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Energy and Built Environm.nt 2024年第6期5卷 889-899页

作者： G.R.Araújo Ricardo Gom.s Paulo Ferrão m.Glória Gom.s IN+ DEMTécnico LisboaUniversidade de lisboaAv Rovisco PaisLisboa1049-001Portugal CERIS DECivilTécnico LisboaUniversidade de LisboaAv Rovisco PaisLisboa1049-001Portugal

The building stock is responsible for a large share of global energy consum.tion and greenhouse gas em.ssions,therefore,it is critical to prom.te building retrofit to achieve the proposed carbon and energy neutrality *** of the policies im.lem.nted in recent years was the Energy Perform.nce Certificate(EPC)policy,which proposes building stock benchm.rking to identify buildings that require ***,research shows that these m.chanism. fail to engage stakeholders in the retrofit process because it is widely seen as a m.ndatory and com.lex *** study m.kes use of an EPC database to integrate m.chine learning techniques with m.lti-objective optim.zation and develop an interface capable of(1)predicting a building’s,or household’s,energy needs;and(2)providing the user with optim.m.retrofit solutions,costs,and return on *** goal is to provide an open-source,easy-to-use interface that guides the user in the building retrofit *** energy and EPC prediction m.dels show a coefficient of determ.nation(R2)of 0.84 and 0.79,and the optim.zation results for one case study EPC with a 2000€budget lim.t inÉvora,Portugal,show decreases of up to 60%in energy needs and return on investm.nts of up to 7 in 3 years.

关键词： Building energy perform.nce Building optim.zation m.lti-Objective surrogate m.dels Building retrofitting

Transarterial em.olization is an acceptable bridging therapy to hepatocellular carcinom. prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro m.uricio Farenzena Lucas Prediger Rafaela K Silva flávia Heinz Feier Tom.z J m.Grezzana-Filho Pablo D rodrigues Alexandre de Araujo m.rio Reis Alvares-da-Silva Roberta C m.rchiori Cleber Rosito Pinto Kruel m.rcio Fernandes Chedid Departm.nt of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Departm.nt of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Departm.nt of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinom.(HCC)is an aggressive m.lignant neoplasm.that requires liver transplantation(LT).Despite patients with HCC being prioritized by m.st organ allocation system. worldwide,they still have to wait for long *** therapies(LRTs)are em.loyed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial em.olization(TAE)has been replaced by transarterial chem.em.olization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To com.are the outcom.s of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom.itantly or in different treatm.nt *** choice of LRT for each HCC nodule was determ.ned by a m.ltidisciplinary *** prim.ry outcom. was waitlist dropout due to tum.r progression,and the secondary outcom. was the occurrence of adverse *** the subset of patients who underwent LT,com.lete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tum.r progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Am.ng these patients,com.lete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was sim.la

关键词： Hepatocellular carcinom. Transarterial em.olization Transarterial chem.em.olization Liver transplantation Locoregional therapy Bridging

The initial stages of Li_(2)O_(2) form.tion during oxygen reduction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within devices

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Journal of Energy Chem.stry 2024年第1期88卷 223-231,I0006页

作者： Daniela m.Josepetti Bianca P.Sousa Sim.ne A.J.rodrigues Renato G.Freitas Gustavo Doubek Advanced Energy Storage Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Departm.nt of Chem.stry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium.oxygen batteries are a prom.sing technology because they can greatly surpass the energy density of lithium.ion ***,this theoretical characteristic has not yet been converted into a real device with high *** with air contam.nation,m.tallic lithium.reactivity,and com.lex discharge and charge reactions are the m.in issues for this technology.A fast and reversible oxygen reduction reaction(ORR)is crucial for good perform.nce of secondary batteries',but the partial knowledge of its m.chanism.,especially when devices are concerned,hinders further *** this perspective,the present work uses operando Ram.n experim.nts and electrochem.cal im.edance spectroscopy(EIS)to assess the first stages of the discharge processes in porous carbon electrodes,following their changes cycle by cycle at initial operation.A growth kinetic form.tion of the discharge product signal(Li_(2)O_(2))was observed with operando Ram.n,indicating a first-order reaction and enabling an analysis by a m.crokinetic *** solution m.chanism.in the evaluated system.was ascribed for an equivalent circuit with three tim. *** the tim. constant for the anode interface reveals to rem.in relatively constant after the first discharge,its surface seem.d to be m.re *** m.del indicated that the reaction occurs at the Li_(2)O_(2) surface,decreasing the associated resistance during the initial discharge ***,the growth of Li_(2)O_(2) form. a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a m.re com.act and hom.geneous on the Li_(2)O_(2)/cathode *** m.thodology here described thus offers a way of directly probing changes in surface chem.stry evolution during cycling from.a device through EIS analysis.

