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Association between serum cartilage oligomeric matrix protein and coronary artery calcification in maintenance hemodialysis patients

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Journal of Geriatric Cardiology 2020年第2期17卷 67-73页

作者： Lahati ha Jun-Bao SHI hai-Yi YU Kun YANG hai-Ning WANG Fang-Fang WANG Jiang-Li haN Department of Cardiology and Institute of Vascular medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijingChina Department of Nephrology Peking University Third HospitalBeijingChina Department of Endocrinology Peking University Third HospitalBeijingChina

Background Coronary artery calcification(CAC)is common in end-stage renal disease(ESRD)patients,and the extent of CAC is closely related to cardiovascular outcomes in ESRD *** oligomeric matrix protein(COmP),as a component of the vascular matrix,has been found to be an inhibitor of arterial calcification in basic ***,there is no clinical research on the correlation between COmP and CAC in maintenance hemodialysis(mHD)*** aim of this study was to explore the relationship between serum COmP levels and CAC and cardiovascular events in mHD *** Serum COmP levels were compared between 54 mHD patients and 66 healthy *** patients were then divided into three groups according to the tertiles of the concentration of COmP level and were followed up for major adverse cardiac events(mACEs),which were defined as a combined end point of new onset angina pectoris,nonfatal myocardial infarction,heart failure,coronary artery revascularization,hospitalization due to angina pectoris and all-cause *** CAC score was calculated based on computed tomography *** The serum COmP level in mHD patients was significantly higher than that in the general population[984.23(248.43-1902.61)ng/mL vs.219.01(97.26-821.92)ng/mL,Pm COmP levels were positively correlated with CAC(r=0.313,P=0.021)and serum parathyroid hormone in mHD patients(r=0.359,Phat after adjusting for age,fasting blood glucose(Glu)and glycosylated hemoglobin(HbAlc),CAC score was an independent predictor in the final model for COmP level(β=0.424,t=3.130,Pharacteristic(ROC)curve showed that COmP≥994 mg/mL had 68.0%sensitivity and 72.4%specificity for the prediction of severe CAC[area under the curve(AUC):0.674,P=0.030,95%CI:0.526-0.882].After a median follow-up of 16 months(8-24 months),there was no difference in the incidence rate of mACEs between the upper,middle and lower serum COmP gr

关键词： Biomarker Cartilage oligomeric matrix protein Coronary artery calcification maintenance hemodialysis

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Wearable and stretchable conductive polymer composites for strain sensors:How to design a superior one?

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Nano materials Science 2023年第4期5卷 392-403页

作者： Liwei Lin Sumin Park Yuri Kim minjun Bae Jeongyeon Lee Wang Zhang Jiefeng Gao Sun ha Paek Yuanzhe Piao Department of Applied Bioengineering Graduate School of Convergence Science and TechnologySeoul National UniversitySeoul08826South Korea Department of Neurosurgery Movement Disorder CenterSeoul National University HospitalHypoxia/Ischemia Disease InstituteCancer Research InstituteSeoul National University College of MedicineSeoul03080South Korea School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouJiangsu225002China Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityHung HomHong Kong SAR999077China Advanced Institutes of Convergence Technology 145 Gwanggyo-roYeongtong-guSuwon-siGyeonggi-do443-270South Korea

Wearable and stretchable strain sensors have potential values in the fields of human motion and health monitoring,flexible electronics,and soft robotic *** wearable and stretchable strain sensors can be directly attached to human skin,providing visualized detection for human motions and personal *** polymer composites(CPC)composed of conductive fillers and flexible polymers have the advantages of high stretchability,good flexibility,superior durability,which can be used to prepare flexible strain sensors with large working strain and outstanding *** review has put forward a comprehensive summary on the fabrication methods,advanced mechanisms and strain sensing abilities of CPC strain sensors reported in recent years,especially the sensors with superior ***,the structural design,bionic function,integration technology and further application of CPC strain sensors are prospected.

