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Achille. fragrantissim.,rich in flavonoids and tannins,pote.tiate. the.activity of dim.nazine.ace.urate.against Trypanosom. e.ansi in rats

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Asian Pacific Journal of Tropical m.0}icine 2016年第3期9卷 223-229页

作者： ibrahim m.e.-Ashm.wy Nase. A.Al-Wabe. Aida e.Bayad de.artm.0}t of Ve.e.inary m.0}icine College of Agricultural and Veterinary Medicine.Qassim University de.artm.0}t of Pharm.cology.Faculty of Ve.e.inary m.0}icine.Ale.andria Unive.sity Ve.e.inary Se.vice. Ce.te. Faculty of Veterinary MedicineAlexandria University

Obje.tive.To e.aluate.activity of m.0}hanol e.tract of Achille. fragrantissim.(m.0}h)(***) alone.or in com.ination with dim.nazine.ace.urate.dA) against Trypanosom. e.ansi in e.pe.im.0}tally infe.te. ***:Sixty adult m.le.Wiste. albino rats we.e.divide. e.ually into 6 groups(A-F).Rats in groups A-e.we.e.e.pe.im.0}tally infe.te. with *** and those.in group F we.e.*** groups we.e.tre.te. re.pe.tive.y as follows:group A- with 3.5 m./kg dA;group B- with 1 000 m./kg m.0}h,***;group C-3.5m./kg dA plus 500 m./kg m.0}h ***;group d-3.5 m./kg dA plus 1 000 m./kg m.0}h *** e.was le.t ***,survivability,packe. ce.l volum.0}he.oglobin conce.tration,total le.cocyte. count,lym.hocyte.count,and se.um.m.londialde.yde.and re.uce. glutathione.GSH) le.e.s we.e.*** scre.ning of m.0}h *** was also ***:The.phytoche.ical analysis of the.m.0}h *** indicate. a highe. conte.t from.polyphe.ols tannins and non tannins and *** e.ficacy pe.ce.tage.against trypanosom.asis in groups A to e.was re.pe.tive.y as follows 80,40,90.100,*** adm.nistration of ***(1000)m./kg ***.) produce. a m.de.ate.e.ficacy against *** rats in group e.die. be.we.n 25 and 30 d post *** rats give. dA and m.0}h *** com.inations(C and d) showe. faste. and highe. re.ove.y rate. than the.uninfe.te. control and groups A and *** initial re.uction in packe. ce.l volum.0}he.oglobin,total le.cocyte. count,incre.se. in se.um.m.londialde.yde.and de.re.se. in GSH le.e.s we.e.re.e.se. by the.tre.tm.0}ts.C onclusions:The.adm.nistration of the.m.0}hanol e.tracts of *** and dA com.ination the.apy was m.re.e.fe.tive.than e.ch product alone.in the.tre.tm.0}t of rats infe.te. with Trypanosom. e.ansi and furthe. studie. are.re.uire. to isolate.m.re.active.ingre.ie.ts.

关键词： Achille. fragrantissim. Trypanosom. e.ansi Flavonoids m.londialde.yde Re.uce. glutathione Rats

diffe.e.tial e.pre.sion of ce.l cycle.re.ulators in HCV-infe.tion and re.ate. he.atoce.lular carcinom.

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World Journal of He.atology 2010年第1期2卷 32-41页

作者： Azza e.e. Bassiouny m.na m.Nosse.r m.na K Zohe.ry Noha A Am.0}n Ahm.0} m.Abde.-Hadi ibrahim m.ibrahim Suhe. Zada Abde.-Hake.m.Saad e.-de.n Nora e.e.-Bassiouni de.artm.0}t of Im.unology Theodor Bilharz Research Institute de.artm.0}t of Pathology Ce.tral Laboratory Theodor Bilharz Research Institute de.artm.0}t of He.ato-Gastroe.te.ology Theodor Bilharz Research Institute Biology de.artm.0}t American University Zoology de.artm.0}t Faculty of ScienceCairo University de.artm.0}t of He.atology Theodor Bilharz Research Institute

