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四神丸对腹泻型肠易激综合征大鼠5-HT信号通路表达的影响

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中国中医急症 2024年第2期33卷 215-218页

作者：魏星旭易梦妮邓娜蔺晓源周赛男湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007

目的通过研究四神丸对腹泻型肠易激综合征(IBs-D)模型大鼠5-羟色胺(5-HT)信号通路表达的影响,进一步揭示其治疗IBs-D的内脏敏感机制。方法sD大鼠32只,随机分为正常组、模型组、四神丸组和得舒特组,采用番泻叶灌胃联合避水应激法制备IBs-... 详细信息

目的通过研究四神丸对腹泻型肠易激综合征(IBs-D)模型大鼠5-羟色胺(5-HT)信号通路表达的影响,进一步揭示其治疗IBs-D的内脏敏感机制。方法sD大鼠32只,随机分为正常组、模型组、四神丸组和得舒特组,采用番泻叶灌胃联合避水应激法制备IBs-D大鼠模型,给药14d后进行Bristol粪便性状量表评分,依据腹壁撤退反射评定内脏疼痛阈值,ELIsA法检测血清5-HT、sERT含量,免疫组化法检测结肠组织5-HT的阳性表达,Westernblotting法检测结肠组织5-HT4R的蛋白表达。结果与正常组比较,模型组大鼠Bristol粪便性状量表评分升高,内脏疼痛阈值降低,血清中5-HT含量增加、sERT含量减少,结肠组织中5-HT的阳性表达升高、5-HT4R的蛋白表达降低(Pstol粪便性状量表评分降低、内脏疼痛阈值升高,血清5-HT含量减少,sERT含量增加,结肠组织5-HT的阳性表达降低、5-HT4R的蛋白表达升高(Ps-D的内脏敏感机制可能与调节5-HT信号通路的表达有关。

关键词：腹泻型肠易激综合征四神丸 5-HT信号通路内脏敏感性大鼠

Frequency Domain Adaptive Learning Algorithm for Thoracic Electrical Bioimpedance Enhancement

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Computers, materials & Continua 2022年第9期72卷 5713-5726页

作者： md Zia Ur Rahman s.Rooban P.Rohini m.V.s.Ramprasad Pradeep Vinaik Kodavanti Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationK L UniversityVaddeswaramGuntur522502Andhra PradeshIndia Department of Computer science and Engineering Faculty of Science and TechnologyICFAI Foundation for Higher EducationHyderabad500082TelanganaIndia Department of Electrical Electronics and Communication EngineeringGITAM Institute of TechnologyGITAM Deemed to be UniversityVisakhapatnam530045Andhra PradeshIndia

The Thoracic Electrical Bioimpedance(TEB)helps to determine the stroke volume during cardiac *** measuring cardiac signal it is contam.nated with *** commonly encountered artifacts are Baseline wander(BW)and muscle artifact(mA),these are physiological and *** the nature of these artifacts is random,adaptive filtering is needed than conventional fixed coefficient filtering *** address this,a new block based adaptive learning scheme is proposed to remove artifacts from TEB signals in clinical *** proposed block least mean square(BLms)algorithm is mathematically normalized with reference to data and *** normalization leads,block normalized Lms(BNLms)and block error normalized Lms(BENLms)*** adaptive artifact cancellers are developed in both time and frequency domains and applied on real TEB quantities contam.nated with physiological *** ability of these techniques is measured by calculating signal to noise ratio improvement(sNRI),Excess mean square Error(EmsE),and misadjustment(mad).Among the considered algorithms,the frequency domain version of BENLms algorithm removes the physiological artifacts effectively then the other counter ***,this adaptive artifact canceller is suitable for real time applications like wearable,remove health care monitoring units.

关键词： Adaptive learning artifact canceller block processing frequency domain thoracic electrical bioimpedance

studying the effect of formic acid and potassium diformate on performance,immunity and gut health of broiler chickens

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Animal Nutrition 2016年第4期2卷 296-302页

作者： naela m.Ragaa Reda m.s.Korany Nutrition and Clinical Nutrition Dept. Fac.Vet.Med. Cairo University Pathology Dept. Fac.Vet.Med. Cairo University

Our trial was conducted to study the effects of formic acid(FA) and potassium di-formate(KDF) in broiler ration on performance, carcass traits, blood biochemical, intestinal microbial load, histological picture of intestine and immune parameters of broilers. In this study 360 one-day-old broiler chicks were divided to 3 groups with 3 replicates of 40 chicks each. The trial continued for 35 days. The control group was fed only basal diet(G1). Group 2(G2) were fed basal diet supplemented with FA(5 g/kg diet), and group 3(G3) received basal diet supplemented with KDF(5 g/kg diet). The results showed that both FA and KDF significantly increased body weight gain(BWG), dressing percentage of broilers and significantly decreased feed conversion ratio(FCR)(P st percent of breast and thigh was observed in G3. The improvement in villus height was observed in G2 and G3 compared with the control one, and the highest was in G3. The results evidence that the using of FA or KDF in broiler feeds have significant effects on performance, immune parameters, and gut health without having any significant effects on blood biochemical. However, KDF is more effective than FA as little amount of FA reaches the small intestine due to metabolism and absorption, whereas KDF permits a proportion of FA to pass through the fore-gut intact and enter the small intestinal tract. In addition, FA has a strong odor and corrosiveness to gastrointestinal tract which limits its use.

