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Evaluating implicit gender bias at Canadian otolaryngology meetings through use of professional title

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 12-17页

作者： Kylen Van Osch Agnieszka Dzioba Khadija Ahmed Andrew macDonald Jamila Skinner Harley Williams Julie E.Strychowsky m.elise graham Department of Otolaryngology-Head&Neck Surgery Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada Department of Otolaryngology London Health Sciences Centre Children's HospitalLondonOntarioCanada Faculty of medicine Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada

Objectives:Increasing numbers of women enter medical school *** number of female physicians in leadership positions has been much slower to *** are also well‐documented differences in the treatment of women as compared to men in professional *** presenters are less likely to be introduced by their professional title(“Doctor”)for grand rounds and conferences,especially with a man performing the *** study reviewed the Canadian Society of Otolaryngology–Head and Neck Surgery(CSOHNS)meetings from 2017 to 2020 to determine the proportion of presenters introduced by their professional title and whether this varied by ***:Recordings from CSOHNS meetings were reviewed and coded for introducer and presenter demographics,including leadership positions and ***‐squared tests of proportion and multivariate logistic regression was used to compare genders and identify factors associated with professional versus unprofessional forms of ***:No significant association was found between professional title use and introducer or presenter *** presenters were introduced with professional title 69.6%of the time,while male presenters were introduced with professional title 67.6%of the time(P=0.69).Residents were introduced with a professional title with the most frequency(75.8%),while attending staff were introduced with a professional title with the least frequency(63.0%)(P=0.02).Conclusions:The lack of gender bias in speaker introductions at recent CSOHNS meetings demonstrates progress in achieving gender equity in *** efforts should continue to define additional forms of unconscious bias that may be contributing to gender inequity in leadership positions.

关键词： attitude of health personnel gender identity Otolaryngology women

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Genomic mosaicism of the Brain:Origin,Impact,and Utility

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Neuroscience Bulletin 2024年第6期40卷 759-776页

作者： Jared H.graham Johannes C.m.Schlachetzki Xiaoxu Yang martin W.Breuss Department of Pediatrics Section of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Department of Cellular and molecular medicine University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Department of Neurosciences University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady Children’s Institute for Genomic medicine San Diego92123CAUSA

Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic ***,research focused on the impact of genomic mosaicism on clinical phenotype—motivated by its involvement in cancers and overgrowth *** recently,we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of cellular lineage and environmental ***,we summarize the current state of the field of genomic mosaicism research with a special emphasis on our current understanding of this phenomenon in brain development and *** the field of genomic mosaicism has a rich history,technological advances in the last decade have changed our approaches and greatly improved our *** will provide current definitions and an overview of contemporary detection approaches for genomic ***,we will discuss the impact and utility of genomic mosaicism.

关键词： Genomics Brain development Brain homeostasis Genomic mosaicism

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Adaptation in brain structure and respiratory and olfactory structures across environmental gradients in African and North American muroid rodents

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Integrative Zoology 2024年第1期19卷 165-181页

作者： Peter J.TAYLOR Aluwani NENGOVHELA Christiane DENYS graham R.SCOTT Catherine m.IVY Department of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Afromontane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Department of mammalogy National MuseumBloemfonteinSouth Africa Institut de Systématique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Department of Biology McMaster UniversityHamiltonOntarioCanada Guglielmo and Shoemaker Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

morphometric studies of 3D micro CT-scanned images can provide insights into the evolution of the brain and sensory structures but such data are still scarce for the most diverse mammalian order of *** reviewed and new data,we tested for convergence to extreme aridity and high elevation in the sensory and brain morphology of rodents,from morphometric data from micro-CT X-ray scans of 174 crania of 16 species of three distantly re-lated African murid(soft-furred mice,Praomyini,laminate-toothed rats,Otomyini,and gerbils,Gerbillinae)clades and one North American cricetid(deer mice and white-footed mice,Peromyscus)*** studies demon-strated convergent evolution acting on the oval window area of the cochlea(enlarged in extremely arid-adapted species of Otomyini and Gerbillinae)and on endocranial volume(reduced in high elevation taxa of Otomyini and Peromyscus).However,contrary to our predictions,we did notfind evidence of convergence in brain struc-ture to aridity,or in the olfactory/respiratory system(turbinate bones)to high *** structure differed,particularly in the petrosal lobules of the cerebellum and the olfactory bulbs,between Otomyini and Gerbillinae,with extreme arid-adapted species in each clade being highly divergent(not convergent)from other species in the same *** observed greater“packing”of the maxillary turbinate bones,which have important respiratory functions,in Peromyscus mice from high and low elevations compared to the high-elevation African Praomyini,but more complex patterns within Peromyscus,probably related to trade-offs in respiratory physiology and heat exchange in the nasal epithelium associated with high-elevation adaptation.

