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Journal of rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez Cristina González-Barreira paula Oreiro-martínez Ana m.García-Deibe Jesús Sanmartín-matalobos matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of materials(imATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity molecule magnet

Alexa,let's train now!——A systematic review and classification approach to digital and home-based physical training interventions aiming to support healthy cognitive aging

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Journal of Sport and Health Science 2024年第1期13卷 30-46页

作者： Fabian Herold paula Theobald Thomas Gronwald Navin Kaushal Liye Zou Eling D.de Bruin Louis Bherer Notger Gmüller research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Body-Brain-mind Laboratory Shenzhen UniversityShenzhen 518060China Institute of Interdisciplinary Exercise Science and Sports medicine MSH Medical School HamburgHamburg 20457Germany Department of Health Sciences School of Health&Human SciencesIndiana UniversityIndianapolisIN 46202USA Department of Health Sciences and Technology Institute of Human Movement Sciences and SportETH ZurichZurich 8093Switzerland Department of Neurobiology Care Sciencesand SocietyKarolinska InstituteStockholm 17177Sweden Department of Health OST-Eastern Swiss University of Applied SciencesSt.Gallen 9001Switzerland montreal Heart Institute MontrealQC H1T 1C8Canada Department of medicine Universite de MontrealMontrealQC H3T 1J4Canada Centre de recherche de l'Institut Universitaire de Geriatrie de montreal MontrealQC H3W 1W5Canada

Background:There is mounting evidence that regular physical activity is an important prerequisite for healthy cognitive ***,the finding that almost one-third of the adult population does not reach the recommended level of regular physical activity calls for further public health *** this context,digital and home-based physical training interventions might be a promising alternative to center-based intervention ***,this systematic review aimed to summarize the current state of the literature on the effects of digital and home-based physical training interventions on adult cognitive ***:In this pre-registered systematic review(PrOSPErO;ID:CrD42022320031),5 electronic databases(Pubmed,Web of Science,Psyclnfo,SPOrTDiscus,and Cochrane Library)were searched by 2 independent researchers(FH and PT)to identify eligible studies investigating the effects of digital and home-based physical training interventions on cognitive performance in *** systematic literature search yielded 8258 records(extra17 records from other sources),of which 27 controlled trials were considered *** reviewers(FH and PT)independently extracted data and assessed the risk of bias using a modified version of the Tool for the assEssment of Study qualiTy and reporting in EXercise(TESTEX scale).results:Of the 27 reviewed studies,15 reported positive effects on cognitive and motor-cognitive outcomes(i.e.,performance improvements in measures of executive functions,working memory,and choice stepping reaction test),and a considerable heterogeneity concerning study-related,population-related,and intervention-related characteristics was noticed.A more detailed analysis suggests that,in particular,interventions using online classes and technology-based exercise devices(i.e.,step-based exergames)can improve cognitive performance in healthy older *** one-half of the reviewed studies were rated as having a high risk of bias with respect

关键词： Brain Cognition Digital health Exercise-cognition Physical activity

The effectiveness of different wear indicators in quantifying wear on railway wheels of freight wagons

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railway Engineering Science 2024年第3期32卷 307-323页

作者： Philipe Augusto de paula Pacheco m.magelli matheus Valente Lopes Pedro Henrique Alves Correa N.Zampieri N.Bosso Auteliano Antunes dos Santos Federal Institute of the Southeast of minas Gerais(IF Sudeste mG) Técnico PanamáStreet 45Santos DumontMG 36246-311Brazil railway Laboratory(Lafer) Universidade Estadual de Campinas(UNICAMP)Mendeleyev Street 200CampinasSP 13083-872Brazil Department of mechanical and Aerospace Engineering Politecnico Di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

railway infrastructure relies on the dynamic interaction between wheels and rails;thus,assessing wheel wear is a critical aspect of maintenance and *** paper focuses on the wheel-rail wear indicator T-gamma(Tγ).Amidst its use,it becomes apparent that Tγ,while valuable,fails to provide a comprehensive reflection of the actual material removal and actual contact format,which means that using only Tγas a target for optimization of profiles is not *** this work,three different freight wagons are evaluated:a meter-gauge and a broad-gauge heavy haul vehicles from South American railways,and a standard-gauge freight vehicle operated in Europe,with different axle loads and dissimilar new wheel/rail *** vehicles are subjected to comprehensive multibody simulations on various *** simulations aimed to elucidate the intricate relationship between different wear indicators:Tγ,wear index,material removal,and maximum wear depth,under diverse curves,non-compensated lateral accelerations(A_(nc)),and *** findings showed a correlation of 0.96 between Tγand wear depth and 0.82 between wear index and material removed for the outer *** the results,the Tγis better than the wear index to be used when analyzing wear depth while the wear index is more suited to foresee the material *** results also show the low influence of A_(nc)on wear index and Tγ.By considering these factors together,the study aims to improve the understanding of wheel-rail wear by selecting the best wear analysis approaches based on the effectiveness of each parameter.

