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Journal of Environmental Sciences 2024年第4期138卷 112-120页

作者： Shuhao Shi Qian Du m.ng Hou Xiaolei Ye Li Yang Shenghui Guo Jianhong Yi Ullah Ehsan Hongbo zeng State Key Laboratory of Complex Nonferrous metal Resources Clean Utilization Faculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China Department of Chemical and materials Engineering University of AlbertaEdmonton T6G 2V4Canada FEmTO-ST Institute(UmR CNRS 6174) Universite de Bourgogne Franche-Comte(UBFC)Universite de technologie de Belfort Montbéliard(UTBM)Site de MontbeliardBelfort F-90010France Faculty of materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

Zeolitic Imidazolate Framework-8(ZIF-8)material was prepared by chemical precipitation *** microstructure and physical properties of the as-prepared samples were characterized by XRD,BET,FESEm and UV *** self-made four-channel measurement device was used to test the gas sensitivity of ZIF-8 material toward ethanol gas under photo-thermal synergistic *** results showed that the sample was typical ZIF-8(E_(g)=4.96 eV)with a regular dodecahedron shape and the specific surface is up to 1793 m^(2)/*** as-prepared ZIF-8 has a gas response value of 55.04 to 100 ppm ethanol at 75℃ and it shows good gas sensing selectivity and repeated *** excellent gas sensitivity can be attributed to the increase of free electron concentration in the ZIF-8 conduction band by photo-thermal synergistic excitation,and the large specific surface area of ZIF-8 material provides more active sites for gas-solid surface *** reaction mechanism of ZIF-8 material under multi-field excitation was also discussed.

关键词： ZIF-8 material Photo-thermal synergistic excitation UV-light irradiation Photon-generated electron and hole Gas-sensitive property

Integrative transcriptome analysis identifies mYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration

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Genes & Diseases 2024年第3期11卷 351-367页

作者： Xinzhu Quiu Hongbo He Hao zeng Xiaopeng Tongg Can Zhang Yupeng Liu Zhan Liao Qing Liu Department of Orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China Department of Sports medicine Research Center of Sports MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China

mYBL2(mYB proto-oncogene like 2)is an emerging prognostic marker for malignant tumors,and its potential role in osteosarcoma and its relationship with immune infiltration in pan-cancer is yet to be *** constructed a transcription factor activity profile of os-teosarcoma using the single-cell regulatory network inference algorithm based on single-cell RNA sequencing data obtained from the Gene Expression ***,we calcu-lated the extent of mYBL2 activation in malignant proliferative *** also explored the association between mYBL2 and chemotherapy resistance in ***,we systematically correlated mYBL2 with immunological signatures in the tumor microenviron-ment in pan-cancer,including immune cell infiltration,immune checkpoints,and tumor immu-notherapy ***,we developed and validated a risk score(mRGS),derived an osteosarcoma risk score nomogram based on mRGS,and tested its ability to predict ***2 and gene enrichment analyses in osteosarcoma and pan-cancer revealed that mYBL2 was positively correlated with cell proliferation and tumor immune ***2 expres-sion positively correlated with SLC19A1 in pan-cancer and osteosarcoma cell ***-cancer immune infiltration analysis revealed that mYBL2 was correlated with myeloid-derived sup-pressor cells,Th2 cell infiltration,CD276,RELT gene expression,and tumor mutation burden.

关键词： Biomarker Immunecheckpoint mYBL2 Osteosarcoma Pan-cancer

Intelligent design and construction of novel APN-based theranostic probe driven by advanced computational methods

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Chinese Chemical Letters 2024年第2期35卷 352-357页

作者： Yingli Zhu Jie Qian Kunqian Yu Jing Hou Yeshuo ma Fei Chen Jie Dong Wenbin zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410083China National Engineering Research Center of Rice and Byproduct Deep Processing School of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Drug Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Geriatrics Third Xiangya HospitalCentral South UniversityChangsha 410013China

multifunctional molecules with both optical signal and pharmacological activity play an important role in drug development,disease diagnosis,and basic theoretical *** N(APN),as a representative tumor biomarker with anti-tumor potential,still lacks a high-precision theranostic probe specifically targeting *** this study,a novel quaternity design strategy for APN theranostic probe was *** proposed strategy utilizes advanced machine learning and molecular dynamics simulations,and cleverly employs the strategy of conformation-induced fluorescence recovery to achieve multi-objective optimization and integration of functional *** this strategy,a unique“Off-On”theranostic probe,ABTP-DPTB,was ingeniously constructed to light up APN through fluorescence restoration,relying on conformation-induced effects and solvent *** from the common diagnostic probes,the intelligent design with non-substrated linkage makes ABTP-DPTB for long-term in-situ *** fabricated probe was used for detecting and inhibiting APN in various environments,with a better in vitro inhibitory than golden-standard drug bestatin.