关键词： 3D morphometrics Africa brain size North America Rodentia sensory evolution

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Experimental Investigation of Thermal Performance of Novel Finned Radiators for Automotive Cooling System

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Journal of Thermal Science 2024年第5期33卷 1726-1743页

作者： SINGH Hardeep TING David S-K READER graham ESHTIAGHI Nicky ICHIYANAGI mitsuhisa SUZUKI Takashi Turbulence&Energy Laboratory University of WindsorWindsor N9B 3P4Canada Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia Department of Engineering and Applied Sciences Sophia UniversityTokyo 102-8554Japan

This research investigates innovative fin-type radiators for automobile engine cooling ***-channel and helical radiators,along with straight type,were analyzed for heat transfer characteristics under various *** uniqueness of this study is evident in the design of microchannel and helical *** helical radiators,the inner rod features 4/8 helical-shaped water galleries,while the outer tube frame with embedded fins remains *** contrast,the microchannel radiators have compact trapezoidal-shaped water galleries with separate fin ***,the novelty of the research is enhanced by the utilization of 3D printing technology in the manufacturing *** constant fin height analysis at varied water and air flow rate,microchannel Water Air Radiator with fin height 10.5 mm(mCWAR10.5)depicted a higher heat transfer rate amongst the *** comparison to Straight Water Air Radiator with fin height 9.5 mm(SWAR9.5),the heat transfer rate is 30.3%and 1.3 times ***,in constant fin surface area analysis,microchannel radiator(mCWAR3.2)illustrates lower heat dissipation than Helical radiator(HWAR138)but higher than HWAR134 and Straight radiator(SWAR6).The examination of pumping loss indicated that the micro-channel radiator outperformed helical radiators due to its lower pressure *** average pressure loss for micro-channel radiators was 0.74 kPa,making it 1.2 times higher than that of a straight radiator(0.62 kPa),indicating a better trade-off.

关键词： heat exchangers multi-channel helical heat exchanger heat transfer 3D printing

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A simple modification to the classical SIR model to estimate the proportion of under-reported infections using case studies in flu and COVID-19

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Infectious Disease modelling 2024年第4期9卷 1147-1162页

作者： Leonid Kalachev Jon graham Erin L.Landguth mathematical Sciences University of MontanaMissoulaUSA Center for Population Health Research School of Public and Community Health SciencesUniversity of MontanaMissoulaUSA

Background:Under-reporting and,thus,uncertainty around the true incidence of health events is common in all public health reporting *** the problem of underreporting is acknowledged in epidemiology,the guidance and methods available for assessing and correcting the resulting bias are ***:We aim to design a simple modification to the Susceptible e Infected e Removed(SIR)model for estimating the fraction or proportion of reported infection ***:The suggested modification involves rescaling of the classical SIR model producing its mathematically equivalent version with explicit dependence on the reporting parameter(true proportion of cases reported).We justify the rescaling using the phase plane analysis of the SIR model system and show how this rescaling parameter can be estimated from the data along with the other model ***:We demonstrate how the proposed method is cross-validated using simulated data with known disease cases and then apply it to two empirical reported data sets to estimate the fraction of reported cases in missoula County,montana,USA,using:(1)flu data for 2016e2017 and(2)COVID-19 data for fall of ***:We establish with the simulated and COVID-19 data that when most of the disease cases are presumed reported,the value of the additional reporting parameter in the modified SIR model is close or equal to one,so that the original SIR model is appropriate for data ***,the flu example shows that when the reporting parameter is close to zero,the original SIR model is not accurately estimating the usual rate parameters,and the re-scaled SIR model should be *** research demonstrates the role of under-reporting of disease data and the importance of accounting for underreporting when modeling simulated,endemic,and pandemic disease *** reporting the“true”number of disease cases will have downstream impacts on predictions of disease dynamics.A simple parameter adjustment

关键词： modeling of epidemics SIR type models flu and COVID-19 Under-reporting parameter Proportion of reported disease cases

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machine learning modeling for fuel cell-battery hybrid power system dynamics in a Toyota mirai 2 vehicle under various drive cycles

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Energy and AI 2024年第3期17卷 406-418页

