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RBC aggregation,deformation and adhesion to endothelium:Role of nitric oxide derived from L-Arginine and sodium.nitroprusside

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 53-65页

作者： m.K.maksimov P.B.Ermolinskiy O.n.Scheglovitova n.n.Sklyankina A.V.muravyov A.E.Lugovtsov A.V.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia n.F.Gamaleya national Research Center for Epidemiology and microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State Pedagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RBCs)are the most abundant hum.n blood *** aggregation and deformation strongly determ.ne blood viscosity which impacts hemorheology and *** turn,RBC properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(nO),which is mainly produced by endothelial cells(EC)from L-arginine am.no acid in the circulatory *** the mechanisms of the RBC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to investigate in vitro:(1)The e®ect of L-arginine induced nO on RBC aggregation and adhesion to endothelium;(2)the nO e®ect on RBC aggregation and deformation induced by L-arginine and sodium.nitroprusside without the presence of endothelium in the *** RBC aggregation and adhesion to a m.nolayer of EC were studied using optical tweezers(OT).The RBC deformability and aggregation without endothelium in the samples were studied using the°ow chamber method and myrenne *** con¯rmed that nO increases deformability and decreases aggregation of *** showed that the soluble guanylate cyclase pathway appears to be the only nO signaling pathway *** the samples with the endothelium,the\bell-shaped"dependence of RBC aggregation force on L-arginine concentration was observed,which improves our knowledge about the process of nO production by ***,data related to L-arginine accumulation by endothelium were obtained:necessity of the presence of extracellular L-arginine stated by other authors was put under *** our study,nO decreased the RBC-endothelium adhesion,however,the tendency appeared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of RBC adhesion to endothelium m.nolayer with OT.

关键词： Red blood cells aggregation L-arginine endothelium optical tweezers myrenne flow chamber

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Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi n Jincy m.Jose Sreelata B.nair Prabha S.n Pappachan S Departm.nt of medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline Super Specialty Hospital PathanamthittaKerala 691523India

Alagille syndrome(ALGS;OmIm#118450)is a highlyvariable,multi-systemic,autosomal dom.nant disorder,caused by mutations in the Jagged Canonical notch Ligand 1(JAG1)gene(20p12.2)or in the neurogenic locus notch homolog protein 2(nOTCH2)gene(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidney,skin,vertebrae,and skeleton.^(1,2)The JAG1 gene has 26 exons and about 90%of the ALGS cases result from pathogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases notch

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A new fluorocarbon adhesive:Inhibiting agglomeration during combustion of propellant via efficient F-Al_(2)O_(3) preignition reaction

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Carbon Energy 2024年第6期6卷 292-305页

作者： Qifa Yao m.n Xia Chao Wang Fanzhi Yang Wei Yang Yunjun luo School of materials Science and Engineering Beijing Institute of TechnologyBeijingChina Key Laboratory of High Energy Density materials Ministry of EducationBeijing Institute of TechnologyBeijingChina School of Aerospace Engineering Beijing Institute of TechnologyBeijingChina Advanced Research Institute of multidisciplinary Science Beijing Institute of TechnologyBeijingChina

Inhibiting the agglomeration of molten alum.num particles packed in the binder network is a promising scheme to achieve efficient combustion of solid *** this investigation,the hydroxyl-term.nated structured fluorinated alcohol compound(PFD)was introduced to modify the traditional polyethylene glycol/polytetrahydrofuran block copolymerization(HTPE)binder;that is,a unique fluorinated polyether(FTPE)binder was synthesized by embedding fluorinated organic segm.nts into the HTPE binder via crosslinking *** FTPE was applied in alum.num-based propellants for the first *** to the complete release of fluorinated organic active segm.nts in the range of 300℃to 400℃,the burning rate of FTPEbased propellant increased from 4.07(0%PFD)to 6.36 mm/s(5%PFD),increased by 56.27%under 1 *** reaction heat of FTPE propellants increased from 5.95(0%PFD)to 7.18 mJ/kg(5%PFD)under 3.0 mPa,indicating that HTPE binder modified with PFD would be conducive to inhibiting the D90 of condensed combustion products(CCPs)dropped by 81.84%from 75.46(0%PFD)to 13.71μm(5%PFD)under 3.0 mPa,in consistent with the significant reduction of alum.num agglomerates observed on the quenched burning surface of the *** results dem.nstrated that a novel FTPE binder with PFD can release fluorinated organic active segm.nts,which motivate preignition reaction with the alum.na shell in the early stage of alum.num combustion,and then enhance the melting diffusion effect of alum.num to inhibit the agglomeration.

