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Waist Circumference Reference Values for Screening Cardiovascular Risk Factors in Chinese Children and Adolescents

Biomedical and Environmental Sciences 2010年第1期23卷 21-31页

作者： GUAN-SHENG mA CHENG-YE Ji JUN mA JiE mi R1TA YT SLiNG FENG XiONG WEi-Li YAN XiAO-Qi HU YAN-PiNG Li SONG-m1NG DU HONG-YUN FANG AND J1NG-XiONG JiANG National institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing100050 China institute of Child and Adolescent Health Peking gniversi07 Health Science Center Beijing100191 China Capital institute of Pediatrics Beijing 100020 China Department of Paediatrics TheChinese University of Hong Kong Hong Kong Special Administrative Re'on China The Children's Hospital of Chongqing medical University Chongqing 400014 China School of Public Health Xinjiang Medical University Wulumuqi 830011 Xinjiang China National Center for Women and Childre's Health Chinese Center for Disease Control and Prevention Beijing 100013 China

Objectives To explore the optimal threshold values of waist circumference （WC） for detecting cardiovascular （CV） risk factors among Chinese children and adolescents. methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China. CV risk factors in this study included hypertension （blood pressure above 95 percentile levels）, dyslipidemia （with one or more of the following three indexes： TG ≥ 1.7 mmol/L, TC ≥ 5.18 mmol/L, and HDL-C ≤ 1.04 mmol/L） and elevated glucose level （fasting plasma glucose ≥5.6 mmol/L）. Receive-operating characteristic analysis （ROC） and logistic regression were employed to derive optimal age- and sex-specific waist circumference references for predicting CV risk factors. Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population, while a remarkable increasing trend occurred from the 90th percentile. The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls, which was at the 90th percentiles for detecting at least two of the above three CV risk factors. in comparison with children with waist circumference below the 75th percentile, the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile, and increased by 6 times among children with waist circumference above the 90th percentile. The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by Bmi category. Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents, respectively.

关键词： Waist circumference Cardiovascular disease risk factor China

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文昌鱼内胚层调整能力的研究

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实验生物学报 1965年第4期 332-347页

作者：叶毓芬陆德裕童夙明中国科学院动物研究所上海第一医学院组织胚胎教研组北京

过去的作者认为文昌鱼卵子在很早的发育时期卵质已有分化。如 Conklin(1933)认为受精后各种器官形成物质已经决定,不能再有变化。Wilson(1893),morgan(1927)则谓卵质的分化是随着卵子的分裂进展的。最近童第周等(1958,1959,1961,1963)... 详细信息

过去的作者认为文昌鱼卵子在很早的发育时期卵质已有分化。如 Conklin(1933)认为受精后各种器官形成物质已经决定,不能再有变化。Wilson(1893),morgan(1927)则谓卵质的分化是随着卵子的分裂进展的。最近童第周等(1958,1959,1961,1963)的分离和配合分裂球的一系列实验

关键词：内胚层物质头部消化道胚胎下胚层解剖部位囊胚期脊索中胚层

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搭桥手术前使用他汀类药物可减少术后房颤的发生率并缩短房颤持续时间

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 31-31页

作者： Ozaydin m. Dogan A. Varol E. 罗亮 Sevket Demirel Kalp merkezi TR-32100 Isparta Turkey

背景：此项观察性研究旨在探讨术前使用或未使用他汀类药物治疗的搭桥手术患者的术后房颤（AF）发生率。方法和结果：研究对象由362例连续患者组成（267例术前使用他汀类药物，95例未使用）。他汀类药物治疗组中糖尿病更为常见（P=0．0... 详细信息

背景：此项观察性研究旨在探讨术前使用或未使用他汀类药物治疗的搭桥手术患者的术后房颤（AF）发生率。方法和结果：研究对象由362例连续患者组成（267例术前使用他汀类药物，95例未使用）。他汀类药物治疗组中糖尿病更为常见（P=0．03）。两组之间其他人口统计学及手术操作变量相似（所有P〉0．05）。与未用他汀类药物组比较，使用他汀类药物组的术后AF较少，持续时间也更短（分别为P=0．03和P=0．0001）。***-meier分析表明，他汀类药物对AF发生风险具有保护作用（P=0．01）。结论：搭桥手术前的他汀类药物治疗可降低术后AF的发生率并缩短其持续时间。

关键词：房颤持续时间他汀类药物术前使用搭桥手术发生率药物治疗人口统计学手术操作

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吸烟加剧慢性酒精性胰腺炎疾病的进展

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 43-43页

作者： maisonneuve P Lowenfels A.B mllhaupt B. 李翔 Epidemi ology Unit European Institute of Oncology Via Ripamonti 435 20141 Milan Italy.Dr

