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Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad Norevik Aleksi m.Huuha Ragnhild N.RФsbjФrgen Linda Hildegard Bergersen Kamilla Jacobsen Rodrigo miguel-dos-Santos Liv Ryan Belma Skender Jose Bianco N.moreira Asgeir Kobro-Flatmoen m.nno p.witter Nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems Neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(mcGill-R-Thyl-App)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(pmyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation Neurons plasma transfusion

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INTERREGIONGAL　ENVIRONmENTAL　STUDY　OF　THE　mARK-VLIET　CATCHmENT

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International Journal of Sediment Research 1997年第2期 1-11页

作者：Ｍ．ＨｕｙｇｅｎｓＲ．ＶｅｒｈｏｅｖｅｎＪ．Ｖ．Ｗｉｔｔｅｒ

ＴｈｅＭａｒｋＶｌｉｅｔｒｉｖｅｒｓｙｓｔｅｍｔｒａｎｓｐｏｒｔｓｂｅｄｍａｔｅｒｉａｌａｎｄｐｏｌｌｕｔｅｄｓｕｓｐｅｎｄｅｄｓｅｄｉｍｅｎｔｓｔｏｔｈｅＶｏｌｋｅｒａｋＺｏｏｍｌａｋｅ，ａｗａｔｅｒｅｎｖｉｒ...

ＴｈｅＭａｒｋＶｌｉｅｔｒｉｖｅｒｓｙｓｔｅｍｔｒａｎｓｐｏｒｔｓｂｅｄｍａｔｅｒｉａｌａｎｄｐｏｌｌｕｔｅｄｓｕｓｐｅｎｄｅｄｓｅｄｉｍｅｎｔｓｔｏｔｈｅＶｏｌｋｅｒａｋＺｏｏｍｌａｋｅ，ａｗａｔｅｒｅｎｖｉｒｏｎｍｅｎｔｏｆｈｉｇｈｌｉｍｎｏｌｏｇｉｃａｌｖａｌｕｅ．Ｔｏｐｒｏｔｅｃｔｔｈｅｌｉｖｉｎｇ，ｗｏｒｋｉｎｇａｎｄｒｅｃｒｅａｔｉｏｎａｒｅａｓｉｎｔｈｉｓｃａｔｃｈｍｅｎｔ，ａｐｒｏｐｅｒｉｎｔｅｇｒａｔｅｄｗａｔｅｒｍａｎａｇｅｍｅｎｔｉｓｅｓｓｅｎｔｉａｌ．Ａｓｙｓｔｅｍａｔｉｃｃｏｎｔｒｏｌａｎｄｓａｎｉｔａｔｉｏｎｏｆｔｈｅｐｏｌｌｕｔｅｄｓｅｄｉｍｅｎｔｓｉｎｔｈｅｒｉｖｅｒｅｎｖｉｒｏｎｍｅｎｔｗｉｌｌｈｅｌｐｔｏｓｔｏｐｆｕｒｔｈｅｒｄｅｇｒａｄａｔｉｏｎｏｆｔｈｅｗａｔｅｒｅｃｏｓｙｓｔｅｍｑｕａｌｉｔｙ．Ｔｈｅｒｅｆｏｒｅ，ａｔｒａｎｓｂｏｕｎｄａｒｙｃｏｌｌａｂｏｒａｔｉｏｎｂｅｔｗｅｅｎＢｅｌｇｉａｎａｎｄＤｕｔｃｈａｕｔｈｏｒｉｔｉｅｓｉｓｓｅｔｕｐｔｏｓｔｕｄｙａｎｄｓａｎｉｔａｔｅｔｈｉｓｉｎｔｅｒｒｅｇｉｏｎａｌｒｉｖｅｒｃａｔｃｈｍｅｎｔ．Ｔｏｉｍｐｒｏｖｅ

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Swallowing threshold parameters of subjects with complete dentures and overdentures

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Open Journal of Stomatology 2011年第3期1卷 69-74页

作者： Dick. J. witter F. Anneke Tekamp Ad p. Slagter Cees m. Kreulen Nico H. J. Creugers 不详

