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葡聚糖和腐植酸:对免疫系统的协同作用

腐植酸 2015年第6期 34-40页

作者： Vaclav Vetvicka Roberto Baigorri Angel m.Zamarre?o jose m.garcia-mina Jean-Claude Yvin 周霞萍樊兴明美国路易斯维尔大学病理学系肯塔基州40292 钛美农业国际鲁利耶集团研发部奥尔科延999019 西班牙纳瓦拉大学化学和土壤化学系潘普洛纳999023 法国钛美农业国际研发部迪纳尔999019 华东理工大学科学技术发展研究院上海200237

腐植酸是由有机物质分解产生的混合物。尽管它们普遍存在,但对它们的生物学效应了解有限,且目前的研究结果存在争议。因此对来源不同且具有不同的生化特性的两种类型的腐植酸的免疫效果进行评估。单独使用这两种腐植酸或与已知发酵衍生... 详细信息

腐植酸是由有机物质分解产生的混合物。尽管它们普遍存在,但对它们的生物学效应了解有限,且目前的研究结果存在争议。因此对来源不同且具有不同的生化特性的两种类型的腐植酸的免疫效果进行评估。单独使用这两种腐植酸或与已知发酵衍生的免疫调节剂葡聚糖结合使用,并测其在细胞(吞噬作用和肿瘤抑制)和体液(抗体的产生和细胞因子的分泌)的免疫反应。研究结果表明,腐植酸是具有生物活性的免疫调节剂,影响体液免疫和细胞免疫反应。此外,本文研究的两种腐植酸在免疫反应的刺激下具有协同效应,为这些天然免疫调节剂的进一步研究提供了支持。

关键词：葡聚糖腐植酸免疫力吞噬作用

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Safety of intravitreal quinupristin/dalfopristin in an animal model

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 373-378页

作者： Veronica E.Giordano Sergio E.Hernandez-Da mota Tania N.A dabache-Guel Armando Castillejos-Cheve Sonia Corredor-Casas Samantha m.Salinas-Longoria Rafael Romero-Vera Juan m.Jimenez-Sierra jose L.Guerrero-Naranjo Virgilio morales-Canton Department of Ophthalmology Retina and Vitreous Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Torres 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico Ophthalmology Service Clinica David Boulevard Garcia de Leon 598 Nueva Chapultepec Morelia Michoacan 58280Mexico Department of Ophthalmology Glaucoma Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Torres 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico Department of Ophthalmology Pathology Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Tortes 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico

AIm： To determine whether different intravitreal doses of quinupristin/dalfopristin lead to electroretinographic or histological changes in the rabbit retina over one month period after injection. mETHODS： Eighteen New Zealand white rabbits were divided into three treatment groups （groups 1 to 3） and different intravitreal doses of quinupristin/dalfopristin were tested in each group. The right eye was injected with the drug and the left eye received intravitreal injection of 5% dextrose water and served as control eye. The doses delivered to each group were 0.1 mg/0.1 mL, 1 mg/0.1 mL and 10 mg/0.1 mL. Simultaneous, bilateral, dark-adapted electroretinography and clinical images of both eyes were obtained in all groups before injection （baseline） and after 7, 14, 21 and 28d, followed by enucleation for histological examination. RESULTS： Subjects in the group 1 showed no signs of toxicity in the electroretinogram when compared with groups 2 and 3 （Kruskall-Wallis test, P=0.000）. By day 7, no electrical response to light stimuli was recorded in the treated eyes in groups 2 and 3, consistent with severe damage due to retinal toxicity. Light microscopy revealedno significant histopathological changes in the group 1, while rabbits in groups 2 and 3 had signs of granulomatous inflammation in most cases. CONCLUSION： Intravitreal 0.1 mg/0.1 mL doses of quinupristin/dalfopristin do not lead to electroretinographic or histological signs of retinal toxicity compared with 1 mg/0.1 mL and 10 mg/O.1 mL in this rabbit model.

