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Journal of Systems Science and Systems Engineering 2020年第5期29卷 590-608页

作者： C.K.m.LEE W.C.TAI Kam K.H.ng Department of Industrial and Systems Engineering The Hon g Kong Polytechnic UniversityHung HornHong Kong SARChina School of mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

The current healthcare system in Hong Kong is experiencing pressure due to constrained resources,with dramatic increases in inpatient services queue lengths,dissatisfaction with the working environment,unacceptable workforce arrangements and high turnover rate of hospital *** maintain the robustness of the healthcare system and a sustainable inpatients flow,the Food and Health Bureau launched a public-private partnership programme to utilise the resources of the public and private *** research investigates the potential for extension of the programme and further enhancing the sustainability of the long-term inpatient services under a mixed public-private healthcare policy via system dynamic *** findings show that an increase of human resources in public hospitals does not substantially improve inpatient flow rate ***,the results from the system dynamic approach provide insights into the expansion of the service areas of the programme and suggest increasing the number of referrals to private hospitals.

关键词： System dynamic models scenario analysis inpatient transferral mixed public-private healthcare system

COVID-19 vaccination and associated factors in Turkish healthcare workers practicing chest medicine

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亚太热带医药杂志：英文版 2023年第3期16卷 110-118页

作者： Abdulsamet Sandal Aylin Güngör Cifci Peri m Arbak Occupational Diseases Clinic Ankara Gazi Mustafa Kemal Occupational and Environmental Diseases HospitalAnkaraTurkey Division of Occupational medicine Department of Chest DiseasesFaculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Chest Diseases Faculty of MedicineDuzce UniversityDuzceTurkey

Objective: To evaluate the COVID-19 vaccination status and related characteristics of Turkish healthcare workers practicing chest ***: A cross-sectional online survey was conducted am.ng the Turkish Thoracic Society members. The survey was started on may 17, 2021, and kept open for seven weeks. The 39-item survey included the COVID-19 vaccination status and demographic, clinical, and occupational characteristics. Results: Of 378 healthcare workers participated in the survey, 354(93.7%) reported receiving at least one dose of the COVID-19 vaccine. A total of 323(91.2%) healthcare workers received CoronaVac vs. BioNTech/Pfizer in 31(8.8%). In the CoronaVac group, 77(23.8%) contracted COVID-19 when not fully vaccinated, and 13(4.0%) when fully vaccinated;however, 16(51.6%) healthcare workers in the BioNTech/Pfizer group got COVID-19 when not fully vaccinated, but any fully vaccinated participants did not contract COVID-19(P=0.003). Regarding vaccine dosing, 328(86.8%) were fully vaccinated, while 50(13.2%) were not. multiple regression analysis for being a non-fully vaccinated healthcare worker demonstrated a significant relationship with having any SARS-CoV-2 infection history(adjusted OR 9.57, 95% CI 3.93-23.26, Png a non-physician healthcare worker(adjusted OR 5.86, 95% CI 2.11-16.26, P=0.001), but a significant negative relationship with full-time working at the time of survey(adjusted OR 0.13, 95% CI 0.03-0.56, P=0.006). Conclusions: Although a majority of healthcare workers were fully vaccinated, occupational and non-occupational characteristics were related to being non-fully vaccinated. Active surveillance regarding the COVID-19 vaccination in healthcare workers is necessary to address specific parameters as barriers to vaccination.

