三维评估2型糖尿病、舒张功能障碍和正常射血分数患者的左心室收缩张力

作     者：Fonseca C. G. Dissanayake A. M. Doughty R.N. 郭宁 

出 版 物：《世界核心医学期刊文摘（心脏病学分册）》 (Digest of the World Core Medical Journals(Cardiology))

年 卷 期：2005年第1卷第4期

页      面：30-30页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：舒张功能障碍 射血分数 心室收缩 三维成像 室壁运动 速度降低 舒张期 磁共振成像 肌组织 超声心动图 

摘      要：Left ventricular(LV) diastolic dysfunction often occurs in patients with type 2 diabetes mellitus(DM) independent of atherosclerotic coronary artery disease, myocardial ischemia, and regional wall motion anomalies. Limited information exi sts on LV myocardial tissue strain in this patient group. We measured 3-dimensi onal(3-D) parameters of LV systolic and diastolic functions in 28 patients who had type 2 DM(age 33 to 70 years), standard echocardiographic evidence of LV dia stolic dysfunction, and normal LV ejection fraction, and 31 normal control subje cts(age 19 to 74 years) who had no evidence of cardiac disease, with multislice cine anatomic and tagged magnetic resonance imaging. Three-dimensional analysis of the resulting images showed that peak systolic mitral valve plane displaceme nt was 12%smaller(p=0.040) and peak diastolic mitral valve plane velocity was 2 1%lower(p=0.008) in patients who had DM than in normal controls. Peak systolic circumferential and longitudinal strains and principal 3-D shortening strain we re 14%, 22%, and 10%smaller, respectively, in the DM group (p 0.001 for each ). Peak diastolic rate of relaxation of circumferential and longitudinal strains and principal 3-D shortening strain were 35%, 32%, and 33%lower, respective ly, in the DM group(p 0.001 for each). Thus, LV systolic circumferential, longi tudinal and 3-D principal strains, and diastolic strain rates are impaired in p atients who have type 2 DM, LV diastolic dysfunction, and normal LV ejection fra ction.