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Computer modeling in Engineering & Sciences 2024年第2期138卷 1951-1979页

作者： Salma khan muhammad Gulistan NasreenKausar Seifedine Kadry Jungeun Kim Department of mathematics and Statistics Hazara UniversityMansehra21120Pakistan Department of mathematics Faculty of Arts and SciencesYildiz Technical UniversityEsenlerIstanbul34210Turkey Department of Applied Data Science Noroff University CollegeKristiansand4612Norway Artificial Intelligence Research Center(AIRC) Ajman UniversityAjman346United Arab Emirates Department of Electrical and Computer Engineering Lebanese American UniversityP.O.Box 13-5053ByblosLebanon Department of Software and CmPSI Konju National UniversityCheonan31080Korea

Tourism is a popular activity that allows individuals to escape their daily routines and explore new destinations for various reasons,including leisure,pleasure,or business.A recent study has proposed a unique mathematical concept called a q−Rung orthopair fuzzy hypersoft set(q−ROFHS)to enhance the formal representation of human thought processes and evaluate tourism carrying *** approach can capture the imprecision and ambiguity often present in human *** the advanced mathematical tools in this field,the study has also incorporated the Einstein aggregation operator and score function into the q−ROFHS values to supportmultiattribute decision-making *** implementing this technique,effective plans can be developed for social and economic development while avoiding detrimental effects such as overcrowding or environmental damage caused by tourism.A case study of selected tourism carrying capacity will demonstrate the proposed methodology.

关键词： q−Rung orthopair fuzzy hypersoft set decision-making tourism carrying capacity aggregation operator

mechanical sensor PDLIm5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations

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Genes & Diseases 2024年第3期11卷 136-139页

作者： Yuchao Yang Shutong Wu Rongmei Qu Congrong Wang Jinyang Wang Asmat Ullah khan You Pan Wenqing Liu Jinhui Zhu muhammad Akram khan Chujiang Xu Jingxing Dai Jun Ouyang Guangdong Provincial Key Laboratory of medical Biomechanics&National Key Discipline of Human Anatomy Schoolof BasicMedical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Laboratory medicine Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of Pathology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Breast Surgery Guangxi Medical University Cancer HospitalNanningGuangxi 530000China Department of Veterinary Pathology Faculty of Veterinary and Animal SciencesPMAS Arid Agriculture UniversityRawalpindi 46300Pakistan Department of Orthopedics TCM-Integrated HospitalSouthern Medical UniversityGuangzhouGuangdong 510000China

Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout ***,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations.

关键词： alterations injuries massive

Acoustofluidic separation of prolate and spherical micro-objects

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microsystems & Nanoengineering 2024年第1期10卷 217-230页

作者： muhammad Soban khan mushtaq Ali Song Ha Lee Keun Young Jang Seong Jae Lee Jinsoo Park Department of mechanical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

most microfluidic separation techniques rely largely on object size as a separation *** ability to separate micro-objects based on their shape is crucial in various biomedical and chemical ***,we develop an ondemand,label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and *** freely rotating non-spherical microobjects were aligned under the progressive acoustic field by the counterrotating radiation torque,and the major axis of the prolate ellipsoids was parallel to the progressive wave *** specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave *** a consequence,the acoustic backscattering decreased,resulting in a decreased magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acoustofluidic shape-based *** conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mechanism underlying the proposed method.A series of experiments with polystyrene microspheres,prolate ellipsoids,and peanut-shaped microparticles were performed for *** quantitative analysis of the separation efficiency,we confirmed the high purity and high recovery rate of the proposed acoustofluidic shapebased separation of *** a bioparticle,we utilize Thalassiosira eccentrica to perform shape-based separation,as the species has a variety of potential applications in drug delivery,biosensing,nanofabrication,bioencapsulation and immunoisolation.

关键词： separation spherical rotating

Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma

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Chinese Journal of Cancer Research 2024年第2期36卷 195-214页

作者： Sana Rashid Yingchuan Sun Umair Ali khan Saddozai Sikandar Hayyat muhammad Usman munir muhammad Usman Akbar muhammad Babar Khawar Zhiguang Ren Xinying Ji malik Ihsan Ullah khan Institute of molecular Biology and Biotechnology University of LahoreLahore 54590Pakistan Department of Internal Oncology(Section Ⅰ) Xuchang Municipal Central HospitalXuchang 461000China Institute of Translational medicine Medical CollegeYangzhou UniversityYangzhou 225001China Australian Institute for Bioengineering&Nanotechnology the University of QueenslandBrisbane 4072Australia Gomal Center of Biochemistry and Biotechnology Gomal UniversityDera Ismail Khan 29111Pakistan Applied molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowal Punjab 51600Pakistan Kaifeng municipal Key Laboratory for Infection and Biosafety Henan International Joint Laboratory of Nuclear Protein RegulationSchool of Basic Medical SciencesHenan UniversityKaifeng 475004China Faculty of Basic medical Subjects Shu-Qing Medical College of ZhengzhouZhengzhou 450064China Department of medicine Huaxian County People's HospitalHuaxian 456400China