Background: Smoking is a recognised risk factor for pancreatic cancer and has been associated with chronic pancreatitis and also with type ii diabetes. Aims: The aim of this study was to investigate the effect of tobacco on the age of dia gnosis of pancreatitis and progression of disease, as measured by the appearance of calcification and diabetes. Patients: We used data from a retrospective coho rt of 934 patients with chronic alcoholic pancreatitis where information on smok ing was available,who were diagnosed and followed in clinical centres in five co untries. methods: We compared age at diagnosis of pancreatitis in smokers versus non-smokers, and used the Cox proportional hazards model to evaluate the effec ts of tobacco on the development of calcification and diabetes, after adjustment for age, sex, centre, and alcohol consumption. Results: The diagnosis of pancre atitis was made, on average, 4.7 years earlier in smokers than in non-smokers ( p = 0.001). Tobacco smoking increased significantly the risk of pancreatic calci fications(hazard ratio (HR) 4.9 (95%confidence interval (Cl) 2.3-10.5)for smok ers v non-smokers) and to a lesser extent the risk of diabetes (HR 2.3 (95%Cl 1.2-4.2)) during the course of pancreatitis. Conclusions: in this study, tobacc o smoking was associated with earlier diagnosis of chronic alcoholic pancreatiti s and with the appearance of calcifications and diabetes,independent of alcohol consumption.

关键词：慢性胰腺炎胰腺钙化胰腺肿瘤比例危险率模型临床中心发病年龄回顾性队列研究发病风险

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糖尿病孕妇剖宫产术后发生伤口并发症的风险

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 23-23页

作者： Takoudes T.C. Weitzen S. Slocum J. malee m. 石磊

This study was undertaken to examine the association be-tween pregestational diabetes mellitus(Dm)and wound complications after cesarean deliv ery(CD).This was a retrospective,observational cohort study in patients with type 1and 2Dm compared with non -Dmcontrols under-going *** complications were d efined as wound infection,wound separation greate r than 1cm,and wound *** was an overall incidence of wound complications of 18.4%(34/185)in Dm versus 5.8%(10/174)in non -Dm(unadjusted odds ratio of 3.7;95%Ci =1.8-7.7).mean body mass index before pregnancy was 30.9in Dm versus 26.5k g /m 2 in non -Dm(Pmultivariable logistic regression model adjusting for body mass index,length of surgery,and previous CD demonstrated a 2.5-fold increased risk of wound complications in Dm patients c ompared with non -Dm patients(95%Ci =1.1-5.5).Pregestational dia-betes is associated with a 2.5-fold i ncrease in wound complications after CD.

关键词：剖宫产术糖尿病孕妇伤口感染手术时间平均体重指数回顾性队列研究模型校正伤口裂开

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三维评估2型糖尿病、舒张功能障碍和正常射血分数患者的左心室收缩张力

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 30-30页

作者： Fonseca C. G. Dissanayake A. m. Doughty R.N. 郭宁

Left ventricular(LV) diastolic dysfunction often occurs in patients with type 2 diabetes mellitus(Dm) independent of atherosclerotic coronary artery disease, myocardial ischemia, and regional wall motion anomalies. Limited information exi sts on LV myocardial tissue strain in this patient group. We measured 3-dimensi onal(3-D) parameters of LV systolic and diastolic functions in 28 patients who had type 2 Dm(age 33 to 70 years), standard echocardiographic evidence of LV dia stolic dysfunction, and normal LV ejection fraction, and 31 normal control subje cts(age 19 to 74 years) who had no evidence of cardiac disease, with multislice cine anatomic and tagged magnetic resonance imaging. Three-dimensional analysis of the resulting images showed that peak systolic mitral valve plane displaceme nt was 12%smaller(p=0.040) and peak diastolic mitral valve plane velocity was 2 1%lower(p=0.008) in patients who had Dm than in normal controls. Peak systolic circumferential and longitudinal strains and principal 3-D shortening strain we re 14%, 22%, and 10%smaller, respectively, in the Dm group (pdiastolic rate of relaxation of circumferential and longitudinal strains and principal 3-D shortening strain were 35%, 32%, and 33%lower, respective ly, in the Dm group(pic circumferential, longi tudinal and 3-D principal strains, and diastolic strain rates are impaired in p atients who have type 2 Dm, LV diastolic dysfunction, and normal LV ejection fra ction.

关键词：舒张功能障碍射血分数心室收缩三维成像室壁运动速度降低舒张期磁共振成像肌组织超声心动图

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