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CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKm supports antitumor immunity

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Cellular & molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda mackenzie m.Lieberman Caitlin m.James Shivana m.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew m.Intlekofer Richard m.Higashi Teresa W.m.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:massachusetts Institute of Technology BostonMA 02139USA Present address:melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the m1 isoform of pyruvate kinase in favor of PKm2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKm alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKm2

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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cellular & molecular Immunology 2024年第2期21卷 103-118页

作者： S.Cankat m.U.Demael L.Swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2,mERS-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKU1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection Universal

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An efficient permutation approach for SbPN-based symmetric block ciphers

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Cybersecurity 2024年第2期7卷 113-130页

作者： mir Nazish m.Tariq Banday Insha Syed Sheena Banday Department of Electronics and Instrumentation Technology University ofKashmirSrinagar 190006India

It is challenging to devise lightweight cryptographic primitives efficient in both hardware and software that can provide an optimum level of security to diverse Internet of Things applications running on low-end constrained ***,an effcient hardware design approach that requires some specific hardware resource may not be effcient if implemented in *** bit Permutation Network based ciphers such as PRESENT and GIFT are effcient,lightweight cryptographic hardware design *** ciphers introduce confusion and diffu-sion by employing a 4×4 static substitution box and bit *** bit-wise permutation is realised by sim-ple rerouting,which is most cost-effective to implement in hardware,resulting in negligible power ***,this method is highly resource-consuming in software,particularly for large block-sized ciphers,with each single-bit permutation requiring multiple *** paper proposes a novel software-based design approach for permutation operation in Substitution bit Permutation Network based ciphers using a bit-banding *** conventional permutation using bit rotation and the proposed approach have been implemented,analysed and compared for GIFT and PRESENT ciphers on ARm Cortex-m3-based LPC1768 development platform with KEIL mDK used as an Integrated Development *** real-time performance comparison between conven-tional and the proposed approaches in terms of memory(RAm/ROm)footprint,power,energy and execution time has been carried out using ULINKpro and ULINKplus debug adapters for various code and speed optimisation *** proposed approach substantially reduces execution time,energy and power consumption for both PRE-SENT and GIFT ciphers,thus demonstrating the effciency of the proposed method for Substitution bit Permutation Network based symmetric block ciphers.

关键词： Lightweight cryptography PRESENT GIFT SbPN Cortex-m LPC1768 Bit-band memory

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Sodium nitroprusside as a signal molecule for up-regulating membrane characteristics,antioxidant defense system to improve flax productivity under water stress

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Oil Crop Science 2024年第03期 160-169页

作者： N.m.Al-Ashkar B.A.Bakry H.m.S.El-Bassiouny m.m.S.Abdallah m.S.Sadak Botany Department Agricultural and Biological Research Institute National Research Centre Field Crops Research Department Agricultural and Biological Research Institute National Research Centre

Water stress is a critical environmental adversity that significantly impacts the growth, development, and yield of flax plants. In this study, flax seeds were cultivated under different water irrigation requirements（WIR）(100%,75%, and 50%) to investigate the effects of exogenously supplied nitric oxide（NO） donor sodium nitroprusside（SNP） as foliar treatments at concentrations of 0.0 mmol/L, 0.5 mmol/L, 1.0 mmol/L, and 2.0 mmol/L. Drought stress led to a significant decrease in plant growth, photosynthetic pigments, yield components such as oil and total carbohydrate percentage. It also resulted in an increase in leaf H2O2production, lipid peroxidation levels and activities of enzymatic antioxidants including polyphenol oxidase, superoxide dismutase, and nitrate reductase enzymes. However, foliar application of SNP improved photosynthetic pigments and antioxidant defense system which mitigated the negative impact of water stress on growth and yield productivity by reducing oxidative damage caused by reactive oxygen species accumulation. The use of SNP also decreased H2O2accumulation levels, lipid peroxidation levels, and improved membrane stability. SNP treatment at concentration of 2 mmol/L showed superior results compared to other concentrations with extremely significant increases observed in yield characteristics such as oil content, total carbohydrate percentages, and unsaturated fatty acids to saturated fatty acids ratio.

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A Survey on model Predictive Control of DFIGs in Wind Energy Conversion Systems

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1085-1104页

作者： Shuo Yan Junyu Chen minghao Wang Yongheng Yang Jose m.Rodriguez STEm College RMIT UniversityMelbourneAustralia Hong Kong Polytechnic University Hong KongChina State Key Laboratory of Internet of Things for Smart City(Um) Department of Electrical and Computer EngineeringUniversity of MacaoMacaoChina College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Universidad San Sebastin Campus BellavistaSantiago de ChileCLSantiago de Chile 000000Chile IEEE

This paper presents a comprehensive study on the model predictive control(mPC)of doubly fed induction generators(DFIG)in wind energy conversion systems(WECS);in particular the mPC of the rotor side *** general principle of prevalent mPC strategies is discussed to introduce the theoretical framework in the first ***,mainstream and high-performance mPC methods of DFIGs have been identified as model predictive current control(mPCC),model predictive torque control(mPTC),and model predictive power control(mPPC).Starting from analyzing dynamic models,these mPC strategies are investigated in terms of operating principles and technical *** paper further investigates implementation of mPC strategies in unbalanced *** on the quantitative and qualitative analysis of several case studies,performance of various mPC schemes is compared and their special features are *** for designing mPC strategies of DFIGs in WECS are provided.

