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Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds

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National Science Review 2018年第5期5卷 642-652页

作者： Zupeng Chen Evgeniya Vorobyeva Sharon mitchell Edvin Fako Nuúria López Sean m.Collins Rowan K.Leary Paul A.midgley RolAND Hauert Javier Pérez-Ramírez Institute for Chemical and Bioengineering Department of Chemistry and Applied BiosciencesETHZurich Institute of Chemical Research of Catalonia (ICIQ) The Barcelona Institute of Science and Technology 3. Department of Materials Science and MetallurgyUniversity of Cambridge 4. EmpaSwiss Federal Laboratories for Materials Science and Technology

Carbon nitrides integrating macroheterocycles offer unique potential as hosts for stabilizing metal atoms due to their rich electronic structure. To date, only graphitic heptazine-based polymers have been ***, we demonstrate that palladium atoms can be effectively isolated on other carbon nitride scaffolds including linear melem oligomers and poly(triazine/heptazine imides). Increased metal uptake was linked to the larger cavity size and the presence of chloride ions in the polyimide structures. Changing the host structure leads to significant variation in the average oxidation state of the metal, which can be tuned by exchange of the ionic species as evidenced by X-ray photoelectron spectroscopy and supported by density functional theory. Evaluation in the semi-hydrogenation of 2-methyl-3-butyn-2-ol reveals an inverse correlation between the activity and the degree of oxidation of palladium, with oligomers exhibiting the highest activity. These findings provide new mechanistic insights into the influence of the carbon nitride structure on metal stabilization.

关键词： single-atom heterogeneous catalysts carbon nitride scaffolds alkyne semi-hydrogenation density functional theory metal–host interaction

Effect of herpesvirus infection on pancreatic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter Hegyi Balázs rdg Zoltán Rakonczai Jr Tamás Takács János Lonovics Annam.ria Szabolcs Réka Sári András Tóth Julius G Papp András Varró m.ria K Kovács mike A Gray Barry E Argent Zsolt Boldogki First Department of medicine Department of Biology Division of Cardiovascular Pharmacology School of Cell and molecular Biosciences

AIm: To examine the effect of acute infection caused by herpesvirus (pseudorabies virus, PRV) on pancreatic ductal ***: The virulent Ba-DupGreen (BDG) and nonvirulent Ka-RREpOlacgfp (KEG) genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein (GFP). Small intra/interlobular ducts were infected with BDG virus (107 PFU/mL for 6 h) or with KEG virus (1010 PFU/mL for 6 h), while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 *** rate of HCO3- secretion [base efflux -J(B-)] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification (1) after sudden blockage of basolateral base loaders with dihydro-4,4,-diisothiocyanatostilbene-2,2,-disulfonic acid (500 μmol/L)and amiloride (200 μmol/L), and (2) after alkali loading the ducts by exposure to NH4Cl. All the experiments were performed in HCO3--buffered Ringer solution at 37 ℃ (n = 5ducts for each experimental condition). Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning ***: The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral antigens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -J(B-) 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -J(B-). After alkali loading the ducts, -J(B-) was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected ***: Incubation with the BDG or KEG strains of PRV results in an effective infection o

关键词：疱疹病毒胰腺细胞胰管分泌病毒感染

The Role of Ultrasound in Intestinal Inflammatory Processes in Children and Adolescents

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Open Journal of Radiology 2013年第4期3卷 215-221页

作者： m. Epifanio Valéria Sgnaolin matteo Baldisserotto Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre Brazil Universidade de Santa Cruz do Sul Santa Cruz do Sul Brazil Universidade de Santa Cruz do Sul Santa Cruz do Sul Brazil Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre Brazil

Purpose: To disseminate the current knowledge about the intestinal inflammatory processes in children and its approach by ultrasound (US) and provide necessary information to pediatricians for early diagnosis through this complementary method. Source of Data: The sources of data were selected by medline, the international manuscripts, international medical journals more relevant in the last 20 years about Gray Scale and Color Doppler Ultrasound in the evaluation of inflammatory bowel disease in children and adolescents. Conclusions: Several authors have suggested that the ultrasound should be the first study in the diagnostic investigation process in suspected inflammatory bowel disease to determine the most affected region and monitor the therapy response. While colonoscopy still remains as the reference diagnostic method, the literature suggests that US can be an extremely useful tool in the context of the suspected diagnosis of a wide variety of intestinal inflammatory processes in children.

