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Journal of Geographical Sciences 2024年第3期34卷 543-570页

作者： DEDE Volkan DENGIZ Orhan DEmIraG tUraN inci tüRKES murat SENOL Hüseyin SERIN Soner Department of Geography Ardahan UniversityArdahan75002Türkiye Department of Soil Science and Plant Nutrition Faculty of AgricultureOndokuz Mayıs UniversitySamsun55139Türkiye Department of Geography Faculty of Human and Social SciencesSamsun UniversitySamsun55080Türkiye Center for Climate Change and Policy Studies Boğaziçi Universityİstanbul34342Türkiye Faculty of Agriculture Department of Soil Science and Plant NutritionIsparta University of Applied SciencesIsparta32200Türkiye Institute of Social Sciences İstanbul Universityİstanbul34119Türkiye

the main aims of the current study are to determine the morphological features of the periglacial landforms(non-sorted step,mud circle,stony earth circle,thufur,and congeliturbation)located on the Ilgaz mountains,examine the physicochemical and mineralogical properties with pedological processes of the soils,and assess of the effects of climatic conditions controlling the development of *** Ilgaz mountains(2587 m a.s.l.),located in the Western Black Sea Region,within the Anatolian mountains,are important in terms of periglacial landforms(mud circles,stony earth circles,thufurs,non-sorted steps,non-sorted stripes,congeliturbation deposits,and block currents).the descriptive statistics of 123 periglacial landforms measured by fieldworks were *** distribution of freezing and thawing in the Ilgaz mountains throughout the year was evaluated,and it was found that freezing takes place between December and march,freezing-thawing takes place in April,may,October and November,and thawing takes place between June and *** to soil properties,organic matter content changes from 1.88%to 12.72%in non-sorted step soils,while it is between 2.03%and 12.24%in stony earth circle *** organic matter is observed to be close to congeliturbation deposits at lower ratios compared to non-sorted steps,stony earth circles and mud *** soil reactions on stony earth circles and non-sorted steps vary between slightly acidic and slightly *** the other hand,soil samples taken from the mud circles are different from those taken from the non-sorted steps and stony earth *** soil reaction is acidic,and pH changes between 4.86 and *** lime content also varies between 2.81%and 32.08%,with an average of 12.02%.the texture properties of soils are dominantly loam and clay loam,as in the non-sorted steps,stony earth circles,and mud *** their mineralogical properties,the XRD study was carried out to determine the primer mineral

关键词： periglacial landforms soil formation climate effect Ilgaz mountains türkiye

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Dose-dependent effect of histamine on antibody generation in vivo

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Asian Pacific Journal of tropical medicine 2010年第2期3卷 112-116页

作者： tripathi t Shahid m Khan Hm Khan ra Siddiqui mU DePartment of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of microbiology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University

Objective:to delineate immunomodulatory role of histamine on antibody generation pr of ile in rabbit in the present dose-dependent histamine ***:the cohort comprised of three groups(Ⅲ,ⅣandⅤ),containing six rabbits each,and received subcutaneous histamine 50μg/kg×bis in die(b.i.d.),100μg/kg×*** 200μg/kg X b.i.d.,respectively for 10 days (starting from the 1st day).they were subsequently immunized on the 3rd day with intravenous injection of sheep blood cell(SRBC)(1×10 cells/mL).GroupⅡ(positive control)(n=6) received vehicle(sterile distilled water) and immunized at day 3 similarly while groupⅠ(negative control) (n=6) remained non-immunized and received only *** experimentations were performed in *** samples were collected on pre-immunization(pre-I)(day 0),as well as on days 7-,14-,21-,28- and 58- post-immunization(post-I).Immunological parameters[total immunoglobulins(Igs),Igm and IgG]were analyzed by enzyme linked immunosorbent assay (ELISA) ***:Histamine could influence a detectable antibody response to SRBC as early as day 7-post-I,which lasted until day 58- *** results were found statistically significant(P< 0.05).Conclusions:Our results provide evidence that histamine has a short-term effect on antibody generation(until its presence in the body),and the antibody generation titer in vivo were affected by the concentration of histamine.

关键词： Histamine Immumomodulation t-cell dependent antibody response Humoral immune response SRBC

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Biodiversity responses to insular fragmentation in Amazonia: two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim maíra Benchimol Danielle Storck-tonon Anderson S.Bueno Isabel L.Jones Gilmar Klein Carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal Laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICmBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams Landbridge Local extinctions Species-area relationships Species diversity tropical forests

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Is there a potential of circulating miRNAs as biomarkers in rheumatic diseases?