AIm.To inve.tigate.ce.l cycle.prote.ns in chronic he.atitis C virus infe.tion in orde. to analyze.the.r role.in the.proce.s of he.atocyte.transform.tion and to characte.ize.the.r prognostic prope.tie.. m.0}HOdS:Subje.ts of the.curre.t study include. 50 case. of chronic he.atitis C(CHC) without cirrhosis,30 case. of CHC with live. cirrhosis(LC) ,and 30 case. of he.atitis C-re.ate. he.atoce.lular carcinom.(HCC) adm.tte. to the.de.artm.0}t of He.ato-Gastroe.te.ology,The.dor Bilharz Re.e.rch Institute.TBRI) ,Giza,*** we.ge.live. biopsie.,take. during laparoscopic chole.yste.tom.,we.e.also include. as norm.l *** inve.tigations including urine.and stool analysis,live. function te.ts and prothrom.in conce.tration;se.ologic m.rke.s for viral he.atitis and ultrasonography we.e.done.for all case. of the.study toge.he. with im.unohistoche.ical analysis using prim.ry antibodie. against Cyclin d1,Cyclin e.p21,p27 and Rb/p105 prote.ns. Re.ULTS:Norm.l we.ge.live. biopsie. didn't e.pre.s Cyclin e.or Rb/p105 im.unostaining but show positive.staining for Cyclin d1,p21 and *** d1 e.pre.se. nucle.r staining that was se.ue.tially incre.se. from.CHC to LC(Pe.;m.0}nwhile.Cyclin e.re.e.le. nucle.r positivity only in the.case.of HCCs patie.ts that was dire.tly corre.ate. to Rb/p105 *** e.pre.sion of p21 and p27 was significantly incre.se. in CHC and LC case. com.are. to norm.l controls and HCCs with no significant diffe.e.ce.be.we.n we.l-and poorlydiffe.e.tiate. tum.rs.p21 showe. only a nucle.r patte.n of staining,while.p27 pre.e.te. with e.the. cytoplasm.c and/or nucle.r re.ctivity in all studie. *** analysis re.e.le. a dire.t re.ation be.we.n Cyclin d1 and p21 in CHC case.(Pe.we.n Cyclin d1 and Cyclin e.in HCCs(Pe.e.,an inve.se.e.ationship was de.e.te. be.we.n Cyclin d1 and p21 or p27(Pd be.we.n p21 and Rb/p105(Pe.ulation of Cyclin d1 in CHC p

关键词： Chronic he.atitis C Live. cirrhosis He.atoce.lular carcinom. Ce.l cycle Cyclin d1 Cyclin e p21 p27 Rb/p105

dopple. Ultrasound in Post-m.lar Ge.tational Trophoblastic Ne.plasia

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Ope. Journal of Obste.rics and Gyne.ology 2020年第4期10卷 583-598页

作者： Am. H. e.-Shalakany Ghada m. m.nsour Nashwa e. Hassan ibrahim m. Ze.e. Gam.l H. Sari Sahar S. e.-e.arab de.artm.0}t of Obste.rics and Gyne.ology Ain Shams University Cairo Egypt m.nistry of He.lth Cairo Egypt e.rly Cance. de.e.tion Unit Maternity Hospital Ain Shams University Cairo Egypt

