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m2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals

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World Journal of Gastroenterology 2020年第21期26卷 2864-2876页

作者： Shereen A Saleh mohamed m Salama marwan m Alhusseini Ghada A mohamed Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11341Egypt

BACKGROUND Assessing liver fibrosis is important for predicting the efficacy of direct-acting antivirals(DAAs)and patient ***-invasive techniques to assess liver fibrosis are becoming ***,serum mac-2 binding protein glycosylation isomer(m2BPGi)was identified as a non-invasive marker of liver *** To investigate the diagnostic accuracy of m2BPGi in assessing liver fibrosis in patients with chronic hepatitis C(CHC)treated with *** From December 2017 to August 2018,80 treatment-naive adult patients with CHC who were eligible for DAAs therapy were consecutively enrolled in this observational cohort *** 12 weeks,65 patients were treated with sofosbuvir/daclatasvir,and 15 patients were treated with sofosbuvir/daclatasvir and a weight-based dose of ribavirin at knowledge and technology association for hepatitis C management clinic,Cairo,*** measured serum m2BPGi levels,PAPAS index,fibrosis-4(FIB-4)score and liver stiffness measurements(LSm)at baseline and 12 weeks after the end of *** m2BPGi levels were measured using enzyme-linked immunosorbent *** All patients achieved sustained virologic response(SVR12)(100%).Serum m2BPGi levels,LSm,FIB-4 score and PAPAS index decreased significantly at SVR12(Pm m2BPGi levels correlated positively with LSm at baseline and SVR12(Pmpared with the FIB-4 score and PAPAS index,m2BPGi was the best marker to distinguish patients with grade F4 fibrosis(AUC=0.801,Pm grade F0-1 fibrosis(AUC=0.713,P=0.012),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.730,Pm grade F0-1 fibrosis(AUC=0.763,Pm2BPGi had the greatest AUCs for differentiating patients with grade F4 fibrosis(AUC=0.844,Pm grade F0-2 fibrosis(AUC=0.893,P=0.002),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.891,P<0.001),and patients with grad

关键词： Hepatitis C virus Liver fibrosis Human mac-2 binding protein Antiviral agents Sustained virologic response Elastography

The influence of β_2AR polymorphisms as a predictor of successful short acting β_2-agonist nebulization during asthmatic exacerbation

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海南医学院学报 2010年第7期16卷 842-846页

作者： Nasir m Nor Hidayah AB rashidi A Rusli I Department of Emergency medicine School of Medical SciencesUniversiti Sains Malaysia Health Campus Department of Pathology Hospital Sultanah Zainab IIKota Bharu Pharmacogenetics Research Group Institute for Research in Molecular MedicineUniversiti Sains Malaysia Health Campus16150 Kubang Kerian

Aim:In this study,we would like to determine associations between β2-Adrenergic Receptor(β2AR)polymorphisms at codon 16 and 27 and the response to short acting β2-agonist during asthmatic ***:This was a prospective cross-sectional study of one year *** hundred and thirty two asthmatic patients were *** mls of venous blood was taken for DNA extraction and then genotyped for the β2AR polymorphisms using multiplex ***'s clinical responses to β2-agonist nebulization were then compared to their genotype to determine the ***:We found that there was no association between β2AR polymorphisms at both codon 16 and 27 with response towards short acting β2-agonist,P=0.315 and P=0.706 ***:We suggested that β2AR polymorphisms at both codon 16 and 27 had no influent on the response to short acting β2-agonist.

关键词：曲马多镇痛效果剂量治疗方法

Transcranial direct current stimulation for auditory verbal hallucinations:a systematic review of clinical trials

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Neural Regeneration Research 2021年第4期16卷 666-671页

作者： Samaneh rashidi myles Jones Eric murillo-Rodriguez Sergio machado Youguo Hao Ali Yadollahpour Department of medical Physics School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Psychology University of SheffieldSheffieldUK Laboratorio de Neurociencias moleculares e Integrativas Escuela de Medicina División Ciencias de la SaludUniversidad Anáhuac MayabMéridaYucatánMéxico Laboratory of Physical Activity Neuroscience Physical Activity Sciences Postgraduate ProgramSalgado de Oliveira UniversityNiteróiBrazil Department of Rehabilitation Shanghai Putuo People’s HospitalShanghaiChina