关键词： agglomeration characteristics alum.num particles combustion fluorine alcohol compounds HTPE propellants

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Advances in poly(heptazine imide)/poly(triazine imide) photocatalyst

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Chinese Chemical Letters 2024年第10期35卷 102-125页

作者： Haojie Song Laiyu luo Siyu Wang Guo Zhang Baojiang Jiang Key Laboratory of Functional Inorganic material Chemistry Ministry of Education of the People's Republic of ChinaSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150000China

Polymeric carbon nitride(PCn)has garnered increasing attention as a metal-free photocatalyst with a suitable band *** efforts to enhance its photocatalytic perform.nce,researchers have exam.ned various PCn materials,including poly(heptazine imide)(PHI)and poly(triazine imide)(PTI),two isomers within the PCn family that exhibit distinct and superior photocatalytic activity compared to other *** challenge,however,lies in the comm.n practice am.ng researchers to categorize PHI and PTI along with other PCn types under the overarching term“g-C_(3)n_(4),”which significantly impedes optimization *** objective of this review is to provide comprehensive insights into the structural features,photoelectrochemical properties,and effective characterization methods employed for distinguishing between PHI and PTI *** review also summarizes various optimization strategies,such as crystallinity adjustm.nts,defect engineering,morphology control,constructing heterojunction,and atomic-level metal loading dispersion,to elevate the photocatalytic activity of PHI and PTI,in addition to summarizing the history of carbon nitride ***,this review highlights the primary applications of PHI and PTI,encompassing nitrogen fixation,biomass conversion,organic synthesis,CO_(2)reduction,pollutant degradation,H_(2)O_(2)production,and photocatalytic water ***,the prospects and challenges associated with further advancing PHI and PTI are thoroughly exam.ned.

关键词： Poly(heptazine imide) Poly(triazine imide) modification Photocatalytic Application

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Effect of Heat Treatm.nt on microstructure and mechanical Properties of multiscale SiC_p Hybrid Reinforced 6061 Alum.num matrix Composites

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Journal of Wuhan University of Technology(materials Science) 2024年第1期39卷 174-181页

作者：吴健铭许晓静 ZHAnG Xu luo Yuntian LI Shuaidi HUAnG Lin Institute for Advanced m.nufacturing and modern Equipm.nt Technology Jiangsu UniversityZhenjiang 212013China

The perform.nce of solid solution aging treatm.nt on alum.num matrix composites prepared by powder metallurgy and reinforced with 6061 alum.num alloy powder as matrix;meanwhile, nano silicon carbide particles(nm Si Cp), submicron silicon carbide particles(1 μm Si Cp) and Ti particles were studied. The Al/Si Cp composite powder was prepared by high-energy ball milling, and then cold-pressed, sintered, hotextruded, and then heat-treated with different solution temperatures and aging times for the extruded composites. Optical microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy(EDS), X-ray diffractometer(XRD) and extrusion testing were used to analyze and test the microstructure and mechanical properties of alum.num matrix composites. The results show that after the multi-stage solid solution at 530 ℃×2 h+535 ℃×2 h+540 ℃×2 h, the particles are mainly equiaxed grains and uniformly distributed. There is no reinforcem.nt agglomeration, and the surface is dense and the insoluble phase is basically dissolved. In the matrix, the strengthening effect is good, and the hardness and compressive strength are 179.43 HV and 680.42 mPa, respectively. Under this solution process, when the alum.num matrix composites are aged at 170 ℃ for 10 h, the hardness and compressive strength can reach their peaks and increase to 195.82 HV and 721.48 mPa, respectively.

