检索结果-南通市图书馆

Characterization of C-N Thin Films Prepared by Ion Beam Sputtering

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of materials Science & Technology 1996年第4期12卷 312-314页

作者： Tian, YJ Ren, XJ Yu, DL He, JL Chen, SZ Li, DC Yu, rc Zhang, m Wang, WK CHINESE ACAD SCI INST PHYSBEIJING 100080PEOPLES R CHINA

C-N thin films have been prepared by ion beam sputtering using pure N-2 as discharge gas. The ratio N/C of the films measured by Auger spectrum is 20% on an average. The results of X-ray diffraction and transmission electron microscopy show that beta-C3N4. phase exists in the films. X-ray photoelectron spectroscopy shows that nitrogen is mostly combined with carbon with triple (C=N) and double (C=N) bonds. The IR absorption shows an absorption bond near 2185 cm(-1) assigned to the C=N, no trace of C-C bond was observed.

关键词： Thin films

Wound healing effect of methanolic leaf extract of Napoleona vogelii(Family:Lecythidaceae) in rats

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical medicine 2014年第8期7卷 620-624页

作者： Adiele LC Adiele rc Enye JC Department of Pharmacology and Toxicology Faculty of PharmacyMadonna UniversityEleleRiver StateNigeria Department of Pharmacy Federal Medical CenterOwerriImo StateNigeria Department of Anatomy and Cell Biology Division of Biomedical SciencesCollege of MedicineUniversity of SaskatchewanSaskatoonSKS7N 5E5Canada Cameco mS Neuroscience Research Center Saskatoon City HospitalSaskatoonSKS7K 0M7Canada

objective:To investigate the wound healing properly of Napoleona vogelii leaf extract in folkloric ***:Roth sexes of adult albino rats(n=25) were used in this study and another group(n=30) were subjected to acute toxicity test(LD_(50)) of the plant *** the LD_(50),three randomized groups of 5 rats were first treated with 10,100,1 000 mg/kg body weight(bw),*** w as followed by a second treatment of 1500,3000,and 5 000 mg/kg bw of the leaf extract with continual monitoring of the animals for mortality or *** wounds(1.3cm) were created on the skin of five groups of 5 rals using surgical blade under *** first group was topically treated with petroleum jelly alone,group 2 was topically applied 400 mg/mL w/v of the reference drug,Neobaein,while group 3-5 were topically treated with 5-50 mg/mL w/v of the plant extract,***:The percentage yield of the extract was 49.80%w/w dry *** phytochemical analysis revealed several bioactive constituents including glycosides,tannins,alkaloids,***,steroids,proteins,and *** LD_(50) was beyond our experimental limit and was not *** concentrations(5,20,and 50mg/mL w/v) of the extract had significant(ANoVA,Pon the incision wounds giving rise to 125%-140% while treatmentawith Neobacin resulted in 150% healing effect on the third treatment regimen compared to the control(100%).Conclusions:These data indicate that Napoleona vogelii leaf extract contains potent bioactive compounds containing wound healing activity,substantiating its use as a wound healer in folkloric medicine.

关键词： Wound healing Napoleona vogelii Petroleum jelly Neobacin Folkloric medicine

A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第1期12卷 378-393页

作者： Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie ma Caitriona m.o’Driscoll Zhuo Yu Jianfeng Guo School of Pharmaceutical Sciences Jilin UniversityChangchun 130021China Laboratory of Cancer Precision medicine The First Hospital of Jilin UniversityChangchun 130021China Pharmacodelivery Group School of PharmacyUniversity College CorkCork T12 YT20Ireland Department of Hepatopathy Shuguang HospitalAffiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(Crc). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TmE). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TmE. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against Crc cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(RoS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(***) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic Crc mouse model, resulting in the conversion of immunosuppressive TmE. Furthermore, the *** achieved significantly longer survival of animals in combination with anti-PD-L1. The study provides a promising strategy for the treatment of Crc.

关键词： Nano drug delivery system Chemotherapy Immunotherapy Combination therapy Immunogenic cell death Reactive oxygen species Tumor microenvironment Colorectal cancer

mediterranean Berries as Inhibitors of Lipid oxidation in Porcine Burger Patties Subjected to Cooking and Chilled Storage

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2013年第11期12卷 1982-1992页

作者： Rui Ganho mario Estévez mónica Armenteros David morcuende Food Science Department ESTMPolytechnic Institute of Leiria Animal Production and Food Science University of ExtremaduraAv.de la Universidad s/n Animal Production and Food Science University of ExtremaduraAv.de la Universidad s/nCáceres 10003Spain