关键词： Ultrasonography Doppler Color Inflammatory Bowel Disease Child

ligelizumab治疗成人和青少年慢性自发性荨麻疹患者的临床研究

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中国临床药理学杂志 2024年第3期40卷 453-453页

作者： mAURER m 戴荣源

德国柏林夏里特医学院mAURER团队报告了2项ligelizumab的3期临床研究结果。PEARL-1和PEARL-2是相同设计的随机、双盲、活性对照和安慰剂对照平行组研究。从46个国家的347个研究点招募了≥12岁的中重度H1-AH难治性慢性自发性荨麻疹(chron... 详细信息

德国柏林夏里特医学院mAURER团队报告了2项ligelizumab的3期临床研究结果。PEARL-1和PEARL-2是相同设计的随机、双盲、活性对照和安慰剂对照平行组研究。从46个国家的347个研究点招募了≥12岁的中重度H1-AH难治性慢性自发性荨麻疹(chronic spontaneous urticaria,CSU)患者,并通过交互反应技术以3∶3∶3∶1的比例随机分配给予ligelizumab 72、120 mg,omalizumab 300 mg或安慰剂,每4周给药1次,持续52周。分配给安慰剂的患者从第24周开始接受ligelizumab 120 mg治疗。主要终点是第12周每周荨麻疹活动评分(urticaria activity score,UAS7)与基线的变化(change-from-baseline,CFB)。

关键词：临床研究结果慢性自发性荨麻疹安慰剂对照交互反应随机分配

Transformation of Supercapacitive Charge Storage Behaviour in a multi elemental Spinel Cumn_(2)O_(4) Nanofibers with Alkaline and Neutral Electrolytes

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Advanced Fiber materials 2021年第4期3卷 265-274页

作者： ria Kunwar Syam G.Krishnan Izan Izwan misnon Fatemeh Zabihi Shengyuan Yang Chun-Chen Yang Rajan Jose Nanostructured Renewable materials Research Laboratory Faculty of Industrial Sciences and TechnologyUniversity Malaysia Pahang26300 KuantanMalaysia Graphene&Advanced 2D materials Research Group(GAmRG) School of Engineering and TechnologySunway UniversityNo.5 Jalan UniversitiBandar Sunway47500 Petaling JayaSelangorMalaysia State Key Laboratory for modification of Chemical Fibers and Polymer materials International Joint Laboratory for Advanced Fiber and Low-Dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghaiPeople’s Republic of China Battery Research Center for Green Energy Ming Chi University of TechnologyNew Taipei CityTaiwan

Electrode material has been cited as one of the most important determining factors in classifying an energy storage system’s charge storage mechanism,i.e.,as battery-type or *** this paper,we show that along with the electrode material,the electrolyte also plays a role in determining the charge storage behaviour of the *** the purpose of our research,we chose multi-elemental spinal type Cumn_(2)O_(4) metal oxide nanofibers to prove the *** material is synthesized as nanofibers of diameter~120 to 150 nm in large scales by a pilot scale electrospinning set *** was then tested in three different electrolytes(1 m KOH,1 m Na_(2)SO_(4) and 1 m Li_(2)SO_(4)),two of which are neutral and the third is alkaline(KOH).The cyclic voltammograms and the galvanostatic charge-discharge of the electrode material in a three-electrode sys-tem measurement showed that it exhibit different charge storage mechanism in different electrolyte *** the neutral electrolytes,a capacitive behaviour was observed whereas a battery-type behaviour was seen for the alkaline *** leads us to conclude that the charge storage mechanism,along with the active material,also depends on the electrolyte used.

关键词： Energy storage materials Electrochemical double layer capacitors Capacitive charge storage Ternary manganates Pseudocapacitors

Golgi protein-73:A biomarker for assessing cirrhosis and prognosis of liver disease patients

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World Journal of Gastroenterology 2020年第34期26卷 5130-5145页

作者： Nikolaos K Gatselis Tamás Tornai Zakera Shums Kalliopi Zachou Asterios Saitis Stella Gabeta Roger Albesa Gary L Norman m.ria Papp George N Dalekos Department of medicine and Research Laboratory of Internal medicine National Expertise Center of Greece in Autoimmune Liver DiseasesGeneral University Hospital of LarissaLarissa 41110Greece Institute of Internal medicine and Hepatology Larissa 41447Greece Department of Internal medicine Division of GastroenterologyUniversity of DebrecenFaculty of MedicineDebrecen H-4032Hungary Department of Research and Development Inova DiagnosticsInc.San DiegoCA 92131United States

BACKGROUND Reliable biomarkers of cirrhosis,hepatocellular carcinoma(HCC),or progression of chronic liver diseases are *** this context,Golgi protein-73(GP73)also called Golgi phosphoprotein-2,was originally defined as a resident Golgi type II transmembrane protein expressed in epithelial *** a result,GP73 expression was found primarily in biliary epithelial cells,with only slight detection in ***,in patients with acute or chronic liver diseases and especially in HCC,the expression of GP73 is significantly up-regulated in *** far,few studies have assessed GP73 as a diagnostic or prognostic marker of liver fibrosis and disease *** To assess serum GP73 efficacy as a diagnostic marker of cirrhosis and/or HCC or as predictor of liver disease *** GP73 serum levels were retrospectively determined by a novel GP73 ELISA(QUANTA Lite®GP73,Inova Diagnostics,Inc.,Research Use Only)in a large cohort of 632 consecutive patients with chronic viral and non-viral liver diseases collected from two tertiary Academic centers in Larissa,Greece(n=366)and Debrecen,Hungary(n=266).Aspartate aminotransferase(AST)/Platelets(PLT)ratio index(APRI)was also calculated at the relevant time points in all *** hundred and three patients had chronic hepatitis B,183 chronic hepatitis C,198 alcoholic liver disease,28 autoimmune cholestatic liver diseases,15 autoimmune hepatitis,and 5 with other liver-related *** duration of follow-up was 50(57)mo[median(interquartile range)].The development of cirrhosis,liver decompensation and/or HCC during follow-up were assessed according to internationally accepted *** particular,the surveillance for the development of HCC was performed regularly with ultrasound imaging and alpha-fetoprotein(AFP)determination every 6 mo in cirrhotic and every 12 mo in non-cirrhotic *** Increased serum levels of GP73(>20 units)were detected at initial evaluation in 277 out of