Hepatocellular carcinoma(HCC) is considered the fifth most prevalent cancer among all types of cancers and has the third most morbidity value. It has the most frequent duplication time and a high recurrence rate. Recently, the most unique technique used is liquid biopsies, which carry many markers;the most prominent is circulating tumor DNA(ctDNA). Varied methods are used to investigate ctDNA, including various forms of polymerase chain reaction(PCR) [emulsion PCR(ePCR), digital PCR(dPCR), and bead, emulsion, amplification, magnetic(BEAming) PCR]. Hence ctDNA is being recognized as a potential biomarker that permits early cancer detection,treatment monitoring, and predictive data on tumor burden are subjective to therapy or surgery. Numerous ctDNA biomarkers have been investigated based on their alterations such as 1) single nucleotide variations(either insertion or deletion of a nucleotide) markers including TP53, KRAS, and CCND1;2) copy number variations which include markers such as CDK6, EFGR, mYC and BRAF;3) DNA methylation(RASSF1A, SEPT9, KmT2C and CCNA2);4) homozygous mutation includes ctDNA markers as CDKN2A, AXIN1;and 5) gain or loss of function of the genes, particularly for HCC. Various researchers have conducted many studies and gotten fruitful ***, there are some drawbacks to ctDNA namely low quantity, fragment heterogeneity, less stability, limited mutant copies and standards, and differential sensitivity. However, plenty of investigations demonstrate ctDNA's significance as a polyvalent biomarker for cancer and can be viewed as a future diagnostic, prognostic and therapeutic agent. This article overviews many conditions in genetic changes linked to the onset and development of HCC, such as dysregulated signaling pathways, somatic mutations, single-nucleotide polymorphisms, and genomic instability. Additionally, efforts are also made to develop treatments for HCC that are molecularly targeted and to unravel some of the genetic pathways that f

关键词： Hepatocellular carcinoma circulating tumor DNA biomarkers single nucleotide variations diagnosis prognosis

Towards Sustainable Grinding of Difficult-to-Cut Alloys-A Holistic Review and Trends

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Chinese Journal of mechanical Engineering 2024年第2期37卷 1-28页

作者： Ning Qian Jiajia Chen Aqib mashood khan Biao Zhao Yurong Chen Wenfeng Ding Yucan Fu Jiuhua Xu Jiangsu Key Laboratory of Precision and micro-manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of mechanical and Electronic Engineering Nanjing Forestry UniversityNanjing 210037China JITRI Institute of Precision manufacturing Nanjing 211805China

Grinding,a critical precision machining process for difficult-to-cut alloys,has undergone continual technological advancements to improve machining ***,the sustainability of this process is gaining heightened attention due to significant challenges associated with the substantial specific grinding energy and the extensive heat generated when working with difficult-to-cut alloys,renowned for their exceptional physical and mechanical *** response to these challenges,the widespread application of massive coolant in manufacturing industries to dissipate grinding heat has led to complex post-cleaning and disposal ***,in turn,has resulted in issues such as large energy consumption,a considerable carbon footprint,and concerns related to worker health and safety,which have become the main factors that restrict the development of grinding *** paper provides a holistic review of sustainability in grinding difficult-to-cut alloys,encompassing current trends and future *** examination extends to developing grinding technologies explicitly tailored for these alloys,comprehensively evaluating their sustainability ***,the exploration delves into innovative sustainable technologies,such as heat pipe/oscillating heat pipe grinding wheels,minimum quantity lubrication,cryogenic cooling,and *** groundbreaking technologies aim to reduce dependence on hazardous coolants,minimizing energy and resource consumption and carbon emissions associated with coolant-related or subsequent disposal *** essence of these technologies lies in their potential to revolutionize traditional grinding practices,presenting environmentally friendly ***,future development trends and research directions are put forward to pursue the current limitation of sustainable grinding for difficult-to-cut *** paper can guide future research and development efforts toward more environmentally friendly

关键词： Grinding Sustainability Cooling Energy consumption Carbon footprint Difficult-to-cut alloys

Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine

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World Journal of Stem Cells 2024年第4期16卷 410-433页

作者： Shafiqa Naeem Rajput Bushra Kiran Naeem Anwar Ali Asmat Salim Irfan khan Dr.Panjwani Center for molecular medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Surgical Unit 4 Dr.Ruth KM Pfau Civil HospitalKarachi 74400Pakistan Department of Physiology University of KarachiKarachi 75270Pakistan Center for Regenerative medicine and Stem Cells Research and Department of Ophthalmology and Visual SciencesThe Aga Khan UniversityKarachi 74800SindhPakistan