The efifciency of extracts from Arbutus unedo L. （AU）, Crataegus monogyna L. （Cm）, Rosa canina L. （rc）, and Rubus ulmifolius Schott. （RU） to inhibit lipid oxidation in raw, cooked and cooked and chilled （2°C/12 d） porcine burger patties, was investigated. The modiifcation of the fatty acid proifle during processing treatments （cooking and chilling）, the quantitative measurements of thiobarbituric acid reactive substances （TBA-RS）, and lipid-derived volatiles, were used as indicators of lipid oxidation. Polyunsaturated fatty acids （PUFA） gradually decreased during cooking and the subsequent storage of cooked burger patties with this decrease being signiifcantly greater （P〈0.05） in control patties than in those with added berry extracts. In accordance, the control patties showed signiifcantly higher TBA-RS numbers and counts of lipid-derived volatiles in all treatments when compared to the berry-added counterparts （P〈0.05）. Results from the present work show, for the ifrst time, that extracts from A. unedo, C. monogyna, R. canina, and R. ulmifolius are promising antioxidants which could enhance the nutritional, safety and sensory properties of porcine burger patties.

关键词： berries lipid oxidation meat pattiesm TBA-RSm polyunsaturated fatty acids lipid-derived volatiles

输血医学领域中的争论——反对作D^u型的检测

在线全文

学校读者我要写书评

暂无评论

国外医学（输血及血液学分册） 1991年第6期14卷 380-382页

作者： Contreras m Knigh rc 周英

自从1946年Stratton论述D^u是一新Rh抗原以来,还没有哪个红细胞抗原引起如此强烈的争论。该抗原是否划规为D阳性或D阴性,亦或需要全部重新检测。作者建议取消D^u这一术语。定义“D^u抗原”是D抗原的一种弱表现型,而不是独立的抗原。然... 详细信息

自从1946年Stratton论述D^u是一新Rh抗原以来,还没有哪个红细胞抗原引起如此强烈的争论。该抗原是否划规为D阳性或D阴性,亦或需要全部重新检测。作者建议取消D^u这一术语。定义“D^u抗原”是D抗原的一种弱表现型,而不是独立的抗原。然而弱抗原并不意味着抗原性弱,而是红细胞膜上D位点数减少.每个正常红细胞有1～3×10~5个D位点,低频率D^u红细胞的D位点少于600个。D^u的定义是与各类抗血清都呈阴性反应。最初认为有两类D^u型:①高频率D^u;这类红细胞被某些抗血清凝集,而这种抗血清通常是不完全的IgG试剂,而不与完全的Igm抗D试剂凝集;②低频率D^u;其只能被间接抗球蛋白试验(IAT,称为D^u试验)检出。Race和sanger报道了各种D^u。

关键词：输血 D^u型检测

Energy-based damage assessment of continuous-span reinforced concrete highway bridges

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2023年第1期22卷 191-209页

作者： S.mahboubi m.R.Shiravand Faculty of Civil Water and Environmental EngineeringShahid Beheshti UniversityTehran ***Iran

This paper conducts a comparative study on seismic damage to reinforced concrete(rc)bridges,using three damage models:Park and Ang,Hindi and Sexsmith,and input energy-based damage(IEBD)indices,and presents a global cumulative damage model based on the IEBD index to establish a practical damage assessment of an overall bridge system.A series of rc bridges are studied under seismic loadings,and to compare the efficiency and reliability of the damage indices,damage curves of rc piers are developed,and damage levels of piers are calculated at design basis earthquake(DBE)and maximum considered earthquake(mCE)*** global cumulative damage index is calculated for bridge models regarding damage values of *** results indicate that the IEBD index shows a gradual progression of damage and provides reasonable values for different damage levels of piers compared to two other damage ***,the global cumulative damage index shows the impact of induced damage to a certain component regarding the damage level of the overall bridge ***,this new approach is a relatively simple and practical tool for seismic damage assessment of rc bridge systems,which can be implemented in finite element models,particularly in the absence of experimental data.

关键词： rc bridge energy-based damage index global cumulative damage index IEBD Index

Damage response of conventionally reinforced two-way spanning concrete slab under eccentric impacting drop weight loading

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2023年第1期19卷 12-34页

作者： S.m.Anas mehtab Alam mohd Shariq Department of Civil Engineering Faculty of Engineering and TechnologyJamia Millia Islamia(A Central University)Accredited with grade A++ by NAACNew Delhi110025DelhiIndia Department of Civil Engineering Netaji Subhas University of Technology(West Campus)New Delhi110073DelhiIndia

