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Utilization of rNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： jorge A.Gutierrez III jeremy L.Barth rodney j.Schlosser Thomas S.Edwards Timothy L.Smith Zachary m.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of regenerative medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CrS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CrS patients without polyps(CrSsNP).methods:Tissue samples were obtained from the superior turbinates of patients with CrSsNP at the time of endoscopic sinus *** subsequently underwent rNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CrSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early response 3[IEr3])had an false discovery rate(FDr)correction adjustedP value considered statistically significant(Preactome functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Pr correction)including IL-4 and IL-13 signaling,IL-10 signaling,and rhodopsin-like ***:rNA sequencing of the superior turbinates in patients with CrSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIEr3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction rNA sequencing

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The effect of swelling agent on the pore characteristics of mesoporous hydroxyapatite nanoparticles

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Progress in Natural Science:materials International 2015年第3期25卷 185-190页

作者： L.Bakhtiari j.javadpour H.r.rezaie m.Erfan m.A.Shokrgozar School of metallurgical and materials Engineering Iran University of Science and Technology School of Pharmacy Shahid Beheshti University of Medical Sciences National Cell Bank of Iran Pasteur Institute of Iran

The effect of swelling agent on the physicochemical properties of mesoporous hydroxyapatite particles synthesized by self-assembly process has been investigated. Cetyl trimethylammonium bromide(CTAB) and 1-dodecanethiol were used as soft template and swelling agent respectively. The results of the field emission scanning electron microscopy(FESEm), X-ray diffraction(XrD), simultaneous thermal analysis(STA), Brunauer-Emmett-Teller(BET) surface area, small-angle X-ray diffraction and Fourier transform infrared spectroscopy(FTIr)assessments revealed that in the case of low concentration, 1-dodecanethiol performed as swelling agent and caused an increase in the pore size. However, at higher concentrations it led to the formation of microemulsion and foamy structures. The optimum swelling agent: surfactant mass ratio in synthesis of mesoporous hydroxyapatite particles with high pore volume was determined to be around 2.1 in this study.

关键词： mesopore Hydroxyapatite Nanoparticle Swelling agent Pore characteristics

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Electron states and electron raman scattering in semiconductor double cylindrical quantum well wire

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Chinese Physics B 2016年第11期25卷 453-460页

作者： m munguía-rodríguez ri Betancourt-riera re Betancourt-riera r riera j m Nieto jalil Departamento de Investigación en Física Universidad de Sonora Apartado Postal 5-88 83190 Hermosillo Sonora México Instituto Tecnológico de Hermosillo. Avenida Tecnologico S/N Col. Sahuaro 83170 Hermosillo Sonora México Tecnológico de monterrey-Campus Sonora Norte. Bulevar Enrique mazón Lopez No. 965 83000 Hermosillo Sonora México

The differential cross section for an electron raman scattering process in a semiconductor GaAs/AlGaAs double quantum well wire is calculated,and expressions for the electronic states are *** system is modeled by considering T = 0 K and also with a single parabolic conduction band,which is split into a subband system due to the *** gain and differential cross-section for an electron raman scattering process are *** addition,the emission spectra for several scattering configurations are discussed,and interpretations of the singularities found in the spectra are *** electron raman scattering studied here can be used to provide direct information about the efficiency of the lasers.

关键词： Electron cylindrical confinement conduction radius decoupling AlGaAs parabolic modeled resonant

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microstructural Development and mechanical Properties of Pm Ti-45Al-2Nb-2mn-0.8 vol.%TiB_2 Processed by Field Assisted Hot Pressing

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journal of materials Science & Technology 2014年第11期30卷 1145-1154页

作者： r.munoz-moreno E.m.ruiz-Navas B.Srinivasarao j.m.Torralba Department of materials Science and Engineering Universidad Carlos Ⅲ de MadridAvda.Universidad 3028911 LeganésMadridSpain ImDEA materials Institute C/Eric Kandel 228906 GetafeMadridSpain