关键词： Wearable strain sensors Conductive polymer composites mechanism Sensing performance

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Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway

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The Journal of Biomedical Research 2017年第5期31卷 408-418页

作者： Zhongbo Liu U-Syn ha Ke Yu Chunli Wu Noriko Yokoyama Xiaolin Zi Departments of Urology University of CaliforniaIrvine Orange CA 92868 USA. Pharmacology University of CaliforniaIrvine Orange CA 92868 USA. Chao Family Comprehensive Cancer Center University of CaliforniaIrvine Orange CA 92868 USA.

Consumption of kava(Piper methysticum Forst) has been linked to reduced cancer risk in the South Pacific *** are major bioactive components in kava root extracts, which have recently demonstrated anti-cancer activities. However, molecular mechanisms of kavalactones' anti-cancer action remain largely unknown. We have identified two kavalactones, yangonin and 5' 6'-dehydrokawain, as potent inducers of autophagic cell death in bladder cancer cells. The effect of yangonin inducing autophagy is associated with increased expression of beclin and *** addition, yangonin increases the expression of LKB1 and decreases the phosphorylation of Akt, PRAS40, rpS6,p70S6 K and 4E-BP1, leading to increased binding of 4E-BP1 to m7 GTP. The growth inhibitory effects of yangonin were attenuated in TSC1 or LKB1 knockout mouse embryonic fibroblasts, suggesting that TSC1 and LKB1 expression may contribute to optimal growth inhibition by yangonin. Furthermore, yangonin reduces the viability of bladder cancer cell lines derived from different stages of human bladder cancer, and acts synergistically with apoptosis-inducing agents such as docetaxel and flavokawain A. Our results support a novel anti-bladder cancer mechanism by yangonin and further studies are needed to assess the potential use of yangonin for bladder cancer prevention and treatment

关键词： yangonin bladder cancer autophagy mTOR

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Legume Green manure and Intercropping for High Biomass Sorghum Production

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Agricultural Sciences 2024年第6期15卷 605-621页

作者： Clark B. Neely Francis m. Rouquette Jr. Cristine L. S. morgan Frank m. Hons William L. Rooney Gerald R. Smith Department of Soil and Crop Science Washington State University Pullman WA USA Texas A&m AgriLife Research Overton TX USA Soil Health Institute Morrisville NC USA Department of Soil and Crop Science Texas A&M University College Station TX USA

Before the advent of cheap, synthetic fertilizers, legumes were commonly used as green manure crops for their ability to fix atmospheric nitrogen (N). A three-year study at Overton, TX examined legume integration into high-biomass sorghum (Sorghum bicolor L.) production systems on a Lilbert loamy fine sand recently cultivated after a fertilized bermudagrass [Cynodon dactylon (L.) Pers.] pasture. In this split-split plot design, ‘Dixie’ crimson clover (Trifolium incarnatum L.) and ‘Iron and Clay’ cowpea (Vigna unguiculata L.) were integrated into a high-biomass sorghum production system to evaluate impacts on N concentration, C concentration, and yield of high-biomass sorghum and their impacts on soil total N and soil organic carbon (SOC). main plots were split into crimson clover green manure (CLGm) and winter fallow (FALL) followed by three sub-plots split into warm-season crop rotations: cowpea green manure (CPGm), cowpea-sorghum intercrop (CPSR), and sorghum monocrop (SORG). Three N fertilizer treatments (0, 45, 90 kg N∙ha−1) were randomized and applied as sub-sub plots. The CLGm increased (P sorghum biomass yield (16.5 t Dm∙ha−1) 28% in year three but had no effect in the first two years. The CPSR treatment reduced sorghum yield up to 62% compared to SORG;whereas CPGm increased sorghum yield 56% and 18% the two years following cowpea incorporation. Rate of N fertilizer had no effect on sorghum biomass yield. Decrease in SOC and soil N over time indicated mineralization of organic N and may explain why no N fertilizer response was observed in sorghum biomass yield. Cowpea showed strong potential as a green manure crop but proved to be too competitive for successful intercropping in high-biomass sorghum production systems.

