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An Overview of Extended Spectrum Beta Lactamases and metallo Beta Lactamases

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Advances in microbiology 2021年第1期11卷 37-62页

作者： Kavita nagshetty B. m. Shilpa Shripad A. Patil C. T. Shivannavar n. G. m.njula Departm.nt of P. G. Studies and Research in microbiology Gulbarga University Gulbarga India Departm.nt of microbiology School of Basic and Applied Sciences (SBAS) Dayananda Sagar University Bengaluru Karnataka India ICmR-national JALmA Institute for Leprosy and Other mycobacterial Diseases Agra Uttar Pradesh India

Antibiotic resistant β-lactamases are diverse and complex enzymes produced by most of the Gram.negative bacteria that are mediated by number of plasmids. The impact of these enzymes has posed a major threat to the health sectors and has challenged the available treatm.nt options for both comm.nity and hospital acquired infections. These include the uncomplicated most severe life-threatening infections. moreover, with resistance to the cephalosporin drugs these mDR strains exhibit co-resistance patterns with different class of antibiotics which is a cause of concern that leads to narrow the limited treatm.nt options. It is alarm.ng situation since there is a steep rise in mDR—Beta lactamase pathogens mainly in Escherichia coli, Klebsiella pneum.niae, Acinetobacter baum.nii and Pseudom.nas aeruginosa. Currently, the clinical detection of Extended Spectrum of β-Lactamases (ESβL) and mβL producing pathogens are carried out by antibiotic sensitivity test on the guidelines of Clinical and Laboratory Standards Institute (formerly the national Committee for Clinical Laboratory Standards) since, the other methods being too expensive. The choice of antimicrobial treatm.nt for infections should rely on the clinical data and the tests (AST) in asymptomatic and mild cases. However, this does not imply for critical infections. The last resorts of treatm.nt for ESβL pathogens are carbapenem and nevertheless, resistances have also been reported for the same. With increasing resistance rate to the antibiotics, it’s very essential to follow the guidelines for detection, implem.ntation of antibiotic rotation to reduce these pathogens, followed by the efficient infection control practices and strategies to avoid such outbreaks.

关键词： ESβL mβL nosocomial Infections

Reliability of quasi integrable and non-resonant Hamiltonian systems under fractional Gaussian noise excitation

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Acta mechanica Sinica 2020年第4期36卷 902-909页

作者： Q.F.Lu W.Q.Zhu m.L.Deng Departm.nt of mechanics State-Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou 310027China

The reliability of quasi integrable and non-resonant Hamiltonian system under fractional Gaussian noise(fGn)excitation is *** rather flat fGn power spectral density(PSD)in most part of frequency band,the fGn is innovatively regarded as a wide-band ***,the stochastic averaging method for quasi integrable Hamiltonian systems under wide-band noise excitation is applied to reduce 2n-dim.nsional original system into n-dim.nsional averaged ltd stochastic differential equations(SDEs).Reliability function and mean first passage time are obtained by solving the associated backward Kolmogorov equation and Pontryagin *** validity of the proposed procedure is tested by applying it to an example and comparing the numerical results with those from m.nte Carlo simulation.

关键词： Reliability Fkst passage time Quasi integrable and non-resonant Hamiltonian systems Fractional Gauss noise

A stable anthraquinone-derivative cathode to develop sodium metal batteries: The role of amm.niates as electrolytes

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Journal of Energy Chemistry 2023年第2期77卷 572-580,I0015页

作者： Débora Ruiz-martínez José m.Orts Roberto Gómez Departam.nt de Química Física i Institut Universitari d’Electroquímica Universitat d’AlacantApartat 99Alicante E-03080Spain

Rechargeable sodium metal batteries constitute a cost-effective option for energy storage although sodium shows some drawbacks in terms of reactivity with organic solvents and dendritic *** we dem.nstrate that an organic dye,indanthrone blue,behaves as an efficient cathode material for the developm.nt of secondary sodium metal batteries when combined with novel inorganic *** electrolytes are amm.nia solvates,known as liquid amm.niates,which can be formulated as naI·3.3nH_(3) and naBF_(4)·2.5nH_(3).They impart excellent stability to sodium metal,and they favor sodium.non-dendritic growth linked to their exceedingly high sodium ion *** advantage is complem.nted by a high specific *** battery described here can last hundreds of cycles at 10 C while keeping a Coulombic efficiency of 99%from the first *** of the high capacity of the cathode and the superior physicochemical properties of the electrolytes,the battery can reach a specific energy value as high as 210 W h kgIB^(-1),and a high specific power of 2.2 kW kgIB^(-1),even at below room temperature(4℃).Importantly,the battery is based on abundant and cost-effective materials,bearing promise for its application in large-scale energy storage.