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Genes & Diseases 2023年第4期10卷 1263-1278页

作者： Klára Prajzlerová Ladislav Senolt mária Filková Institute of Rheumatology Prague 12800Czech Republic Department of Rheumatology First Faculty of MedicineCharles UniversityPrague 12800Czech Republic

t microRNAs(miRNAs)are small non-coding single-stranded RNAs of about 22 nucle-otides in length that act as post-transcriptional regulators of gene *** on the complementarity between miRNA and target mRNA,cleavage,destabilization,or transla-tional suppression of mRNA occurs within the RISC(RNA-induced silencing complex).As gene expression regulators,miRNAs are involved in a variety of biological *** of miRNAs and their target genes contribute to the pathophysiology of many diseases,including autoimmune and inflammatory *** are also present extracellularly in their sta-ble form in body *** incorporation into membrane vesicles or protein complexes with Ago2,HDL,or nucleophosmin 1 protects them against ***-free miRNAs can be deliv-ered to another cell in vitro and maintain their functional ***,miRNAs can be considered mediators of intercellular *** remarkable stability of cell-free miRNAs and their accessibility in body fluid makes them potential diagnostic or prognostic bio-markers and potential therapeutic *** we provide an overview of the potential role of circulating miRNAs as biomarkers of disease activity,therapeutic response,or diagnosis in rheumatic *** circulating miRNAs reflect their involvement in the pathogenesis,while for plenty,their pathogenetic mechanisms remain to be *** miRNAs described as biomarkers were also shown to be of therapeutic potential,and some miRNAs arealready tested in clinical trials.

关键词： Biomarker Diagnosis miRNA Rheumatic diseases therapy

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Ground-state mass of ^(22)Al and test of state-of-the-art ab initio calculations

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Chinese Physics C 2024年第3期48卷 72-78页

作者：孙铭泽于越王新鹏王猛李健国张玉虎 K.Blaum 陈祖毅陈瑞九邓涵宇付超义葛文文黄文嘉焦红扬李红蕙李宏福罗胤芳廖挺 YuALitvinov 司敏帅鹏史金阳王茜邢元明徐星徐瑚珊许甫荣袁琪 t.Yamaguchi 颜鑫亮杨建成原有进周小红周旭张敏曾奇 CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and technology University of Chinese Academy of SciencesBeijing 100049China max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany GSI Helmholtzzentrum für Schwerionenforschung Planckstraße 164291 DarmstadtGermany Advanced Energy Science and technology Guangdong Laboratory Huizhou516007China State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China Department of Physics Saitama UniversitySaitama 338-8570Japan School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

the ground-state mass excess of the t_(z)=−2 drip-line nucleus ^(22)Al is measured for the first time as 18103(10)keV using the newly-developed Bρ-defined isochronous mass spectrometry method at the cooler storage ring in *** new mass excess value allowed us to determine the excitation energies of the two low-lying 1+states in ^(22)Al with significantly reduced uncertainties of 51 *** compared to the analogue states in its mirror nucleus ^(22)F,the mirror energy differences of the two 1^(+)states in the ^(22)Al-^(22)F mirror pair are determined to be−625(51)keV and−330(51)*** excitation energies and mirror energy differences are used to test the state-of-the-art ab initio valence-space in-medium similarity renormalization group calculations with four sets of interactions derived from the chiral effective field *** mechanism leading to the large mirror energy differences is investigated and attributed to the occupation of theπs_(1/2) orbital.

关键词： nuclear mass Bρ-defined ImS mirror energy difference ab initio VS-ImSRG calculations chiral interactions

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radiolarian and Planktic Foraminifera Biostratigraphy of the Early Albian Organic Rich Beds of Fahdene Formation,Northern tunisia

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Journal of Earth Science 2014年第1期25卷 45-63页