关键词： High-Biomass Sorghum Legumes Green manure Intercrop Cowpea Crimson Clover Soil Organic Carbon Soil Nitrogen

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Facile Synthesis of Porous Carbon Nitride Spheres with Hierarchical Three-Dimensional mesostructures for CO_(2) Capture

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Nano Research 2010年第9期3卷 632-642页

作者： Qiang Li Jianping Yang Dan Feng Zhangxiong Wu Qingling Wu Sung Soo Park Chang-Sik ha Dongyuan Zhao Department of Chemistry and Shanghai Key Laboratory of molecularCatalysis and Innovative materials Laboratory of Advanced MaterialsFudan UniversityShanghai 200433China Department of Polymer Science and Engineering Pusan National UniversityGeumjeong-guBusan 609-735Korea

Porous carbon nitride(CN)spheres with partially crystalline frameworks have been successfully synthesized via a nanocasting approach by using spherical mesoporous cellular silica foams(mCFs)as a hard template,and ethylenediamine and carbon tetrachloride as *** resulting spherical CN materials have uniform diameters of ca.4μm,hierarchical three-dimensional(3-D)mesostructures with small and large mesopores with pore diameters centered at ca.4.0 and 43 nm,respectively,a relatively high BET surface area of~550 m^(2)/g,and a pore volume of 0.90 cm^(3)/***-resolution transmission electron microscope(HRTEm)images,wide-angle X-ray diffraction(XRD)patterns,and Raman spectra demonstrate that the porous CN material has a partly graphitized *** addition,elemental analyses,X-ray photoelectron spectra(XPS),Fourier transform infrared spectra(FT-IR),and CO_(2) temperature-programmed desorption(CO_(2)-TPD)show that the material has a high nitrogen content(17.8 wt%)with nitrogen-containing groups and abundant basic *** hierarchical porous CN spheres have excellent CO_(2) capture properties with a capacity of 2.90 mmol/g at 25℃and 0.97 mmol/g at 75℃,superior to those of the pure carbon materials with analogous *** can be mainly attributed to the abundant nitrogen-containing basic groups,hierarchical mesostructure,relatively high BET surface area and stable ***,the presence of a large number of micropores and small mesopores also enhance the CO_(2) capture performance,owing to the capillary condensation effect.

关键词： mesoporous materials carbon nitride nanocasting sphere hard template CO_(2)capture

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西格列汀调节FOXO3-FOXm1信号通路对肺癌细胞化疗敏感性的影响及机制研究

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河北医学 2024年第4期30卷 529-536页

作者：哈图锡林通嘎拉嗄梁秀平范惠芳陈海波内蒙古自治区人民医院内蒙古呼和浩特010017 内蒙古医科大学基础医学院内蒙古呼和浩特010110

目的:研究西格列汀(SIT)调节叉头框蛋白O3(FOXO3)-叉头蛋白m1(FOXm1)信号通路对肺癌细胞化疗敏感性的影响及机制。方法:体外培养人肺癌细胞A549及其顺铂(DDP)耐药细胞A549/DDP,均以0、0.5、1、2、3、4mmoL/L的SIT处理,以CCK-8法测定各组... 详细信息

目的:研究西格列汀(SIT)调节叉头框蛋白O3(FOXO3)-叉头蛋白m1(FOXm1)信号通路对肺癌细胞化疗敏感性的影响及机制。方法:体外培养人肺癌细胞A549及其顺铂(DDP)耐药细胞A549/DDP,均以0、0.5、1、2、3、4mmoL/L的SIT处理,以CCK-8法测定各组A549及A549/DDP细胞活力并筛选出SIT最佳作用浓度。将A549/DDP细胞随机分为对照组、SIT(2mmoL/L)组、si-NC组(转染空载质粒)、SIT(2mmoL/L)+si-FOXO3(转染FOXO3 siRNA质粒)组,以SIT和质粒分组处理的同时以0、2、4、8、16、32mg/L DDP处理,然后以CCK-8法测定各组细胞化疗耐药指数。将A549/DDP细胞随机分为对照组、SIT(2mmoL/L)组、DDP(4mg/L)组、DDP(4mg/L)+si-NC组、DDP(4mg/L)+SIT(2mmoL/L)组、DDP(4mg/L)+SIT(2mmoL/L)+si-FOXO3组,分组处理后分别以CCK-8法、克隆形成实验及流式细胞实验测定各组A549/DDP细胞增殖、凋亡;以免疫印迹法检测各组A549/DDP细胞增殖(C-myc、PCNA)、凋亡{Bax、cleaved多聚ADP核糖聚合酶(PARP)}、耐药{P-糖蛋白(P-gp)、多药耐药相关蛋白(mRP1)、mRP2、乳腺癌耐药蛋白(BCRP)}与用FOXO3-FOXm1通路相关蛋白表达。结果:与对照组相比,SIT组细胞化疗耐药指数降低(P0.05);与SIT组相比,SIT+si-FOXO3组细胞化疗耐药指数升高(Pmyc及PCNA蛋白表达降低(Pmyc及PCNA、P-gp、mRP1、mRP2、BCRP、FOXm1蛋白表达降低(PmRP1、mRP2、BCRP、FOXm1蛋白表达降低(Pmyc及PCNA、P-gp、mRP1、mRP2、BCRP、FOXm1蛋白表达降低(P0.05)。与DDP+SIT组相比,DDP+SIT+si-FOXO3组A549/DDP细胞活力、克隆形成率、C-myc及PCNA、P-gp、mRP1、mRP2、BCRP、FOXm1蛋白表达升高(Pm1信号传导而下调耐药蛋白表达,增强肺癌细胞化疗敏感性,进而提高DDP对肺癌DDP耐药细胞的杀伤作用。