A γ-TiAI intermetallic alloy, Ti-45Al-2Nb-2mn （at.%）-0.8 vol.%TiB2, has been processed from gas atomized praalloyed powder by field assisted hot pressing （FAHP）. An initial analysis of the prealloyed powder helped on the understanding of the intermetallic sintering behavior. Atomized powder consisted of α metastable phase that transformed into α2＋γ equilibrium phases by thermal treating. Different powder particle microstructures were found, which influence the microstructure development of the FAHP T-TiAI material depending on the sintering temperature. Duplex, nearly lamellar and fully lamellar microstructures were obtained at the sintaring temperatures above 1000 ℃. Lower consolidation temperatures, below 1000 ℃, led to the formation of an AI rich phase at powder particle boundaries, which is deleterious to the mechanical properties. High compressive yield strength of 1050 mPa was observed in samples with FAHP duplex microstructures at room temperature. Whereas nearly lamellar and fully lamellar microstructures showed yield strength values of 655 and 626 mPa at room temperature and 440 and 425 mPa at 750 ℃, respectively, which are superior in comparison to similar alloys processed by other techniques. These excellent properties can be explained due to the different volume fractions of the α2 and γ phases and the refinement of the Pm microstructures.

关键词： Titanium aluminides Powder metallurgy microstructure mechanical properties Field assisted sintering

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Age-hardening behavior,corrosion mechanisms,and passive film structure of nanocrystalline Al-V supersaturated solid solution

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journal of materials Science & Technology 2023年第4期135卷 1-12页

作者： j.Christudasjustus m.r.Felde C.S.Witharamage j.Esquivel A.A.Darwish C.Winkler r.K.Gupta Department of materials Science and Engineering North Carolina State UniversityRaleighNC 27606United States Department of Chemical Biomolecular and Corrosion EngineeringThe University of AkronAkronOH 44325United States

The effect of age-hardening on microstructure,hardness,and corrosion of an Al-5at.%V alloy,produced us-ing high-energy ball milling and subsequent cold compaction,has been *** alloy exhibited a grain size below 100 nm and extremely high solid solubility of V in Al(3.1 at.%).The age-hardening was carried out at 150,200,and 250℃.The peak-aged condition of 150℃ demonstrated the highest hardness-transpired from grain refinement,precipitation,and solid solution *** corrosion re-sistance of the Al-5at.%V alloy was studied as a function of aging *** peak-aged condition retained the corrosion resistance while it deteriorated in the over-aged ***,the cor-rosion resistance of the ball-milled Al alloys in all the aging conditions was superior to that of pure *** passive film structure and origin of corrosion were studied using scanning/transmission electron mi-croscopy(S/TEm).The high corrosion resistance of the alloy was attributed to the V enrichment at the film/metal interface and deposition of V on the cathodic phases,which suppresses the dissolution of Al within the pit and therefore promotes repassivation in the early stages of corrosion.

关键词： Al alloys Nanocrystalline alloy Age-hardening Ball milling Corrosion Hardness

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Further Studies of the Cap Pushing response in Honey Bees (Apis mellifera)

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Natural Science 2024年第5期16卷 45-64页

作者： riley j. Wincheski Kiri Li N. Stauch Laura m. Grossner maya B. Zepeda james W. Grice Charles I. Abramson Department of Psychology Oklahoma State University Stillwater USA Laboratory of Comparative Psychology and Behavioral Biology Oklahoma State University Stillwater USA Department of Earth and Environmental Sciences California State University Fresno USA

The Cap Pushing response (CPr) is a free-flying technique used to study learning and memory in honey bees (Apis mellifera). The series of experiments outlined in this paper aimed to test whether honey bees exhibit the cognitive concept of “expectancy” utilizing the CPr in a weight differentiation paradigm. Five previous experiments in our laboratory have explored whether the concept of expectancy can account for honey bee performance and have all failed to support the cognitive interpretation. The first experiment examined if bees could differentiate between the two caps in the amount of force they used to push the cap and the distance the cap was pushed when the caps were presented one at a time. The second experiment explored cap weight preference by presenting bees with a choice between the two caps. The third and fourth experiments tested the bee’s ability to expect reward or punishment based on cap weight. results revealed that bees were found to have a strong preference for the light cap and therefore were not able to expect reward or punishment based on cap weight. These experiments contribute to the debate on whether bees have “cognitive” representations and continue to support the behaviorist interpretation.

