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Alexa,let's train now!——A systematic review and classification approach to digital and home-based physical training interventions aiming to support healthy cognitive aging

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Journal of Sport and health Science 2024年第1期13卷 30-46页

作者： Fabian herold Paula Theobald Thomas Gronwald Navin Kaushal Liye Zou eling D.de Bruin Louis Bherer Notger Gmüller Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Body-Brain-mind Laboratory Shenzhen UniversityShenzhen 518060China Institute of Interdisciplinary Exercise Science and Sports medicine MSH Medical School HamburgHamburg 20457Germany Department of health Sciences School of Health&Human SciencesIndiana UniversityIndianapolisIN 46202USA Department of health Sciences and Technology Institute of Human Movement Sciences and SportETH ZurichZurich 8093Switzerland Department of Neurobiology Care Sciencesand SocietyKarolinska InstituteStockholm 17177Sweden Department of health OST-Eastern Swiss University of Applied SciencesSt.Gallen 9001Switzerland montreal heart Institute MontrealQC H1T 1C8Canada Department of medicine Universite de MontrealMontrealQC H3T 1J4Canada Centre de Recherche de l'Institut Universitaire de Geriatrie de montreal MontrealQC H3W 1W5Canada

Background:There is mounting evidence that regular physical activity is an important prerequisite for healthy cognitive ***,the finding that almost one-third of the adult population does not reach the recommended level of regular physical activity calls for further public health *** this context,digital and home-based physical training interventions might be a promising alternative to center-based intervention ***,this systematic review aimed to summarize the current state of the literature on the effects of digital and home-based physical training interventions on adult cognitive ***:In this pre-registered systematic review(PROSPERO;ID:CRD42022320031),5 electronic databases(Pubmed,Web of Science,Psyclnfo,SPORTDiscus,and Cochrane Library)were searched by 2 independent researchers(FH and PT)to identify eligible studies investigating the effects of digital and home-based physical training interventions on cognitive performance in *** systematic literature search yielded 8258 records(extra17 records from other sources),of which 27 controlled trials were considered *** reviewers(FH and PT)independently extracted data and assessed the risk of bias using a modified version of the Tool for the assEssment of Study qualiTy and reporting in EXercise(TESTEX scale).Results:Of the 27 reviewed studies,15 reported positive effects on cognitive and motor-cognitive outcomes(i.e.,performance improvements in measures of executive functions,working memory,and choice stepping reaction test),and a considerable heterogeneity concerning study-related,population-related,and intervention-related characteristics was noticed.A more detailed analysis suggests that,in particular,interventions using online classes and technology-based exercise devices(i.e.,step-based exergames)can improve cognitive performance in healthy older *** one-half of the reviewed studies were rated as having a high risk of bias with respect

关键词： Brain Cognition Digital health Exercise-cognition Physical activity

Viscoelastic stress change from the 1931 m_(w)7.8 Fuyun earthquake and its impacts on seismic activity around the Altai mountains

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Geodesy and Geodynamics 2024年第4期15卷 326-337页

作者： Yali Shao jiankun he Xinguo Wang Youjia Zhao Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The 1931 m_(w)7.8 Fuyun earthquake occurred around the Altai mountains, an intracontinental deformation belt with limited active strain-rate accumulation. To explore whether seismic activity in this deformation belt was affected by stress interaction among different active faults, we calculate the Coulomb failure stress change(ΔCFS) induced by the Fuyun earthquake due to coseismic deformation of the elastic crust and postseismic viscoelastic relaxation of the lower crust and upper mantle. Numerical results show that the total ΔCFS at a 10-km depth produced by the Fuyun earthquake attains approximately 0.015-0.134 bar near the epicenter, and just before the occurrence of the 2003 m_(w)7.2 Chuya earthquake, which distances about 400 km away from the Fuyun earthquake. Among the increased ΔCFS,viscoelastic relaxation from 1931 to 2003 contributes to approximately 0.014-0.131 bar, accounting for>90% of the total ΔCFS. more importantly, we find that for the recorded seismicity in the region with a radius of about 270 km to the Fuyun earthquake from 1970 to 2018, the percentage of earthquakes that fall in positive lobes of ΔCFS resolved on the NNW-SSE Fuyun strike-slip fault, on the NWW-SEE Irtysh strike-slip fault, and on the NW-SE Kurti reverse fault is up to 67.22%-91.36%. Therefore, the predictedΔCFS suggests that the impact of the 1931 m_(w)7.8 Fuyun earthquake on seismic activity around the Altai mountains is still significant as to hasten occurrence of the 2003 m_(w)7.2 Chuya earthquake at a relatively far distance and to trigger its aftershocks in the near-field even after several decades of the mainshock.

