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Antioxidative, cytotoxic, and anti-metastatic potentials of Laurencia obtusa and Ulva lactuca seaweeds

Asian Pacific Journal of Tropical Biomedicine 2021年第7期11卷 308-316页

作者： Reem Al monla Yahya Salma Achraf Kouzayha Hala gali-muhtasib Zeina Dassouki Hiba mawlawi Laboratory of Applied Biotechnology(LBA3B) AZM Center for Research in Biotechnology and its ApplicationsDoctoral School for Sciences and TechnologyLebanese UniversityTripoliLebanon Department of Biology American University of BeirutLebanon Center for Drug Discovery American University of BeirutRiad El Solh 11072020BeirutLebanon

Objective:To investigate the antioxidant and cytotoxic properties of the most active extracts from Ulva lactuca and Laurencia obtusa against colon and cervical cancer cell ***:The antioxidant radical scavenging activity of the algal extracts was estimated using the 2,2-diphenyl-1-picrylhydrazyl colorimetric ***,the cytotoxic potential of these bioactive extracts was studied against HCT-116 and HeLa cells by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide *** healing analysis was adopted to evaluate the antimetastatic effects of protein extracts from both *** cycle analysis was performed by flow cytometry,and apoptotic bodies were detected using 4′,6-diamidino-2-phenylindole fluorescent *** acids of hydrolyzed protein extract were separated and identified chromatographically by high performance liquid ***:The green algae Ulva lactuca had higher lipid content than Laurencia obtusa,whereas the latter had higher protein content with high antioxidant *** extracts had significant dose-and time-dependent cytotoxicity and anti-metastatic activity against HCT-116 *** b extracts of both algae obtained from the chloroform:hexane solvent lipid-free residue caused morphological changes and induced apoptosis of HCT-116 *** analysis revealed that apoptosis induced upon Laurencia obtusa protein b treatment was triggered via the ROS pathway,causing a significant increase in the sub-G_(1) *** and arginine(5.94 and 5.47μm,respectively)were the most common amino acids in Laurencia obtusa protein b ***:Proteins of Laurencia obtusa and Ulva lactuca could be considered as an adjuvant nutraceutical source of pro-apoptotic and anti-metastatic biomolecules against colon cancer.

关键词： macroalgae Laurencia obtusa Ulva lactuca Reactive oxygen species Apoptosis

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Thymoquinone anticancer activity is enhanced when combined with royal jelly in human breast cancer

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World Journal of Clinical Oncology 2021年第5期12卷 342-354页

作者： maya m moubarak Nour Chanouha Najwa Abou Ibrahim Hala Khalife Hala gali-muhtasib Department of Biology American University of BeirutBeirut 1107-2020Lebanon Rammal Rammal Laboratory(ATAC group) Faculty of Sciences IHadath 1003Lebanon Department of Biology and Center for Drug Discovery American University of BeirutBeirut 1107-2020Lebanon

BACKGROUND Breast cancer is the most common cause of the majority of cancer-related deaths in women,among which triple-negative breast cancer is the most aggressive type of breast cancer diagnosed with limited treatment ***(TQ),the main bioactive constituent of Nigella sativa,has been extensively studied as a potent anticancer molecule against various types of *** products such as the royal jelly(RJ),the nutritive secretion fed to honeybee queens,exhibit a variety of biological activities besides its anticancer ***,the anticancer activity of the combination of TQ and RJ against breast cancer is still *** To investigate cytotoxicity of RJ in FHs 74 Int cells and the anticancer effects of TQ,RJ,and their combinations in the mDA-mB-231 cell *** Cells were treated with TQ,RJ,and their combinations for 24 *** 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,we determined the half-maximal inhibitory concentration of *** blue and 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays were then performed to assess the cell viability in response to different treatment *** death and cycle regulation were investigated using propidium iodide deoxyribonucleic acid staining followed by flow cytometry in response to a single dose of TQ,RJ,and their *** for cleaved caspase 3 and Ki67 expression was used to determine apoptosis induction and changes in cell *** TQ alone inhibited cell viability in a dose-dependent manner at concentrations below and above the half-maximal inhibitory *** exhibited relatively nontoxic effects against mDA-mB-231 cells and FHs 74 Int small intestinal cells at concentrations below 5μg/*** doses of RJ(200μg/mL)had greater toxicity against mDA-mB-231 ***,the inhibition of cell viability was most pronounced in response to 15μmol/L TQ and 5μg/mL RJ.A dose of 15μmol/L TQ caused a