Aim: To compare the chewing process and swallowing threshold parameters of subjects with complete dentures and overdentures with data obtained from subjects with complete natural dentitions. metho-dology: The chewing process in terms of swallowing threshold parameters of four groups of subjects with complete dentures (all females) was quantified by sieving particles after chewing of an artificial test ‘food’ and compared with that of subjects with com-plete natural dentitions as a reference group (33 sub-jects). All subjects (except those of the reference group) had a complete denture in the upper jaw. Regarding the lower jaw two groups with complete dentures (with high (24 subjects), respectively low mandible (12 subjects)) and two groups with overdentures (implant-retained (22 subjects), respectively natural root supported (19 subjects)) were composed. Results: The ‘overdenture-implants’ group needed significantly more chewing cycles and time (mean: 45 cycles in 32 seconds) until ‘swallowing’ compared to the group with complete natural dentitions (mean: 26 cycles in 19 seconds until ‘swallowing’). Also the ‘complete denture-low mandible’ group needed sig-nificantly more cycles and time (mean: 52 cycles in 44 seconds) until ‘swallowing’ than the complete dentition group. In the ‘overdenture-natural roots’ group these outcomes (33 cycles in 24 seconds) were not significantly different compared with the complete dentition group. The ‘complete denture-high mandi-ble’ group (32 cycles in 26 seconds) needed not sig-nificantly more cycles until ‘swallowing’, however time until ‘swallowing’ was significantly longer com-pared to the complete dentition group. All denture groups had significantly larger mean particle sizes when ‘swallowing’ (sizes in the order of 3 mm) than the natural dentition group (about 2 mm). Conclusion: Despite efforts to compensate for a reduced chewing efficiency, subjects with complete dentures (including overdentures) had 50% larger median particl

关键词： Swallowing Threshold Chewing Efficiency Complete Denture Overdenture Oral Implant

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A Vietnamese version of the 14-item oral health impact profile (OHIp-14VN)

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Open Journal of Epidemiology 2012年第1期2卷 28-35页

作者： Anneloes E. Gerritsen Thoa C. Nguyen Dick J. witter Ewald m. Bronkhorst Nico H. J. Creugers Department of Community and Restorative Dentistry College of Dental Science Radboud University Nijmegen Medical Centre Nijmegen The Netherlands Department of Oral Function and prosthetic Dentistry College of Dental Science Radboud University Nijmegen Medical Centre Nijmegen The Netherlands Department of prosthodontics Faculty of Dentistry Cantho University of Medicine and Pharmacy Cantho Vietnam

Aim: To validate a Vietnamese short version (OHIp- 14VN) for use in epidemiological studies. methods: The original English-language version was translated into Vietnamese, back translated and after some revisions tested for psychometric properties. Subjects (n = 724) were asked to self-administer a questionnaire but could ask for assistance. Convergent validity was tested by investigating associations between OHIp domain and total scores, and dichotomized self-reported satisfaction with 1) the dentition in general, 2) chewing function, and 3) esthetics. Groups validity was evaluated by comparing OHIp scores of subjects having ≤6 molars vs. >6 molars and tooth decay vs. no decay. Test-retest reliability was investigated in a convenience sample (n = 54) and expressed in Intraclass Correlation Coefficients (ICCs). Internal consistency was assessed by Cronbach’s alpha and average interitem correlation coefficients. Results: Validity: all associations were in the hypothesized directions. Differences in mean OHIp total were statistically sig-nificant for all discriminative variables. OHIp scores completed with assistance were significantly lower than those from self-administered questionnaires and therefore analyzed separately. For both administration formats differences in mean scores were still significant for “satisfaction” but for having ≤6 molars or decay the differences lost significance for most domain and total scores. Reliability: ICCs ranged from 0.54 - 0.74. Internal consistency: Cronbach’s alphas for OHIp total scores were 0.93 (self-administered) and 0.91 (with assistance). Average interitem correlation coefficients ranged from 0.26 - 0.67 (self-administered) and 0.28 - 0.69 (with assistance). Conclusions: This Vietnamese version of the OHIp-14 demonstrated good construct validity and acceptable reliability for OHIp total scores however OHIp-14VN domain scores should be interpreted with caution.

关键词： Oral Health Impact profile OHIp-14 Vietnamese Version Validation Administration Format

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A Life Cycle Assessment Based Evaluation of a Coupled Wastewater Treatment and Biofuel production paradigm

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Journal of Environmental protection 2013年第9期4卷 1018-1033页

作者： monica C. Rothermel Amy E. Landis William J. Barr Kullapa Soratana Kayla m. Reddington matthew K. Weschler Grace witter Willie F. Harper De- partment of Systems Engineering and management Air Force Institute of Technology WPAFB USA Department of Civil and Environmental Engineering University of Pittsburgh Pittsburgh USA School of Sustainable Engineering and the Built Environment Global Institute of Sustainability Arizona State University Engineering G-Wing Tempe USA

A laboratory experiment was performed to determine the feasibility of coupling a conventional wastewater treatment system with an algal photobioreactor (pBR) for the removal of nutrients from wastewater and production of renewable resources. An activated sludge batch reactor was set up in series with an algal pBR to feed synthetic wastewater to Chlorella vulgaris. The nutrient concentration in the water as well as lipid content, carbohydrate content, and growth rate of the algal biomass were tested over 10 cycles to determine the capabilities of the coupled system. The study revealed complete nutrient removal in some cycles, with the average final nutrient content of 2 mg-p/L and 3 mg-N/L in effluent of the pBR. The algae biomass contained 24% ± 3% lipids and 26% ± 7% carbohydrates by dry weight. A life cycle assessment revealed the highest energy demand occurred during harvesting of the algal mixture through centrifugation or filtration, but the highest global warming and eutrophication impacts were due to CO2 use and pBR construction material production. It is feasible for the system to treat wastewater while generating renewable resources, but the system must be optimized to reduce life cycle environmental impacts and result in a net energy gain before large-scale implementation is possible.