关键词： endophthalmitis quinupristin/dalfopristin retinal toxicity

Concordance among pulse wave velocity assessment methods:A network meta-analysis

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Chinese medical Journal 2024年第17期137卷 2137-2139页

作者： Iván Cavero-Redondo Irene Sequí-Domínguez Alicia Saz-Lara jose Luis garcia-Klepzig maribel Lucerón-Lucas-Torres Irene martínez-García Celia Álvarez-Bueno Vicente martínez-Vizcaíno CarVasCare Research Group Facultad de Enfermería de CuencaUniversidad de Castilla-La ManchaCuenca 16071Spain Facultad de Ciencias de la Salud Universidad Autónoma de ChileTalca 3460000Chile Health and Social Research Center Universidad de Castilla-La ManchaCuenca 16071Spain Internal medicine Department San Carlos University HospitalMadrid 28040Spain Universidad Politécnica y Artística del Paraguay Asunción 2024Paraguay

To the Editor:Arterial stiffness signifies early structural and functional changes in the arterial *** wave velocity(PWV)stands out as the most validated method for noninvasive arterial stiffness quantification,serving as the gold standard for assessing aortic *** estimates the transit time of the pulse between waves at distinct sites in the vascular tree.

关键词： arterial stiffness pulse

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菲律宾丘陵地土壤保持

中国水土保持 2002年第7期 18-18页

作者： Richard T.Yao,jose Nestor m.garcia UPLB Foundation Inc 4031 College Laguna University of the Philippines Los Baos 4031 College Laguna Philippines philippines

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菲律宾丘陵地土壤保持

中国水土保持 2002年第7期 14-14页

作者： Richard T.Yao jose Nestor m.garcia UPLB Foundation Inc4031 CollegeLagunaUniversity of the Philippines Los Baos4031 CollegeLaguna Philippinesphilippines

Thermal,infrared spectroscopy and molecular modeling characterization of bone:An insight in the apatite-collagen type I interaction

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Advances in Biological Chemistry 2013年第2期3卷 215-223页

作者： Alejandro Heredia m.ria Colin-garcia miguel A.Pena-Rico jose Grácio Flavio F.Contreras-Torres Andrés Rodríguez-Galván Lauro Bucio Vladimir A.Basiuk Departamento de Radiaciones y Radioquímica Instituto de Ciencias NuclearesUNAMD.F.MéxicoMéxico Nanotechnology Research Division Centre for Mechanical Technology&AutomationUniversity of AveiroAveiroPortugal S.I.O.V.Instituto de Geología UNAMD.F.MéxicoMéxico Departamento de Estado Sólido Instituto de FísicaUniversidad Nacional Autónoma de México(UNAM)D.F.MéxicoMéxico Instituto de Biotecnología UNAMD.F.MéxicoMéxico Departamento de Fisica de Plasmas y de Intearcción de Radiación con la materia Instituto de Ciencias NuclearesUNAMD.F.MéxicoMéxico

An insight into the interaction of collagen type I with apatite in bone tissue was performed by using differential scanning calorimetry, Fourier transform infrared spectroscopy, and molecular modeling. Scanning electron microscopy shows that bone organic content incinerate gradually through the different temperatures studied. We suggest that the amide regions of the type I collagen molecule (mainly C=O groups of the peptide bonds) will be important in the control of the interactions with the apatite from bone. The amide I infrared bands of the collagen type I change when interacting to apatite, what might confirm our assumption. Bone tissue results in a loss of thermal stability compared to the collagen studied apart, as a consequence of the degradation and further combustion of the collagen in contact with the apatite microcrystals in bone. The thermal behavior of bone is very distinctive. Its main typical combustion temperature is at 360°C with a shoulder at 550°C compared to the thermal behavior of collagen, with the mean combustion peak at ca. 500°C. Our studies with molecular mechanics (mm+ force field) showed different interaction energies of the collagen-like molecule and different models of the apatite crystal planes. We used models of the apatite (100) and (001) planes;additional two planes (001) were explored with phosphate-rich and calcium-rich faces;an energetic preference was found in the latter case. We preliminary conclude that the peptide bond of collagen type I is modified when the molecule interacts with the apatite, producing a decrease in the main peak from ca. 500°C in collagen, up to 350°C in bone. The combustion might be related to collagen type I, as the ΔH energies present only small variations between mineralized and non-mineralized samples. The data obtained here give a molecular perspective into the structural properties of bone and the change in collagen properties caused by the interaction with the apatite. Our study can be useful to un