关键词： Anticancer activity Breast cancer cells Drug combination Natural products Royal jelly Thymoquinone

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A planar defect spin sensor in a two-dimensional material susceptible to strain and electric fields

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npj Computational materials 2023年第1期9卷 775-782页

作者： Péter Udvarhelyi Tristan Clua-Provost Alrik Durand Jiahan Li James H.Edgar Bernard Gil Guillaume Cassabois Vincent Jacques Adam.gali Wigner Research Centre for Physics P.O.Box 49H-1525 BudapestHungary Budapest University of Technology and Economics Institute of PhysicsDepartment of Atomic PhysicsMűegyetem rakpart 3.1111 BudapestHungary Laboratoire Charles Coulomb Universitéde Montpellier and CNRS34095 MontpellierFrance Tim Taylor Department of Chemical Engineering Kansas State UniversityManhattanKS 66506USA

The boron-vacancy spin defect(V_(B)^(-))in hexagonal boron nitride(hBN)has a great potential as a quantum sensor in a two-dimensional material that can directly probe various external perturbations in atomic-scale proximity to the quantum sensing ***,we apply first-principles calculations to determine the coupling of the VB electronic spin to strain and electric *** work unravels the interplay between local piezoelectric and elastic effects contributing to the final response to the electric *** theoretical predictions are then used to analyse optically detected magnetic resonance(ODmR)spectra recorded on hBN crystals containing different densities of V_(B)^(-) *** prove that the orthorhombic zero-field splitting parameter results from local electric fields produced by surrounding charge *** work paves the way towards applications of V_(B)^(-) centres for quantitative electric field imaging and quantum sensing under pressure.

关键词： defect quantum boron

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An L-band emitter with quantum memory in silicon

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npj Computational materials 2022年第1期8卷 2498-2503页

作者： Péter Udvarhelyi Anton Pershin Péter Deák Adam.gali Wigner Research Centre for Physics P.O.Box 49H-1525BudapestHungary Budapest University of Technology and Economics Institute of PhysicsDepartment of Atomic PhysicsMűegyetem rakpart 3.1111BudapestHungary

Fluorescent centres in silicon have recently attracted great interest,owing to their remarkable properties for quantum ***,we demonstrate that the C-centre in silicon can realise an optically readable quantum register in the L-band wavelength region where the transmission losses in commercial optical fibres are *** in-depth theoretical characterisation confirms the assignment of the C-centre to the carbon-oxygen interstitial pair *** further explore its magneto-optical properties,such as hyperfine and spin-orbit coupling constants from first principles calculations,which are crucial for tight control of the quantum states of the triplet electron *** on this data,we set up quantum optics protocols to initialise and read out the quantum states of the electron spin,and realise a quantum memory by transferring quantum information from the electron spin to proximate ^(29)Si nuclear *** findings establish an optically readable long-living quantum memory in silicon where the scalability of qubits may be achieved by CmOS-compatible technology.

关键词： quantum centre optics

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Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients

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World Journal of Gastroenterology 2017年第10期23卷 1881-1890页

作者： Shira Zelber-Sagi Shiran Bord gali Dror-Lavi matthew Lee Smith Samuel D Towne Jr Assaf Buch muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet Department of Gastroenterology TelAviv Medical Center School of Public Health University of Haifa Institute of Gerontology College of Public HealthThe University of Georgia Texas A&m University School of Public HealthCollege Station The Sackler Faculty of medicine Tel-Aviv University Family medicine Department Tel-Aviv and Dan Petach-TikvaClalit Health ServicesRabin Medical Center Internal medicine A Galler medical Center Bar-Ilan University

To describe the relationships between non-alcoholic fatty-liver disease (NAFLD) patient’s disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle *** cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the Tel-Aviv medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsAg or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption (≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a self-report structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions (0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire (FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients’ illness perceptions, and assess the extent to which the data fit a prediction of nutritional *** study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years (range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. most of the study par

关键词： Non-alcoholic fatty-liver disease Physical activity Diet Illness perception Self-efficacy

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Effects of antibacterial compounds produced by Saccharomyces cerevisiae in Koumiss on pathogenic Escherichia coli O8 and its cell surface characteristics

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Journal of Integrative Agriculture 2017年第3期16卷 742-748页