关键词： alum.num matrix composites Si C particles multiscale hybrid enhancem.nt heat treatm.nt mechanical properties

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Unlocking the potential of bispecific ADCs for targeted cancer therapy

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Frontiers of medicine 2024年第4期18卷 597-621页

作者： Hongye Zeng Wenjing ning Xue Liu Wenxin luo ningshao Xia State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen361102China national Institute of Diagnostics and Vaccine Developm.nt in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsNational Innovation Platform for Industry-Education Integration in Vaccine Researchthe Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical SciencesXiamen UniversityXiamen361102China

Antibody–drug conjugates(ADCs)are biologically targeted drugs composed of antibodies and cytotoxic drugs connected by *** innovative compounds enable precise drug delivery to tumor cells,m.nimizing harm to normal tissues and offering excellent prospects for cancer ***,m.noclonal antibody-based ADCs still present challenges,especially in terms of balancing efficacy and *** antibodies are alternatives to m.noclonal antibodies and exhibit superior internalization and selectivity,producing ADCs with increased safety and therapeutic *** this review,we present available evidence and future prospects regarding the use of bispecific ADCs for cancer treatm.nt,including a comprehensive overview of bispecific ADCs that are currently in clinical *** offer insights into the future developm.nt of bispecific ADCs to provide novel strategies for cancer treatm.nt.

关键词： antibody-drug conjugate bispecific antibody bispecific ADC cancer

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Transform.ng nanoscale VO_(2)(B) into a scalable sodium-ion electrode

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nano Research 2024年第10期17卷 8809-8818页

作者： Yunkai luo Swetha Chandrasekaran Bintao Hu Randy Chen marcus Worsley Bruce Dunn Departm.nt of materials Science and Engineering University of CaliforniaLos AngelesCA 90095USA Lawrence Livermore national Laboratory CA 94550USA

The intermittent nature of renewable energies requires highly reliable grid-level energy storage approaches.A critical consideration in developing this technology is the areal capacity which determ.nes battery perform.nce and influences the cost of battery *** related importance is finding new ways of developing scalable *** recent years,threedim.nsional(3D)printing of conductive scaffolds has emerged as an alternative to overcome the scalability limitations of commercial tape cast *** research carried out in the current study dem.nstrates a successful scalability pathway for nanoscale VO_(2)(B),a desirable cathode for sodium-ion batteries which has a nano-flower morphology with a crystallite sizeng VO_(2)(B)onto a graphene aerogel scaffold,we were able to achieve mass loading of over 100 mg·cm^(-2) and still possess an areal capacity of 10 mAh·cm^(-2) at a current density of 5 mA·cm^(-2).moreover,after 1000 cycles,these electrodes retained 75% to 80% of their initial *** at high loading levels,the electrodeposited VO_(2)(B)exhibits pseudocapacitive material signatures such as a box-like voltammetry response,linear galvanostatic response,and no phase change upon *** scalability of the VO_(2)(B)electrode is dem.nstrated in a series of experim.nts which show the areal capacity to scale upon increase in both mass loading and electrode thickness,with only small changes in specific *** study establishes that nanoscale materials can be scaled up to achieve thick electrodes without compromising their electrochemical properties.

关键词： nano VO_(2)(B) sodium-ion battery scalable electrodes three-dim.nsional(3D)printed scaffold additive m.nufacturing

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Controlling reversible complexation-mediated polymerization(RCmP)via deep eutectic solvents:fast kinetics,narrow molecular weight distribution and mechanistic insights

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Science China Chemistry 2024年第8期67卷 2728-2736页

作者： Xin Fu Zhen Lu Shen Li Zheng-Hong luo Lin-Xi Hou Departm.nt of materials-Oriented Chemical Engineering College of Chemical EngineeringFuzhou UniversityFuzhou 350116China Departm.nt of Chemical Engineering School of Chemistry and Chemical EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200030China Chemical Engineering Zhicheng College of Fuzhou UniversityFuzhou 350116China Qingyuan Innovation Laboratory Quanzhou 362801China

The exploitation of new green polymerization avenues for the effective synthesis of polymers by reversible-deactivation radical polymerization plays a critical role in pursuing the developm.nt of polymeric *** this work,serials of deep eutectic solvents(DES)with intermolecular-hydrogen-bonding interaction were constructed as catalysts and medium for actuating reversible complexation-mediated polymerization(RCmP)for the first time,yielding methacrylate polymers with high m.nomer conversion and narrow dispersion molecular weight in both water and oil *** mechanism and elem.ntary reaction of RCmP were explored deeply,revealing that the complexation of initiator with DES to generate radicals was a ratecontrolling step and intermolecular-hydrogen-bond was primary factor to influence polymerization ***,the insights of density functional theory calculations revealed that negative electrostatic potential ensured nucleophilic *** investigation dem.nstrated the considerable potential of DES for RCmP,which is anticipated for other polymerization applications as a novel medium mode.

