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CLONINg AND ORgANIZATION OF BOVINE mETALLOTHIONEIN gENES

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Chinese Science Bulletin 1989年第11期34卷 953-956页

作者：沈孝宙杨卫民彭红 m.g.peterson J.F.B.mERCER SAVIO L.C.WOO Laboratories of Reproductive Biology and Department of Endocrinology Institute of Zoology Academia Sinica Beijing Birth Defects Research Institute Royal Children's Hospital Parkville Australia Department of Cell Biology Baylor College of Medicine Texas Medical Center Houston TX 77030 USA

I. INTRODUCTIONmetallothioneins(mT) are ubiquitously distributed in animal and plant kingdoms. They are cysteine-rich proteins that specifically bind heavy metal ions, such as cadmium, zinc, mercury and copper. The high expression of the mT gene could be induced by heavy metals in vitro and in vivo. The first transgenic mice obtained by Palmiter et al. in 1982 were introduced with an exogenous growth hormnoe gene

关键词： bovine metallothionein gene gene organization genomic cloning.

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牛金属硫蛋白基因的克隆及其组织结构的研究

科学通报 1988年第16期33卷 1267-1269页

作者：沈孝宙,杨卫民,彭红,m.g.peterson,J.F.B.mercer,Savio L.C.Woo 中国科学院动物研究所生殖生物学开放研究实验室中国科学院动物研究所生殖生物学开放研究实验室中国科学院动物研究所生殖生物学开放研究实验室澳大利亚皇家儿童医院澳大利亚皇家儿童医院美国贝勒医学院细胞生物系北京北京北京帕克威利帕克威利休斯敦

金属硫蛋白(metallothionein。简称mT)是广泛分布在动植物界的一组富含半胱氨酸的蛋白,能特异结合重金属,如镉、锌、汞和铜等。在生物体内,重金属离子可诱导mT基因的表达。1982年美国Palmiter等人首次成功地获得高效表达外源生长激素的... 详细信息

金属硫蛋白(metallothionein。简称mT)是广泛分布在动植物界的一组富含半胱氨酸的蛋白,能特异结合重金属,如镉、锌、汞和铜等。在生物体内,重金属离子可诱导mT基因的表达。1982年美国Palmiter等人首次成功地获得高效表达外源生长激素的“基因移植”

关键词：牛金属硫蛋白基因基因的组织结构基因组克隆

Integrated Single-cell multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation

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genomics, Proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： manickam Ashokkumar Wenwen mei Jackson J.peterson Yuriko Harigaya David m.murdoch David m.margolis Caleb Kornfein Alex Oesterling Zhicheng guo Cynthia D.Rudin Yuchao Jiang Edward P.Browne Department of medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA Department of genetics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of medicine Duke UniversityDurhamNC 27708USA Department of Computer Science Duke UniversityDurhamNC 27708USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA Department of Biology Texas A&M UniversityCollege StationTX 77843USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

Despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary CD4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXP1 and gATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal Primary CD4þT cell Single-cell multiomics HIV-regulating factor machine learning

Blood metal concentrations and cardiac structure and function in total joint arthroplasty patients

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World Journal of Orthopedics 2024年第8期15卷 773-782页

作者： Peter C Brennan Stephanie m peterson Thomas J O'Byrne mariana L Laporta Cody C Wyles Paul J Jannetto garvan C Kane maria Vassilaki Hilal maradit Kremers Department of Orthopedic Surgery Mayo ClinicRochesterMN 55905United States Department of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Department of Anesthesiology and Perioperative medicine Mayo ClinicRochesterMN 55905United States Department of Laboratory medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Cardiovascular Diseases Mayo ClinicRochesterMN 55905United States

BACKgROUND There is concern regarding potential long-term cardiotoxicity with systemic distribution of metals in total joint arthroplasty(TJA)*** To determine the association of commonly used implant metals with echocardiographic measures in TJA *** The study comprised 110 TJA patients who had a recent history of high chromium,cobalt or titanium *** underwent two-dimensional,three-dimensional,Doppler and speckle-strain transthoracic echocardiography and a blood draw to measure metal *** and sex-adjusted linear and logistic regression models were used to examine the association of metal concentrations(exposure)with echocardiographic measures(outcome).RESULTS Higher cobalt concentrations were associated with increased left ventricular end-diastolic volume(estimate 5.09;95%CI:0.02-10.17)as well as left atrial and right ventricular dilation,particularly in men but no changes in cardiac *** titanium concentrations were associated with a reduction in left ventricle global longitudinal strain(estimate 0.38;95%CI:0.70 to 0.06)and cardiac index(estimate 0.08;95%CI,-0.15 to-0.01).CONCLUSION Elevated cobalt and titanium concentrations may be associated with structural and functional cardiac changes in some *** studies are warranted to better understand the systemic effects of metals in TJA patients.