Transcranial direct current stimulation(tDCS)has been reportedly beneficial for different neurodegenerative *** has been reported as a potential adjunctive or alternative treatment for auditory verbal hallucination(AVH).This study aims to review the effects of tDCS on AVH in patients with schizophrenia through combining the evidence from randomized clinical trials(RCTs).The databases of PsycINFO(2000–2019),Pubmed(2000–2019),EmBASE(2000–2019),CINAHL(2000–2019),Web of Science(2000–2019),and Scopus(2000–2019)were systematically *** clinical trials with RCT design were selected for final analysis.A total of nine RCTs were eligible and included in the *** RCTs were included in the final *** them,six RCTs reported a significant reduction of AVH after repeated sessions of tDCS,whereas three RCTs did not show any advantage of active tDCS over sham *** current studies showed an overall decrease of approximately 28%of AVH after active tDCS and 10%after sham *** tDCS protocols targeting the sensorimotor frontal-parietal network showed greater treatment effects compared with the protocols targeting other *** this regard,cathodal tDCS over the left temporoparietal area showed inhibitory effects on *** most effective tDCS protocol on AVHs was twice-daily sessions(2 mA,20-minute duration)over 5 consecutive days(10 sessions)with the anode over the left dorsolateral prefrontal cortex and the cathode over the left temporal *** patient-specific and diseasespecific factors such as young age,nonsmoking status,and higher frequencies of AVHs seemed to be the predictors of treatment *** together,the results of tDCS as an alternative treatment option for AVH show controversy among current literatures,since not all studies were ***,the studies targeting the same site of the brain showed that the tDCS could be a promising treatment option to reduce *** RCTs,with larger sample sizes,should be con

关键词： auditory verbal hallucinations dorsolateral prefrontal cortex effective protocol randomized clinical trial,schizophrenia temporoparietal area transcranial direct current stimulation treatment efficacy

T_(m)-Eigenvalues of Odd-Order Tensors

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Communications on Applied mathematics and Computation 2022年第4期4卷 1258-1279页

作者： m.Pakmanesh Hamidreza Afshin Department of mathematics Vali-e-Asr University of RafsanjanRafsanjanIran

In this paper,we propose a definition for eigenvalues of odd-order tensors based on some ***,we define the Schur form and the Jordan canonical form of such tensors,and discuss commuting families of ***,we prove some e... 详细信息

关键词： T_(m)-product T_(m)-eigenvalue T_(m)-Schur form T_(m)-Jordan canonical form Odd-order tensor F_(m)-upper(lower)triangular tensor

S-band low noise amplifier using 1μm InGaAs/InAlAs/InP pHEmT

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Journal of Semiconductors 2012年第2期33卷 58-63页

作者： Z.Hamaizia N.Sengouga m.C.E.Yagoub m.missous Laboratory of materials Semiconductors and metallic University of Med Khider RF and microwave Research Group School of Electrical Engineering and Computer ScienceUniversity of OttawaOttawa ONKIN 6N5 Canada microelectronic & Nanostructure Group School of Electric and Electronic EngineeringUniversity of ManchesterUK

This paper discusses the design of a wideband low noise amplifier（LNA） in which specific architecture decisions were made in consideration of system-on-chip implementation for radio-astronomy *** LNA design is based on a novel ultra-low noise InGaAs/InAlAs/InP *** and non-linear modelling of this pHEmT has been used to design an LNA operating from 2 to 4 GHz.A common-drain in cascade with a common source inductive degeneration,broadband LNA topology is proposed for wideband *** proposed configuration achieved a maximum gain of 27 dB and a noise figure of 0.3 dB with a good input and output return loss（S11〈—10 dB,S22〈—11 dB）.This LNA exhibits an input 1-dB compression point of-18 dBm,a third order input intercept point of 0 dBm and consumes 85 mW of power from a 1.8 V supply.

关键词： HEmT InGaAs InP SKADS telescope LNA

Regenerative capacity of müller cells and their modulation as a tool to treat retinal degenerations

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Neural Regeneration Research 2023年第1期18卷 139-140页

作者： Federica m.Conedera Volker Enzmann Advanced microscopy Program Center for Systems BiologyMassachusetts General HospitalBostonMAUSA Wellman Center for Photomedicine Massachusetts General HospitalBostonMAUSA(Conedera FM)Department of OphthalmologyUniversity HospitalUniversity of BernBernSwitzerland Department of Biomedical Research University of BernBernSwitzerland

Vision is one of our most precious senses,and its impairment has a high socio-economic *** the industrialized world,degenerative diseases of the retina lead to vision loss,particularly among the *** degenerations include,for instance,retinitis pigmentosa,age-related macular degeneration,and diabetic *** treatments are evolving to manage late-stage symptoms of retinal degenerations,no effective therapies to recover vision loss *** degeneration often involves loss or damage to specialized neural cells,such as photoreceptors,and their death stimulates the activation and proliferation of müller cells(Salman et al.,2021).

