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Epidemiological and clinical characteristics of CoVID-19 in a Brazilian public hospital

World Journal of Clinical Cases 2023年第8期11卷 1761-1770页

作者： Fillipe Dantas Pinheiro Luana Weber Lopes Rafael santos Dantas miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito m.ria Luísa Cordeiro santos Geovani moreno santos Júnior m.ria Teresa Araújo de Lorenzo Barcia Renata de Amorim marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas miranda marques Guilherme Barretos Campos márcio Vasconcelos oliveira Dulciene m.ria de magalhães Queiroz Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Hospital Geral de Vitória da Conquista Vitória da Conquista 45030-160BahiaBrazil Departamento de Ciências da Saúde Universidade Estadual do Sudoeste da Bahia(UESB)Vitória da Conquista 45083-900BahiaBrazil Faculdade de medicina Universidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

BACKGRoUND The coronavirus disease 2019(CoVID-19)pandemic has become a major health concern *** that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and *** To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill CoVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease *** This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian *** The patients had a median age of 65.60±15.78 *** was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the *** least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with *** and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective *** This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected *** associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features.

关键词： CoVID-19 Epidemiology Symptoms Comorbidities Laboratory parameters

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling o. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines o.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUoN TAGGING

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micropropagation of Eucalyptus grandis×*** AEC 224 clone

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Journal of Forestry Research 2017年第1期28卷 29-39页

作者： Cassiana de oliveira Juliana Degenhardt-Goldbach Gisela manuela de Franca Bettencourt Erika Amano Luziane Franciscon marguerite Quoirin Department of Plant Science Federal University of Parana1540Rua dos FuneionariosCuritibaParanaBrazil Embrapa-Forest 111Estrada da RibeiraColomboParanaBrazil Department of Technology Federal University of Parana210avenida CelFrancisco Heraiclito dos SantosCuritibaParanaBrazil Department of Botany Federal University of Parana210avenida CelFrancisco Heraiclito dos SantosCuritibaParanaBrazil

Genetic transformation systems require protocols that allow regenerating transgenic plants from transformed tissues. This study aimed to establish a protocol for indirect organogenesis in leaf explants of a Eucalyptus grandis x E. urophylla AEC 224 clone. During callogenesis stage, several concentrations of NAA and then NAA or 2,4-D combined with TDZ were tested in JADS culture medium for 30 days, followed by subculture of the explants in the regeneration medium, containing 5.0 μm BA and 0.5 μm NAA for another 30 days. In these media, the explant oxidation rate was high （95 %）. Thus, in order to reduce oxidation, different ;culture media were compared： WPm, mS, JADS and modified QL, followed by explant transfer onto regeneration medium. The highest percentage of regeneration and the lowest oxidation rate were achieved on WPm medium. Then, NAA and 2,4-D were tested in combination with TDZ and also TDZ and BA combined with NAA in WPm medium. The most efficient culture media in terms of shoot regeneration were WPm supplemented with 0.25 μm TDZ and 0.1μm NAA during 30 days for callus induction and then with 5.0 μm BA and 0.5 μm NAA for another 30 days. This protocol yielded a regeneration rate of 43 %, with a low oxidation of tissues. A rooting experiment was conducted using half strength mS medium and comparing three concentrations of IBA （2.46, 4.90 and 7.35μm）. The highest rooting percentage （35 %） was obtained on medium containing 2.46μm IBA. once the shoots were rooted, acclimatization in a greenhouse was not challenging and plant survival reached 100 %.

关键词： Callogenesis Eucalyptus urograndis organogenesis WPm culture medium

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From Helicobacter pylori infection to gastric cancer:Current evidence on the immune response

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World Journal of Clinical oncology 2022年第3期13卷 186-199页

作者： Vinícius Lima de Souza Gonçalves m.ria Luísa Cordeiro santos marcel Silva Luz Hanna santos marques Breno Bittencourt de Brito Filipe Antônio França da Silva Cláudio Lima Souza márcio Vasconcelos oliveira Fabrício Freire de melo Universidade Estadual do Sudoeste da Bahia Campus Vitória da ConquistaVitória da Conquista 45083-900BahiaBrazil Universidade Federal da Bahia Instituto Multidisciplinar em SaúdeVitória da Conquista 45029-094BahiaBrazil

Gastric cancer(GC)is the result of a multifactorial process whose main components are infection by Helicobacter pylori(***),bacterial virulence factors,host immune response and environmental *** development of the neoplastic microenvironment also depends on genetic and epigenetic changes in oncogenes and tumor suppressor genes,which results in deregulation of cell signaling pathways and apoptosis *** review summarizes the main aspects of the pathogenesis of GC and the immune response involved in chronic inflammation generated by ***.