关键词： Sodium metal batteries Anthraquinone-based cathode Vat dye Indanthrone blue Inorganic electrolytes Liquid amm.niates

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砼的7天早期养护

河南建材 1999年第2期 43-46页

作者： m. n. Haque 吴蓉河南省建筑科学研究院

适当而足够的养护对提高砼的质量、耐久性和强度是必不可少的。然而,在实际工程中,多数砼构筑物都没有得到足够的养护。不管有意或无意中断或停止早期养护,都会破坏水化的进程。如果砼含有辅助性胶结材料(SCm),如粉煤灰(FA)、磨成细粉... 详细信息

适当而足够的养护对提高砼的质量、耐久性和强度是必不可少的。然而,在实际工程中,多数砼构筑物都没有得到足够的养护。不管有意或无意中断或停止早期养护,都会破坏水化的进程。如果砼含有辅助性胶结材料(SCm),如粉煤灰(FA)、磨成细粉的粒状高炉矿渣(GGBFS)或凝聚硅灰(CSF),且浇注后的砼即遇到热和干燥的环境,砼的养护工序就更为重要了。因此,许多建筑规范和研究人员都强调砼和砼构筑物早期7天养护的重要性。

关键词：中断养护早期养护拌合料压强度养护制度超塑化剂早期水化吸水率早期湿养护胶结材

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Possibility of non-invasive diagnosis of gastric mucosal precancerous changes

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World Journal of Gastroenterology 2004年第21期10卷 3146-3150页

作者： Victor D.Pasechnikov Sergey Z.Chukov Sergey m. Kotelevets Alexander n. mostovov Varvara P. mernova maria B. Polyakova Departm.nt of Therapy Medical AcademyStavropolRussian Federation Departm.nt of Pathology Medical AcademyStavropolRussian Federation

AIm: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further developm.nt of gastric ***: One hundred and seventy-eight consecutive Helicobacter pylori ( H pylori)-positive dyspeptic patients after detection of serum levels of pepsinogen-1 (PG-1) and gastrin-17 (G-17) by enzyme imm.noassay were proposed for endoscopy and histology. The serologic and morphologic results were compared with estimating the sensitivity, specificity and prognostic values of the ***: There was statistically significant reverse dependence between the grade of stomach mucosal antral or corpus atrophy and the proper decreasing of serum G17 or PG1 levels. The serologic method was quite sensitive in the diagnosis of non-atrophic and severe antral and corpus gastritis. Also, it was characterized by the high positive and negative prognostic ***: Detection of serum G-17 and PG1 levels can be offered as the screening tool for atrophic gastritis. The positive serologic results require further chromoendoscopy with mucosal biopsy, for revealing probable progressing of atrophic process with developm.nt of intestinal metaplasia, dysplasia or gastric cancer.

关键词： Helicobacter pylori Atrophy Biological markers Biopsy Gastric mucosa Gastrins Gastritis Helicobacter Infections Hum.ns Imm.noenzyme Techniques mass Screening Pepsinogen A Precancerous Conditions Sensitivity and Specificity

Geophysical modeling with Satellite Gravity Data: Eigen-6C4 vs. GGm Plus

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Engineering（科研） 2021年第12期13卷 690-706页

作者： miguel Camacho Rom.n Alvarez Posgrado en Ciencias de la Tierra Universidad Nacional Autónoma de México Mexico City Mexico Rom.n Alvarez Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas (IIMAS) Universidad Nacional Autónoma de México CDMX Mexico City Mexico

Satellite data sets are an asset in global gravity collections;their characteristics vary in coverage and resolution. new collections appear often, and the user must adapt fast to their characteristics. Their use in geophysical modeling is rapidly increasing;with this in m.nd we compare two of the most densely populated sets: EIGEn-6C4 and GGmplus. We characterize them in terms of their frequency histograms, Free Air anomalies, power spectrum, and simple Bouguer anomalies. The nature of the digital elevation models used for data reduction is discussed. We conclude that the GGmplus data set offers a better spatial resolution. To evaluate their effect in geophysical modelling, we chose an inland region with a prom.nent volcanic structure in which we perform 3D inversions of the respective Bouguer anomalies, obtaining density variations that in principle can be associated with the geologic materials and the structure of the volcanic edifice. model results are analyzed along sections of the inverted data;we conclude that the GGmplus data set offers higher resolution in the cases analyzed.

