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Excellent photoluminescence and electrochemical properties of Sm^(3+) doped Ca_(2)mgSi_(2)O_(7) nanophosphor:Display and electrochemical sensor applications

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Journal of Rare Earths 2024年第6期42卷 1046-1055,I0002页

作者： R.B.Basavaraj K.Sureshkumar D.p.Aarti m.B.madhusudana Reddy G.Nagaraju T.Ramakrishnappa G.R.Navyashree K.R.Venkatesha Babu K.S.Hemalatha Department of physics BMS Institute of Technology and ManagementBangalore560064India Department of Chemistry BMS Institute of Technology and ManagementBangalore560064India Department of Chemistry School of Applied SciencesREVA UniversityBangalore560064India Energy materials ResearchLaboratory Department of ChemistrySiddaganga Institute of TechnologyTumakuru57203KarnatakaIndia School of physical Sciences REVA UniversityBangalore560057Indi Department of physics Govt.Science CollegeBengaluru560001India Department of physics Maharani Science College for WomenMaharani Cluster UniversityBengaluru560001India

A series of orange-red light emitting Ca_(2)mgSi_(2)O_(7):Sm^(3+)nanopowders were fabricated via low-cost ecofriendly green combustion technique using Aloe vera gel as *** phase purity of the samples were confirmed by the powder X-ray diffraction(pXRD)*** single-phase tetragonal structure is observed from the pXRD results with no additional impurity *** band gap energy of the fabricated powders was estimated by diffuse reflectance spectra(DRS)and is found to be in the range of 4.01-5.98 eV.A high resolution scanning electron microscope(SEm)was used to study the morphological behaviour of the ***-like structures are observed from the SEm *** particle size was evaluated by transmission electron microscopy(TEm)and is found to be~50 *** interplanar distance is found to be 0.53 *** properties were systematically studied in *** phosphors are successfully excited at 403 nm NUV light,producing reddish-orange characteristic *** emission peaks are centered at 558(^(4)G_(5/2)→^(6)H_(5/2)),607(^(4)G_(5/2)→^(6)H_(7/2))and 645 nm(^(4)G_(5/2)→^(6)H_(9/2)),*** the observed peaks the red emanation(^(4)G_(5/2)→^(6)H_(7/2))is stronger than the orange emission(^(4)G_(5/2)→^(6)H_(5/2))in the current *** photoluminescent concentration quenching is noticed above 5 mol%Sm^(3+)ion doping *** dipole-dipole interaction resulting in cross relaxation is found to be the principal cause of concentration quenching *** color features such as Commission Internationale de I’Eclairage(CIE)and correlated color temperature(CCT)were studied in *** optimized chromaticity coordinates were estimated to be(0.6363,0.3632),which fall in the reddish-orange *** average CCT value obtained is 3362 *** average color purity is found to be~82%.Sm^(3+)incorporated Ca_(2)mgSi_(2)O_(7) samples are possible contender for single white light generation commercial candidates owing to

关键词： Green combustion photoluminescence Orange-red emission Color purity Sensors Rare earths

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QCD sum rule study of J^(p)=1^(±)exotic states with two heavy quarks in the molecular picture

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Chinese physics C 2024年第6期48卷 31-37页

作者： T.m.Aliev S.Bilmis m.Savcı Department of physics Middle East Technical UniversityAnkara06800Turkey TUBITAK ULAKBIm Ankara06510Turkey

In this study,the spectroscopic parameters of exotic molecular states composed of mesons containing two heavy quarks(scalar-axial and pseudoscalar-axial meson combinations)are investigated within the QCD sum *** findings reveal that molecular states containing charm quarks do not form bound states,whereas states with b-quarks can form exotic molecular *** observation has significant implications for understanding the structure of these exotic states.