关键词： Theranostic probe Artificial intelligence Conformational restriction Fluorescence restoration Design strategy

Field experimental study on the effect of thawed depth of frozen alpine meadow soil on rill erosion by snowmelt waterflow

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International Soil and Water Conservation Research 2024年第1期12卷 54-63页

作者： Ying Zheng Xiaonan Shi Fan Zhang Tingwu Lei Chen zeng Xiong Xiao Li Wang Guanxing Wang State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100101China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing210098China College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China College of Geographic Science Hunan Normal UniversityChangsha410081China

Soil erosion by snow or ice melt waterflow is an important type of soil erosion in many high-altitude and high-latitude regions and is further aggravated by climate *** snowmelt waterflow erosion process is affected by soil freeze-thaws and is highly dynamically *** this study,a methodology was developed to conduct in situ field experiments to investigate the effects of the thawed depth of the frozen soil profile on snowmelt waterflow *** method was implemented on an alpine meadow soil slope at an altitude of 3700 m on the northeastern Tibetan *** erosion experiments involved five thawed soil depths of 0,10,30(35),50,and 80(100)mm under two snowmelt waterflow rates(3 and 5 L/min).When the topsoil was fully frozen or shallow-thawed(≤10 mm),its hydrothermal and structural properties caused a significant lag in the initiation of runoff and delayed soil erosion in the initial *** runoff and sediment concentration curves for fully frozen and shallow-thawed soil showed two-stage patterns characteristic of a sediment supply limited in the early stage and subject to hydrodynamic-controlled processes in the later ***,this effect did not exist where the thawed soil depth was greater than 30 *** deep-thawed cases(≥30 mm)showed normal hydrograph and sedigraph patterns similar to those of the unfrozen *** findings of this study are important for understanding the erosion rates of partially thawed soil and for improving erosion simulations in cold regions.

关键词： Snowmelt waterflow erosion Hillslope erosion process Soil freeze and thaw Runoff generation In situ experimental method

Periplaneta americana extract promotes infectious diabetic ulcers wound healing by downregulation of LINC01133/SLAmF9

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Chinese Journal of Natural medicines 2024年第7期22卷 608-618页

作者： YAng Yuhang HUAng Jun LI Xintian LIN Renjing WAng Xiaoyan XIAO Ge zeng Juanni WAng Zhenquan Department of Anorectal Disease 1 The Second Affiliated Hospital of Hunan University of Traditional Chinese MedicineChangsha 410005China Department of Anorectal Disease 3 The Second Affiliated Hospital of Hunan University of Traditional Chinese MedicineChangsha 410005China Laboratory of Vascular Biology and Translational medicine Medical SchoolHunan University of Chinese Medicine/Hunan Provincial Key Laboratory of Vascular Biology and Translational MedicineChangsha 410208China

Wound healing in diabetic ulcers remains a significant clinical challenge,primarily due to bacterial infection and impaired *** americana extract(PAE)has been widely used to treat diabetic wounds,yet its underlying mechanisms are not fully *** study aimed to elucidate these mechanisms by analyzing long non-coding RNA(lncRNA)expressions in the wound tissues from diabetic anal fistula patients treated with or without PAE,using high-throughput *** blood monocytes from patients were differentiated into m0 macrophages with human macrophage colony-stimulating factor(hmCSF)and subsequently polarized into m1 macrophages with *** results indicated that LINC01133 and SLAmF9 were downregulated in wound tissues of patients treated with ***,PAE suppressed m1 macrophage polarization and enhanced human umbilical vein endothelial cell(HUVEC)proliferation,migration,and *** effects were diminished when LINC01133 or SLAmF9 were ***,LINC01133 was shown to upregulate SLAmF9 through interaction with *** of SLAmF9 reversed the effects of LINC01133 silencing on macrophage polarization and HUVEC *** conclusion,PAE facilitates the healing of infected diabetic ulcers by downregulating the LINC01133/SLAmF9 pathway.