关键词： Acidifiers Broiler Growth parameters Gut health

Computation of PoA for selfish Node Detection and Resource Allocation Using Game Theory

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Computer systems science & Engineering 2023年第11期47卷 2583-2598页

作者： s.Kanmani m.murali Department of CsE SRM Institute of Science and TechnologyKattankulathur603203India Department of Computing Technologies SRM Institute of Science and TechnologyKattankulathur603203India

The introduction of new technologies has increased communication network coverage and the number of associating nodes in dynamic communication networks(DCN).As the network has the characteristics like decentralized and dynamic,few nodes in the network may not associate with other *** uncooperative nodes also known as selfish nodes corrupt the performance of the cooperative ***,the nodes cause congestion,high delay,security concerns,and resource *** study presents an effective selfish node detection method to address these *** Price of Anarchy(PoA)and the Price of stability(Pos)in Game Theory with the Presence of nash Equilibrium(NE)are discussed for the selfish Node *** is a novel experiment to detect selfish nodes in a network using ***,the least response dynamic-based Capacitated selfish Resource Allocation(CsRA)game is introduced to improve resource usage among the *** suggested strategy is simulated using the solar Winds simulator,and the simulation results show that,when compared to earlier methods,the new scheme offers promising performance in terms of delivery rate,delay,and throughput.

关键词： Dynamic communication network(DCN) price of anarchy(PoA) nash equilibrium(NE) capacitated selfish resource allocation(CsRA)game game theory price of stability(Pos)

Variability of Carbonate Pedofeatures in a Loess-Paleosol sequence and their Use for Paleoreconstructions

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Journal of mountain science 2009年第2期6卷 155-161页

作者： Kovda.I sycheva s. Lebedeva m. Inozemtzev s. Institute of Geography Staromonetny 29119017 Moscow Russia Institute of soil science Pyjevsky 7 119017 Moscow Russia Dept. of soil science Moscow State University Leninskiye Gory119998 Moscow Russia

Carbonate pedofeatures were studied in details in a loess-paleosol pedocomplex near Kursk, in the central part of the European Plain. The soils studied included a modern Chernozem and five Pleistocene paleosols. Carbonate morphologies and distributions were described in the field. Various morphologies were sampled for further studies including micromorphology in thin sections and submicroscopic studies under a scanning electron microscope. The complex approach of investigation at macro-, micro-, and submicroscopic levels found that most of carbonate pedofeatures are secondary and multiphase. many of them are related to cryogenic features. The general trend was of decreasing carbonate content in the older paleosols except for increased content in the 1st and 3rd paleosols. most of carbonate morphologies are similar in the modern soil and paleosols, but pseudomycelium was found only in the modern Chernozem, while soft masses and impregnations are associated with the paleosols. Detailed study on carbonate attributes revealed their specific features in the modern soil and in paleosols. Veins have dissolution features under the modern environment and seem to reprecipitate in form of pseudomycelium. Coatings in paleosols at a depth of the Ist paleosol include specific fine tubes. Powdery soft masses and impregnations in the paleosols are strongly related to cryogenic fissures and paleopermafrost level. Under sEm they consist of tiny crystals, much smaller than in regular soft masses. several types of hard concretions were identified：rounded, irregular and platy. small concretions in the modern Chernozem have similar morphology and similar 14C-age as the rounded concretions of the upper paleosols. They are expected to represent the same generation of concretions. Platy concretions fill the bottom part of the large fissures. The 14C-age of hard concretions varies from 3310±80 yrs. B.P in the Ist paleosol up to 20 400 yrs. B.P. in the 3^rd. As a result we found the reflectio

关键词： Loess-paleosol pedocomplex pedogeniccarbonates macr- and microforms

Oxidized mitochondrial Dna sensing by sTING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine

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Cellular & molecular Immunology 2021年第9期18卷 2211-2223页

作者： Chunju Fang Fei mo Li Liu Jing Du min Luo Ke men Feifei na Wei Wang Hanshuo Yang Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan University610041 ChengduP.R.China Department of Oncology Guizhou Provincial People’s Hospital550002 GuiyangGuizhouP.R.China