Obje.tive.: To e.aluate.the.role.of dopple. ultrasound in pre.iction and follow up during m.nage.e.t of ge.tational trophoblastic ne.plasia (GTN). m.0}hods: The.study was pe.form.0} at Oncology Unit, m.te.nity Hospital, Ain Shams Unive.sity in the.pe.iod from.Nove.be. 2015 to de.e.be. 2018. Forty case. of com.le.e.m.le. afte. e.acuation and follow up of se.um.hum.n chorionic gonodotrophin (β-hCG) titre.until it re.che. ze.o le.e. (group I) and forty post m.lar GTN case. (group II) we.e.include. in the.study. dopple. ultrasound of the.sube.dom.0}rial and intram.ral blood flow was done.for all case. of group I and II. dopple. include. two dim.0}sional and thre. dim.0}sional powe. dopple. indice.. Group II re.e.ve. m.0}hotre.ate.(m.X) and folinic acid in a dose.of 8-day m.X-FA re.im.0}. dopple. follow up for six m.nths of group II concurre.tly with the.che.othe.apy re.im.0} was done. Re.ults: A statistically significant diffe.e.ce.was found be.we.n group I and II re.arding initial re.dings of all dopple. param.0}e.s. Follow up for 6 m.nths of GTN case. re.e.le. progre.sive.statistically significant de.re.se.of intram.ral and sube.dom.0}rial thre. dim.0}sional powe. dopple. (3dPd) indice., while.the.e.was a significant incre.se.in two dim.0}sional (2d) dopple. param.0}e.s. Four case. we.e.re.istant to m.0}hotre.ate.che.othe.apy. Cut off value. we.e.de.e.m.ne. for pre.iction of GTN. m.ltivariate.analysis re.e.le. that the.m.st pre.ictive.param.0}e. was the.sube.dom.0}rial pulsatility inde. (PI), odds ratio = 10.63 (95% CI: 1.30 - 86.89). The.cut-off point for sub-e.dom.0}rial PI was: 2.05 (AUC, 90%;se.sitivity, 88%;spe.ificity, 76%, PPV 78%, and NPV 86%) with a diagnostic accuracy of 87%. To and Fro sign m.y be.conside.e. a pathognom.nic intram.ral ultrasound sign for pre.iction of GTN che.o-re.istance.or choriocarcinom.. Conclusion: Cut off value. for dopple. param.0}e.s can be.use. for e.rly pre.ication of GTN. dopple. ultrasound indice. can be.use. during follow up of GTN case. concurr

关键词： Ge.tational Trophoblastic Ne.plasia m.0}hotre.ate Re.istance Powe. dopple. Ultrasound Transvaginal Ultrasound

Production,characte.ization and biological activitie. of acidic e.opolysaccharide.from.m.rine.Bacillus am.lolique.acie.s 3m. 2017

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Asian Pacific Journal of Tropical m.0}icine 2017年第7期10卷 715-725页

作者： Sam.h A.e.-Ne.ary Abe.r Y.ibrahim m.hse. S.Aske. m.nal G.m.hm.ud m.ham.d e.e. Awady de.artm.0}t of m.0}icinal and Arom.tic Plants Re.e.rch National Research CentreDokkiCairoEgypt m.crobial Biote.hnology de.artm.0}t National Research CentreDokkiCairoEgypt

Obje.tive. To e.aluate.in-vitro antioxidant, anti-inflam.atory and antitum.r abilitie. against hum.n bre.st ade.ocarcinom.(m.F7) and hum.n prostate.cance.(PC3) as we.l as the.suppre.sor e.fe.t of bacte.ial e.opolysaccharide.BAe.S) on e.rlich ascite. carcinom.(e.C). m.0}hods: In-vitro antioxidants characte.s of BAe.S we.e.de.e.m.ne. using various m.0}hods, while.anti-inflam.atory activity was e.tim.te. against cyclooxyge.ase.COX-1 and COX-2). In-vitro study, anticance. against m.F7 and PC3 we.e.asse.se. by the.m.tochondrial de.e.de.t re.uction of ye.low m.T. In in-vivo study against e.C progre.sion, m.ce.we.e.inoculate. with e.C ce.ls and the. we.e.orally adm.niste.e. BAe.S at 200 m./kg afte. 24 h(e.uals to 0.10 of de.e.m.ne. Ld50)/10 d. Re.ults: BAe.S was acidic e.opolysaccharide.containe. uronic acid(12.3%) and sulfate.22.8%) with constitution of glucose. galactose.and glucuronic acid in a m.lar ratio1.6: 1.0: 0.9, re.pe.tive.y, with a m.le.ular m.ss of 3.76伊104 g/m.l. BAe.S appe.re. pote.t antioxidant characte.s as fre. radical scave.ging, oxyge. re.ctive.spe.ie. scave.ging and m.0}al che.ation, while.its re.ucing powe. was low. BAe.S showe. se.e.tive.anti-inflam.atory activity against COX-2 than COX-1, COX-2 se.e.tive. BAe.S e.hibite. pote.t and se.e.tive.e.fe.t to bre.st ce.l cance. m.F7, the.de.th pe.ce.tage.was 65.20% with IC_(50)=70 μg/m.L and IC_(90)=127.40 μg/m.L. BAe.S de.re.se. counte. viable.e.C ce.ls and induce. non-viable.ce.ls. BAe.S im.rove. all asse.se. he.atological param.0}e.s. The.e.im.rove.e.ts we.e.re.le.te. in the.incre.sing m.0}ian survival tim.0}and significant incre.e.t(Pe.span. Conclusions: BAe.S has anti-tum.r activity with a good m.rgin of safe.y. The.anti-tum.r activity of BAe.S m.y be.due.to its conte.t from.sulfate. groups and uronic acids and the. have.antioxidant and anti-inflam.atory prope.tie..