关键词： Periplaneta americana extract Infectious diabetic ulcers m1 macrophage polarization LINC01133 SLAmF9

Rh(Ⅱ)-catalyzed intermolecular carboamination of pyridines via double Csp^(2)-H bond activations

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Science China Chemistry 2024年第1期67卷 374-382页

作者： Zhongfeng Luo Jingxing Jiang Lifang Zou Xiaoyu Zhou Junshan Liu Zhuofeng Ke Fengjuan Chen Huanfeng Jiang Wei zeng Key Laboratory of Functional molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641China School of materials Science and Engineering PCFM LabSun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Chinese medicine Pharmaceutics School of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510515China

We disclose the development of the Rh-catalyzed amine-directed remote 5,6-carboamination protocol of pyridines via dual Csp^(2)-H functionalizations.A variety of readily available 2-aminopyridines and 1,2,3-triazoles are allowed for coupling cyclization to access polyfunctionalized *** studies including DFT calculations unveil that relay carbenoidelectrophilic addition to pyridines and the sequential pyridyl Csp^(2)-H amination are involved in this *** postsynthetic utility of this methodology is showcased by versatile and site-selective modification of azaindoles.

关键词： Rh-catalysis azaindoles pyridyl Csp^(2)-H bond carboamination coupling-cyclization

mixed D-vine copula-based conditional quantile model for stochastic monthly streamflow simulation

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Water Science and Engineering 2024年第1期17卷 13-20页

作者： Wen-zhuo Wang zeng-chuan Dong Tian-yan Zhang Li Ren Lian-qing Xue Teng Wu College of Water Resources and Hydrology Hohai UniversityNanjing 210098China Yellow River Research Center Hohai UniversityNanjing 210098China

Copula functions have been widely used in stochastic simulation and prediction of ***,existing models are usually limited to single two-dimensional or three-dimensional copulas with the same bivariate block for all *** address this limitation,this study developed a mixed D-vine copula-based conditional quantile model that can capture temporal *** model can generate streamflow by selecting different historical streamflow variables as the conditions for different months and by exploiting the conditional quantile functions of streamflows in different months with mixed D-vine *** up-to-down sequential method,which couples the maximum weight approach with the Akaike information criteria and the maximum likelihood approach,was used to determine the structures of multivariate Dvine *** developed model was used in a case study to synthesize the monthly streamflow at the Tangnaihai hydrological station,the inflow control station of the Longyangxia Reservoir in the Yellow River *** results showed that the developed model outperformed the commonly used bivariate copula model in terms of the performance in simulating the seasonality and interannual variability of *** model provides useful information for water-related natural hazard risk assessment and integrated water resources management and utilization.

关键词： Stochastic monthly streamflow simulation mixed D-vine copula Conditional quantile model Up-to-down sequential method Tangnaihai hydrological station

Alignment error modeling and control of a double-sided microlens array during precision glass molding

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microsystems & Nanoengineering 2024年第2期10卷 311-322页

作者： Zihao zeng Tianfeng Zhou Qian Yu Jia Zhou Gang Wang Qiuchen Xie Zifan Wang Xiaoqiang Yao Yubing Guo School of medical Technology Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing100081China School of mechanical Engineering Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing100081China

Double-sided microlens arrays(DSmLAs)include combinations of two single-sided mLAs to overcome positioning errors and greatly improve light transmissivity compared to other types of *** glass molding(PGm)is used to fabricate DSmLAs,but controlling alignment errors during this process is *** this paper,a mold assembly was manufactured with a novel combination of materials to improve the alignment accuracy of mold cores during PGm by using the nonlinear thermal expansion characteristics of the various materials to improve the DSmLA alignment *** establishing a mathematical model of the DSmLA alignment error and a thermal expansion model of the mold-sleeve pair,the relationship between the maximum alignment error of the DSmLA and the mold-sleeve gap was *** research provides a method to optimize the mold-sleeve gap and minimize the alignment error of the *** measured DSmLA alignment error was 10.56μm,which is similar to the predicted maximum alignment *** measurements showed that the uniformity of the homogenized beam spot was 97.81%,and the effective homogeneous area accounted for 91.66%of the total *** proposed method provides a novel strategy to improve the performance of DSmLAs.