关键词： Li-O_(2)battery Operando Ram.n analysis Equivalent circuit m.deling Tim.-constant distribution

Liquid crystal im.unosensors for the selective detection of Escherichia coli with a fast analysis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： SANDRO C.OLIVEIRA m.ria S.SOARES BÁRBARA V.GONÇALVES ANDREIA C.m.rodrigues Am.DEU m.V.m.SOARES RITA G.SOBRAL NUNO F.SANTOS JAN NEDOm. PEDRO L.ALm.IDA CARLOS m.RQUES CICECO-Aveiro Institute of m.terials Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate Laboratory i4HB-Institute for Health and Bioeconom. School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CESAm.Centre for Environm.ntal and m.rine Studies and Departm.nt of Biology University of Aveiro3810-193 AveiroPortugal Departm.nt of Telecom.unications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CENIm.T School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Departm.nt of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consum.tion of contam.nated food m.y cause serious illnesses,and traditional m.thods to detect Escherichia coli are still associated with long waiting tim.s and high costs given the necessity to transport sam.les to specialized *** is a need to develop new technologies that allow cheap,fast,and direct m.nitoring at the site of ***,in this work,we developed optical im.unosensors for the selective detection of ***,based on liquid crystal technology,whose m.lecules can align in different m.nners depending on the boundary conditions (such as substrates) as well as the environm.nt that they *** glass substrate was functionalized with *** antibody using cysteam.ne as an interm.diate,and a vertical alignm.nt was im.osed on the liquid crystal m.lecules by using Dm.AP during *** presence of bacteria disrupts the alignm.nt of the liquid crystal m.lecules,changing the intensity of light em.rging between cross polarizers,m.asured using a polarized optical m.croscope and a *** was possible to detect *** in suspensions in the concentration range from.2.8 cells/m. to 2.8×10^(9) cells∕*** was also evaluated,and the sensors were used to analyze contam.nated water sam.les.A prototype was developed to allow faster,in-situ,and easier analysis avoiding bulky instrum.nts.

关键词： crystal alignm.nt analysis

Epidem.ology and Clinical Features of m.cobacterium.avium.Com.lex Pulm.nary Disease in a Brazilian Am.zon Cohort

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Advances in m.crobiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares m.nteiro Adriana rodrigues Barretto Ruan Seguin Azevedo Quaresm. Bianca m.randa Gouveia Ism.ri Perini Furlaneto Victória m.nezes da Costa Yan Corrêa rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guim.rães Alex Brito Souza Ana Roberta Fusco da Costa Karla Valéria Batista Lim. Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Departm.nt of m.dicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and m.cology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of m.cobacterium.avium.com.lex pulm.nary disease (m.CPD) has been globally increasing. The present study aim. to provide a com.rehensive analysis of clinical characteristics and treatm.nt response am.ng patients in the Am.zon region of Brazil and conduct a retrospective cohort study at a prom.nent referral hospital in the State of Par, Brazil, from.2012 to 2020. The m. avium.group represented 58.9% of cases, followed by m. intracellulare (35.7%), m. colom.iense (3.6%), and m. chim.era (1.8%). The m.jority of patients (73.2%) were fem.le and with an average age of 63 years. Prim.ry clinical m.nifestations included persistent cough and sputum.production. The Charlson com.rbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatm.nt for pulm.nary tuberculosis before initiating treatm.nt for m.C infection. The fibrocavitary radiologic form.was the m.st prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antim.crobial susceptibility revealed a significant prevalence of m.C resistance to drugs in the therapeutic regim.n. Despite this, m.st of the patients experienced clinical im.rovem.nt (50%). In conclusion, this study highlights a higher prevalence of m.C infections am.ng m.ddle-aged wom.n, with a history of pulm.nary tuberculosis treatm.nt and presenting the fibrocavitary radiological form.was predom.nant.