作者： CHEN Yu-jie WANG Chun-jie HOU Wen-qian WANG Xiao-shuo gali Bing-ga HUASAI Si-mu-jide YANG Si-qin WU A-qi-ma ZHAO Yu-fei WU Ying-ga CHEN Ao-ri-ge-le Vocational and Technical College Inner Mongolia Agricultural University Baotou 014109 P.R. China College of Animal Science Inner Mongolia Agricultural university Hohhot 010018 P.R. China College of Veterinary medicine Inner Mongolia Agricultural University Hohhot 010018 P.R. China

The effects of antibacterial compounds produced by Saccharomyces cerevisiae in Koumiss on pathogenic Escherichia coli O8 and its cell surface characteristics were *** isolated from Koumiss produced antibacterial compounds which were active against pathogenic *** O8 as determined by the Oxford cup *** aqueous phases from *** at p H=2.0（S2）and pH=8.0（S8）were extracted and tested,*** organic acids of S2 and S8 were determined by high performance liquid chromatography（HPLC）,and the concentrations of killer toxins were determined by enhanced bicinchoninic acid（BCA）Protein Assay *** minimum inhibition concentration（mIC）and the minimum bactericidal concentration（mBC）of S2 and S8 on *** O8 were determined by the broth microdilution *** effects of S2 and S8 on the growth curve of *** O8 were determined by turbidimetry,and the hydrophobicities of *** O8 cell surface were determined using the microbial adhesion to solvents method,the permeation of *** O8 cell membrane were determined by the o-nitrophenyl-β-D-galactoside（ONPG）*** phases at pH 2.0 and 8.0had larger inhibition zones and then S2 and S8 were obtained by *** main component in S2 was citric acid and it was propanoic acid in *** organic acids and killer toxins were also *** the mICs of S2 and S8 on *** O8 were 0.025 g m L^-1,the mBCs were 0.100 and 0.200 g m L^-1,*** normal growth curve of *** O8was S-shaped,however,it changed after addition of S2 and *** O8 was the basic character,and had a relatively hydrophilic *** hydrophobicity of *** O8 cell surface and the permeation of *** O8 cell membrane were increased after adding S2 and *** present study showed that S2 and S8 inhibit the growth of pathogenic *** O8and influence its cell surface characteristics.

关键词： antibacterial compound Saccharomyces cerevisiae Escherichia coil hydrophobicity permeation

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糖尿病增加了人类缺血和非缺血心肌的细胞凋亡和坏死:caspase和多聚二磷酸腺苷-核糖聚合酶的作用

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 58-59页

作者： Chowdhry m.F. Vohra H.A. galianes m. 韩瑞娟 Cardiac Surgery Unit Department of Cardiovascular Sciences Glenfield Hospital Leicester United Kingdom Dr.

目的:糖尿病是心脏手术后发病率和死亡率的重要预测因素,但其原因仍不明确。因此,本研究旨在阐明人类缺血和非缺血糖尿病心肌的细胞死亡是否比非糖尿病心肌更多,并探讨潜在的机制。

关键词：糖尿病代谢病细胞凋亡 caspase 聚合酶多聚酶转肽酶人类核糖戊糖二磷酸腺苷

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Central and peripheral neurological involvement in monoclonal gammopathies of undetermined significance

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World Journal of Neuroscience 2013年第4期3卷 282-286页

作者： Edvina galiè maria Luisa Dell’ Acqua marta maschio Tatiana Koudriavtseva Emidio De marco Bruno Jandolo Division of Neurology Nuovo Ospedale Civile Sant’Agostino Estens Modena Italy Division of Neurology Regina Elena National CancerInstitute Roma Italy Division of Radiology Libera Università Campus Biomedico Roma Italy

Several studies have suggested a pathogenetic role of paraproteinaemias in PNS damage. Over the few last years, the presence of symptomatic or subclinical PNS lesions in CNS diseases like multiple sclerosis has been described. On the other hand, CNS demyelinating lesions and cervical atrophy have been re- ported in patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Very few cases of mGUS associated with CNS disease alone or with both CNS and PNS disease have been re- ported. Since 1999, we have been studying 16 patients (8 m, 8 F), with a mean age 60.2 ± 13.4, affected by mGUS associated with symptomatic neurological central and/or peripheral diseases. Patients affected with lymphomas, lupus erithematosus and other immunological diseases were excluded. Involvement of both PNS and CNS was not associated to a particular type of paraproteinemia: monoclonal Igm were found in 8 patients;monoclonal IgG in 6 patients and mono- clonal IgA in 1 patient and Igl in 1 patient. High anti- nervous system autoantibodies were found in 10/16 patients and antimAG antibodies were detected in patients with paraproteinemic demyelinating neuropathy (PDN). High reactivity anti-nervous system might support the hypothesis of a pathogenetic role of mGUS in these neurological diseases. Nevertheless, at present, we cannot exclude that there is only a circumstantial association between mGUS and neurological damages, particularly concerning CNS.