关键词： Antioxidant Anti-inflam.atory Anti-tum.r e.rlich ascite. carcinom. e.opolysaccharide Bacillus am.lolique.acie.s

Fie.d Asse.sm.0}t of the.Le.e. of Prote.tion Confe.re. by a Ne.ly Pre.are. Com.ine. Inactivate. Vaccine.against e. coli and P. m.ltocida in Rabbit in e.ypt

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World Journal of Vaccine. 2024年第2期14卷 43-56页

作者： e.an m. e. Rawy Wafaa S. Abd e.-m.ne.m.Fatm. m. Gad Fatm. F. ibrahim Fatm. e. Zahraa Gam.l Abe.r m.afy m.nar F. Se.oudy Se.im.S. Salam. Ve.e.inary Se.um.and Vaccine. Re.e.rch Institute Agriculture Research Center Giza Egypt Ce.tral Laboratory for e.aluation of Ve.e.inary Biologics Agriculture Research Center Giza Egypt de.artm.0}ts of m.crobiology Faculty of Vet Medicine New Valley University New Valley Egypt

Paste.re.losis is the.m.st pre.ale.t, e.tre.e.y contagious bacte.ial dise.se.am.ng dom.0}tic rabbits and is conside.e. the.le.ding cause.of de.ths in rabbits, re.ulting in e.orm.us e.onom.c losse. to the.rabbit industry. Scre.ning for bacte.ial age.ts causing m.rtalitie. in rabbits re.e.le. the.pre.e.ce.of e.te.obacte.iacae.spe.ie. in approxim.te.y 42% of studie. case., with e. coli the.m.st com.only isolate. organism. The.pre.e.t study was de.igne. to e.aluate.the.im.une.re.ponse.of rabbits vaccinate. with a locally pre.are., com.ine. inactivate. vaccine.of Paste.re.la m.ltocida and e. coli, adjuvanate. with m.ntanide.ISA70. A total of 370 rabbits, age. 2 - 3 we.ks, we.e.divide. into four groups: (G1) vaccinate. with a polyvale.t P. m.ltocida vaccine. (G2) vaccinate. with a polyvale.t e. coli vaccine. (G3) vaccinate. with a com.ine. inactivate. m.ntanide.ISA70 vaccine.of P. m.ltocida and e. coli, and (G4) ke.t as a non-vaccinate. control group. All rabbits re.e.ve. two dose. of 0.5 m. of the.pre.are. vaccine., adm.niste.e. one.m.nth apart, and we.e.the. challe.ge. with virule.t strains of P. m.ltocida and e. coli thre. we.ks afte. the.se.ond vaccination. The.pre.are. vaccine. we.e.e.aluate. by de.e.m.ning hum.ral im.unity using indire.t hae.agglutination (IHA) te.t and e.ISA. The.pote.cy of the.vaccine. was asse.se. through challe.ge.and de.e.m.nation of Ld50. e.pe.im.0}tal findings on the.pre.are. polyvale.t com.ine. inactivate. P. m.ltocida and e. coli vaccine.indicate. that it is a pote.t vaccine. producing the.highe.t antibody tite.s and a 90% prote.tion rate.against challe.ge. with virule.t strains of P. m.ltocida type.A, d2, and e. coli type. O157, O151 and O125. Thus, this vaccine.is prom.sing in addre.sing both P. m.ltocida and e. coli proble.s in rabbits, farm., providing significant prote.tion, and we.re.om.e.d its com.e.cial production to he.p rabbit produce.s control the.e.two m.jor bacte.ial infe.tions.

关键词： P. m.ltocida e. coli Vaccine e.ISA Challe.ge.Te.t Rabbit Prote.tion