关键词： Gastric cancer Helicobacter pylori Chronic inflammation Host immune response

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Influence of Helicobacter pylori oncoprotein CagA in gastric cancer:A critical-reflective analysis

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World Journal of Clinical oncology 2022年第11期13卷 866-879页

作者： Fabrício Freire de melo Hanna santos marques Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos marcel Silva Luz Kádima Nayara Teixeira Cláudio Lima Souza márcio Vasconcelos oliveira Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094Brazil Campus Toledo Universidade Federal do ParanáToledo 85919899Brazil

Gastric cancer is the fifth most common malignancy and third leading cancerrelated cause of death *** pylori is a Gram-negative bacterium that inhabits the gastric environment of 60.3%of the world’s population and represents the main risk factor for the onset of gastric *** is the most important virulence factor in ***,and is a translocated oncoprotein that induces morphofunctional modifications in gastric epithelial cells and a chronic inflammatory response that increases the risk of developing precancerous *** translocation and tyrosine phosphorylation,CagA moves to the cell membrane and acts as a pathological scaffold protein that simultaneously interacts with multiple intracellular signaling pathways,thereby disrupting cell proliferation,differentiation and *** these alterations in cell biology increase the risk of damaged cells acquiring pro-oncogenic genetic *** this sense,once gastric cancer sets in,its perpetuation is independent of the presence of the oncoprotein,characterizing a“hit-and-run”carcinogenic ***,this review aims to describe ***-and CagA-related oncogenic mechanisms,to update readers and discuss the novelties and perspectives in this field.

关键词： Helicobacter pylori Virulence factors CagA Gastric cancer EPIYA motifs Hit-and-run carcinogenesis

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Temporomandibular Disorder in University Students of the Parque das Rosas Campus, Universidade Estácio de SáThat Practice Sports

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Health 2016年第1期8卷 18-23页

作者： Rosineli Paz Cabral manuel Eduardo moiolli-Rodrigues Flávia Lima Kleinsorgen motta Francisco Carlos Kleinsorgen de Souza motta Juliana Rocha da Silva Larissa malheiros Neide martins Leonardo Trepte André Luiz G. Abrão Adalgisa maiworm Luiz Carlos oliveira Raphael Lemgruber Cardoso Adriano Arnóbio Giuseppe Antonio Presta Danúbia da cunha de Sá Caputo Sebastião David santos Filho Éric Heleno F. F. Frederico mario Bernardo-Filho Severo de Paoli Universidade Estácio de Sá—Campus R9—GEPS R9 Rio de Janeiro Brasil Universidade Estácio de Sá—Campus Parque das Rosas Rio de Janeiro Brasil Departamento de Biofísica e Biometria Instituto de Biologia Roberto Alcantara Gomes Universidade do Estado de Rio de Janeiro Rio de Janeiro Brasil Programa de Pós-Graduacao em Fisiopatologia Clínica e Experimental Faculdade de Ciências Médicas Universidade do Estado do Rio de Janeiro Rio de Janeiro Brasil UniFacex—Centro Universitário do Facex Natal Brasil Programa de Pós-Graduacao em Biociências Instituto de Biologia Roberto Alcantara Gomes Universidade do Estado do Rio de Janeiro Rio de Janeiro Brasil

The stomatognathic system (SS) is a functional unit of the body that depends on the balance of several tissues. It consists of various structures, including the temporomandibular joint. Temporomandibular disorder (TmD) can occur due to alterations in the SS. The Fonseca Anamnestic Index (FAI) is a scale used to evaluate and to characterize the TmD Type: no DTm, mild, moderate and severe. The aim is to evaluate the prevalence of signs and symptoms related to TmD in university students of the Parque das Rosas Campus, Universidade Estácio de Sá that practice sports. This investigation was approved (CAAE number 325678413.9.0000.5284). Two hundred eighth students (110 male and 98 female, aged 19 - 35 years) accepted to be in this investigation. All the participants answered a General Questionnaire (GQ) and the FAI. The GQ had questions about the age, sex and the presence of TmD. The FAI was used. A statistical difference (p > 0.05) was not found about the presence of TmD. Among the female, an elevated number of the students with signal or symptoms related to the temporomandibular with statistic significance (p observed. In the population without TmD, the prevalence of this disorder is higher between male than female. Considering the FAI, among the female students, there is a prevalence of the mild Type. Considering the evaluation of the type of TmD among the male and female students no difference was found between male and female to the types mild and moderate, however, the prevalence of the severe Type is higher in female than in male with statistical significance. In conclusion, TmD is a relevant clinical condition with an important prevalence among the university students. moreover, the type of the TmD could be considered due to prevalence of the Type Severe among the women.

关键词： Temporomandibular Disorder University Student Fonseca Anamnestic Index Prevalence

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Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review

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World Journal of Clinical oncology 2021年第2期12卷 69-94页

作者： m.riana miranda Sampaio m.ria Luísa Cordeiro santos Hanna santos marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan santos Apolonio Camilo Santana Silva Luana Kauany de Sásantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães m.riana Novaes santos Breno Bittencourt de Brito Filipe Antônio França da Silva márcio Vasconcelos oliveira Cláudio Lima Souza Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Chronic myeloid leukemia(CmL)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia *** advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of *** discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CmL patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL *** kinase inhibitors(known as TKIs)are the standard therapy for CmL and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of *** therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these *** this background,this article aims at providing an overview on CmL clinical management and a summary on the main targeted drugs available in that context.