关键词： QCD sum rules exotic mesons molecular states

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Integrated Single-cell multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation

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Genomics, proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： manickam Ashokkumar Wenwen mei Jackson J.peterson Yuriko Harigaya David m.murdoch David m.margolis Caleb Kornfein Alex Oesterling Zhicheng Guo Cynthia D.Rudin Yuchao Jiang Edward p.Browne Department of medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of medicine Duke UniversityDurhamNC 27708USA Department of Computer Science Duke UniversityDurhamNC 27708USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA Department of Biology Texas A&M UniversityCollege StationTX 77843USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

Despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary CD4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXp1 and GATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal primary CD4þT cell Single-cell multiomics HIV-regulating factor machine learning

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Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review

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Journal of pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth p.R.Vikram Tegginamath pramod Kumar Gunjan Kumar Narasimha m.Beeraka Rajashree Deka Sheik mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri padmanabhan Ravandur S.Chandan pramod Kumar Bannimath Gurupadayya Department of pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare pvt.Ltd. New Delhi110076India Department of pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(ApIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity mutagenicity molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

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A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres m.Angélica michea Ákos Végvári marion Arce Valentina pérez marcela Alcota Alicia morales Rolando Vernal mauricio Budini Roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and molecular pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SNCA,FTH1,HSpB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

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A novel diurnal and seasonal variation analysis of BTEX in Bengaluru urban area

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Research in Cold and Arid Regions 2024年第1期16卷 14-19页

作者： H.N.Sowmya m.Dinamani G.p.Shivashankara H.K.Ramaraju B.S.Surendra Vijaya V.Shanbhag R.prajwal Department of Civil Engineering Dayananda Sagar College of EngineeringBangalore 560078India Department of Chemistry Dayananda Sagar College of EngineeringBangalore 560078India Department of physics GFGCVijayanagarBengaluru 560040India

In the urban atmosphere of Bengaluru, various volatile organic compounds(VOCs), particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), have shown an increasing trend in concentration. The present research was conducted during summer and monsoon seasons, focusing on Kadubeesanahalli, a high-traffic area within the Bengaluru metropolitan City. Hourly sample data was collected using a BTEX analyzer(model GC955-600) and subsequently transformed into daily, monthly, and seasonal values. The study revealed distinct patterns in benzene concentrations. Benzene levels were lowest during the early morning hours, specifically from 1:00 *** 7:00 a.m.. Concentrations then increased from 7:00 a.m. to 9:00 a.m. and again from 4:00 p.m. to 11:00 p.m.,corresponding to the morning and evening peak traffic hours. However, between 10:00 a.m. and 4:00 p.m., the concentration decreased due to reduced traffic levels. These diurnal variations in benzene concentration are influenced by meteorological parameters. Comparing the two seasons, higher concentrations of Benzene, EthylBenzene, and mp-xylene were observed during the summer season. This increase is attributed to the elevated temperatures during summer, which promote the vaporization of BTEX compounds. Conversely, lower BTEX concentrations were recorded during the monsoon season due to the wet deposition process. The observed positive correlation(r > 0.5) among BTEX parameters strongly suggests a common source, most likely originating from vehicular emissions.

关键词： BTEX Summer variation meteorological parameters Correlation

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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany m.Zúñiga Forrest L.Baker Helena Batatinha Charles R.pedlar Shane C.Burgess michael p.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory medicine and pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of medicine The University of ArizonaTucsonAZ 85724USA Department of pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

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Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and Human Wellness 2024年第3期13卷 1608-1616页

作者： Hyo-Geun Lee H.H.A.C.K.Jayawardhana Fengqi Yang D.p.Nagahawaththa N.m.Liyanage Kyung-mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon min-Cheol Kang Department of marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food processing Korea Food Research InstituteWanju 55365Republic of Korea Department of pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

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Effects of site preparation methods on soil physical properties and outplanting success of coniferous seedlings in boreal forests

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Journal of Forestry Research 2024年第2期35卷 70-80页