关键词： degeneration diseases impairment

Effects of the partial replacement of La by m(m=Ce,Ca and Sr) in La_(2-x)m_xCuO_4 perovskites on catalysis of the water-gas shift reaction

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Journal of Natural Gas Chemistry 2010年第6期19卷 567-574页

作者： S.S.maluf E.m.Assaf Institute de Química de So Carlos Universidade de So PauloAv.Trabalhador Socarlense400 So CarlosSP 13560-970Brazil

The performance of La2-x m x CuO4 perovskites （where m=Ce,Ca or Sr） as catalysts for the water-gas shift reaction was investigated at 290℃ and 360℃.The catalysts were characterized by EDS,XRD,N2 adsorption-desorption,XPS and *** XRD results showed that all the perovskites exhibited a single phase （the presence of perovskite structure）,suggesting the incorporation of metals in the perovskite *** XPS and XANES results showed the presence of Cu2＋ on the *** perovskites that exhibited the best catalytic performance were La 2 x Ce x CuO 4 perovskites,with CO conversions of 85% 90%.moreover,these perovskites have higher surface areas and larger amounts of Cu on the *** Ce has a higher filled energy level than the other metals,increasing the energy of the valence band of Ce and providing more electrons for the ***,the La1.80Ca0.20CuO4 perovskite showed a good catalytic performance.

关键词： perovskites water-gas shift reaction lanthanum copper calcium cerium strontium

Nanoporous carbons as promising novel methane adsorbents for natural gas technology

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Journal of Natural Gas Chemistry 2011年第6期20卷 664-668页

作者： Ali morad rashidi Roghaye Lotfi Amideddin Nouralishahi mohammad Ali Khodagholi masoud Zare Faeghe Eslamipour Nanotechnology Research Center Research Institute of Petroleum IndustryWest Blvd.Azadi Sport ComplexP.O.Box:14665-1998TehranIran

Nanoporous carbons were synthesized using furfuryl alcohol and sucrose as precursors and mCm-41 and mordenite as nanoporous *** produced nanoporous carbons were used as adsorbent for methane *** average pore diameter of the samples varied from 3.9 nm to 5.9 nm and the BET surface area varied from 320m2/g to 824m2/*** volumetric adsorption experiments revealed that mCm-41 and sucrose had better performance compared with mordenite and furfuryl alcohol,***,the effect of precursor to template ratio on the structure of nanoporous carbons and their adsorption capacities was *** nanoporous carbon produced from mCm-41 mesoporous molecular sieve partially filled by sucrose shows the best methane adsorption capacity among the tested samples.

关键词： nanoporous carbon mCm-41 adsorbed natural gas (ANG) methane adsorption

Petrology, geochemistry, radioactivity, and m–W type rare earth element tetrads of El Sela altered granites, south eastern desert,Egypt

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Acta Geochimica 2019年第1期38卷 95-119页

作者： A.m.El mezayen m.A.Heikal m.G.El-Feky H.A.Shahin I.K.Abu Zeid S.R.Lasheen Geology Department Faculty of Science Al Azhar University Nuclear material Authority

The southern part of the Eastern Desert of Egypt—about 30 km southwest of Abu-Ramad city—is mainly covered by ophiolitic rocks(Sul Hamed), island arc assemblage, younger granites(muscovite granites of Qash Amer and two mica granites of El Sela), and various acidic and basic dikes. Field, petrological, and geochemical studies indicate that the El Sela shear zone has been subject to hydrothermal and supergene alteration such as kaolinization, albitization, sericitization, and hematitization. It is invaded by quartz ENE–WSW veins associated with hydrothermal alteration accompanied by radioactive mineralization. The investigated younger granitic rocks had very low contents of compatible elements, such as Cr, Ni,and Co; and high contents of incompatible elements, such as Zr, and large ion lithophiles, such as Sr, especially in the El Sela shear zone. major oxide and trace element analyses revealed calc-alkaline affinity and peraluminous *** highly differentiated granitic rocks' lower Zr/Hf and higher Y/Ho than the normal ratio are consistent with hydrothermal alteration. most samples had rare earth element(REE)-patterns with an m-type tetrad effect in the first and fourth segments and a W-type tetrad in the third segment. The average ∑REE in the studied granites was lower than the world granite average; the ratio of light to heavy REEs greater. The main radioactive, uranium-bearing, and uraniferous Fe and mn minerals are uranothorite,autunite, uranophane and autunite as compounds, kasolite,columbite, xenotime, uranophane-bearing zircon and jarosite, silver-bearing pyrite, hematite, and autunite-bearing pyrolusite.

关键词： Geochemistry REE-tetrad effect Radioactive minerals Radiometric measurements Qash Amer El Sela