Subepidermal Autoimmune Bullous Disease Associated With Monoclonal Gammopathy of Unknown Significance and Unexpected Positive Direct Nikolsky Phenomenon:A Case Report

作     者：Gamze Tas-Aygar Müzeyyen Gonül Aysun Gokce Münire Cagin Taş-Aygar Gamze;Gönül Müzeyyen;Gökçe Aysun;Çağın Münire

作者机构：Dermatology ClinicUniversity of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06110Turkey Pathology ClinicUniversity of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06110Turkey 

出 版 物：《International Journal of Dermatology and Venereology》 (国际皮肤性病学杂志（英文）)

年 卷 期：2021年第4卷第1期

页      面：45-47页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：subepidermal autoimmun bullous diseases gammopathy MGUS Nikolsky phenomenon case report 

摘      要：Introduction:Numerous dermatoses associated with monoclonal gammopathy have been reported in the *** autoimmune bullous diseases(SABD)are one of them which were not *** presentation:A 68-year-old male patient was admitted to our clinic with erosions on the oral mucosa,tense blisters,erosions,and ulcers on the trunk and *** vesicle formation was detected in the skin *** examination revealed positivity for the Nikolsky *** disease was unresponsive to conventional treatments and dysphagia and hoarseness *** patient was screened for malignancy due to his unresponsiveness to the treatments and his severe oral mucosal ***-G MGUS was detected in the ***:The Nikolsky sign is an indicator of acantholysis and is known as a specific finding for ***,when we look at gammopathy-associated autoimmune bullous dermatoses,skin fragility has been reported in ***,the meaning of fragility is not *** diagnosis of all these patients was Ig-M *** patient was presented because of non-IgM MGUS,direct Nikolsky positivity,and severe mucosal ***:Nikolsky positivity may be a clue for gammopathy-related subepidermal autoimmune bullous diseases.