关键词： Apis mellifera Cap Pushing response Cognition Learning

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Biodiversity Assessment of Avifauna in the Forest reservation of Aurora State College of Technology (ASCOT), Philippines

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Open journal of Ecology 2024年第4期14卷 292-308页

作者： Afed S. Daiwey Heherson B. Ong Emerson V. Barcellano Edmundo C. Gumpal michelle Ann m. Calubaquib rafael j. Padre School of Forestry and Environmental Sciences Aurora State College of Technology Baler Philippines College of Forestry and Environmental Science Isabela State University Cabagan Philippines College of Agriculture Isabela State University Cabagan Philippines College of Engineering Isabela State University Echague Philippines

The research study was conducted to assess and quantify the current status of avifauna biodiversity assets of Aurora State College of Technology’s Forest reservation in Baler, Aurora, Philippines. Assessment of avifaunal diversity was undertaken by traversing the four established circular plots having a radius of 125 meters or 250 meters diameters each as permanent monitoring stations. Study revealed a total number of 151 Individual species, classified into 23 genera and 21 families. Eighteen of these species are endemic while the remaining five were fully migrated birds. All birds observed were classified as Least Concern (LC) species according to the International Union for Conservation of Nature’s red List of Threatened Species and the updated list of the Birds of the World online. Its abundance, richness and diversity index were calculated using Shannon Diversity Index (H') while Pielou’s evenness (j') for distribution of species. Forest reservation of ASCOT has more even (0.756 j') and moderate diversity (2.812 H') observation on avifauna in general. However, this avian population evaluation was threatened into a verge of extinction due to natural and anthropological threats that causes forest deforestation. Such deforestation of habitat causes dwindling of wildlife territory leading to the scarcity of bird’s population. Thus, the assessment was conducted to aid ASCOT administration find significant plans to ensure sustainable conservation and protection of the remaining avifauna species in the reservation area.

关键词： Biodiversity Avifauna Abundance Species richness Species Diversity

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Understanding the mechanism of Nanoparticle Formation in a Wire Explosion Process by Adopting the Optical Emission Technique

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Plasma Science and Technology 2013年第6期15卷 562-569页

作者： B.DEBALINA m.KAmArAj S.r.CHAKrAVArTHI N.j.VASA r.SArATHI Dept.of metallurgical and materials Engg. IIT MadrasChennai 600036India Dept.of Aerospace Engg. IIT MadrasChennai 600036India Dept.of Engineering Design IIT MadrasChennai 600036India Dept.of Electrical Engg. IIT MadrasChennai 600036India

In the present study nano-tungsten carbide particles were generated in a wire explosion *** plasma generated during the wire explosion process was analyzed using optical emission spectroscopy（OES）.The impact of ambient pressure on the plasma temperature,electron density and plasma lifetime was *** variations of the plasma produced under different experimental conditions were *** produced nanoparticles were characterized through wide angle X-ray diffraction（WAXD） and transmission electron microscopy（TEm） studies. Particles produced with a negative DC charging voltage had a larger mean size when compared to a positive charging *** dependence on the plasma duration was observed where plasma was sustained for a longer duration with a negative DC charging voltage.