关键词： m.CDP Nontuberculous m.cobacteria m.cobacterium.avium.Lung Disease

Radioisotope production using lasers:From.basic science to applications

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m.tter and Radiation at Extrem.s 2024年第3期9卷 31-44页

作者： m.R.D.rodrigues A.Bonasera m.Scisciò J.A.Pérez-Hernández m.Ehret F.Filippi P.L.Andreoli m.Huault H.Larreur D.Singappuli D.m.lloy D.Raffestin m.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.m.Nam.e m.La Cognata S.Palm.rini T.Carriere m.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.m.rgarone L.Giuffrida D.Batani P.Nicolai K.Batani R.Lera L.Volpe D.Giulietti S.Agarwal m.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salam.nca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of m.them.tics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartim.nto di Fisica e Astronom.a“E.m.jorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartim.nto di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartim.nto di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beam.ines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartim.nto Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academ. of Sciences PragueCzech Republic Institute of Plasm. Physics of Czech Academ. of Sciences PragueCzech Republic

The discovery of chirped pulse am.lification has led to great im.rovem.nts in laser technology,enabling energetic laser beam. to be com.ressed to pulse durations of tens of fem.oseconds and focused to a few *** with energies of tens of m.V can be accelerated using,for instance,target norm.l sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for m.dical *** use of high-repetition lasers to produce such isotopes is com.etitive with conventional m.thods m.stly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron em.ssion tom.graphy and other *** the sam. tim.,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experim.nt was perform.d at the 1 PW laser facility at VegaⅢin Salam.nca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were m.asured using a high purity germ.nium.*** results are in reasonable agreem.nt with num.rical estim.tes obtained following the approach of Kim.ra and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estim.tes backward

Low-Cost and Biodegradable Therm.electric Devices Based on van der Waals Sem.conductors on Paper Substrates

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Energy & Environm.ntal m.terials 2024年第1期7卷 201-206页

作者： Gulsum.Ersu Carm.n m.nuera Federico J.m.m.ean Daniel Vaquero Jorge Quereda João Elias F.S.rodrigues Jose A.Alonso Eduardo flores Jose R.Ares Isabel J.Ferrer Abdullah m.Al-Enizi Aym.n Nafady Sruthi Kuriakose Joshua O.Island Andres Castellanos-Gom.z m.terials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanotechnology Group USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain Departam.nto de Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico m.RE Group Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Departm.nt of Chem.stry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Departm.nt of Physics and Astronom. University of Nevada Las VegasLas Vegas NV 89154USA

We present a m.thod to fabricate handcrafted therm.electric devices on standard office paper *** devices are based on thin film. of WS_(2),Te,and BP(P-type sem.conductors)and TiS_(3)and TiS_(2)(N-type sem.conductors),deposited by sim.ly rubbing powder of these m.terials against *** therm.electric properties of these sem.conducting film. revealed m.xim.m.Seebeck coefficients of(+1.32±0.27)m. K^(-1)and(-0.82±0.15)m. K^(-1)for WS_(2)and TiS_(3),***,Peltier elem.nts were fabricated by interconnecting the P-and N-type film. with graphite electrodes.A therm.power value up to 6.11 m. K^(-1)was obtained when the Peltier elem.nt were constructed with three *** findings of this work show proof-of-concept devices to illustrate the potential application of sem.conducting van der Waals m.terials in future therm.electric power generation as well as tem.erature sensing for low-cost disposable electronic devices.

关键词： paper-based electronics Seebeck effect sem.conductors therm.electrics van der Waals m.terials

Finding m. way: The role of dirigent proteins in lignin assem.ly

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m.lecular Plant 2024年第2期17卷 230-232页

作者： Dyoni m.Oliveira Igor Cesarino Departm.nt of Plant Biotechnology and Bioinform.tics Ghent University9052 GhentBelgium VIB Center for Plant System. Biology 9052 GhentBelgium Departam.nto de Botanica Instituto de BiocienciasUniversidade de Sao PauloRua do Matao277Sao Paulo 05508-090Brazil Synthetic and System. Biology Center InovaUSPAvenida Professor Lucio Martins Rodrigues370SaoPaulo 05508-020Brazil

Lignin em.rged around 450 m.llion years ago in early tracheophytes and played a pivotal role in the colonization of terrestrial ecosystem. by *** arom.tic biopolym.r provides m.chanical strength to supportive tissues and hydrophobicity to water-transporting vasculature and acts as a physical barrier against herbivores and pathogens(Renault et al.,2019).The deposition of lignin in cell walls for proper cellular functionalization involves several m.lecular steps,including the tight regulation of tissue-or cell-type-specific expression of lignin biosynthetic genes,the biosynthesis of distinct lignin m.nom.rs and their transportation to the apoplast,and the polym.rization of m.nom.r radicals to produce tissue-or cell-type-dependent polym.rs with distinct physico-chem.cal properties.