作者： m Ben Fadhel t Zouaghi A Amri m Ben Youssef Département de Géologie Faculté des Sciences de Gafsa-Campus Universitaire Sidi Ahmed Zarrouk–2112 Département des Géoressources CERTE–Technopole de Borj Cédria

the lower part of Fahdene Formation outcropping in northeastern tunisia is repre- sented by pelagic sequences and characterized by an important siliciclastic fraction that includes ra- diolarian and organic-rich beds of Allam member. Litho-biostratigraphic analysis based on planktic foraminifera and radiolaria shows that deposition of organic-rich beds of Allam member is confined to the microhedbergella rischi Zone through the lower part of ticinella primula Zone. Age diagnostic radiolaria recovered from these beds has been identified to constrain a direct age of black shale depo- sition. the assemblages can be correlated with the radiolarian biochronozone U.A.10-11 indicating an Early Albian to early middle Albian in age. radiolarian assemblages composed of species characteris- tic of U.A.10 biochronozone （A. montisserei, D. gracilis） are associated with radiolarian taxa belonging to Costata Zone （U.A.9 Pseudoeucyrtis hanni and thanarla pseudodecora）, which can be correlated with Dercourt member in the Ionian Zone and Paquier level of the Vocontian Basin （southeast of France）. Biostratigraphic and abundance curves analysis has demonstrated significant diversification of cryptocephalic Nassellaria and Archaeodictyomitrae, probably adapted to eutrophic conditions that characterized the Aptian-Albian transition. Ecological conditions may have governed the stratigraphic range of many cosmopolitan taxa （i.e., Pseudodictyomitrae lodogaensis） compared with stratigraphic distributions schemes reported from other domains. the timing of black shales deposition was dia- chronic due to local geodynamic conditions and upwelling currents distribution. the Allam black shales are correlative with the oceanic anoxic event OAElb which is characterized by the widespread of supraregionnally organic-rich beds in the mediterranean tethys basins across the Aptian-Albian transition.

关键词： northeastern tunisia Albian Allam member black shale radiolaria planktic foraminifera.

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Numerical simulation of mHD natural convection flow in a wavy cavity filled by a hybrid Cu-Al2O3-water nanofluid with discrete heating

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Applied mathematics and mechanics(English Edition) 2020年第9期41卷 1345-1358页

作者： C.REVNIC t.GROSAN m.SHEREmEt I.POP Faculty of Pharmacy University of Medicine and PharmacyCluj-Napoca 400012Romania Department of mathematics Babes-Bolyai UniversityCluj-Napoca 400084Romania Department of theoretical mechanics Tomsk State UniversityTomsk 634050Russia

We consider the combined effect of the magnetic field and heat transfer inside a square cavity containing a hybrid nanofluid(Cu-Al2O3-water).the upper and bottom walls of the cavity have a wavy *** temperature of the vertical walls is lower,the third part in the middle of the bottom wall is kept at a constant higher temperature,and the remaining parts of the bottom wall and the upper wall are thermally *** magnetic field is applied under the angleγ,an opposite clockwise *** the numerical simulation,the finite element technique is *** ranges of the characteristics are as follows:the rayleigh number(10^3≤ra≤10^5),the Hartmann number(0≤Ha≤100),the nanoparticle hybrid concentration(ϕAl2O3,ϕCu=0,0.025,0.05),the magnetic field orientation(0≤γ≤2π),and the Prandtl number Pr,the amplitude of wavy cavity A,and the number of waviness n are fixed at Pr=7,A=0.1,and n=3,*** comparison with a reported finding in the open literature is done,and the data are observed to be in very good *** effects of the governing parameters on the energy transport and fluid flow parameters are *** results prove that the increment of the magnetic influence determines the decrease of the energy transference because the conduction motion dominates the fluid *** the rayleigh number is raised,the Nusselt number is increased,*** moderate rayleigh numbers,the maximum ratio of the heat transfer takes place for the hybrid nanofluid and then the Cu-nanofluid,followed by the *** nature of motion and energy transport parameters has been scrutinized.

关键词： magnetohydrodynamics natural convection hybrid nanofluid heat transfer bottom heater wavy top and bottom enclosure

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the influence of porosity on tablet subdivision

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Particuology 2020年第6期18卷 192-196页

作者： maira t.teixeira Livia L.Sa-Barreto Izabel C.Silva tais Gratieri Guilherme m.Gelfuso Ricardo N.marreto mariana Landin marcilio Cunha-Filho Laboratory of Food Drugs and Cosmetics(LTMAC)University of Brasilia(UnB)70910-900 BrasiliaDFBrazil Laboratory of Nanosystems and Drug Delivery Devices(NanoSYS) Federal University of GoiasGoianiaGO.Brazil Departamento de Farmacologia Farmacia y Tecnologia Farmaceutica1+D Farma Group(Gl-1645)Universidade de Santiago de CompostelaSpain