关键词： deep eutectic solvent reversible complexation-mediated polymerization intermolecular hydrogen bonding density functional theory elem.ntary reaction steps

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Surface Coating Enabling Sulfide Solid Electrolytes with Excellent Air Stability and Lithium Compatibility

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Energy & Environm.ntal materials 2024年第6期7卷 41-49页

作者： m.n luo Changhong Wang Yi Duan Xuyang Zhao Jiantao Wang Xueliang Sun national Power Battery Innovation Center GRINM Group Corporation LimitedBeijing 100088China China Automotive Battery Research Institute Co. Ltd.Beijing 100088China General Research Institute for Nonferrous MetalsBeijing 100088China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingbo 315200China

All-solid-state lithium metal batteries(ASSLmBs)featuring sulfide solid electrolytes(SEs)are recognized as the most promising next-generation energy storage technology because of their exceptional safety and much-improved energy ***,lithium dendrite growth in sulfide SEs and their poor air stability have posed significant obstacles to the advancem.nt of sulfide-based ***,a thin layer(approximately 5 nm)of g-C_(3)n_(4)is coated on the surface of a sulfide SE(Li_(6)PS_(5)Cl),which not only lowers the electronic conductivity of Li_(6)PS_(5)Cl but also achieves remarkable interface stability by facilitating the in situ formation of ion-conductive Li3n at the Li/Li_(6)PS_(5)Cl ***,the g-C_(3)n_(4)coating on the surface can substantially reduce the formation of H_(2)S when Li_(6)PS_(5)Cl is exposed to humid *** a result,Li-Li symmetrical cells using g-C_(3)n_(4)-coated Li_(6)PS_(5)Cl stably cycle for 1000 h with a current density of 0.2 mA cm^(-2).ASSLmBs paired with LinbO_(3)-coated Lini_(0.6)mn_(0.2)Co_(0.2)O_(2)exhibit a capacity of 132.8 mAh g^(-1)at 0.1 C and a high-capacity retention of 99.1%after 200 ***,g-C_(3)n_(4)-coated Li_(6)PS_(5)Cl effectively mitigates the self-discharge behavior observed in *** surface-coating approach for sulfide solid electrolytes opens the door to the practical implem.ntation of sulfide-based ASSLmBs.

关键词： anode interface g-C_(3)n_(4)coating Li_(6)PS_(5)Cl lithium dendrite inhibition solidstate lithium metal batteries

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Cost-effective fabrication of liquid metals via a laser induced graphene stamp for highly-stretchable integrated optoelectronics

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nano Research 2024年第8期17卷 7603-7613页

作者： Weiqi Sun Li Xiang Zebang luo Hui Wang Dong Li Anlian Pan College of materials Science and Engineering Hunan UniversityChangsha 410082China

Stretchable electronics have found widespread applications in various fields such as wearable electronics,soft robots,and *** an important promising alternative of traditional rigid conductors,liquid metals have dem.nstrated imm.nse potential to provide high conductivity and stretchability for the stretchable electronic ***,limited by their fluidity and high surface tension,challenges remain in achieving liquid metal patterns with low-cost,high-precision,large-scale,and complex ***,a fabrication technique was proposed based on laser-induced graphene(LIG)stamps to enable liquid metal self-selectively adhere to *** metal patterns could thus be achieved in different designed geometries and could be transferred onto stretchable *** liquid metal patterns exhibit exceptional electrical conductivity(3.24×10^(6)S/m even under 1000%strain),high stretchability(1000%strain,maximum of 2500%),small resistance changes under significant deformations(with a quality factor of 62.5 under 1000%strain),and high resolution(down to 50μm).Utilizing the patterned liquid metals,a stretchable integrated multifunctional optoelectronic system was dem.nstrated,encompassing a stretchable display matrix,a pressure sensor array,a wireless powering coil,and cardiovascular sensors,which further highlight the remarkable application potential of liquid metals in optoelectronic user-interaction and advanced physiological m.nitoring.

关键词： liquid metal wettability selective adhesion transfer printing stretchable electronics

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