heat requirements for olives to flower, with an average mean temperature accumulation of 1 446 ℃ In Reguengos, 1 642 ℃ in Valenga do Douro, and 1 703℃ In Braga to reach the onset of flowering. The best initial date for this accumulation was 1 January.

关键词： flowering season heat requirements olives pollen Portugal

Stable Weakly Shadowable Volume-preserving Systems Are Volume-hyperbolic

在线全文

学校读者我要写书评

暂无评论

Acta mathematica Sinica,English Series 2014年第6期30卷 1007-1020页

作者： m.rio BESSA manseob LEE Sandra VAZ Universidade da Beira Interior Rua Marquês d’vila e Bolama 6201-001 Covilh Portugal Department of mathematics Mokwon University Daejeon 302-729 Republic of Korea

We prove that any C1-stable weakly shadowable volume-preserving diffeomorphism defined on a compact manifold displays a dominated splitting E ⊕ F. moreover, both E and F are volume-hyperbolic. Finally, we prove the version of this result for divergence-free vector fields. As a consequence, in low dimensions, we obtain global hyperbolicity.

关键词： Weak shadowing dominated splitting hyperbolicity

Solutions for submucosal injection: What to choose and how to do it

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第7期25卷 777-788页

作者： Rui Castro Diogo Libanio Inês Pita m.rio Dinis-Ribeiro Department of Gastroenterology Portuguese Oncology Institute of Porto CIDES/CINTESIS Faculty of Medicine University of Porto

During the past decades, endoscopic resection techniques have gradually improved and gained more importance for the management of premalignant lesions and early cancers. These endoscopic resection techniques can be divided in 3 major groups: snare polipectomy, endoscopic mucosal resection(EmR) and endoscopic submucosal dissection(ESD). The use of submucosal injection is essential for the majority of EmR techniques and is an integral part of ESD,whereas during polipectomy it is not crucial in most cases except to prevent bleeding in large polyps and/or those with large stalks as an alternative to mechanical methods. Injection provides a lifting up effect of the lesion separating it from the muscular layer, thereby reducing thermal injury and the risk of perforation and bleeding while also facilitating en-bloc resection by improving technical feasibility. With this work, we aim to review the most common endoscopic resection techniques and the importance of submucosal injection in each one of them. For that, we present some of the most commonly used submucosal injection solutions, taking into account their advantages and disadvantages. We also discuss, based on current recommendations and our own experience, how and when to preform submucosal injection, depending on lesions features and endoscopic resection technique that′s being used, to assure complete resection and to prevent associated adverse events. Finally, we also present and discuss some new proposed submucosal injection solutions,endoscopic resection techniques and devices that may have a major impact on the future of therapeutic endoscopy.

关键词： Snare polipectomy Endoscopic mucosal resection Endoscopic submucosal dissection Submucosal injection Submucosal injection solution

Using BlazePose on Spatial Temporal Graph Convolutional Networks for Action Recognition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, materials & Continua 2023年第1期74卷 19-36页

作者： motasem S.Alsawadi El-Sayed m.El-kenawy miguel rio Electronic and Electrical Engineering Department University College LondonLondonWC1E 7JEEngland Department of Communications and Electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt

The ever-growing available visual data(i.e.,uploaded videos and pictures by internet users)has attracted the research community’s attention in the computer vision ***,finding efficient solutions to extract knowledge from these sources is ***,the BlazePose system has been released for skeleton extraction from images oriented to mobile *** this skeleton graph representation in place,a Spatial-Temporal Graph Convolutional Network can be implemented to predict the *** hypothesize that just by changing the skeleton input data for a different set of joints that offers more information about the action of interest,it is possible to increase the performance of the Spatial-Temporal Graph Convolutional Network for HAR ***,in this study,we present the first implementation of the BlazePose skeleton topology upon this architecture for action ***,we propose the Enhanced-BlazePose topology that can achieve better results than its ***,we propose different skeleton detection thresholds that can improve the accuracy performance even *** reached a top-1 accuracy performance of 40.1%on the Kinetics *** the NTU-RGB+D dataset,we achieved 87.59%and 92.1%accuracy for Cross-Subject and Cross-View evaluation criteria,respectively.

关键词： Action recognition BlazePose graph neural network OpenPose skeleton spatial temporal graph convolution network

Consolidation of soft clay foundation improved by geosyntheticreinforced granular columns:Numerical evaluation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock mechanics and Geotechnical Engineering 2021年第5期13卷 1173-1181页

作者： Nima R.Alkhorshid Gregório L.S.Araujo Ennio m.Palmeira Institute of Integrated Engineering Federal University of Itajubáe Itabira CampusItabiraMinas Gerais35903-087Brazil Department of Civil and Environmental Engineering University of BrasíliaBrasíliaDistrito Federal70910-900Brazil

Soft clays are problematic soils as they present high compressibility and low shear *** are several methods for improving in situ conditions of soft *** on the geotechnical problem’s geometry and characteristics,the in situ conditions may require reinforcement to restrain instability and construction *** columns reinforced by geosynthetic material are widely used to reduce settlements of embankments on soft *** also accelerate the consolidation rate by reducing the drainage path’s length and increasing the foundation soil’s bearing *** this study,the performance of encased and layered granular columns in soft clay is investigated and *** numerical results show the significance of geosynthetic stiffness and the column length on the embankment ***,the results show that granular columns may play an important role in dissipating the excess pore water pressures and accelerating the consolidation settlements of embankments on soft clays.