关键词： Wear index Wear volume Wear modeling Dynamic simulation

Solar-assisted photocatalytic water splitting using defective UiO-66 solids from modulated synthesis

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Nano research 2024年第5期17卷 4134-4150页

作者： Celia m.rueda-Navarro m.r.a Cabrero-Antonino paula Escamilla Valentín Díez-Cabanes Dong Fan Pedro Atienzar Belén Ferrer Ignacio Vayá Guillaume maurin Herme G.Baldoví Sergio Navalón Departamento de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto de Ciencia molecular(ICmOL) Universitat de ValènciaPaterna 46980Spain ICGm Univ.MontpellierCNRSENSCMMontpellier34095France Instituto de Tecnología Química(UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

metal-organic frameworks(mOFs)are attracting increasing interests as photocatalysts for solar-driven hydrogen production from *** paper reports on a comparative study of using either acetic acid(AA)or trifluoroacetic acid(TFA)as the representative UiO-66 organic modulators for synthesizing visible light responsive UiO-66(Zr)-X(X:NH_(2) or NO_(2))photocatalysts for water *** results show that photocatalytic hydrogen generation from a water/methanol mixture can be improved by varying the nature and amount of the modulator employed to prepare the different UiO-66(Zr)-X(X:NH_(2) or NO_(2))solid ***-66(Zr)-NH_(2) was the most active photocatalyst,followed by UiO-66(Zr)-NO_(2),both prepared with 12 equivalents of AA with respect to the organic *** UiO-66(Zr)-NH_(2) solid was more active than the parent mOF in photocatalytic overall water splitting(OWS)(H_(2) and O_(2) production of 450 and 160μmol·g^(-1),respectively,in 5 h;apparent quantum yield(AQY)at 400 nm of 0.06%)in the absence of methanol and compares favourably with analogous *** on the photocatalytic activity of the most active solids of both series was obtained by means of a series of techniques,including ultraviolet-visible(UV-vis)diffuse reflectance,X-ray photoelectron spectroscopy(XPS),laser flash photolysis(LFP),electron spin resonance(ESr),photoluminescence and photoelectrochemical measurements together with density functional theory(DFT)*** results showed that organic acid modulators can be used to enhance the photocatalytic activity of missing linker UiO-66 defective materials in solar-powered water splitting.

关键词： heterogeneous photocatalysis metal-organic frameworks(mOFs) UiO-66 materials carboxylic acid modulators water splitting solar light

Dysregulated microrNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

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World Journal of Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improta-Caria Filipe Ferrari João Lucas Penteado Gomes Paloma Brasilio Villalta Úrsula paula renóSoci ricardo Stein Edilamar m Oliveira Laboratory of Biochemistry and molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of metabolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departments of Internal medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other *** this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microrNAs(m.r.as),remain *** are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological ***,the signaling pathways and biological processes regulated by m.r.as that are associated with T2D and BC have not yet been *** review aims to identify dysregulated m.r.as in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： Type 2 diabetes Breast cancer microrNAs molecular mechanisms

Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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Ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán matías mastrangelo marcelo Nosetto Pablo E.Villagra Ezequiel Balducci martín Pinazo roxana P.Eclesia Alejandra Von Wallis Sebastián Villarino Francisco Alaggia marina González Polo Silvina manrique Pablo A.meglioli Julián rodríguez-Souilla martín mónaco Jimena E.Chaves Ariel medina Ignacio Gasparri Eugenio Alvarez Arnesi m.r.a paula barral Axel von müller Norberto m.Pahr Josefina Uribe Echevarria Pedro Fernández marina morsucci Dardo López Juan manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco Laura Cavallero Gualberto Zalazar Guillermo martínez Pastur Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroecosistemas y Paisajes rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y medioambiente (INIBIOmA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en Energía No Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección Nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ecología regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad Nacional de rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroecosistemas y Paisajes rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigaciones en maderas (LImAD) Universidad Nacional de La Plata (UNLP) Administración de Parques Nacionales (APN) Parque Nacional Los Alerces Centro de Estudios Ambientales Integrados (CEAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（NDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United Nations Framework Conven-tion on Climate Change（UNFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（rEDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest reference Emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google Earth Engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on Enhanced Vegetation Index（EVI） and land surface temperature（LST） images from Landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity Native forest Climate change mitigation modelling resilience

The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar Science 2024年第1期35卷 63-77页

作者： paula BONA Juliana STErLI marcelo Saúl de la FUENTE Eduardo OLIVErO m.r.a S.FErNÁNDEZ marcelo rEGUErO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Austral de Investigaciones Científicas-CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian Sea and final dismemberment of Southern *** this context,Eocene marine vertebrates from Seymour(marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic Coast of South *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the Leticia Formation(late-mid Eocene)at Cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to Dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late Cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the Leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the La meseta and Submeseta formations(Antarctica)and the Waihao and Burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles Dermochelyidae Paleogene La meseta Formation Submeseta Formation Leticia Formation

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Exclusive breastfeeding greater than 50%, success of education in a university hospital in Bogotá: Case-control study

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World Journal of Clinical Pediatrics 2024年第1期13卷 23-30页