作者： Adithya Legala matthew Kubesh Venkata Rajesh Chundru graham Conway Xianguo Li Southwest Research Institute San AntonioTXUSA Department of mechanical and mechatronics Engineering University of WaterlooWaterlooOntarioCanada

Electrification is considered essential for the decarbonization of mobility sector, and understanding and modeling the complex behavior of modern fuel cell-battery electric-electric hybrid power systems is challenging, especially for product development and diagnostics requiring quick turnaround and fast computation. In this study, a novel modeling approach is developed, utilizing supervised machine learning algorithms, to replicate the dynamic characteristics of the fuel cell-battery hybrid power system in a 2021 Toyota mirai 2nd generation (mirai 2) vehicle under various drive cycles. The entire data for this study is collected by instrumenting the mirai vehicle with in-house data acquisition devices and tapping into the mirai controller area network bus during chassis dynamometer tests. A multi-input - multi-output, feed-forward artificial neural network architecture is designed to predict not only the fuel cell attributes, such as average minimum cell voltage, coolant and cathode air outlet temperatures, but also the battery hybrid system attributes, including lithium-ion battery pack voltage and temperature with the help of 15 system operating parameters. Over 21,0000 data points on various drive cycles having combinations of transient and near steady-state driving conditions are collected, out of which around 15,000 points are used for training the network and 6,000 for the evaluation of the model performance. Various data filtration techniques and neural network calibration processes are explored to condition the data and understand the impact on model performance. The calibrated neural network accurately predicts the hybrid power system dynamics with an R-squared value greater than 0.98, demonstrating the potential of machine learning algorithms for system development and diagnostics.

关键词： Artificial neural network(ANN) Proton exchange membrane fuel cell(PEmFC) Fuel cell electric vehicle(FCEV) Fuel cell-battery electric-electric hybrid power system Data based models Lithium-ion battery(LiB)

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The variation of DOm during long distance water transport by the China South to North Water Diversion Scheme and impact on drinking water treatment

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 85-100页

作者： Hankun Yang Yujuan Li Hongyu Liu Nigel J.D.graham Xue Wu Jiawei Hou mengjie Liu Wenyu Wang Wenzheng Yu State Key Laboratory of Environmental Aquatic Chemistry Key Laboratory of Drinking Water Science and TechnologyResearch Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China School of Environment and municipal Engineering Qingdao Technological UniversityQingdao266033China Colleges of Forestry Northeast Forestry UniversityHarbin150006China Department of Civil and Environmental Engineering Imperial College LondonSouth Kensington CampusLondonSW7 2AZUK School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing100081China State Key Laboratory of Separation membrane Processes School of Environment Science and EngineeringTiangong UniversityTianjin300387China

In this study,samples were taken from three locations,upstream to downstream,along the central route project of the China South to North Water Diversion(SNWD)scheme in summer and *** were used to reveal the variations of dissolved organic matter(DOm)during the water transfer process,and the effects of these variations on drinking water treatment and disinfection by-products formation potential(DBPs-FP).The results showed that polysaccharides accumulate in summer and reduce in winter with flow distance,which has an important effect on the overall properties of DOm,as well as on the performance of coagulation,ultrafiltration,and the formation of *** substances,and their hydrophilic content,also increased in summer and decreased in winter with flow *** contrast,the concentration of small organic substances(mW≤1000 Da)increased in both summer and winter with flow distance,which affected both nanofiltration(NF)membrane fouling and *** results provide a useful case study of spatial and temporal changes in raw water DOm during long distance water transfer and their impact on the treatment and quality of drinking water from the SNWD.

关键词： Long-distance water transfer The China South to North Water Diversion Scheme Coagulation membrane filtration Disinfection by-products

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Efficiency of a modular Cleanroom for Space Applications

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Fluid Dynamics & materials Processing 2024年第3期20卷 547-562页

作者： matthew R.Coburn Charlie Young Chris Smith graham Schultz miguel Robayo Zheng-Tong Xie Faculty of Engineering and Physical Sciences University of SouthamptonSouthamptonSO171BJUK Plastron UK Ltd. Westcott Venture ParkWestcottHP180XBUK Renewable Energy Group University of ExeterExeterTR109FEUK

A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of *** Reynolds Averaged Navier-Stokes(URANS)models have been used to study the related flow field and particulate matter(Pm)*** outcomes of the URANS models have been validated through comparison with equivalent large-eddy *** attention has been paid to the location and shape of the air intakes and their orientation in space,in order to balance the Pm convection and diffusion inside the *** a cyclone-type flow pattern inside the cleanroom is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES Pm RANS unsteady flow exponential decay