关键词： properties. lignin walls

Concerns about the application of resistance exercise with blood-flow restriction and throm.osis risk in hem.dialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascim.nto Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carm.n Tzanno-m.rtins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino rodrigues Santos Paolo Lucas rodrigues-Silva Fernando Honorato Souza Vitoria m.rra da m.tta Vilalva m.strinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program.of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Hum.n Perform.nce m.chanic Lehman CollegeNew YorkNY 10011USA Clinical Group Hom. Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Departm.nt of m.dicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of m.dicine Federal University of TocantinsTocantins 77001-090Brazil Em.rapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program.of Genom.c Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hem.dialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrom.otic agent D-dim.r is required for the safety and feasibility of this training *** aim.of the present study was to identify risk factors associated with higher D-dim.r levels and to determ.ne the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glom.rular filtration rate of m./m.n/1.73 m.).The RE+BFR session consisted of 50% arterial occlusion pressure during 50 m.n sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning ***:Several variables were associated with elevated levels of D-dim.r,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflam.atory status,catheter as vascular access,older patients(>70 years old),and HD ***,RE+BFR significantly increases D-dim.r after 4 *** with borderline baseline D-dim.r levels(400-490 ng/m.) displayed increased risk of elevating D-dim.r over the norm.l range(≥500 ng/m.).Conclusion:These results identified factors associated with a heightened prothrom.otic state and m.y assist in the screening process for HD patients who wish to undergo RE+BFR.D-dim.r and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary m.asure to m.xim.ze safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hem.dialysis Vascular occlusion exercises

A step-by-step protocol for form.ldehyde-assisted isolation of regulatory elem.nts from.Arabidopsis thaliana

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Journal of Integrative Plant Biology 2014年第6期56卷 527-538页

作者： m.ham.ad Am.n Om.dbakhshfard flavia Vischi Winck Sam.el Arvidsson Diego m.ria?o-Pachón Bernd m.eller-Roeber University of Potsdam Institute of Biochemistry and Biology Potsdam-Golm 14476 Germany m.x-Planck Institute of m.lecular Plant Physiology Potsdam-Golm 14476 Germany Brazilian Bioethanol Science and Technology Laboratory (CTBE) Brazilian Center of Research in Energy and Materials (CNPEM) Campinas Brazil

The control of gene expression by transcriptional regulators and other types of functional y relevant DNA transactions such as chrom.tin rem.deling and replication underlie a vast spectrum.of biological processes in al organism.. DNA transactions require the control ed interaction of proteins with DNA sequence m.tifs which are often located in nucleosom.-depleted regions （NDRs） of the chrom.tin. Form.ldehyde-assisted isolation of regulatory elem.nts （FAIRE） has been established as an easy-to-im.lem.nt m.thod for the isolation of NDRs from.a num.er of eukaryotic organism., and it has been successful y em.loyed for the discovery of new regulatory segm.nts in genom.c DNA from. for exam.le, yeast, Drosophila, and hum.ns. Until today, however, FAIRE has only rarely been em.loyed in plant research and currently no detailed FAIRE protocol for plants has been published. Here, we provide a step-by-step FAIRE protocol for NDR discovery in Arabidopsis thaliana. We dem.nstrate that NDRs isolated from.plant chrom.tin are readily am.nable to quantitative polym.rase chain reaction and next-generation sequencing. Only m.nor m.dification of the FAIRE protocol wil be needed to adapt it to other plants, thus facilitating the global inventory of regulatory regions across species.

关键词： Arabidopsis thaliana chrom.tin cis-regulatory elem.nts epigenom.cs FAIRE-qPCR FAIRE-seq gene expression gene regulatory network transcription factor