关键词： COVID-19 Vaccine Health personnel Occupational medicine Occupational diseases

Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells

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Cellular & molecular Immunology 2016年第1期13卷 119-131页

作者： Rhonda L Taylor mark N Cruickshank mahdad Karimi han Leng ng Elizabeth Quail Kenneth m Kaufman John B Harley Lawrence J Abraham Betty P Tsao Susan A Boackle Daniela Ulgiati School of Pathology and Laboratory medicine Centre for Genetic Origins of Health and Disease The University of Western Australia Crawley WA Australia Biochemistry and molecular Biology School of Chemistry and Biochemistry The University of Western Australia Crawley WA Australia Telethon Kids Institute The University of Western Australia Crawley WA Australia Cincinnati Children's Hospital medical Center Cincinnati OH USA US Department of Veterans Affairs medical Center Cincinnati OH USA Division of Rheumatology Department of Medicine University of California at Los Angeles Los Angeles CA USA Division of Rheumatology University of Colorado School of Medicine Aurora CO USA

Complement receptor 2 （CR2/CD21） is predominantly expressed on the surface of mature B cells where it forms part of a coreceptor complex that functions, in part, to modulate B-cell receptor signal strength. CR2/CD21 expression is tightly regulated throughout B-cell development such that CR2/CD21 cannot be detected on pre-B or terminally differentiated plasma cells. CR2/CD21 expression is upregulated at B-cell maturation and can be induced by IL-4 and CD40 signaling pathways. We have previously characterized elements in the proximal promoter and first intron of CR2/CD21 that are involved in regulating basal and tissue-specific expression. We now extend these analyses to the CR2/CD21 core promoter. We show that in mature B cells, CR2/~D21 transcription proceeds from a focused TSS regulated by a non-consensus TATA box, an initiator element and a downstream promoter element. Furthermore, occupancy of the general transcriptional machinery in pre-B versus mature B-cell lines correlate with CR2/CD21 expression level and indicate that promoter accessibility must switch from inactive to active during the transitional B-cell window.

关键词： B cells core promoter CR2/CD21 molecular biology transcription factor

Lowered testosterone in male obesity： mechanisms, morbidity and management

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Asian Journal of Andrology 2014年第2期16卷 223-231,I0008页

作者： mark ng Tang Fui Department of medicine Austin Health University of Melbourne Melbourne Department of Endocrinology Austin Health Melbourne Victoria Australia

With increasing modernization and urbanization of Asia, much of the future focus of the obesity epidemic will be in the Asian region. Low testosterone levels are frequently encountered in obese men who do not otherwise have a recognizable hypothalamic-pituitary-testicular （HPT） axis pathology. moderate obesity predominantly decreases total testosterone due to insulin resistance-associated reductions in sex hormone binding globulin. more severe obesity is additionally associated with reductions in free testosterone levels due to suppression of the HPT axis. Low testosterone by itself leads to increasing adiposity, creating a self-perpetuating cycle of metabolic complications. Obesity-associated hypotestosteronemia is a functional, non-permanent state, which can be reversible, but this requires substantial weight loss. While testosterone treatment can lead to moderate reductions in fat mass, obesity by itself, in the absence of symptomatic androgen deficiency, is not an established indication for testosterone therapy. Testosterone therapy may lead to a worsening of untreated sleep apnea and compromise fertility. Whether testosterone therapy augments diet- and exercise-induced weight loss requires evaluation in adequately designed randomized controlled clinical trials.

关键词： androgens hypogonadism obesity testosterone weight loss

On compact splitting complex submanifolds of quotients of bounded symmetric domains

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Science China mathematics 2017年第6期60卷 1057-1076页

作者： mOK ngaim.ng ng SuiChung Department of mathematics The University of Hong Kong Department of mathematics Shanghai Key Laboratory of PMMPEast China Normal University