关键词： Altai mountains Fuyunearthquake Coulomb failure stress change Viscoelasticrelaxation Seismic activity

Inversion of O_(2) 1.27 μm nightglow emissions: A climatological analysis using satellite Limb-Viewed spectra and Harmonic analysis method

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Earth and Planetary Physics 2024年第4期8卷 632-640页

作者： YiYi Sui YaJun Zhu QiuYu Chen maoSheng he JiYao Xu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China

This study employs a linear inversion algorithm to retrieve volume emission rates(VERs)of molecular O_(2) nightglow at 1.27μm,utilizing Limb-Viewed spectra obtained from the SCanning Imaging Absorption spectrometer for Atmospheric for CHartographY(SCIAmACHY)payload on board the Envisat *** retrieved results are compared with VERs data from the SABER payload on the Thermosphere Ionosphere mesosphere Energetics and Dynamics(TImED)satellite,exhibiting *** will help to facilitate accurate revelation of spatial distribution and periodic variation in O_(2) *** are extracted monthly within the altitude range of 75-110 km from 2002 to 2012,yielding a climatology of spatial and temporal *** meridional structure exhibits two maxima,at the equator and at 45°*** August and October,the VERs exhibit a meridional bimodal structure,with the weaker one above the equator and the stronger one above 45°*** April,the VERs reach their annual ***,harmonic analysis reveals significant temporal variations on different *** emission shows characteristics of annual and semi-annual variation,and a non-linear long-term trend associated with solar cycle activity.

关键词： VERs O_(2)1.27μm nightglow SCIAmACHY

AZGP1P2/UBA1/RBm15 Cascade mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPm1 m6A modification

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Research 2024年第3期6卷 151-167页

作者： Hong Wang Jj Liu Xiaojun Zhu Bin Yang Zuping he Xudong Yao Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Urologic Cancer Institute School of MedicineTongji UniversityShanghaiChina. Department of Urology Surgery The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina. The Key Laboratory of model Animals and Stem Cell Biology in Hunan Province School of MedicineHunan Normal UniversityThe Engineering Research Center of Reproduction and Translational Medicine of Hunan ProvinceChangshaChina Shanghai Key Laboratory of Reproductive medicine Shanghai Jiao Tong University School of MedicineShanghaiChina.

Prostate cancer(PCa)is a common malignant tumor with high morbidity and mortality *** prostate cancer stem cell(PCSC)model provides novel insights into the pathogenesis of PCa and its therapeutic ***,the roles and molecular mechanisms of specific genes in mediating fate decisions of PCSCs and carcinogenesis of PCa remain to be *** this study,we have explored the expression,function,and mechanism of AZGP1P2,a pseudogene of AZGP1,in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer(CRPC).We revealed that AZGP1P2 was downregulated in CRPC cell lines and PCSCs,while it was positively associated with progression-free *** of the AZGP1P2 enhanced the sensitivity of docetaxel treatment in CRPCs via inhibiting their *** pull-down associated with mass spectrometry analysis,co-immunoprecipitation assay,and RNA immunoprecipitation assay demonstrated that AZGP1P2 could bind to UBA1 and RBm15 as a“writer”of methyltransferase to form a ***1,an E1 ubiquitin-activating enzyme,contributed to RBm15 protein degradation via ubiquitination *** RNA immunoprecipitation assay displayed that RBm15 controlled the mRNA decay of TPm1 in m6A ***,a xenograft mouse model and patient-derived organoids showed that the therapeutic effect of docetaxel in CRPC was increased by AZGP1P2 in ***,these results imply that AZGP1P2 mediates the stemness and apoptosis of PCSCs and promotes docetaxel therapeutic effect by suppressing tumor growth and metastasis via UBA1/RBm15-mediated TPm1 mRNA decay in CRPC.

关键词： Prostate TPm1 m6A

A Label-Free Deoxyribozyme Sensor for m^(6)A Demethylase Activity Detection

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Chinese Journal of Chemistry 2024年第9期42卷 951-956页

作者： Xiuyuan Wang Shusheng Yu Yuqiu he Fuan Wang Xiaoqing Liu College of Chemistry and molecular Sciences Wuhan UniversityWuhanHubei 430072China

A label-free deoxyribozyme(DNAzyme)biosensor for m^(6) demethylase activity detection is *** demethylase FTO(Fat mass and obesity-associated protein),an important m^(6) demethylase of ALKBH demethylase family is present,the m^(6) group is specifically demethylated,and the cleavage activity of DNAzyme is *** allows the cleavage product that contains G-quadruplex sequence to bind to thioflavin T(ThT)and generate fluorescence *** biosensor shows high specificity and sensitivity,and fast reaction *** study demonstrates a new design of allosteric DNAzyme for *** method represents the first label-free nucleic acid biosensor for FTO assay,providing a feasible route towards inhibitors screening.

关键词： DNAzyme Analytical methods Biosensing m^(6)A demethylation Fluorescence

Waldenström macroglobulinemia:a challenging case treated with anti-CD19 CAR-T cell therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 719-722页

作者： Yang YANG Xiaolin GU Jingsong he Yongxian HU Zhen CAI Bone marrow Transplantation Center Department of Hematologythe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310006China Department of hematology Putuo People’s HospitalZhoushan 316100China

Waldenström macroglobulinemia(Wm)is characterized by lymphoplasmacytic lymphoma associated with large amounts of monoclonal immunoglobulin m(Igm)protein(Owen et al.,2003).Common signs and symptoms include fatigue due to anemia,lymph node enlargement,hepatosplenomegaly,thrombocytopenia,symptoms related to high viscosity,and peripheral neuropathy,among *** significant advances in Wm treatment,this type of indolent lymphoma remains incurable,with a wide array of patient outcomes(Ruan et al.,2020).In recent years,chimeric antigen receptor T(CAR-T)cell therapy targeting cluster of differentiation 19(CD19)has shown unprecedented response rates and durability in the treatment of B-cell *** this report,we describe a challenging case of Wm that involved multiple extramedullary sites,relapsed,and was refractory to chemotherapy,immunotherapy,and targeted *** anti-CD19 CAR-T cell therapy,the tumor burden significantly decreased and the patient’s condition remained stable at the writing of this report.