关键词： Wastewater Biofuels Life Cycle Assessment Nitrogen Carbohydrate

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加拿大海达瓜伊m_W7.8地震期间同震沉降的潮间带生物指示物

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世界地震译丛 2017年第4期48卷 326-348页

作者： peter J.Haeussler Robert C.witter Kelin Wang 徐勇不详中国地震局地球物理勘探中心

2012年10月28日海达瓜伊m_W7.8地震是沿加拿大不列颠哥伦比省大倾斜汇聚的夏洛特皇后边缘的大型逆冲区地震。由于在250km的破裂区域内只有6个全球定位系统(GpS)测点和2个检潮仪台站,大地测量没有很好约束同震变形。为了更好地约束垂直... 详细信息

2012年10月28日海达瓜伊m_W7.8地震是沿加拿大不列颠哥伦比省大倾斜汇聚的夏洛特皇后边缘的大型逆冲区地震。由于在250km的破裂区域内只有6个全球定位系统(GpS)测点和2个检潮仪台站,大地测量没有很好约束同震变形。为了更好地约束垂直同震变形,我们测量了相对于震后5个月、25个测点海平面由自然条件控制的两个固着潮间带生物的生长上限。测量了岩藻(双列藻属,617个测点)和常见的橡子藤壶(藤壶属,686个测点)的位置。本研究重点探讨了该群岛的西侧,破裂模型表明有大规模垂直位移,同时也调查了远离推断破裂区的场点,以对照不受垂直位移影响的生物的上限。同时还做了322次海平面测量,以使用TpXO7.2潮汐模型,而不是使用全球定位系统确定的椭圆高度将生长极限与潮汐基准面相关联。用3种方法检查该数据都表明莫尔兹比岛西海岸由于2012年10月28日的海达瓜伊地震而出现了0.4~0.6m的沉降。我们的数据,在误差范围内,与海达瓜伊西海岸两个全球定位系统测点的数据一致,且与该群岛近海而非之下的大型逆冲破裂的破裂模型一致。

关键词：同震全球定位系统 mW7.8 生物指示物潮汐基准面潮间带潮汐模型藤壶破裂区潮汐变化

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对禽逆转录病毒特别是J亚群白血病病毒感染的回顾

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山东家禽 2002年第6期15卷 45-47页

作者：李增光阿里.m.法得里青岛正大有限公司 266109

禽白血病病毒(ALV)和网状内皮增生征病毒(REV)是造成家禽自然感染的致瘤性病毒中最常见的两种逆转录病毒(payne and Fadly,1997;witter,1997).除了引起肿瘤和其他生产性问题以外,ALV和REV还会对活毒疫苗产生潜在性污染.ALV对鸡的污染广... 详细信息

禽白血病病毒(ALV)和网状内皮增生征病毒(REV)是造成家禽自然感染的致瘤性病毒中最常见的两种逆转录病毒(payne and Fadly,1997;witter,1997).除了引起肿瘤和其他生产性问题以外,ALV和REV还会对活毒疫苗产生潜在性污染.ALV对鸡的污染广泛且具有显著的经济重要性;由于ALV引起肿瘤和降低生产效益所造成的经济损失,估计每年大约在数百万美元.另一方面,由于REV很少被检出(其实它广泛存在),至今尚未被看作是一种重要的经济性疾病问题(witter,1997).

关键词：禽逆转录病毒 J亚群白血病病毒感染肉鸡传播发生率肿瘤诊断控制

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对禽逆转录病毒特别是J亚群白血病病毒感染的回顾

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当代畜禽养殖业 2002年第1期 15-17页

作者：阿里·m·法得里李增光不详青岛正大有限公司

引言禽白血病病毒(ALV)和网状内皮增生症病毒(REV)是造成家禽自然感染的致瘤性疾病中最常见的两种逆转录病毒(Davne and Fadly,1997,witter,1997)。除了引起肿瘤和其他生产性问题以外,ALV和REV还会对活毒疫苗产生潜在性污染。ALV对鸡... 详细信息

引言禽白血病病毒(ALV)和网状内皮增生症病毒(REV)是造成家禽自然感染的致瘤性疾病中最常见的两种逆转录病毒(Davne and Fadly,1997,witter,1997)。除了引起肿瘤和其他生产性问题以外,ALV和REV还会对活毒疫苗产生潜在性污染。ALV对鸡的感染广泛且具有显著的经济重要性;由于ALV引起肿瘤和降低生产效益所造成的经济损失,估计每年大约在数百万美元。另一方面,由于REV很少被检出(其实它广泛存在)。

关键词：禽白血病病毒逆转录病毒 J亚群病毒感染传播发生率诊断

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