Rh(Ⅱ)-catalyzed intermolecular carboamination of pyridines via double Csp^(2)-H bond activations
作者机构:Key Laboratory of Functional Molecular Engineering of Guangdong ProvinceSchool of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641China School of Materials Science and EngineeringPCFM LabSun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Chinese Medicine PharmaceuticsSchool of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510515China
出 版 物:《Science China Chemistry》 (中国科学(化学英文版))
年 卷 期:2024年第67卷第1期
页 面:374-382页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金:supported by the National Natural Science Foundation of China(22271100,21973113) the Key-Area Research and Development Program of Guangdong Province(2020-B010188001) the Guangdong Basic and Applied Basic Research Foundation(2023A1515010070) the China Postdoctoral Science Foundation(2021M701243)
主 题:Rh-catalysis azaindoles pyridyl Csp^(2)-H bond carboamination coupling-cyclization
摘 要:We disclose the development of the Rh-catalyzed amine-directed remote 5,6-carboamination protocol of pyridines via dual Csp^(2)-H functionalizations.A variety of readily available 2-aminopyridines and 1,2,3-triazoles are allowed for coupling cyclization to access polyfunctionalized *** studies including DFT calculations unveil that relay carbenoidelectrophilic addition to pyridines and the sequential pyridyl Csp^(2)-H amination are involved in this *** postsynthetic utility of this methodology is showcased by versatile and site-selective modification of azaindoles.