关键词： CD19 globulin durability

m^(6)A modification in cardiovascular disease:With a focus on programmed cell death

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Genes & Diseases 2024年第5期11卷 272-284页

作者： Wen Li Yao Liu Ruiyan Xu Yuan Zong Lu he Jun Hu Guohua Li Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseDepartment of PathophysiologyMOE Key Lab of Rare Pediatric DiseasesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular medicine The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Obstetrics and Gynecology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

N^(6)-methyladenosine(m^(6)A)methylation is one of the most predominant internal RNA modifications in eukaryotes and has become a hot spot in the field of epigenetics in recent *** diseases(CVDs)are a leading cause of death *** evidence demonstrates that RNA modifications,such as the m^(6)A modification,are associated with the development and progression of many diseases,including *** increasing body of studies has indicated that programmed cell death(PCD)plays a vital role in ***,the molecular mechanisms underlying m^(6)A modification and PCD in CVDs remain poorly ***,elaborating on the highly complex connections between the m^(6)A mechanisms and different PCD signaling pathways and clarifying the exact molecular mechanism of m^(6)A modification mediating PCD have significant meaning in developing new strategies for the prevention and therapy of *** is great potential for clinical application.

关键词： Apoptosis Autophagy Cardiovascular diseases Ferroptosis N^(6)-methyladenosine Programmed cell death Pyroptosis

m^(6)A modification of plant virus enables host recognition by NmD factors in plants

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Science China(Life Sciences) 2024年第1期67卷 161-174页

作者： Hao he Linhao Ge Yalin Chen Siwen Zhao Zhaolei Li Xueping Zhou Fangfang Li State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310029China

N^(6)-methyladenosine(m^(6)A)is the most abundant eukaryotic mRNA modification and is involved in various biological *** evidence has implicated that m^(6)Amodification is an important anti-viral defense mechanism in mammals and plants,but it is largely unknown how m^(6)Aregulates viral infection in *** we report the dynamic changes and functional anatomy of m^(6)Ain Nicotiana benthamiana and Solanum lycopersicum during Pepino mosaic virus(PepmV)infection.m^(6)Amodification in the PepmV RNA genome is conserved in these two *** of the m^(6)Awriters,mRNA adenosine methylase A(mTA),and HAKAI inhibit the PepmV RNA accumulation accompanied by increased viral m^(6)Amodifications,whereas deficiency of these writers decreases the viral RNA m^(6)Alevels but enhances virus *** study reveals that the cytoplasmic YTH-domain family protein NbECT2A/2B/2C as m^(6)Areaders are involved in anti-viral ***-protein interactions indicate that NbECT2A/2B/2C interact with nonsense-mediated mRNA decay(NmD)-related proteins,including NbUPF3 and NbSmG7,but not with NbUPF1.m^(6)Amodification-mediated restriction to PepmV infection is dependent on NmD-related *** findings provide new insights into the functionality of m^(6)Aanti-viral activity and reveal a distinct immune response that NmD factors recognize the m^(6)Areaders-viral m^(6)ARNA complex for viral RNA degradation to limit virus infection in plants.

关键词： m^(6)A Pepino mosaic virus plant defense m^(6)A readers NmD factors

Prediction of liquid circulation flow rate in RH degasser:improvement of decarburization at low atmospheric pressure

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Journal of Iron and Steel Research International 2024年第7期31卷 1661-1667页

作者： Gu-jun Chen Sheng-ping he College of materials Science and Engineering Yangtze Normal UniversityChongqing 400044China College of materials Science and Engineering Chongqing UniversityChongqing 400044China

The two-fluid model coupled with population balance model was used for simulating the gas-liquid flow in the Ruhrstahl-heraeus(RH)*** predicted circulation flow rate was compared with that measured from a water model experiment to validate the mathematical ***,influence of snorkel immersion depth on liquid circulation flow rate was numerically investigated under an atmospheric pressure of 101 and 84 kPa,*** result indicates that the circulation flow rate of the RH degasser in the high-altitude area was severely reduced because of the decrease in atmospheric ***,increasing the snorkel immersion depth from 0.5 to 0.7 m can compensate for the decrease in atmospheric *** test result indicates that decarburization rate is significantly enhanced by increasing the snorkel immersion *** optimization,the percentage of heats with a final carbon content less than 0.002 wt.%is significantly increased from 22.0%to 96.4%.

关键词： RH degasser Two-fluid model Population balance model-Circulation flow rate Decarburization Snorkel immersion depth