关键词： multiple Sclerosis (mS) monoclonal Gammopathies of Undetermined Significance (mGUS) Peripheral Nervous System (PNS) Involvement Nervous System (CNS) Involvement Central

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Functional optoacoustic neuro-tomography for scalable whole-brain monitoring of calcium indicators

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Light(Science & Applications) 2016年第1期5卷 288-294页

作者： X Luís Deán-Ben gali Sela Antonella Lauri moritz Kneipp Vasilis Ntziachristos Gil G Westmeyer Shy Shoham Daniel Razansky Institute for Biological and medical Imaging(IBmI) Helmholtz Center MunichNeuherbergGermany Institute of Developmental Genetics Helmholtz Center MunichNeuherbergGermany Department of medicine Technical University of MunichMunichGermany Department of Biomedical Engineering Technion-Israel Institute of TechnologyHaifaIsrael

Non-invasive observation of spatiotemporal activity of large neural populations distributed over entire brains is a longstanding goal of *** developed a volumetric multispectral optoacoustic tomography platform for imaging neural activation deep in scattering *** can record 100 volumetric frames per second across scalable fields of view ranging between 50 and 1000 mm^(3) with respective spatial resolution of 35–200μ*** performed in immobilized and freely swimming larvae and in adult zebrafish brains expressing the genetically encoded calcium indicator GCamP5G demonstrate,for the first time,the fundamental ability to directly track neural dynamics using optoacoustics while overcoming the longstanding penetration barrier of optical imaging in scattering *** newly developed platform thus offers unprecedented capabilities for functional whole-brain observations of fast calcium dynamics;in combination with optoacoustics'well-established capacity for resolving vascular hemodynamics,it could open new vistas in the study of neural activity and neurovascular coupling in health and disease.

关键词： functional neuro-imaging genetically encoded calcium indicators high spatiotemporal resolution large-scale brain activity optoacoustic tomography photoacoustics real-time imaging

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Ethnopharmacological Survey of Plants Used for the Treatment of Stomach,Diabetes,and Ophthalmic Diseases in Sudhan gali,Kashmir,Pakistan

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云南植物研究 2006年第5期28卷 535-542页

作者： muhammad Waseem m.Amin Ullah Shah Rizwana Aleem Qureshi Iqbal muhammad Rabia Afza Saeeda Yousaf World Wildlife Fund Pakistan Quaid-e-Azam University IslamabadPakistan Kohat University ofScience & Technology KohatPakistan University of Peshawar Pakistan

The present paper represents the ethnopharmacological survey of Sudhan gali,Kashmir,*** study revealed that 12 plant species belonging to 11 families were used for the treatment of stomach,diabetes and ophthalmic diseases by the local people in Sudhan *** millefolium,Aconitum heterophyllum,Berberis lycium,Polygonum amplexicaule,mentha longifolia,Paeonia emodi,Plantago lanceolata were locally used for stomach related problems treatment;Berberis lycium,Skimmia lareola,Solanum dulcamara for diabetes and Geranium wallichianum,Artemisia vulgaris,Solanum dulcamara,and Corydalis crassifolia used for the treatment of ophthalmic *** species Berberis lycium and Solanum dulcamara have multipurpose *** is used to treat stomach as well as diabetes while latter is used to treat not only to diabetes but also ophthalmic *** to IUCN categories,out of these 12 plant species collected and marketed,Polygonum amplexicaule and Paeonia emodi are endangered,Aconitum heterophyllum;Berberis lycium species are vulnerable while Plantago lanceolata and Skimmia lareola species are *** availability of these medicinal plants has decreased during the past 20 years and these are facing a drastic biotic pressure due to their extensive usage and non-scientific methods of *** is quite evident that these valuable native medicinal plants species are going to decline in number and ultimately will become extinct if no timely proper conservation strategies are adopted.

关键词： medicinal plants IUCN Biotic pressure Conservation Ethnopharmacology

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