关键词： Chronic myeloid leukemia Breakpoint cluster region-Abelson murine leukemia Immunotherapy Tyrosine kinase inhibitors Philadelphia chromosome Diagnosis

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Highlighting CoVID-19:What the imaging exams show about the disease

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World Journal of Radiology 2021年第5期13卷 122-136页

作者： Lorena Sousa de Carvalho Ronaldo Teixeira da Silva Júnior Bruna Vieira Silva oliveira Yasmin Silva de miranda Nara Lúcia Fonseca Rebouças matheus Sande Loureiro Samuel Luca Rocha Pinheiro Regiane santos da Silva Paulo Victor Silva Lima medrado Correia m.ria José Souza Silva Sabrina Neves Ribeiro Filipe Antônio França da Silva Breno Bittencourt de Brito m.ria Luísa Cordeiro santos Rafael Augusto oliveira Sodré Leal márcio Vasconcelos oliveira Fabrício Freire de melo Department of Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Coronavirus disease 2019(CoVID-19),a global emergency,is caused by severe acute respiratory syndrome coronavirus *** gold standard for its diagnosis is the reverse transcription polymerase chain reaction,but considering the high number of infected people,the low availability of this diagnostic tool in some contexts,and the limitations of the test,other tools that aid in the identification of the disease are *** this scenario,imaging exams such as chest X-ray(CXR)and computed tomography(CT)have played important *** is useful for assessing disease progression because it allows the detection of extensive consolidations,besides being a fast and cheap *** the other hand,CT is more sensitive for detecting lung changes in the early stages of the disease and is also useful for assessing disease *** note,ground-glass opacities are the main CoVID-19-related CT *** emission tomography combined with CT can be used to evaluate chronic and substantial damage to the lungs and other organs;however,it is an expensive *** ultrasound(LUS)has been shown to be a promising technique in that context as well,being useful in the screening and monitoring of patients,disease classification,and management related to mechanical ***,LUS is an inexpensive alternative available at the ***,magnetic resonance imaging,although not usually requested,allows the detection of pulmonary,cardiovascular,and neurological abnormalities associated with ***,it is important to consider the challenges faced in the radiology field in the adoption of control measures to prevent infection and in the follow-up of post-CoVID-19 patients.

关键词： SARS-CoV-2 CoVID-19 Pneumonia Pandemic Radiology Tomography

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Effects of nutrients on immunomodulation in patients with severe CoVID-19:Current knowledge

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World Journal of Critical Care medicine 2022年第4期11卷 201-218页

作者： Bruna Teixeira da Costa Glauber Rocha Lima Araújo Ronaldo Teixeira da Silva Júnior Luana Kauany de Sásantos Vinícius Lima de Souza Gonçalves Daniel Bastos Alves Lima Beatriz Rocha Cuzzuol Jonathan santos Apolonio Lorena Sousa de Carvalho Hanna santos marques Camilo Santana Silva Isadora de Souza Barcelos márcio Vasconcelos oliveira Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Recent research has demonstrated that critically ill patients with coronavirus disease 2019(CoVID-19)show significant immune system *** to that,some nutrients that influence immunomodulation have been suggested as a form of treatment against the *** review collected the information on the impact of vitamins on the prognosis of CoVID-19,with the intention of facilitating treatment and prevention of the disease risk status in *** collected information was obtained using the Pubmed electronic database by searching for articles that relate CoVID-19 and the mechanisms/effects of the nutrients:Proteins,glucose,lipids,vitamin B12,vitamin D,calcium,iron,copper,zinc,and magnesium,including prospective,retrospective,and support *** findings reveal an optimal response related mainly to omega-3,eicosapentaenoic acid,docosahexaenoic acid,calcium,and iron that might represent benefits in the treatment of critically ill ***,nutrient supplementation should be done with caution due to the limited availability of randomized controlled studies.

关键词： CoVID-19 Immunomodulation Patient care Vitamins Nutrients micronutrients

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Correction to“Performance of a serological Igm and IgG qualitative test for CoVID-19 diagnosis:An experimental study in Brazil”

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World Journal of Experimental medicine 2023年第3期13卷 47-49页

作者： Fabrício Freire de melo Lilian martins oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira Rafael santos Dantas miranda Dórea Breno Bittencourt de Brito Hanna santos marques Fabian Fellipe Bueno Lemos marcel Silva Luz Samuel Luca Rocha Pinheiro Gifone Aguiar Rocha Dulciene m.ria de magalhães Queiroz Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Departamento de Pediatria Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Departamento de Clínica médica Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Correction to“Freire de melo F,martins oliveira Diniz L,Nélio Januário J,Fernando Gonçalves Ferreira J,Dórea RSDm,de Brito BB,marques HS,Lemos FFB,Silva Luz m,Rocha Pinheiro SL,de magalhães Queiroz *** of a serological Igm and IgG qualitative test for CoVID-19 diagnosis:An experimental study in *** J Exp med 2022;12(5):100-103[PmID:36196438 DoI:10.5493/wjem.v12.i5.100]”.In this article,we identified an issue with the“Acknowledgments”***,we then provide a recognition section for our supporting institutions.

关键词： Correction CoVID-19 serological testing Serologic tests Rapid diagnostic

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