关键词： Bone,Collagen Type I Apatite Differential Scanning Calorimetry(DSC) molecular modeling Fourier Transform Infrared(FTIR)Spectroscopy

XAANTAL2 （AGL14） Is an Important Component of the Complex Gene Regulatory Network that Underlies Arabidopsis Shoot Apical meristem Transitions

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molecular Plant 2015年第5期8卷 796-813页

作者： Rigoberto V. Perez-R.u.iz Berenice garcia-Ponce Nayelli marsch-martinez Yamel Ugartechea-Chirino mitzi Villajuana-Bonequi Stefan de Folter Eugenio Azpeitia jose Davila-Velderrain David Cruz-Sanchez Adriana Garay-Arroyo m.ria de la Paz Sanchez Juan m. Estevez-Palmas Elena R. Alvarez-Buylla Instituto de Ecologia Universidad Nacionat Autonoma de Moxico 3er Circuito Exterior s/no Junto al Jardin Bot~nico and Centro de Ciencias de la ComplejidadCiudad Universitaria Coyoacan 04510 Mexico D.F. Mexico Laboratorio Nacional de Genemica para la Biodiversidad (Langebio) Centro de Investigaci6n y de Estudios Avanzados del Instituto Polit~cnico Nacional(CINVESTAV-IPN) Km. 9.6 Carretera Irapuato - Leen AP 629 36821 Irapuato Guanajuato Mexico University of California 431 Koshland Hall Berkeley CA 94720 USA These authors contributed equally to this article. present address: Departamento de Biotecnologia y Biquimica Centro de )nvestigaci6n y de Estudios Avanzados del Instituto Polit6cnico Nacional(CINVESTAV-IPN) Km. 9.6 Libramiento Norte Carr. Irapuato-Leen 36821 Irapuato Guanajuato Mexico present address: max Planck Institute for Plant Breeding Research D-50829 Cologne Germany Present address: INria Project-Team Virtual Plants/CIRAD/INRA UMR AGAP Campus St Priest - BAT 5 CC 05018 860 rue de St Priest 34095 Montpellier Cedex5 France

In Arabidopsis thaliana, multiple genes involved in shoot apical meristem （SAm） transitions have been char- acterized, but the mechanisms required for the dynamic attainment of vegetative, inflorescence, and floral meristem （Vm, Im, Fm） cell fates during SAm transitions are not well understood. Here we show that a mADS-box gene, XAANTAL2 （XAL2/AGL14）, is necessary and sufficient to induce flowering, and its regula- tion is important in Fm maintenance and determinacy, xal2 mutants are late flowering, particularly under short-day （SD） condition, while XAL2 overexpressing plants are early flowering, but their flowers have vege- tative traits. Interestingly, inflorescences of the latter plants have higher expression levels of LFY, AP1, and TFL1 than wild-type plants. In addition we found that XAL2 is able to bind the TFL1 regulatory regions. On the other hand, the basipetal carpels of the 35S：：XAL2 lines lose determinacy and maintain high levels of WUS expression under SD condition. To provide a mechanistic explanation for the complex roles of XAL2 in SAm transitions and the apparently paradoxical phenotypes of XAL2 and other mADS-box （SOCl, AGL24） over- expressors, we conducted dynamic gene regulatory network （GRN） and epigenetic landscape modeling. We uncovered a GRN module that underlies Vm, Im, and Fm gene configurations and transition patterns in wild- type plants as well as loss and gain of function lines characterized here and previously. Our approach thus provides a novel mechanistic framework for understanding the complex basis of SAm development.

关键词： XAL2/AGL14 mADS-box TFL1 SAm transitions floral reversion gene regulatory networks,epigenetic landscape modeling

Improving wood volume predictions in dry tropical forest in the semi-arid Brazil

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Journal of Arid Land 2020年第6期12卷 1046-1055页

作者： Robson B de LImA Patrícia A B BARRETO-garcia Alessandro de PAULA Jhuly E S PEREIRA Flávia F de CARVALHO Silvio H m GOmES Department of Forest Engineering State University of AmapáMacapá68900070Brazil Department of Forest Science State University of Southwest BahiaVitória da Conquista 45083900Brazil Universidade Federal de Lavras Lavras 37200900Brazil Universidade de São Paulo Piracicaba 13418900Brazil