作者： Aleksey S.Ilintsev Elena N.Nakvasina Alexander p.Bogdanov Northern Research Institute of Forestry 13 Nikitova Str.Arkhangelsk 163062Russian Federation Department of Silviculture and Forest management Northern(Arctic)Federal University Named After M.V.LomonosovSevernoy Dviny Emb.17Arkhangelsk 163002Russian Federation

This study assessed the effect of patch scarification and mounding on the physical properties of the root layer and the success of tree planting in various types of *** study was conducted on 12 forest sites in taiga forests of the European part of Russia.A total of 54 plots were set up to assess seedling survival;root collar diameter,height,and heigh increment were measured for 240 seedlings to assess *** the rooting layer,240 soil samples were taken to determine physical *** study showed that soil treatment methods had no effect on bulk density and total porosity in Cladina ***,reduced soil moisture was noted,particularly in mounds,resulting in increased *** myrtillus sites,there were increased bulk density,reduced soil moisture,and total porosity in the *** treatment in polytrichum sites resulted in reduced soil moisture and increased aeration *** the myrtillus and polytrichum sites,patch scarification had no effects on physical *** polytrichum sites,survival rates,heights,and heigh increments of bareroot Norway spruce seedlings in mounds were higher than in patches;however,the same did not apply to *** Cladina and myrtillus sites,there was no difference in growth for bareroot and containerised seedlings with different soil *** conditions and soil types should be considered when applying different soil treatment methods to ensure high survival rates and successful seedling growth.

关键词： Boreal forests mechanical site preparation patch scarification mounding Soil properties Containerised seedlings Bareroot seedlings

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Why and how to use the SeqCode

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mLife 2024年第1期3卷 1-13页

作者： Wiliam B.Whitman maria Chuvochina Brian p.Hedlund Konstantinos T.Konstantinidis marike palmer Luis m.Rodriguez-R lain Sutcliffe Fengping Wang Deparment of microbioogy University of GeorgiaAthensGeorgiaUAA Schoolof Chemistry and molecular Biosciences Australian CentreforEogenomicsThe Universty of QueenslandSt LuciaAustralia University of Nevada Las Vegas Las VegasNevadaUSA Schol of Civil and Environmental Engineering and School of Biological SciencesGeorgia Institute of TechnologyAtlantaGeorgiaUSA Department of microbiology University of ManitobaWinnipegManitobaCanada School of Life Sciences University of Nevada Las VegasLas VegasNevadaUSA Department of microbiology and Digital Science Center(DiSC) University of InnsbruckInnsbruckAustria Faculty of Health&Life Sciences Northumbria UniversityNewcastle upon TyneUK School of Oceanography International Center for Deep Life InvestigationShanghai Jiao Tong UniversityShanghaiChina

The SeqCode,formally called the Code of Nomenclature of prokaryotes Described from Sequence Data,is a new code of nomenclature in which genome sequences are the nomenclatural types for the names of prokaryotic *** similar to the International Code of Nomenclature of prokaryotes(ICNp)in structure and rules of priority,it does not require the deposition of type strains in international culture ***,it allows for the formation of permanent names for uncultured prokaryotes whose nearly complete genome sequences have been obtained directly from environmental DNA as well as other prokaryotes that cannot be deposited in culture *** the diversity of uncultured prokaryotes greatly exceeds that of readily culturable prokaryotes,the SeqCode is the only code suitable for naming the majority of prokaryotic *** start date of the SeqCode was January 1,2022,and the online Registry(https://***)was created to ensure valid publication of *** SeqCode recognizes all names validly published under the ICNp before *** that date,names validly published under the SeqCode compete with ICNp names for *** a result,species can have only one name,either from the SeqCode or ICNp,enabling effective communication and the creation of unified taxonomies of uncultured and cultured *** SeqCode is administered by the SeqCode Committee,which is comprised of the SeqCode Community and elected administrative *** with an interest in the systematics of prokaryotes is encouraged to join the SeqCode Community and participate in the development of this resource.

关键词： genome sequences metagenome-assembled genomes nomenclature SeqCode

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