Exposure to ionizing radiation,a physical treatment that inactivates live tumor cells,has been extensively applied to enhance the antitumor responses induced by cancer cell vaccines in both animal research and human clinical ***,the mechanisms by which irradiated cells function as immunogenic tumor vaccines and induce effective antitumor responses have not been fully ***,we demonstrate that oxidized mitochondrial Dna(mtDna)and stimulator of interferon genes(sTING)signaling play a key roles in the enhanced antitumor effect achieved with an irradiated tumor cell *** in ROs and oxidized mtDna 8-OHG content could be induced in irradiated tumor *** mtDna derived from irradiated tumor cells gained access to the cytosol of dendritic cells(DCs).Oxidized mtDna,as a DAmP or adjuvant,activated the sTING-TBK1-IRF3-IFN-β pathway in DCs,which subsequently cross-presented irradiated tumor cell-derived antigens to CD8^(+)T cells and elicited antitumor *** results of our study provide insight into the mechanism by which an irradiated cell vaccine mediates antitumor immunity,which may have implications for new strategies to improve the efficacy of irradiated vaccines.

关键词： Irradiated tumor cell vaccine Oxidized mitochondrial Dna sTING signaling

Unstructured Oncological Image Cluster Identification Using Improved Unsupervised Clustering Techniques

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Computers, materials & Continua 2022年第7期72卷 281-299页

作者： s.sreedhar Kumar syed Thouheed Ahmed Qin Xin s.sandeep m.madheswaran syed muzamil Basha Dr.T.Thimmaiah Institute of Technology VTUKGFKarnatakaIndia school of Computing&Information Technology REVA UniversityBengaluruIndia Faculty of science and Technology University of the Faroe IslandsFaroe IslandsDenmark K s school of Engineering BengaluruIndia muthayammal Engineering College RasipuramTamil NaduIndia

This paper presents,a new approach of medical Image Pixels Clustering(mIPC),aims to trace the dissimilar patterns over the magnetic Resonance(mR)image through the process of automatically identify the appropriate number of distinct clusters based on different improved unsupervised clustering schemes for enrichment,pattern predication and deeper *** proposed mIPC consists of two stages:clustering and *** the clustering stage,the mIPC automatically identifies the distinct number of dissimilar clusters over the gray scale mR image based on three different improved unsupervised clustering schemes likely improved Limited Agglomerative Clustering(iLIAC),Dynamic Automatic Agglomerative Clustering(DAAC)and Optimum N-means(ONm).In the second stage,the performance of mIPC approach is estimated by measuring Intra intimacy and Intra contrast of each individual cluster in the result of mR image based on proposed validation method namely shreekum Intra Cluster measure(sICm).Experimental results showthat the mIPC approach is better suited for automatic identification of highly relative dissimilar clusters over the mR cancer images with higher Intra closeness and lower Intra contrast based on improved unsupervised clustering schemes.

关键词： magnetic resonance image unsupervised clustering scheme intra intimacy intra contrast iLIAC shreekum intra cluster measure medical image clustering

Changes in myelinated Nerve Fibers and skeletal muscle of Rats Exposed to High Doses of Permethrin

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Biomedical and Environmental sciences 1990年第2期3卷 139-145页

作者： m.J.CAVALIERE m.Y.s.mAEDA L.W.s.sHIH F.R.PUGA Instituto and Instituto Biológico Caixa Postal 711901000 Sào Paulo Brazil

Neurological signs and segmcntal demyelination in a cervical nerve were observed in rats treated orally with permethrin (300 mg/kg/day) for 5 days. Inflammatory and degenerative signals were recorded in the diaphragm muscle. These effects were more intense with the trade grade than with the technical grade product. The possible influence of the percentage of cisitrans isomers on the intensity of the observed effects is discussed. 5 imi Academic ***.

关键词： Changes in myelinated Nerve Fibers and skeletal muscle of Rats Exposed to High Doses of Permethrin

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老年住院患者潜在不适当用药情况分析

中国临床保健杂志 2024年第3期27卷 394-398页

作者：倪清清王勇王娜陈琼林凤梅王柯莉安徽医科大学附属滁州医院药剂科滁州239000

目的调查分析老年住院患者潜在不适当用药情况,减少用药风险。方法参照《中国老年人潜在不适当用药判断标准(2017年版)》,对安徽医科大学附属滁州医院8423例65岁以上老年患者用药情况进行评价,检出潜在的不适当用药处方。结果5107例(60.... 详细信息

目的调查分析老年住院患者潜在不适当用药情况,减少用药风险。方法参照《中国老年人潜在不适当用药判断标准(2017年版)》,对安徽医科大学附属滁州医院8423例65岁以上老年患者用药情况进行评价,检出潜在的不适当用药处方。结果5107例(60.63%)患者均存在潜在的不适当用药,其中与药物种类相关不适当用药7658项,与疾病状态相关不适当用药860项,主要涉及抗血小板药物、非甾体抗炎药、胰岛素、苯二氮[艹卓]类。老年患者潜在不适当用药的关键影响因素为联合用药数。结论老年患者普遍存在潜在不适当用药情况,应积极采取药学干预。

关键词：处方不当潜在不当用药清单影响因素分析住院病人老年人