BACKGROUND Stem cells are undifferentiated cells that possess the potential for self-renewal with the capacity to differentiate into multiple *** humans,their limited numbers pose a challenge in fulfilling the necessary demands for the regeneration and repair of damaged tissues or *** suggested that mesenchymal stem cells(mSCs),necessary for repair and regeneration via transplantation,require doses ranging from 10 to 400 million ***,the limited expansion of mSCs restricts their therapeutic *** To optimize a novel protocol to achieve qualitative and quantitative expansion of mSCs to reach the targeted number of cells for cellular transplantation and minimize the limitations in stem cell therapy *** Human umbilical cord(hUC)tissue derived mSCs were obtained and *** cultured cells were subjected to the following evaluation pro-cedures:Immunophenotyping,immunocytochemical staining,trilineage differentiation,population doubling time and number,gene expression markers for proliferation,cell cycle progression,senescence-associatedβ-galactosidase assay,human telomerase reverse transcriptase(hTERT)expression,mycoplasma,cytomegalovirus and endotoxin *** Analysis of pluripotent gene markers Oct4,Sox2,and Nanog in recultured hUC-mSC revealed no significant *** immunophenotypic markers CD90,CD73,CD105,CD44,vimentin,CD29,Stro-1,and Lin28 were positively expressed by these recultured expanded mSCs,and were found negative for CD34,CD11b,CD19,CD45,and *** recultured hUC-mSC population continued to expand through passage *** gene expression of Pax6,BmP2,and TGFb1 showed no significant variation between recultured hUC-mSC ***,a significant increase(Pmitotic phase of the cell cycle was observed in recultured *** senescence markers(hTERT expression andβ-galactosidase activity)did not show any negative effect on recultured hUC-

关键词： Human umbilical cord mesenchymal stem cells Expansion Cell proliferation In vitro expansion Senescence

Advances in Zika virus vaccines and therapeutics:A systematic review

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Asian Pacific Journal of Tropical medicine 2024年第3期17卷 97-109页

作者： Shiza malik Khalid muhammad Omar Ahsan muhammad Tahir khan Ranjit Sah Yasir Waheed Bridging Health Foundation Rawalpindi 46000Pakistan Department of Biology College of SciencesUAE University15551Al AinUnited Arab Emirates Department of medicine Foundation University Medical CollegeFoundation University IslamabadIslamabad 44000Pakistan INTI International University Persiaran Perdana BBN Putra Nilai71800 NilaiNegeri SembilanMalaysia Institute of molecular Biology and Biotechnology the University of LahoreKM Defence RoadLahore 58810Pakistan Zhongjing Research and Industrialization Institute of Chinese medicine Zhongguancun Scientific ParkNanyang 473006China Department of microbiology Tribhuvan University Teaching HospitalInstitute of MedicineKathmandu 44600Nepal Department of microbiology Dr.D.Y.Patil Medical CollegeHospital and Research CentreDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Gilbert and Rose-marie Chagoury School of medicine Lebanese American UniversityByblos 1401Lebanon

Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults *** wide transmission route and alarming spread rates are of great concern to the scientific *** trials have been conducted to develop treatment options for ZIKV *** review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection.A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic *** results indicate that several therapeutic interventions are being tested against ZIKV infection,such as DNA vaccines,subunit vaccines,live-attenuated vaccines,virus-vector-based vaccines,inactivated vaccines,virus-like particles,and mRNA-based *** addition,approved anti-ZIKV drugs that can reduce the global burden are *** many vaccine candidates for ZIKV are at different stages of development,none of them have received Food and Drug Authority approval for use up to *** issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway.

关键词： Zika virus Infection Therapeutics Antiviral agents Vaccines Therapies Treatment Novel therapeutic Clinical management

Carcinoembryonic antigen in the diagnosis,treatment,and follow-up of focal liver lesions

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 999-1007页

作者： Osman Nuri Dilek Dilaraİrem Arslan Kahraman Gökhan Kahraman Department of Surgery İzmir Katip Celebi UniversitySchool of Medicineİzmir 35150Turkey Department of Patology Merzifon KMP State HospitalAmasya 5300Turkey Department of Radiology Suluova State HospitalAmasya 5500Turkey

In this editorial review,we comment on the article published in the recent issue of the World Journal of Gastrointestinal *** antigen(CEA)is a fetal glycoprotein and can be secreted in very small amounts from healthy adults after *** is widely used not only for diagnostic tumor markers but also importantly for the management of some gastrointestinal *** most common clinical use is surveillance for the monitoring of colorectal ***,CEA can become elevated in several malign or benign characterized *** CEA level may vary depending on the location of the lesion,whether it metastasizes or not,and its histopathological *** has been determined that cases with high preoperative CEA have a more aggressive course and the risk of metastasis to the lymph tissue and liver *** this editorial review,we focused on evaluating the role of CEA in clinical practice with a holistic approach,including the diagnostic and prognostic significance of CEA in patients with focal liver lesions,the role of CEA in follow-up after definitive surgery,and also hepatic resection for metastasis,and the management of all patients with raised CEA.