关键词： Total joint arthroplasty metal-on-metal Cardiotoxicity Heart failure Echocardiography Cobalt

An analysis of air pollution associated with the 2023 sand and dust storms over China:Aerosol properties and Pm_(10) variability

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geoscience Frontiers 2024年第2期15卷 155-168页

作者： mikalai Filonchyk michael P.peterson Lifeng Zhang Haowen Yan Faculty of geomatics Lanzhou Jiaotong UniversityLanzhou 730070China gansu Provincial Engineering Laboratory for National geographic State monitoring Lanzhou 730070China Department of geography/geology University of Nebraska OmahaOmahaNE 68182USA

Every spring,a large part of China is confronted with sand and dust storms(SDS)–mainly originating in the gobi(including Chinese and mongolian gobi)and Taklamakan *** march-April 2023,most of northern,northwestern and northeastern China was struck by three sandstorms that affected an area with more than 500 million *** this study,aerosol optical,microphysical and radiative properties were studied during these SDS events using an integrated approach that combines satellite,terrestrial and re-analysis *** results showed that dusty conditions were observed in most areas north of the Yangtze River(Chang Jiang)with daily average Pm_(10)concentrations exceeding 1000 lg/m^(3) in many *** aerosol optical depth(AOD)at 550 nm during three SDS events exceeded a value of 1 throughout nearly the entire northern part of the *** AERONET data obtained from the AOE_Baotou site showed a significant increase in total AOD and a corresponding decrease in AE during the *** single scattering albedo(SSA),asymmetry parameter(ASY),real refractive index(RRI)and imaginary refractive index(IRI)values indicate an abundance of scattering coarse-mode *** radiative forcing(ARF)at top of the atmosphere and at the earth’s surface was nearly always negative during the period and ranged from48.5 to+2.7 Wm^(-2)and from180.8 to66.6 Wm^(-2),resulting in high positive ARF values at ATm(from+63.8 to+132.3 Wm^(-2)).Each of these affects the heating of the atmosphere and cooling on the earth’s *** atmospheric heating rates ranged from 1.8 to 3.7 K day*** formation of these SDS mainly resulted from the passage of cold fronts associated with low pressure systems in the gobi and Taklamakan deserts,creating conditions for dust to rise into the atmosphere and move further downwind.

关键词： Dust storm Pm_(10) Aerosol optical depth Radiative forcing VIIRS AERONET

global wild rice germplasm resources conservation alliance:World Wild-Rice Wiring

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molecular Plant 2024年第4期17卷 516-518页

作者： Xiaoming Zheng Disna Ratnasekera Jiayu Fan Robert J.Henry Beng-Kah Song Kenneth m.Olsen Bal Krishna Joshi maria Celeste N.Banaticla-Hilario Tonapha Pusadee Adane getachew melaku Yeyinou Laura Estelle Loko Koukham Vilayheuang gavers K.Oppong Samuel Aduse Poku peterson W.Wambugu Song ge Aldo merotto Junior Ohn mar Aung Ramaiah Venuprasad Ajay Kohli Wenbin Zhou Qian Qian National Key Facility for Crop gene Resources and genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Sanya National Research Institute of Breeding in Hainan Chinese Academy of Agricultural SciencesBeijing 100081China International Rice Research Institute DAPO Box 7777Metro Manila 4031Philippines Department of Agricultural Biology Faculty of AgricultureUniversity of RuhunaMatara 81000Sri Lanka Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China Hainan University Haikou 570228China ARC Centre of Excellence for Plant Success in Nature and Agriculture University of QueenslandBrisbaneQLD4072Australia School of Science Monash University Malaysia47500 Bandar SunwaySelangor 47500Malaysia Department of Biology Washington University in St.LouisSt.LouisMO 63130-4899USA National Agriculture genetic Resources Center(genebank) KhumaltarPO Box 3055KathmanduNepal Plant Biology Division Insttute of Biological SciencesUniversity of the Pilippines Los BanosLos BanosLaguna 4031Philippines Division of Agronomy Department of Plant and Soil SciencesFaculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Bio and Emerging Technology Institute Addis Ababa 1165Ethiopia National University of Sciences TechnologiesEngineering and Mathematics(UNSTIM)Dassa-ZouméBP 14Benin National genebank Rice and Cash Crops Research CenterNAFRIVientiane 0605Lao PDR Plant Sciences and the Bioeconomy Rothamsted ResearchHarpenden AL52JQUK UK Future Food Beacon of Excellence and School of Biosciences and University of Nottingham Nottingham LE125RDUK Department of Plant and Environmental Biology University of GhanaAccraGhana Kenya Agricultural and Livestock Research Organization Genetic Resources Research InstituteNairobi 00200Kenya Institute of Botany Chinese Academy of SciencesBeijing 100093China Federal University of Rio grande do Sul UFRGSPorto Alegre 91501-970RSBrazil Department of Agricultur