关键词：肺癌西格列汀 FOXO3-FOXm1 化疗敏感性

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Application of powdered activated carbon coating to fabrics in a hybrid filter to enhance mercury removal

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Journal of Environmental Sciences 2019年第6期31卷 58-65页

作者： Jin-Ho Sung Seung-Ki Back Eun-Song Lee ha-Na Jang Yong-Chil Seo Youn-Suk Kang myong-Hwa Lee Department of Environmental Engineering Yonsei University J-E Tech Co. Ltd Department of Environmental Engineering Kangwon National University

Elemental mercury(Hg0) is predominant constituent of flue gas emitted from coal-fired power plants. Adsorption has been considered the best available technology for removal of Hg0 from flue gas. However, adsorbent injection increases the amount of ash generated. In the present study, powdered activated carbon(PAC) was coated on polytetrafluoroethylene/glass fiber filters to increase Hg0 removal while concurrently reducing the amount of ash generated. The optimal PAC coating rate was determined in laboratory experiments to ensure better Hg0 removal with low pressure drop. When PAC of particle size less than 45 μm was used, and the areal density was 50 g/m2, the pressure drop remained under 30 Pa while the Hg0 removal efficiency increased to 15.8% from4.3%. The Hg0 removal efficiency also increased with decrease in filtration velocity. The optimal PAC coating rate was applied on a hybrid filter(HF), which was combined with a bag filter and an electrostatic precipitator in a single chamber. Originally designed to remove fine particulates matter, it was retrofitted to the flue gas control device for simultaneous Hg0 removal. By employing the PAC coating, the Hg removal efficiency of the HF increased to 79.79% from 66.35%. Also, a temporary reduction in Hg removal was seen but this was resolved following a cleaning cycle in which the dust layer was removed.

关键词： mercury Hybrid filter Activated carbon Coating filter Coal-fired power plant

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上海地铁2号线车厢气流组织分析

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上海海事大学学报 2018年第2期39卷 55-59页

作者：郝胜男于凤娇郑学林上海海事大学商船学院上海201306

为研究用数值模拟方法分析地铁车厢环境的可行性,通过实测得到上海地铁2号线的车厢内温度和风速数据,利用CFD模拟其车厢气流组织。通过调整送风温度、送风速度和客流密度,得到满足人体舒适度的最佳送风参数:夏季满载时,送风温度为20℃,... 详细信息

为研究用数值模拟方法分析地铁车厢环境的可行性,通过实测得到上海地铁2号线的车厢内温度和风速数据,利用CFD模拟其车厢气流组织。通过调整送风温度、送风速度和客流密度,得到满足人体舒适度的最佳送风参数:夏季满载时,送风温度为20℃,送风速度为1.53 m/s;夏季超载时,送风温度为17℃,送风速度为2 m/s。本文形成了研究地铁车厢环境的完整体系,为上海地铁车厢气流组织优化设计以及舒适性研究提供参考。

关键词：上海地铁气流组织 CFD 送风温度送风速度

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Effects of moxibustion or moxa smoke on serum lipids and carotid plaque stability in atherosclerotic mice