关键词： EIGEn-6C4 GGmplus Satellite Gravity Data 3D inversions nevado de Toluca

Influence of Plastic Deformation and Aging Process on microstructure and Tensile Properties of Cast Ti-6Al-2Sn-2Zr-2mo-1.5Cr-2nb-0.1Si Alloy

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Open Journal of metal 2021年第2期11卷 11-20页

作者： mostafa S. S. El-Deeb Khaled m. Ibrahim S. S. mohamed Ramadan n. Elshaer modern Academy for Engineering and Technology Cairo Egypt Central metallurgical R & D Institute Cairo Egypt Shoubra Faculty of Engineering Benha University Cairo Egypt Tabbin Institute for metallurgical Studies Cairo Egypt

In the present work, titanium alloy with a composition of Ti-6.5Al-3mo-1.9nb-2.2Sn-2.2Zr-1.5Cr (TC21) was subjected to plastic deformation and aging processes. A Plastic deformation at room temperature with 2%, 3% and 4% stroke strain was applied on the studied samples. Then, the samples aged at 575°C for 4 hr. By applying different plastic deformation ratios, the structure revealed an elongated and thin m>βm>-phase embedded in an m>αm>-phase. Secondary m>αm>-platelets were precipitated in the residual m>βm>-phase. maximum hardness (HV440) was obtained for 4% deformed + aged samples. m.nimum hardness (HV320) was recorded for the as-cast samples without deformation. The highest ultimate tensile strength of 1311 mPa was obtained for 4% deformed + aged samples due to presence of high amount of dislocation density as well as precipitation of secondary m>αm>-platelets in the residual m>βm>-phase. The lowest ultimate tensile strength of 1020 mPa was reported for as-cast samples. maximum elongation of 14% was registered for 4% deformed + aged samples and m.nimum one of 3% was obtained for as-cast samples. Hence, strain hardening + aging can enhance considerably the elongation of TC21 Ti-alloy up to 366% and 133% in case of applying 4% deformation + aged compared to as-cast and aged samples without applying plastic deformation, respectively.

关键词： TC21 Ti-Alloy Strain Hardening microstructure Aging Hardness Tensile

Downregulation of Scar Fibroblasts by Antineoplastic Drugs: A Potential Treatm.nt for Fibroproliferative Disorders

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Surgical Science 2016年第6期7卷 258-271页

作者： m. Georgina Uberti Yvonne n. Pierpont Rajat Bhalla Karan Desai martin C. Robson Wyatt G. Payne Institute for Tissue Regeneration Repair & Rehabilitation Bay Pines V.A. Healthcare System Bay Pines USA Division of Plastic Surgery University of South Florida Tampa USA

The various fibroproliferative disorders affecting hum.ns have in comm.n excess fibroblast activity and persistent overexpression or dysregulated activity of transform.ng growth factor beta (TGF-β). Cancer has m.ny similar characteristics. Antineoplastic drugs can downregulate fibroblast activity and cytokine growth factors. This study evaluates the effect of six antineoplastic drugs on keloid and Dupuytren’s disease fibroblasts. Keloid, normal scar, Dupuytren’s affected palmar fascia, and normal palmar fascia fibroblasts were grown and seeded into Fibroblast Populated Collagen Lattices (FPCLs). The FPCLs were treated with one of six antineoplastic drugs or left untreated as controls. At 7 days, supernatants were extracted from all FPCLs and assayed for expression of Transform.ng Growth Factor beta (TGF)-β1 and TGF-β2. All six antineoplastic drugs significantly inhibited FPCL contraction in both fibroproliferative conditions compared with the untreated controls (p β1 and TGF-β2 expression was downregulated in the supernatants of all FPCLs by the drug exposure. Cytotoxicity did not occur in these studies and was not the reason for the results. Although antineoplastic drugs can have significant side effects when given systemically, these results may be m.nimized when given to small areas involved in fibroproliferative scarring or when given topically or intralesionally. These in vitro results suggest that antineoplastic drugs may have a utility for treating various fibroproliferative disorders and warrant further investigation.

关键词： Scar Fibroblasts Antineoplastic Drugs Fibroproliferative Disorders Dupuytren’s Disease Keloid

利用仰卧位乳腺mRI对计划采取肿瘤整形外科手术的病人进行乳腺癌定位的可能性

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国际医学放射学杂志 2019年第3期 371-372页

作者：田恬 S.Joukainen A.masarwah m.K?n?nen m.Husso A.Sutela V.K?rj? Departm.nt of Surgery Division of Plastic SurgeryKuopio University Hospital

摘要目的前瞻性研究仰卧位乳腺mRI在乳腺癌保乳手术中应用的可行性。方法除了诊断性俯卧位乳腺mRI外,还对病人在手术体位进行了皮肤标志物在内的辅助仰卧

关键词：仰卧位 mRI