关键词： optical emission wire explosion tungsten carbide life time nano particle

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Bulking Up the Bay-Position Substituents Enables Enhanced Selectivity of C_(s)‑Symmetric Boron Subphthalocyanine−Subnaphthalocyanine Hybrids

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Precision Chemistry 2024年第4期2卷 161-181页

作者： Nina F.Farac Alan j.Lough Timothy P.Bender Department of Chemical Engineering and Applied Chemistry University of TorontoTorontoOntario M5S 3E5Canada Department of Chemistry University of TorontoTorontoOntario M5S 3H6Canada Department of materials Science and Engineering University of TorontoTorontoOntario M5S 3E4Canada Department of mechanical and Industrial Engineering University of TorontoTorontoOntario M5S 3G8Canada

The precise synthesis of subporphyrinoid hybrids withπ-expanded topologies and unique material properties plays a promising role in the design of functional ***,selective,and controllable routes to boron subphthalocyanine−subnaphthalocyanine hybrids,Bsub(Pc_(3‑p)-Nc_(p))s,are desirable for this purpose yet synthetically challenging due to random mixtures of C_(s-),C_(3v-),and,in some cases,C_(1)-symmetric compounds that form during traditional statistical mixed ***,we addressed this issue by developing a sterically driven mixed cyclotrimerization with enhanced selectivity for the targeted C_(s)-symmetric hybrid and complete suppression of sterically crowded macrocyclic *** process,coupled with a rationally designed precursor bearing bulky phenyl substituents,enabled the synthesis and characterization of bay-position phenylated Ph_(2)-(r_(p))_(8)Bsub(Pc_(2)-Nc_(1))hybrids with halogens(rp=Cl or F)in their peripheral isoindole *** selectivity ranged between 59 and 72%with remarkable yields,significantly higher than that of conventional mixed *** findings were augmented by theoretical calculations on precursor Lewis basicity as guiding principles into hybrid macrocycle ***,the incorporation of unfused phenyl groups and halogen atoms into the hybrid framework resulted in fine-tuned optical,structural,electronic,and electrochemical *** straightforward approach achieved improved selectivity and controlled narrowing of the product distribution,affording the efficient synthesis of structurally sophisticated Bsub(Pc_(2)-Nc_(1))*** then expands the library of 3-dimensionalπ-extended macrocycles for use in a range of applications,such as in optoelectronic devices with precisely tailored optical properties.

关键词： subphthalocyanine hybrids low-symmetry aromatic macrocycle selective cyclotrimerization sterically driven chemistry broad absorption material properties

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Lessons learned from the Youngstown, Ohio induced earthquake sequence from january 2011 to january 2012

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journal of rock mechanics and Geotechnical Engineering 2017年第5期9卷 783-796页

作者： A.P.morris D.A.Ferrill G.r.Walter A.m.Price K.j.Smart r.j.Skoumal m.r.Brudzinski B.S.Currie Southwest research Institute Culebra Road 6220 San Antonio TX 78238-5166 USA United States Geological Survey Earthquake Science Center 345 Middlefield Rd Building 3A RM 113 Menlo Park CA 94025 USA Department of Geology and Environmental Earth Science Miami University Oxford OH 45056 USA

The Youngstown earthquake sequence of 2011 is one of the clearest examples of inadvertently induced seismicity for which detailed documentation is *** this paper,we investigate(i) likely stress states in the vicinity of the injection well,(ii) a range of likely permeability scenarios,and(iii) relatively simple methods by which induced seismicity can be evaluated and *** use relocated hypocenters from the seismic sequence to construct a basement fault structure,which is then used to serve as a reference surface within the basement,and on which we calculate the effects of pore pressure changes induced by the injection activities of the Northstar #1 injection *** also deduce an in situ(preinjection) strike-slip stress regime,where ρ2≈ρ3,and it is consistent with both recent earthquake data and published stress estimates for the *** the reactivation characteristics of the basement are known or assumed,a critical or threshold slip tendency can be determined and the basement faults can be analyzed for the likelihood of reactivation in a perturbed pore pressure *** of well injection pressures and simulated pore pressure perturbations within the basement below the injection well indicates that permeability anisotropy is necessary to generate sufficient pore pressure perturbation to induce fault *** of the well’s injection history show that our estimate of in situ stress state,coupled with a highly anisotropic permeability structure,can generate sufficient pore pressure perturbation on the inferred basement structure to cause reactivation,potentially slipping an area of approximately 4×10~5 m~2.

关键词： Induced seismicity Wastewater injection Slip tendency

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