CLONING AND ORGANIZATION OF BOVINE METALLOTHIONEIN GENES

作     者：沈孝宙 杨卫民 彭红 M.G.PETERSON J.F.B.MERCER SAVIO L.C.WOO 

作者机构：Laboratories of Reproductive Biology and Department of Endocrinology Institute of Zoology Academia Sinica Beijing Birth Defects Research Institute Royal Children's Hospital Parkville Australia Department of Cell Biology Baylor College of Medicine Texas Medical Center Houston TX 77030 USA 

出 版 物：《Chinese Science Bulletin》 (科学通报(英文版))

年 卷 期：1989年第34卷第11期

页      面：953-956页

核心收录：

学科分类：07[理学] 08[工学] 

基　　金：Project supported in part by a grant-in-aid from Rockefeller Foundation  New York 

主　　题：bovine metallothionein gene gene organization genomic cloning. 

摘      要：I. INTRODUCTIONMetallothioneins(MT) are ubiquitously distributed in animal and plant kingdoms. They are cysteine-rich proteins that specifically bind heavy metal ions, such as cadmium, zinc, mercury and copper. The high expression of the MT gene could be induced by heavy metals in vitro and in vivo. The first transgenic mice obtained by Palmiter et al. in 1982 were introduced with an exogenous growth hormnoe gene