关键词： sided alignment error

In situ formed mg(BH_(4))_(2) for improving hydrolysis properties of mgH_(2)

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Journal of magnesium and Alloys 2024年第3期12卷 1204-1214页

作者： Yongyang Zhu mili Liu lim.ng zeng Yin Wang Daifeng Wu Rui Li Qing Zhou Renheng Tang Fangm.ng Xiao Institute of Resources Utilization and Rare Earth Development Guangdong Provincial Key Laboratory of Rare Earth Development and ApplicationGuangdong Academy of SciencesGuangzhou 510650China School of materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510641China

The hydrolysis of mgH_(2) delivers high hydrogen capacity(15.2 wt%),which is very attractive for real-time hydrogen ***,the formation of a surface passivation mg(OH)_(2) layer and the large excess of H_(2)O required to ensure complete hydrolysis are two key challenges for the mgH_(2) hydrolysis ***,a low-cost method is reported to synthesize mgH_(2)@mg(BH_(4))_(2) composite via ball-milling mgH_(2) with cheap and widely available B_(2)O_(3)(or B(OH)_(3)).By adding small amounts of B_(2)O_(3),the in-situ formed mg(BH_(4))_(2) could significantly promote the hydrolysis of mgH_(2).In particular,the mgH_(2)–10 wt%B_(2)O_(3) composite releases 1330.7 mL·g^(−1) H_(2)(close to 80%theoretical hydrogen generation H_(2))in H_(2)O and 1520.4 mL·g^(−1) H_(2)(about 95%)in 0.5 m mgCl_(2) in 60 min at 26℃ with hydrolysis rate of 736.9 mL·g^(−1)·min^(−1) and 960.9 mL·g^(−1)·min^(−1) H_(2) during the first minute of the hydrolysis,*** addition,the mgCl_(2) solution allows repeated use by filtering and exhibits high cycle stability(20 cycles),therefore leading to much reduced capacity loss caused by the excess H_(2)*** show that by introducing B_(2)O_(3) and recycling the 0.5 m mgCl_(2) solution,the system hydrogen capacity can approach 5.9 wt%,providing a promising hydrogen generation scheme to supply hydrogen to the fuel cells.

关键词： Hydrolysis mgH_(2) mg(BH_(4))_(2) Hydrogen generation B_(2)O_(3) mgCl_(2)

Incidence and mortality of Cancers in Female Genital Organs—China,2022

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China CDC weekly 2024年第10期6卷 195-202,I0003,I0004页

作者： Kexin Sun Bingfeng Han Hongmei zeng Shaom.ng Wang Li Li Ru Chen Rongshou Zheng Wenqiang Wei National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Introduction:This study presented the incidence and mortality rates of cancers affecting the female genital organs in China,along with their trends spanning from 2010 to ***:700 population-based cancer registries provided relevant cancer incidence and mortality data for the year *** these,106 registries had continuous monitoring data suitable for trend analysis from 2010 to *** focused specifically on cancers affecting female genital organs(ICD10=C51-C54,C56)and projected their incidences and mortalities in China for 2022 based on data from 2018 and the trends observed from 2010 to ***-standardized incidence rate(ASIR)and mortality rate(ASmR)were calculated using Segi’s world standard ***:In 2022,there were an estimated 296,300 new cases and 104,900 deaths from female cancers in *** for vulva(C51),vagina(C52),cervix uteri(C53),corpus uteri(C54),and ovary(C56)were 0.32,0.23,13.83,6.84,and 5.68 per 100,000 *** for corpus uteri and ovary cancers were higher in urban *** for vulva,vagina,cervix,corpus uteri,and ovary cancers were 0.14,0.08,4.54,1.05,and 2.64 per 100,000 population,*** for ovarian cancer was higher in urban *** and ASmRs for most female genital organ cancers increased from 2010 to 2018,although the rate of increase for vulvar and cervical cancers in rural areas has slowed ***:Tailored cancer prevention and control programs specific to each region are necessary to address the growing disease burden.

关键词： ICD10 mortality organs