We study compact complex submanifolds S of quotient manifolds X =Ω/F of irreducible bounded symmetric domains by torsion free discrete lattices of automorphisms, and we are interested in the characterization of the totally geodesic submanifolds am.ng compact splitting complex submanifolds S C X, i.e., under the assumption that the tangent sequence over S splits holomorphically. We prove results of two types. The first type of results concerns S C X which are characteristic complex submanifolds, i.e., embedding Ω as an open subset of its compact dual manifold m by means of the Borel embedding, the non-zero （1, 0）-vectors tangent to S lift under a local inverse of the universal covering map π → X to minimal rational tangents of m. We prove that a compact characteristic complex submanifold S C X is necessarily totally geodesic whenever S is a splitting complex submanifold. Our proof generalizes the case of the characterization of totally geodesic complex submanifolds of quotients of the complex unit ball B^n obtained by mok （2005）. The proof given here is however new and it is based on a monotonic property of curvatures of Hermitian holomorphic vector subbundles of Hermitian holomorphic vector bundles and on exploiting the splitting of the tangent sequence to identify the holomorphic tangent bundle Ts as a quotient bundle rather than as a subbundle of the restriction of the holomorphic tangent bundle Tx to S. The second type of results concerns characterization of total geodesic submanifolds am.ng compact splitting complex submanifolds S C X deduced from the results of Aubin （1978） and Yau （1978） which imply the existence of Kahler-Einstein metrics on S C X. We prove that compact s- plitting complex submanifolds S C X of sufticiently large dimension （depending on ） are necessarily totally geodesic. The proof relies on the Hermitian-Einstein property of holomorphic vector bundles associated to TS, which implies that endomorphisms of such bundles are parallel, and the co

关键词： bounded symmetric domains tangent sequence splitting complex submanifolds varieties of minimal rational tangents K/ihler-Einstein metrics

Boson star superradiance

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Science China(Physics,mechanics & Astronomy) 2024年第6期67卷 69-78页

作者： He-Yu Gao Paul m.Saffin Yi-Jie Wang Qi-Xin Xie Shuang-Yong Zhou School of Physical Sciences University of Science and Technology of ChinaHefei 230026China School of Physics and Astronomy University of NottinghamUniversity ParkNottingham NG72RDUK Interdisciplinary Center for Theoretical Study University of Science and Technology of ChinaHefei 230026China Peng Huanwu Center for Fundamental Theory Hefei 230026China

Recently,it has been realized that in some systems internal space rotation can induce energy amplification for scattered waves,similar to rotation in real *** particularly,it has been shown that energy extraction is possible for a Q-ball,a stationary non-topological soliton that is coherently rotating in its field *** this paper,we generalize the analysis to the case of boson stars,and show that the same energy extraction mechanism still works for boson stars.

关键词： superradiance boson star field space rotation

Assessment of bisphenols in children's toy and baby products in the middle East

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Emerging Contaminants 2024年第3期10卷 336-342页

作者： K.martínez-Guijarro B.Gevao m.Porcelli S.Al-Salem Saif Uddin m.Bahloul H.Taqi m.Hajeyah D.Krishnan S.Rajagopalan A.Boota Environment Pollution and Climate Program Kuwait Institute for Scientific ResearchP.O.Box 23884SafatKuwait EPA Sierra Leone

A major concern from the scientific community has been raised since evidence of Bisphenol A(BP-A)can leach out from the products where they are incorporated as well as its endocrine disrupting effects observed in animals and ***-A and several related chemicals such as Bisphenol AP(BP-AP),Bisphenol B(BPeB),Bisphenol S(BPeS),Bisphenol AF(BP-AF),Bisphenol(BPeP),Bisphenol Z(BP-Z)were analyzed in this ***-A and BP-S were the only bisphenols detected in the samples analyzed in this *** median(range;mean)concentrations of BP-A found in this study was 321 ng/g(11-200932;4893 ng/g).The analysis was carried out by sonicating 0.1 g of a cryo-milled sample aliquot in methanol followed by UPLC-mS/mS *** concentrations of BP-A were found in several products labeled as BP-A free such as nursing bottles which are particularly problematic from the children's exposure point of *** study presents the first reliable bisphenols in children's toys and baby products commercialized in the middle *** is,however,a need to continue monitoring these compounds,especially in low-cost toys,and the so-called BP-A-free products,which appear to have high levels of target contaminants and can pose an exposure risk for infants and children in the region.