关键词： Biomarker Golgi protein-73 Hepatic fibrosis Cirrhosis Hepatocellular carcinoma Hepatitis B Hepatitis C Aspartate aminotransferase/Platelets ratio index score

Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease

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World Journal of Gastroenterology 2012年第25期18卷 3254-3259页

作者： Kriszta molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos m.ria Papp András Arató Gábor Veres First Department of Pediatrics Semmelweis UniversityH-1083 BudapestHungary Research Group for Pediatrics and Nephrology Semmelweis University and Hungarian Academy of SciencesH-1083 BudapestHungary SE-mTA "Lendulet" Diabetes Research Group H-1083 BudapestHungary Second Department of Pathology Semmelweis UniversityH-1091 BudapestHungary First Department of medicine Semmelweis UniversityH-1083 BudapestHungary Second Department of medicine University of Debrecen H-4032 Debrecen Hungary

AIm:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).mETHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy *** IBD patients,specimens were obtainedboth from inflamed and non-inflamed *** iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,*** localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent ***:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P milarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P med colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P med mucosa of patients with CD were similar to *** mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with *** of iAP mRNA in patients with noninflamed mucosa and in controls were ***-localization of iAP with TLR4 showed intense staining with a dotted-like *** was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the ***,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups ***:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in *** on our results,administration of exogenous iAP enzyme to pa

关键词：碱性磷酸酶肠道疾病肠黏膜儿童溃疡性结肠炎免疫荧光染色蛋白水平 Toll样受体

多壁纳米碳管对磷酸铁锂正极材料热稳定性及表面形貌的影响(英文)

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新型炭材料 2013年第1期28卷 1-7页

作者： m.ria Filkusová Andrea Fedorková Renáta Oriňáková Andrej Oriňák Zuzana Nováková Lenka Skantárová Department of Physical and Theoretical Chemistry Faculty of Science Comenius University Mlynská|Dolina SK-842 15 Bratislava 4 Slovak Republic Department of Physical Chemistry Faculty of Science P.J. afárik University Moyzesova 11 SK-04154 Koice Slovak Republic Department of Electrical and Electronic Technology Faculty of Electrical Engineering and Communication Brno University of Technology Czech Republic Department of Analytical Chemistry Faculty of Science Comenius University Mlynská|Dolina SK-842 15 Bratislava 4 Slovak Republic

合成了一种新型的LiFePO4/多壁纳米碳管(mWCNTs)复合正极材料。通过mWCNTs和PPy-PEG粘结剂有机地在LiFePO4颗粒间构成三维网络导电结构,并借助SEm、TGA和高分辨裂解气相色谱,研究了LiFePO4-mWCNT正极材料的表面形貌和热稳定性。结果表明... 详细信息

合成了一种新型的LiFePO4/多壁纳米碳管(mWCNTs)复合正极材料。通过mWCNTs和PPy-PEG粘结剂有机地在LiFePO4颗粒间构成三维网络导电结构,并借助SEm、TGA和高分辨裂解气相色谱,研究了LiFePO4-mWCNT正极材料的表面形貌和热稳定性。结果表明,500℃下该材料的热分解程度非常小,说明mWCNTs和PPy-PEG的复合是提高LiFePO4正极材料的热稳定性和改善表面形貌的有效途径。

关键词：多壁纳米碳管多吡咯磷酸铁锂锂离子电池

microbial phenolic metabolites are associated with better frontal lobe cognition

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Food Science and Human Wellness 2024年

作者： Inés Domínguez-López Isabella Parilli-moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Casta?er Ramon Estruch Emili Ros Rosa m.Lamuela-Raventós Lipid Clinic Endocrinology and Nutrition Service Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic 08036 Barcelona Spain Unit of Cardiovascular Risk and Nutrition Institut Hospital del mar de Investigaciones médicas (ImIm) Department of Preventive medicine and Public Health University of Navarra Departament de Nutrició Ciències de l'Alimentació i Gastronomía Facultat de Farmacia Universitat de Barcelon (UB) Av.de Joan XXII Department of Endocrinology Hospital Clinic IDIBAPS Barcelona Spain Department of Internal medicine Hospital Clinic Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS) University of Barcelona CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Institut de Nutrició i Seguretat Alimentària (INSA) Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (mPm) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDImED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary mPm (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and mPm， and a score was calculated as the weighted sum of mPm. A higher mPm score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-mPm was associated with better frontal cognitive performance in an older mediterranean population.

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