关键词： Carcinoembriyonic antigen Liver Focal liver lesions metastasis Surgery Prognosis Surveillance

Synthesis and Characterization of Poly Styrene-Co-Poly 2-Hydroxyethylmethacrylate (HEmA) Copolymer and an Investigation of Free-Radical Copolymerization Propagation Kinetics by Solvent Effects

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Open Journal of Polymer Chemistry 2024年第1期14卷 63-93页

作者： Anaif m. Alhewaitey Ishrat khan Naif m. Alhawiti Department of Chemistry Clark Atlanta University Atlanta USA Department of Chemistry University of Tabuk Tabuk Saudi Arabia CAHFS University of California Davis Davis California

A series of homo and copolymers of styrene (ST) and 2-hydroxyethyl methacrylate (HEmA) in three different media (bulk, tetrahydrofuran, and benzene) have been investigated by free radical polymerization method. The samples obtained from the synthesis were characterized by Fourier Transform-Infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H NmR), atomic force microscopy (AFm), and differential scanning calorimetry (DSC). The results show that the synthesis of the polymers is more feasible under neat conditions rather than solvent directed reaction. moreover, the DSC data shows that the polystyrene obtained is amorphous in nature and therefore displayed only a glass transition signal rather than crystallization and melting peaks. In addition, this study indicates that homolopolymerization of styrene via free radical polymerization tends to be preferable in less polar solvents like THF than in non-polar solvents like benzene. Benzene might destabilize the formation of the reactive radicals leading to the formation of the products. In summary, the homolpolymerization of styrene is more feasible than the homopolymerization 2-hydroxyethyl methacrylate under the experimental setup used. Styrene is more reactive than 2-hydroxyethyl methacrylate than free radical polymerization reaction due in part of the generation of the benzylic radical intermediate which is more stable leading to the formation of products than alkyl radical which are less stable. Furthermore, polymerization of styrene under neat conditions is preferable in solvent-assisted environments. The choice of solvent for the synthesis of these polymers is crucial and therefore the selection of solvent that leads to the formation of a more stable reaction intermediate is more favorable. It is worth noting that the structure of the proposed copolymer consists of a highly polar and hydrophilic monomer, 2-hydroxyethyl methacrylate and a highly non-polar and hydrophobic monome

关键词： 2-Hydroxyethyl methacrylate Polymerization

Enhanced Steganalysis for Color Images Using Curvelet Features and Support Vector machine

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Computers, materials & Continua 2024年第1期78卷 1311-1328页

作者： Arslan Akram Imran khan Javed Rashid mubbashar Saddique muhammad Idrees Yazeed Yasin Ghadi Abdulmohsen Algarni Faculty of Computer Science and Information Technology Department of Computer ScienceSuperior UniversityLahore54000Pakistan machine Learning Code(mLC)Lab Meharban HouseHouse Number 209Zafar ColonyOkara56300Pakistan Information Technology Services University of OkaraOkara56310Pakistan Department of Computer Science&Engineering University of Engineering&Technology LahoreNarowal CampusNarowal51601Pakistan Department of Computer Science and Software Engineering Al Ain UniversityAl Ain11671Abu Dhabi Department of Computer Science King Khalid UniversityAbha61421Saudi Arabia

Algorithms for steganography are methods of hiding data transfers in media *** machine learning architectures have been presented recently to improve stego image identification performance by using spatial information,and these methods have made it feasible to handle a wide range of problems associated with image *** with little information or low payload are used by information embedding methods,but the goal of all contemporary research is to employ high-payload images for *** address the need for both low-and high-payload images,this work provides a machine-learning approach to steganography image classification that uses Curvelet transformation to efficiently extract characteristics from both type of *** Vector machine(SVm),a commonplace classification technique,has been employed to determine whether the image is a stego or *** Wavelet Obtained Weights(WOW),Spatial Universal Wavelet Relative Distortion(S-UNIWARD),Highly Undetectable Steganography(HUGO),and minimizing the Power of Optimal Detector(miPOD)steganography techniques are used in a variety of experimental scenarios to evaluate the performance of the *** WOW at several payloads,the proposed approach proves its classification accuracy of 98.60%.It exhibits its superiority over SOTA methods.

关键词： Curvelets fast fourier transformation support vector machine high pass filters steganography