关键词： Bisphenols Bisphenol A(BP-A) Bisphenol S(BPeS) Children Toys

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数据挖掘与建模进展

国外科技新书评介 2005年第7期 12-13页

作者： W．ching（编） m.ng（编）胡海伦 University of Hong Kong China （Eds.）美国康涅狄格大学电气工程系

数据挖掘与数据模型化是两个热门的课题，它们都在快速地发展。由于其广泛的应用和丰富的研究内容，引起许多专业人员和学术界人士的极大兴趣。2002年6月27～28日在香港举行了“数据挖掘与数据建模研究讨论会”。这个讨论会得到了香港... 详细信息

数据挖掘与数据模型化是两个热门的课题，它们都在快速地发展。由于其广泛的应用和丰富的研究内容，引起许多专业人员和学术界人士的极大兴趣。2002年6月27～28日在香港举行了“数据挖掘与数据建模研究讨论会”。这个讨论会得到了香港大学数学研究所和香港数学学会的支持。本书是这次讨论会的论文集，会议的主题有两个：数据挖掘与数据建模，数据挖掘涉及了模式的发现、群集算法、

关键词：数据挖掘数据建模研究讨论会大学数学专业人员模型化学术界香港研究所

Improved GaN grown on Si(111) substrate using ammonia flow modulation on SiN_x mask layer by mOCVD

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Science China(Technological Sciences) 2009年第9期52卷 2758-2761页

作者： ng KaiWei LAU Keimay Department of Electrical and Electronic Engineering Hong Kong University of Science & Technology Clear Water BayKowloon Hong Kong China

In this paper,1 μm n-GaN was grown by using varied and fixed ammonia flow (NH3) on SiNx mask layer on Si(111) substrate using metal organic chemical vapor deposition (mOCVD). In-situ optical reflectivity traces of GaN growth show that the three-to two-dimensional process has been prolonged by using varied ammonia flow on SiNx mask layer method compared with that grown by fixing ammonia flow. Structural and optical properties were characterized by high-resolution X-ray diffraction and photolu-minescence,and compared with the sample grown by fixing ammonia flow,GaN grown using the varied ammonia flow on SiNx mask layer showed better structure and optical quality. It was assumed that the low NH3 flow in the initial growth stage considerably increased the GaN island density on the nano-porous SiNx layer by enhancing vertical growth. Lateral growth was significantly favored by high NH3 flow in the subsequent step. As a result,the improved crystal and optical quality was achieved utilizing NH3 flow modulation for GaN buffer growth on Si(111) substrate.

关键词： GaN epilayer mOCVD NH3 modulation

Zinc-oxide/PDmS-clad tapered fiber saturable absorber for passively mode-locked erbium-doped fiber laser

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Chinese Physics B 2021年第5期30卷 384-389页

作者： F D muhammad S A S Husin E K ng K Y Lau C A C Abdullah m A mahdi Department of Physics Faculty of ScienceUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Wireless and Photonics Networks Research Centre Faculty of EngineeringUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Electronics and Nanoengineering Tietotie 3Aalto University02150 EspooFinland

We propose and demonstrate a passively mode-locked erbium-doped fiber laser(EDFL)based on zinc-oxide/polydimethylsiloxane(ZnO/PDmS)saturable absorber(SA)that evanescently interacts with the light on a tapered *** ZnO/PDmS composite is coated on the whole surface of the tapered fiber to guarantee the maximum efficiency of the SA device,with a measured insertion loss of 0.87 dB and a modulation depth of 6.4%.The proposed laser can generate soliton mode-locking operation at a threshold power of 33.07 *** generated output pulse yields a repetition rate and pulse width of 9.77 mHz and 1.03 ps,*** results indicate that the proposed ZnO/PDmS-clad tapered fiber could be useful as an efficient,compatible,and low-cost SA device for ultrafast laser applications.

关键词： zinc-oxide saturable absorber tapered fiber mode-locked fiber laser