关键词： Geosynthetic Embankment Granular column Consolidation Soft soil

Recent advances and applications of machine learning in solidstate materials science

在线全文

学校读者我要写书评

暂无评论

npj Computational materials 2019年第1期5卷 394-429页

作者： Jonathan Schmidt m.rio R.G.marques Silvana Botti miguel A.L.marques Institut für Physik Martin-Luther-Universität06120 Halle-WittenbergHalle(Saale)Germany Institut für Festkörpertheorie und-optik Friedrich-Schiller-Universität JenaMax-Wien-Platz 107743 JenaGermany

One of the most exciting tools that have entered the material science toolbox in recent years is machine *** collection of statistical methods has already proved to be capable of considerably speeding up both fundamental and applied *** present,we are witnessing an explosion of works that develop and apply machine learning to solid-state *** provide a comprehensive overview and analysis of the most recent research in this *** a starting point,we introduce machine learning principles,algorithms,descriptors,and databases in materials *** continue with the description of different machine learning approaches for the discovery of stable materials and the prediction of their crystal *** we discuss research in numerous quantitative structure–property relationships and various approaches for the replacement of first-principle methods by machine *** review how active learning and surrogate-based optimization can be applied to improve the rational design process and related examples of *** major questions are always the interpretability of and the physical understanding gained from machine learning *** consider therefore the different facets of interpretability and their importance in materials ***,we propose solutions and future research paths for various challenges in computational materials science.

关键词： learning gained starting

A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2020年第2期9卷 118-131页

作者： Sandra I.Anjo Patrícia Valério dos Santos Luiza Rosado Graça Baltazar Inês Baldeiras Diana Pires Andreia Gomes Cristina Januário miguel Castelo-Branco m.rio Grãos Bruno manadas CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal Faculty of medicine University of CoimbraCoimbraPortugal Centro de Investigação em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Centro Hospitalar Cova da Beira E.P.ECovilhãPortugal Neurology Department Centro Hospitalar e Universitário de CoimbraCoimbraPortugal Coimbra Institute for Biomedical Imaging and Translational Research(CIBIT) CoimbraPortugal Biocant Biotechnology Transfer AssociationCantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)CoimbraPortugal

Background The identification of circulating biomarkers that closely correlate with Parkinson’s Disease(PD)has failed several times in the ***,in this pilot study,a translational approach was conducted,allowing the evaluation of the plasma levels of two mitochondrial-related proteins,whose combination leads to a robust model with potential diagnostic value to discriminate the PD patients from matched *** The proposed translational approach was initiated by the analysis of secretomes from cells cultured under control or well-defined oxidative stress conditions,followed by the identification of proteins related to PD pathologic mechanisms that were altered between the two *** pipeline was further translated into the analysis of undepleted plasma samples from 28 control and 31 PD *** From the secretome analysis,several mitochondria-related proteins were found to be differentially released between control and stress conditions and to be able to distinguish the two ***,two mitochondrial-related proteins were found to be significantly changed in a PD cohort compared to matched ***,a linear discriminant model with potential diagnostic value to discriminate PD patients was obtained using the combination of these two *** proteins are associated with apoptotic mitochondrial changes,which may correspond to potential indicators of cell ***,one of these proteins,the VPS35 protein,was reported in plasma for the first time,and its quantification was only possible due to its previous identification in the secretome *** In this work,an adaptation of a translational pipeline for biomarker selection was presented and transposed to neurological diseases,in the present case Parkinson’s *** novelty and success of this pilot study may arise from the combination of:i)a translational research pipeline,where plasma samples are interrogated using knowledge previously ob

关键词： mitochondrial-related proteins SWATH-mS Parkinson's disease Biomarker discovery Blood-biomarker Secretomes Oxidative stress

Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2022年第1期9卷 1131-1142页

作者： Ana Beatriz Sousa Artur P.Águas m.rio A.Barbosa Judite N.Barbosa i3S—Instituto de Inovaçäo e Investigaçäo em Saúde Universidade do PortoRua Alfredo Allen2084200-125 PortoPortugal INEB—Instituto de Engenharia Biomédica Rua Alfredo Allen2084200-125 PortoPortugal ICBAS—Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira2284050-313 PortoPortugal UmIB—Unit for multidisciplinary Biomedical Research of ICBAS—Instituto de Ciências Biomédicas de Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira2284050-313 PortoPortugal

Successful wound healing is a process that has three overlying phases:inflammatory,proliferative and *** wounds are characterized by a perpetuated inflammation that inhibits the proliferative and remodeling phases and impairs the wound *** are key modulators of the wound healing ***,they are responsible for the wound cleaning and for the phagocytosis of pathogens and afterwards they lead to the resolution of the inflammatory response and they express growth factors important for angiogenesis and cytokines and growth factors needed for cell proliferation and deposition of extracellular *** phenotype of the macrophage changes gradually throughout the healing process from the initial m1 pro-inflammatory phenotype characteristic of the acute response to the m2 pro-regenerative phenotype that allows an accurate tissue *** chronic wounds,m1 pro-inflammatory macrophages persist and impair tissue *** such,immunomodulatory biomaterials arise as promising solutions to accelerate the wound healing *** this review,we discuss the importance of macrophages and their polarization throughout the different phases of wound healing;macrophage dysfunction in chronic wounds and the use of immunomodulatory biomaterials to overcome the critical problem of chronic wounds-the continued inflammatory phase that impairs healing.

关键词： wound healing chronic wounds macrophage immunomodulatory biomaterials