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Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1596-1612页

作者： Hamzah Z Farooq michael James Jane Abbott Patrick Oyibo Pip Divall Naheed Choudhry graham R Foster Blizard Institute Queen Mary University of LondonLondon E12ATUnited Kingdom School of Health and Psychological Sciences University of LondonLondon EC1V 0HBUnited Kingdom University Hospitals of Leicester Library University Hospitals of Leicester NHS TrustLeicester LE39QPUnited Kingdom

BACKGROUND Hepatitis C virus(HCV)is a blood-borne virus which globally affects around 79 million people and is associated with high morbidity and *** infection leads to cirrhosis in a large proportion of patients and often causes hepatocellular carcinoma(HCC)in people with *** the 6 HCV genotypes(G1-G6),genotype-3 accounts for 17.9%of *** genotype-3 responds least well to directly-acting antivirals and patients with genotype-3 infection are at increased risk of HCC even if they do not have *** To systematically review and critically appraise all risk factors for HCC secondary to HCV-G3 in all ***,we studied possible risk factors for HCC due to HCV-G3 in the literature from 1946 to *** This systematic review aimed to synthesise existing and published studies of risk factors for HCC secondary to HCV genotype-3 and evaluate their strengths and *** searched Web of Science,medline,EmBASE,and CENTRAL for publications reporting risk factors for HCC due to HCV genotype-3 in all settings,*** Four thousand one hundred and forty-four records were identified from the four databases with 260 records removed as *** thousand eight hundred and eighty-four records were screened with 3514 *** hundred and seventy-one full-texts were assessed for eligibility with seven studies included for *** the seven studies,three studies were retrospective case-control trials,two retrospective cohort studies,one a prospective cohort study and one a cross-sectional study *** were based in hospital settings with four in Pakistan,two in South Korea and one in the United *** total number of participants were 9621 of which 167 developed HCC(1.7%).All seven studies found cirrhosis to be a risk factor for HCC secondary to HCV genotype-3 followed by higher age(five-studies),with two studies each showing male sex,high alpha feto-protein,directly-acting antivirals trea

关键词： Hepatocellular carcinoma Hepatitis C Genotype 3 Systematic review Blood-borne viruses Liver cancer

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A dicistrovirus increases pupal mortality in Spodoptera frugiperda by suppressing protease activity and inhibiting larval diet consumption

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Journal of Integrative Agriculture 2024年第8期23卷 2723-2734页

作者： meixue Sun Tong Li Yingjie Liu Kenneth Wilson Xingyu Chen Robert I.graham Xianming Yang Guangwei Ren Pengjun Xu Key Laboratory of Tobacco Pest monitoring&Integrated management Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdao 266101China Institute of Plant Protection Henan Academy of Agricultural SciencesZhengzhou 450000China Staff Development Institute of China National Tobacco Corporation Zhengzhou 450000China Lancaster Environment Centre Lancaster UniversityLancaster LA14YWUK Department of Rural Land Use Scotland’s Rural CollegeCraibstone CampusAberdeen AB01ABUK State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China

Understanding interactions between viruses and their hosts is conducive to enabling better application of viruses as biocontrol *** viruses carried by parasitic wasps enhance the parasitic efficiency of wasp-larvae by protecting them against the immune system of their Lepidopteran ***,the relationship between prey pests and viruses found in predatory natural enemies remains ***,we report the interaction between Arma chinensis virus-1(AcV-1),originally isolated from a predatory natural enemy,Arma chinensis(Hemiptera:Pentatomidae),and one of its prey species,Spodoptera frugiperda(Lepidoptera:Noctuidae).The results showed that the AcV-1 virus appeared harmful to the novel host *** by inhibiting larval diet consumption and increasing pupal ***,sequencing data indicated that the virus altered the gene expression profiles of *** analysis showed that the proteasome and phagosome pathways related to protein degradation and immune response were significantly *** the expression levels of digestive enzyme genes did not change significantly,the total protease activity of AcV-1 virus-positive individuals was significantly decreased,suggesting that the virus inhibited diet consumption of *** via the down-regulation of digestive enzyme *** results indicate that a virus initially isolated in a predatory natural enemy can decrease the fitness of its prey *** virus was found to impact the host proteasome and phagosome pathways related to protein degradation and immunity,providing a potential mechanism to enhance controlling efficiency.

关键词： Arma chinensis virus-1 diet consumption fitness transcriptome protease activity

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