The volumetric variability of dry tropical forests in Brazil and the scarcity of studies on the subject show the need for the development of techniques that make it possible to obtain adequate and accurate wood volume *** this study,we analyzed a database of thinning trees from a forest management plan in the Contendas de SincoráNational Forest,southwestern Bahia State,*** data set included a total of 300 trees with a trunk diameter ranging from 5 to 52 ***,validation and statistical selection of four volumetric models were *** to the difference in height values for the same diameter and the low correlation between both variables,we do not suggest models which only use the diameter at breast height(DBH)variable as a predictor because they accommodate the largest estimation *** comparing the best single entry model(Hohenald-Krenn)with the Spurr model(best fit model),it is noted that the exclusion of height as a predictor causes the values of 136.44 and 0.93 for Akaike information criterion(AIC)and adjusted determination coefficient(R2 adj),which are poorer than the second best model(Schumacher-Hall).Regarding the minimum sample size,errors in estimation(root mean square error(RmSE)and bias)of the best model decrease as the sample size increases,especially when a larger number of trees with DBH≥15.0 cm are randomly *** sampling by diameter class produces smaller volume prediction errors than random sampling,especially when considering all *** summary,the Spurr and Schumacher-Hall models perform *** models suggest that the total variance explained in the estimates is not less than 95%,producing reliable forecasts of the total volume with *** estimates indicate that the bias around the average is not greater than 7%.Our results support the decision to use regression methods to build models and estimate their parameters,seeking stratification strategies in diameter classes for the sample trees.

关键词： volume modeling minimal sample size Caatinga Spurr model forest management

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The use of high resolution anterior segment optical coherence tomography for the characterization of conjunctival lymphoma, conjunctival amyloidosis and benign reactive lymphoid hyperplasia

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Eye and Vision 2019年第1期6卷 123-130页

作者： Nandini Venkateswaran Carolina mercado Ann Q.Tran Armando garcia Pedro Francisco monsalve Diaz Sander R.Dubovy Anat Galor Carol L.Karp Bascom Palmer Eye Institute University of Miami Miller School of Medicine900 NW 17th StreetMiamiFL 33136USA Department of Ophthalmology Miami Veterans Administration Medical CenterMiamiFLUSA

Background:Conjunctival lymphoma,conjunctival amyloidosis and benign reactive lymphoid hyperplasia(BRLH)are conditions that often have a similar appearance on the ocular *** use of high resolution anterior segment optical coherence tomography(HR-OCT)enables clinicians to evaluate distinctive differences in tissue morphology and cellular patterns in various ocular surface *** this study,we characterize the morphological differences seen in conjunctival lymphoma,conjunctival amyloidosis and BRLH on HR-OCT ***:A retrospective chart review was performed of patients with biopsy proven conjunctival lymphoma,conjunctival amyloidosis and BRLH between 2012 and 2019 at the Bascom Palmer Eye *** were excluded if HR-OCT imaging was not performed on initial ***:Thirty-four total eyes of 27 patients were *** eyes had conjunctival lymphoma(16 patients),8 eyes had conjunctival amyloidosis(6 patients)and 6 eyes had BRLH(5 patients).All conditions appeared clinically as pink,red or yellow subepithelial lesions but had different features on *** lymphoma,HR-OCT images typically showed homogenous,dark subepithelial lesions with smooth borders,containing monomorphic dot-like ***-OCT images of amyloidosis typically showed heterogeneous,dark lesions with irregular borders,often containing hyperreflective linear ***-OCT images of BRLH showed variable infiltration of the subepithelial tissue,at times with homogenous lesions containing dot-like infiltrates like lymphoma and other times with more hyperreflective,subepithelial *** cytometry and gene rearrangement was needed for final differentiation between BRLH and lymphoma ***:Distinctive features on HR-OCT of conjunctival lymphoma,conjunctival amyloidosis and BRLH can help characterize these lesions beyond what is apparent with the clinical *** studies can further validate this technology’s use with m

关键词： High resolution anterior segment optical coherence tomography Ocular surface imaging Ocular surface lesions Conjunctival lymphoma Conjunctival amyloidosis Benign reactive lymphoid hyperplasia