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Journal of Traditional Chinese medical Sciences 2020年第3期7卷 325-332页

作者： Rui Zhang Lue ha Rui He Yueping Huang hao Wang Baixiao Zhao School of Acupuncture-moxibustion and Tuina Beijing University of Chinese MedicineBeijing100029China

Objective:To observe the effects of moxibustion or moxa smoke on serum lipids,aorta and liver pathology,and carotid plaque stability in ***:Fifty-four 8-week-old ApoE^-/- mice were randomly divided into three groups(untreated,moxibustion,and moxa smoke)and received a high-fat *** wild-type C57 BL/6 mice of the same age were used as *** intervention(none,moxibustion between the nipples,or 10 e15 mg/m^3 moxa smoke)was applied to restrained mice 20 min per day,six days per week,for 12 *** the end of the experimental period,we measured serum lipids and apolipoprotein,stained thoracic aortas and livers to observe pathological changes,and used immunohistochemical staining to assess the levels of a-smooth muscle actin,CD68,tumor necrosis factor-α,nuclear transcription factor-κB,and P38 mitogen-activated protein *** also measured the levels of matrix metalloproteinase-2 and 9 and tissue metalloproteinase ***:After 12 weeks,lipid metabolism disorder and atherosclerotic plaques were observed in the ApoE^-/- *** or moxa smoke reduced the levels of serum total cholesterol,triglycerides,low density lipoprotein,and very low density lipoprotein but did not affect the levels of high density lipoprotein,apolipoprotein A1,or oxidized low density *** or moxa smoke suppressed pathological changes in thoracic aortas and livers,increased fiber cap thickness,the fiber cap thickness/intimal medial thickness ratio,and collagen area percentage,and reduced extracellular *** with moxibustion or moxa smoke increased a-smooth muscle actin and reduced CD68 and the vulnerability index,suppressed tumor necrosis factor-α and nuclear transcription factor-κB expression,and did not affect P38 mitogen-activated protein kinase *** lowered the levels of matrix metalloproteinase-2 and 9 and increased those of tissue metalloproteinase ***:moxibustion or moxa smo

关键词： Atherosclerosis matrix metalloproteinase Vulnerability index Tissue metalloproteinase inhibitor

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Comparison of the meibomian gland dysfunction in patients with chronic ocular graft-versus-host disease and Sjogren's syndrome

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 393-400页

作者： Won Choi Jun Young ha Ying Li Jung han Choi Yong Sok Ji Kyung Chul Yoon Department of Ophthalmology and Research Institute of medical Sciences Chonnam National University Medical School and Hospital

AIm: To investigate the abnormalities in the meibomian gland in patients with dry eye disease(DED) associated with chronic ocular graft-versus-host disease(coGVHD) in comparison with Sj?gren's syndrome(SS), a major form of aqueous deficient DED and meibomian gland dysfunction(mGD), a common cause of evaporative ***: A total 135 eyes of 135 subjects included in this study: patients with DED associated with coGVHD(n=30), patients with SS(n=35), patients with mGD(n=35), and normal controls(n=35). All participants completed the Ocular Surface Disease Index(OSDI) questionnaire, ocular surface examination [Schirmer test, tear film breakup time(TFBUT), and ocular surface staining], and meibomian gland assessment [meiboscore(gland dropout detected on meibography using infrared camera of the Keratograph 5 m), meibum expressibility score(mES), meibum quality score(mQS), lid margin abnormality]. In addition, correlations of meibomian gland characteristics with ocular surface parameters as well as disease severity score were investigated in coGVHD ***: The coGVHD group showed significantly higher meiboscore, mES, and mQS than the other 3 groups(all Pmeters of meibomian gland showed a significant correlation each other and those of ocular surface. The correlation between meibomian gland parameters and severity score of co GVHD was also established(meiboscore, r=0.62; mES, r=0.47; mQS, r=0.47; lid margin abnormality score, r=0.55; all Pmorphology and worse glandfunction than other types of DED. In addition, meibomian gland damage is not only associated with ocular surface damage but also disease severity of coGVHD.

关键词： chronic ocular graft-versus-host disease Sjogren's syndrome dry eye disease meibomian gland dysfunction meibography

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