Reinforced concrete(rc)structures are generally designed to carry quasi-static gravity loads through almost indispensable components namely slab,however,it may be subjected to high intense loads induced from the impact of projectiles generated by the tornado,falling construction equipment,and also from accidental explosions during their construction and service *** due to rock/boulder falls do occur on the structures located especially in hilly *** loadings are not predictable but may cause severe damage to the slab/*** stimulates structural engineers and researchers to investigate and understand the dynamic response of rc structures under such impulsive *** research work first investigates the performance of 1000×1000×75 mm^(3)conventionally reinforced two-way spanning normal strength concrete slab with only tension reinforcement(0.88%)under the concentric impact load(1035 N)using the finite element method based computer code,ABAQUS/*** impact load is delivered to the centroid of the slab using a solid-steel cylindroconical impactor(drop weight)with a flat nose of diameter 40 mm,having a total mass of 105 kg released from a fixed height of 2500 *** popular concrete constitutive models in ABAQUS namely;Holmquist-Johnson-Cook(HJC)and Concrete Damage Plasticity(CDP),with strain rate effects as per fib moDEL CoDE 2010,are used to model the concrete material behavior to impact loading and to simulate the damage to the *** slab response using these two models is analyzed and compared with the impact test *** strain rate effect on the reinforcing steel bars has been incorporated in the analysis using the malvar and Crawford(1998)approach.A classical elastoplastic kinematic idealization is considered to model the steel impactor and support *** reveal that the HJC model gives a little overestimation of peak displacement,maximum acceleration,and damage of the slab while the predictions given by

关键词： rc slabs Impact loading Eccentric impacts Concrete models Finite element analysis Damage profiles Stresses Peak acceleration Failure modes Damage dissipation energy Cracking Drop-weight locations

Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第2期12卷 292-297页

作者： rc mallant-Hent m mooij BmE von Blomberg RK Linskens AA van Bodegraven PHm Savelkoul Department of Gastroenterology VU University Medical CenterAmsterdamThe Netherlands Department of medical microbiology and Infection Control VU University Medical CenterAmsterdamThe Netherlands Department of Immunology VU University Medical CenterAmsterdamThe Netherlands Department of Gastroenterology St Anna ZiekenhuisGeldropThe Netherlands

瞄准：调查在粘膜 S 的 ASCA 和存在之间的关联。在 CD， ulcerative (UC ) 病人和控制的一张人口的啤酒 DNA。方法：S。cerevisiae 特定的教材和一根荧光灯的探针为 5' exonuclease 实时 PCR (Taqman ) 试金被设计，它是用为在实时的 P... 详细信息

瞄准：调查在粘膜 S 的 ASCA 和存在之间的关联。在 CD， ulcerative (UC ) 病人和控制的一张人口的啤酒 DNA。方法：S。cerevisiae 特定的教材和一根荧光灯的探针为 5' exonuclease 实时 PCR (Taqman ) 试金被设计，它是用为在实时的 PCR 产品的察觉的一根荧光灯标签的探针的一个同质的系统。我们在一组 76 煽动性的肠疾病(IBD ) 与 ASCA 调查结果分析了 PCR 结果的关系病人(31 CD， 45 UC ) 并且 22 健康控制(HC ) 。结果：ASCA (IgA 或 IgG ) 在 19 是积极的(61%) 有 CD 的病人， 12 (27%) 与 HC 的 UC 和没有。PCR 扩大在 10 从最后的结果被禁止并且排除(22%) UC 病人， 7 (22%) CD 病人，并且 6 (30%) HC。在里面仅仅， 15 粘膜取样， S。啤酒 DNA 被实时 PCR 检测，包括 7 (29%) 在 CD， 7 (19%) 在 UC， 1 (6%) 在 HC。在 4 CD 并且在 4 个 UC 病人， ASCA 和粘膜 S。啤酒是积极的。粘膜 S。啤酒在 3 UC，和 3 个 CD 病人在有否定 ASCA IgA 和 IgG 的联合是在场的。结论：自从 S 的存在，我们结束那。在结肠的粘膜活体检视标本的啤酒是很稀罕的， ASCA 是不大可能的被连续暴露向 S 解释。在粘膜的啤酒。因此， ASCA 形成必须在生命更早发生，层次在免疫学的此后仍然保持相对稳定易受影响的人。

关键词： ASCA 酿酒酵母肠粘膜 IBD DNA 血清抗体

obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第35期12卷 5735-5738页

作者： Deha Erdogan olivier rc Busch Erik AJ Rauws otto m van Delden Dirk J Gouma Thomas m van Gulik Department of Surgery Academic Medical Center University of Amsterdam The Netherlands Department of Hepatology Academic Medical Center University of Amsterdam The Netherlands Department of Surgery Radiology Academic Medical Center University of Amsterdam The Netherlands

Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ErcP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ErcP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ErcP is a useful tool to differentiate extraductal from intraductal obstruction.

关键词：黄疸肝胆癌囊腺癌治疗