Wild relatives of crop are key genetic resources serving as diversity reservoirs for crop improvement under changing ***(Oryza sativa)is one of the most important crops in the world,providing staple food for half of the world's *** rice is thus a critical germplasm resource for sustained global food security,ensuring high production yields,improved quality,and stress resistance in the face of climate *** rice is closely related to domesticated rice and has a rich genetic diversity and exceptional adaptability to extreme *** has played a pivotal role in the history of rice hybridization and has become a key resource for rice breeding *** identification of wild-type cytoplasmic male sterility resources paved the way for the achievement of the“three lines”goal in hybrid rice,leading to a significant increase in rice *** addition,the use of resistance alleles found in wild rice is making rice production more resilient to losses caused by environmental ***,wild rice germplasm resources are threatened due to habitat destruction and other anthropogenic *** the same time,the lack of centralized distribution of wild rice has hampered the sharing of basic information on wild rice resources and the utilization and conservation of wild rice in each country,as well as collaboration among scientists.

关键词： germplasm breeding crops

mining diversity of the natural biorefinery housed within Tipula abdominalis larvae for use in an industrial biorefinery for production of lignocellulosic ethanol

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Insect Science 2010年第3期17卷 303-312页

作者： Dana m. Cook Joy Doran-peterson microbiology Department University of Georgia Athens Georgia USA

Although they are the largest taxonomic group of animals, relatively few insects have been examined for symbiotic relationships with micro-organisms. However, this is rapidly changing because of the potential for examination of the natural insectmicrobe-lignocellulose interactions to provide insights for biofuel technology. micro-organisms associated with lignocellulose-consuming insects often facilitate the digestion of the recalcitrant plant diet; therefore these microbial communities may be mined for novel lignocellulose-degrading microbes, or for robust and inexpensive biocatalysts necessary for economically feasible biofuel production from lignocellulose. These insect-microbe interactions are influenced by the ecosystem and specific lignocellulose diet, and appre- ciating the whole ecosystem-insect-microbiota-lignocellulose as a natural biorefinery provides a rich and diverse framework from which to design novel industrial processes. One such natural biorefinery, the Tipula abdominalis larvae in riparian ecosystems, is reviewed herein with applications for biochemical processes and overcoming challenges involved in conversion of lignocellulosic biomass to fuel ethanol. From the dense and diverse T. abdominalis larval hindgut microbial community, a cellulolytic bacterial isolate, 27C64, demonstrated enzymatic activity toward many model plant polymers and also produced a bacterial antibiotic. 27C64 was co-cultured with yeast in fermentation of pine to ethanol, which allowed for a 20% reduction of commercial enzyme. In this study, a micro-organism from a lignocellulose-consuming insect was successfully applied for improvement of biomass-to-biofuel technology.

关键词： ethanol hydrolytic enzymes insect-associated microorganisms lignocellulose

An efficient method for unfolding kinetic pressure driven VISAR data

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High Power Laser Science and Engineering 2015年第3期3卷 50-58页

作者： m.Hess K.peterson A.Harvey-Thompson Sandia National Laboratories

Velocity Interferometer System for Any Reflector(VISAR) [Barker and Hollenbach, J. Appl. Phys. 43, 4669(1972)]is a well-known diagnostic that is employed on many shock physics and pulsed-power experiments. With the VISAR diagnostic, the velocity on the surface of any metal flyer can be found. For most experiments employing VISAR, either a kinetic pressure [grady, mech. mater. 29, 181(1998)] or a magnetic pressure [Lemke et al., Intl J. Impact Eng. 38,480(2011)] drives the motion of the flyer. moreover, reliable prediction of the time-dependent pressure is often a critical component to understanding the physics of these experiments. Although VISAR can provide a precise measurement of a flyer's surface velocity, the real challenge of this diagnostic implementation is using this velocity to unfold the timedependent pressure. The purpose of this paper is to elucidate a new method for quickly and reliably unfolding VISAR data.

关键词： laser driven blast wave pulsed-power VISAR

Stabilization of cubic ordering of zirconium dioxide nanoclusters on silicon with laser ablation

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Rare metals 2007年第S1期26卷 10-13页

作者： KUZ'mENKO A P peterson m B KUZ'mENKO N A ZAVODINSKY V g PUgACHEVSKY m A DOBROmYSLOV m B Laboratory Quantum Electronic & Laser Technology Pacific National University Institute for materials Science FEB RAS

Regimes of continuous and pulsed laser action on high-melting oxide compounds of ZrO2 were found with the aim of obtaining steady coatings on monocrystal silicon on laser ablation.X-ray phase analyses,scanning and atomic-force microscopy reveal that the coatings obtained are of nanocluster structure with the cubic *** this case the nanoclusters reach several hundreds of nanometers in *** assumption was made that on laser ablation of ZrO2 thermostabilization may take place where a minimum of the surface energy is attained just at cubic ordering.

关键词： laser ablation thermostabilization atomic-force microscopy nanocluster structure monocrystal silicon