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Subepidermal Autoimmune Bullous Disease Associated With monoclonal Gammopathy of Unknown Significance and Unexpected Positive Direct Nikolsky Phenomenon:A Case Report

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International Journal of Dermatology and Venereology 2021年第1期4卷 45-47页

作者： Gamze Tas-Aygar müzeyyen Gonül Aysun Gokce m.nire cagin Dermatology Clinic University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06110Turkey Pathology Clinic University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06110Turkey

Introduction:Numerous dermatoses associated with monoclonal gammopathy have been reported in the *** autoimmune bullous diseases(SABD)are one of them which were not *** presentation:A 68-year-old male patient was admitted to our clinic with erosions on the oral mucosa,tense blisters,erosions,and ulcers on the trunk and *** vesicle formation was detected in the skin *** examination revealed positivity for the Nikolsky *** disease was unresponsive to conventional treatments and dysphagia and hoarseness *** patient was screened for malignancy due to his unresponsiveness to the treatments and his severe oral mucosal ***-G mGUS was detected in the ***:The Nikolsky sign is an indicator of acantholysis and is known as a specific finding for ***,when we look at gammopathy-associated autoimmune bullous dermatoses,skin fragility has been reported in ***,the meaning of fragility is not *** diagnosis of all these patients was Ig-m *** patient was presented because of non-Igm mGUS,direct Nikolsky positivity,and severe mucosal ***:Nikolsky positivity may be a clue for gammopathy-related subepidermal autoimmune bullous diseases.

关键词： subepidermal autoimmun bullous diseases gammopathy mGUS Nikolsky phenomenon case report

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