A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical ***,tablet subdivisions were studied as a functi on of tablet *** tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose ***,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of *** assays were corre lated to the subdivision performs *** increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the *** all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision *** in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision *** trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

关键词： tablet subdivision Porosity mass variation mass loss Friability Hardness

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A deep convolutional neural network for real-time full profile analysis of big powder diffraction data

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npj Computational materials 2021年第1期7卷 671-679页

作者： Hongyang Dong Keith t.Butler Dorota matras Stephen W.t.Price Yaroslav Odarchenko rahul Khatry Andrew thompson Vesna middelkoop Simon D.m.Jacques Andrew m.Beale Antonis Vamvakeros Department of Chemistry University College London20 Gordon StreetLondon WC1H 0AJUnited Kingdom ScimL Scientific Computer DivisionSTFCRutherford Appleton LaboratoryHarwell OX110QXUnited Kingdom Finden Limited Merchant House5 East St Helens StreetAbingdon OX145EGUnited Kingdom National Physical Laboratory Hampton RoadTeddington TW110LWUnited Kingdom Flemish Institute for technological Research VITO NVBoeretang 200Mol 2400Belgium Research Complex at Harwell Rutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotOX110FA OxfordshireUnited Kingdom Present address:Diamond Light Source Harwell Science and Innovation CampusDidcotOxfordshire OX110DEUnited Kingdom Present address:the Faraday Institution Quad OneHarwell Science and Innovation CampusOX110RA OxfordshireUnited Kingdom

We present Parameter Quantification Network(PQ-Net),a regression deep convolutional neural network providing quantitative analysis of powder X-ray diffraction patterns from multi-phase *** network is tested against simulated and experimental datasets of increasing complexity with the last one being an X-ray diffraction computed tomography dataset of a multi-phase Ni-Pd/CeO_(2)-ZrO_(2)/Al_(2)O_(3) catalytic material system consisting of ca.20,000 diffraction *** is shown that the network predicts accurate scale factor,lattice parameter and crystallite size maps for all phases,which are comparable to those obtained through full profile analysis using the Rietveld method,also providing a reliable uncertainty measure on the *** main advantage of PQNet is its ability to yield these results orders of magnitude faster showing its potential as a tool for real-time diffraction data analysis during in situ/operando experiments.

关键词： network powder analysis

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Lattice Boltzmann Simulation of magnetic Field Effect on Electrically Conducting Fluid at Inclined Angles in rayleigh-Bénard Convection

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Energy Engineering 2021年第1期118卷 15-36页

作者： t.Ahmed S.Hassan m.F.Hasan m.m.molla m.A.taher S.C.Saha Department of mathematics and Physics North South UniversityDhaka1229Bangladesh Center for Applied Scientific Computing(CASC) North South UniversityDhaka1229Bangladesh Department of Engineering&Physical Sciences La Trobe UniversityMelbourneVIC 3086Australia Department of mathematics Dhaka University of Science and TechnologyGazipurBangladesh School of mechanical and mechatronic Engineering University of Technology SydneyUltimoAustralia

the magneto-hydrodynamics(mHD)effect is studied at different inclined angles in rayleigh-Bénard(RB)convection inside a rectangular enclosure using the lattice Boltzmann method(LBm).the enclosure is filled with electrically conducting fluids of different *** characteristics are defined by Prandtl number,*** considered Pr values for this study are 10 and *** influence of other dimensionless parameters rayleigh numbers ra=10^(3);10^(4);10^(5);10^(6) and Hartmann numbers Ha=0,10,25,50,100,on fluid flow and heat transfer,are also investigated considering different inclined anglesφof magnetic field by analyzing computed local Nusselt numbers and average Nusselt *** results of the study show the undoubted prediction capability of LBm for the current *** simulated results demonstrate that the augmentation in heat transfer is directly related to ra values,but it is opposite while observing the characteristics of Ha ***,it is also found thatφhas a significant impact on heat transfer for different ***,isotherms are found to be always parallel to the horizontal axis at ra=10^(3) as conduction overcomes the convection in the heat transfer,but this behaviour is not seen at ra=10^(4) when Ha>***,at ra=10^(6),oscillatory instability appears but LBm is still able to provide a complete map of this predicted beha*** appropriate validation with previous numerical studies demonstrates the accuracy of the present approach.

关键词： Average rate of heat transfer Hartmann number lattice Boltzmann method magnetic field effect rayleigh-Bernard convection

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