作者： marcela murillo Galvis Sofia Ortegon Ochoa Clara Eugenia Plata García m.r.a paula Valderrama Junca Dayanna Alejandra Inga Ceballos Daniel mauricio mora Gómez Claudia m Granados martin rondón Department of Pediatrics Hospital Universitario San IgnacioBogotá110111Colombia Department of Clinical Epidemiology and Biostatistics Pontifica Universidad JaverianaBogotá110111Colombia

BACKGrOUND maintenance rates of exclusive breastfeeding(EBF)worldwide are low,thus,one of the objectives of the summary of policies on breastfeeding(BF)in world nutrition goals for 2025 are that at least 50%of infants under six months of age receive EBF that *** Objective of this study is to document the rates of EBF in children born in San Ignacio University Hospital(HUSI)and identify factors associated with *** To document the percentages of EBF in those that were born at HUSI and identify factors associated to their *** This is a study of cases and controls in an analytic,retrospective cohort that took children born alive between January 2016 and January 2019 at HUSI located in the city of Bogotá,*** receiving information about BF at HUSI was able to maintain EBF up until 4 mo(Or=1.65;95%CI:1.02-2.66).The presence of gynecologic and obstetric comorbidities(Or=0.32;95%CI:0.12-0.83),having mastitis(Or=0.56;95%CI:0.33-0.94),and receiving information from mass media(Or=0.52;95%CI:0.31-0.84)are factors associated with not maintaining *** receiving education at a Women-and Child-Friendly Institution was the only significant factor to achieve EBF until 4 mo,with a frequency greater than the one reported in the country,which matches multiple studies where counseling and individualized support on BF achieve this *** about BF and early detection of obstetric/gynecologic complications must be strengthened among the healthcare staff in charge of mothers during ***,strategies must be promoted to continue BF such as creating milk banks with the objective of increasing BF rates even when mothers return to work.

关键词： Breastfeeding Women-and Child-Friendly Institutional Strategy Strategies Adherence Education

Long-term monitoring reveals the effect of precipitation and silviculture on Nothofagus regeneration in Northern Patagonia mixed forests

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Ecological Processes 2024年第02期13卷 103-117页

作者： Georgina Sola Camila mateo Alejandro Dezzotti paula marchelli Hernán Attis Beltrán renato Sbrancia Luis Chauchard marcelo González Pe?alba martín Lara Verónica El mujtar Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Asentamiento Universitario San martín de los Andes (AUSmA-UNCo) Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB) Instituto Nacional de Tecnología Agropecuaria (INTA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Departamento de Conservación y manejo Parque Nacional Lanín- Administración de Parques Nacionales (PNL-APN)

Background Tree regeneration is a key component of resilience because it promotes post-disturbance recovery of forests. Northwestern Patagonia from Argentina is occupied by Nothofagus alpina（Na）, N. obliqua（No）, and N. dombeyi（Nd） forests that grow along an intense precipitation gradient, managed throughout shelterwood silvicultural system by technicians of the Lanin Natural reserve. The objective of this study was to evaluate the influence of seeding cuttings over the dynamics of Nothofagus mixed forests across landscape（precipitation gradient） based mainly on the composition and abundance of tree regeneration, permanent sampling plots and generalized linear mixed models. In particular, we analysed:（i） the structure of sexual and asexual regeneration during 20 years after harvest（the dynamics of managed forests）, and（ii） the structure of sexual regeneration in primary and managed forests after > 20 years of harvest（the effect of silviculture）.results Nd was the most abundant species in the regeneration of managed forests during all periods in both sites despite its lower contribution to the adult cohort. During the 10–20 years period after harvest, the humid site exhibited higher regeneration density than the mesic site(120,000 and 6000 ind ha-1, respectively), and it decreased afterwards. The number of established regeneration（> 2 m height） was lower for Na in the mesic site and for No in the humid site(0 and 57 ind ha-1, respectively). However, in comparison to No, Na showed a higher number of sprouted stumps and sprouts per stump, and a higher sprout height in the mesic site. No exhibited higher sprout m.r.ality in the humid site. Finally, the regeneration of primary forests showed lower density and height, and a more balanced composition than that of managed *** The silvicultural effects on the mixed forest regeneration dynamics was strongly influenced by the condition of sites. Therefore, management prescriptions should be adj

关键词： Nothofagus alpina Nothofagus obliqua Nothofagus dombeyi Basal sprouting Shelterwood silvicultural system Ecological resilience

The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

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molecular Plant 2024年第7期17卷 1129-1150页

作者： paula Berman Luis Alejandro de Haro Ana-rita Cavaco Sayantan Panda Younghui Dong Nikolay Kuzmich Gabriel Lichtenstein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit meir Ilana rogachev Asaph Aharoni Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The maurice and Vivienne Wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel Present address:Department of Cell and metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA Department of Botany and Plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones and Development regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the cactus Lophophora williamsii(Peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing with comprehensive chemical profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six catalytic steps in the mescaline biosynthetic pathway,and an N-methyltransferase enzyme that N-methylates all phenethylamine intermediates,likely modulating mescaline levels in ***,we reconstructed the mescaline biosynthetic pathway in both Nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mescaline *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mescaline,safeguarding this valuable natural resource for future generations.

关键词： mescaline Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling