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neurocircuit regeneration by extracellular matrix reprogramm.n.

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neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian n.Levasseur Kimberly m.Alonge Departm.n. of medicinal Chemistry University of WashingtonSeattleWAUSA Departm.n. of Chemistry University of WashingtonSeattleWAUSA Departm.n. of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosam.n.glycan(GAG)scaffolds,constitutes 20%-40% of the hum.n.brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programm.n.

Acid-treated carbon nanotubes and their effects on mortar strength

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Frontiers of Structural and Civil Engineering 2016年第2期10卷 180-188页

作者： m. ELKASHEF K. WAnG m.n. ABOU-ZEID Civil Construction and Environmental Engineering Department Iowa State University Ames IA 50011-2151 USA Construction and Architectural Engineering Departm.n. The American University in Cairo Egypt

In the present study, multi-walled carbon nanotubes （mWCnTs） were treated in an acidic mixture solution, made with nitric and sulfuric acids in a ratio of 3：1 by volume. The durations of the treatm.n. were 100 and 180 m.n. The defects of these treated mWCnTs were exam.n.d using Ram.n.spectroscopy. The attachm.n. of hydroxyl functional groups to the walls of the mWCnTs were verified using FTIR spectroscopy. The dispersion of CnTs with acid treatm.n. is assessed using UV-Vis spectroscopy and Scanning Electron microscopy （SEm）. The results indicate that the duration of the acid treatm.n. has significant effect on both the degree of defects and functionality of the mWCnT. The compressive strength of mortar increased with the addition of the acid-treated mWCnTs; however, no appreciable difference was noted for the two treatm.n. durations under this study.

关键词： carbon nanotubes concrete composites nanomaterials cem.n.

LASER HEAT TREATInG RESEARCH OF THREE KInDS OF HIGH SPEED STEEL

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Acta metallurgica Sinica(English Letters) 1999年第5期12卷 757-760页

作者： Liu, W.n. Fang, m.n. Xing, J. Liu, Y.W. Changchun Inst of Optics and Fine Mechanics Changchun China

After laser quenching and tempering of three kinds of annealed tool high-speed steel(W18Cr-4V, W9mo3Cr4V1, W6mo5Cr4V2) test samples, the microhardness measurer was used to test the samples and some problems, such as the hardness and depth of hardening-quenching layer were analyzed. Furthermore, after laser quenching and tempering of the quenched and three-time tempered high-speed steel (W18Cr4V) and its hardness analyzing, different results of laser-quenching samples were obtained under different initial heat-treating.

关键词： Hardening Heat treatm.n. Laser beam effects microhardness Phase transitions Quenching

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison n.DeVore marisol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Departm.n. of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to exam.n. the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairm.n.s to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

multiparametric Linear Programm.n. for Control

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

第二十七届中国控制会议

作者： morari m. Jones C.n. Zeilinger m.n. Bari m. Automatic Control Lab ETH ZurichPhysikstrasse 3ETL I28CH-8092 ZurichSwitzerland

ISBN: (纸本)9787811243901

Constrained finite time optimal control problems can be expressed as mathematical programs parameterized by the current state of the system:the so-called multi-parametric *** problems have received a great deal of attention in the control comm.n.ty during the last few years because solving the parametric program is equivalent to synthesizing the optimal state-feedback *** m.n. cases of interest,the resulting synthesized controllers are simple piecewise-affine functions,which enables receding horizon control to be used not only in slowly sampled systems requiring powerful computers but now also in high-speed embedded *** primary limitation of these optimal’explicit solutions’is that the complexity can grow quickly with problem *** this talk I will introduce new methods to compute approximate explicit and online control laws that can trade-off time and space complexity against sub-optimality while providing guarantees of stability and feasibility.

关键词： Parametric linear programm.n. Approximation Explicit model predictive control

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro martín-Belm.n.e Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Departm.n. of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatm.n. with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatm.n. of tamoxifen or matrix pellets as a control(placebo).We used von Frey m.n.filam.n.s and the“up-down method”to evaluate mechanical *** treatm.n. decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory am.n. acid transporter 1/glutamate aspartate transporter and excitatory am.n. acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory am.n. acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Gut virome:new key players in the pathogenesis of inflammatory bowel disease

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World Journal of methodology 2025年第2期15卷 27-43页

作者： Helal F Hetta Rehab Ahmed Yasm.n.n Ramadan Hayam Fathy mohammed Khorshid mohamed m mabrouk mai Hashem Departm.n. of medical microbiology and Imm.n.logy Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Departm.n. of Internal medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt Departm.n. of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt Departm.n. of Internal medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt Departm.n. of Tropical medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host imm.n.logical response,environm.n.al exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly am.n. individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral comm.n.ties in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developm.n.al axonal competition and synapse elim.n.tion

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura nadal marta Tomàs Carolina Silvera-Sim.n.m.n.l m.Santafé maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the developm.n. of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses perform.n. different activity levels leads to their elim.n.tion or *** have extensively studied the involvem.n. of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal developm.n. and synapse elim.n.tion process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developm.n.al synapse elim.n.tion,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvem.n. of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developm.n.al *** dynamic changes that occur simultaneously in several nerve term.n.ls and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the tim.n. and fate of the competitive interactions between the different axon *** downstream displacem.n. of the PKA/PKC activity ratio to lower values,both in competing nerve term.n.ls and at postsynaptic sites,plays a relevant role in controlling the elim.n.tion of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve term.n.ls)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elim.n.tion serine kinases tropomyosin-related kinase receptorB