Rh(Ⅱ)-catalyzed intermolecular carboamination of pyridines via double Csp^(2)-H bond activations

作     者：Zhongfeng Luo Jingxing Jiang Lifang Zou Xiaoyu Zhou Junshan Liu Zhuofeng Ke Fengjuan Chen Huanfeng Jiang Wei Zeng 

作者机构：Key Laboratory of Functional Molecular Engineering of Guangdong ProvinceSchool of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641China School of Materials Science and EngineeringPCFM LabSun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Chinese Medicine PharmaceuticsSchool of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510515China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2024年第67卷第1期

页      面：374-382页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(22271100,21973113) the Key-Area Research and Development Program of Guangdong Province(2020-B010188001) the Guangdong Basic and Applied Basic Research Foundation(2023A1515010070) the China Postdoctoral Science Foundation(2021M701243) 

主　　题：Rh-catalysis azaindoles pyridyl Csp^(2)-H bond carboamination coupling-cyclization 

摘      要：We disclose the development of the Rh-catalyzed amine-directed remote 5,6-carboamination protocol of pyridines via dual Csp^(2)-H functionalizations.A variety of readily available 2-aminopyridines and 1,2,3-triazoles are allowed for coupling cyclization to access polyfunctionalized *** studies including DFT calculations unveil that relay carbenoidelectrophilic addition to pyridines and the sequential pyridyl Csp^(2)-H amination are involved in this *** postsynthetic utility of this methodology is showcased by versatile and site-selective modification of azaindoles.