关键词： Doubly fed induction generator(DFIG) model predictive control(mPC) wind energy

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Commentary on “Does light-intensity physical activity moderate the relationship between sitting time and adiposity markers in adolescents?”

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Journal of Sport and Health Science 2024年第4期13卷 453-454页

作者： Barbara E.Ainsworth Amanda m.Ferland School of Exercise and Health Shanghai University of SportShanghai 200433China Department of Orthopedics Tongji UniversityShanghai 200092China

In the September 2022 issue of the Journal of Sport and Health Science,Ayala et al.1 published results from a cross-sectional study where they tested the hypothesis that light intensity physical activity(LIPA,1.6-2.9 metabolic equivalents(mETs))moderates the relationship between sitting time and adiposity in 219 Australian adolescents aged 14±1.6 years(mean±SD).

关键词： metabolic light

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modeling mitochondria,where are the numbers?

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Neural Regeneration Research 2024年第7期19卷 1435-1436页

作者： Adrian m.Davies Alan G.Holt University Center Shrewsbury ShrewsburyShropshireUK

models and simulations are particularly useful for exploring ideas and concepts in the biological sciences that are expe rimentally *** silico methods are also gaining acceptance with regulatory authorities as an alte... 详细信息

关键词： eliminate authorities acceptance

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Green retrofitting of heritage buildings based on(3Ts)framework:An applied case study

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Frontiers of Architectural Research 2024年第4期13卷 776-798页

作者： Alaa O.Shehata Asmaa m.Hassan merhan m.Shahda Naglaa A.megahed Architectural Engineering and Urban Planning Department Faculty of EngineeringPort Said UniversityPort SaidEgypt

Diverse heritage architecture characterizes Port Said in Egypt,reflecting European and Arab *** Canal heritage villas comprise 25%of the total listed heritage buildings in the ***,it is important to retrofit them,aligning with the Sustainable Development Goals(SDGs).By reviewing the previous literature related to the green retrofitting of heritage buildings,the(3Ts)framework can be considered a holistic framework that covers the latest trends due to its three components:targets,tools,and tasks,which help the success of the process through a holistic vision of supporting building information modeling(BIm)technologies and organizing stakeholders’*** paper aims to apply the(3Ts)framework to Suez Canal heritage villas in Port Said,*** applied study is based on how stakeholders perceive their input and decision-making,measuring the climate parameters,proposing several green retrofits,and integrating them into green *** of scenarios is conducted by utilizing the Design Builder simulation ***,the Skelion plugin calculates the photovoltaic system’s(PVs)energy *** results indicated that the total energy savings could reach approximately 12%e74%and nearly 10%e73%CO₂emissions reduction without affecting heritage values.

关键词： Green retrofitting Heritage buildings BIm BES Suez Canal heritage villas Port Said/Egypt

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millimetric devices for nerve stimulation:a promising path towards miniaturization

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Neural Regeneration Research 2024年第8期19卷 1702-1706页

作者： Ryan m.Dorrian Anna V.Leonard Antonio Lauto Spinal Cord Injury Research Group School of BiomedicineThe University of AdelaideAdelaideSAAustralia School of Science Western Sydney UniversityPenrithNSWAustralia

Nerve stimulation is a rapidly developing field,demonstrating positive outcomes across several *** potential benefits,current nerve stimulation devices are large,complicated,and are powered via implanted pulse *** facto rs necessitate invasive surgical implantation and limit potential *** nerve stimulation devices to millimetric sizes would make these interventions less invasive and facilitate broader therapeutic ***,device miniaturization presents a serious engineering *** review presents significant advancements from several groups that have overcome this challenge and developed millimetricsized nerve stimulation *** are based on antennas,mini-coils,magneto-electric and optoelectronic materials,or receive ultrasound *** highlight key design elements,findings from pilot studies,and present several considerations for future applications of these devices.

关键词： biomedical engineering deep brain stimulation electrical engineering electrical stimulation neuromodulation peripheral nerve stimulation

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multiple scales method for analyzing a forced damped rotational pendulum oscillatorwithgallows

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Communications in Theoretical Physics 2024年第5期76卷 58-67页

作者： Haifa A Alyousef Alvaro H Salas B m Alotaibi S A El-Tantawy Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of mathematics and Statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum system with gallows and periodic excited *** multiple scales method(mSm)is applied to solve the proposed *** types of rotational pendulum oscillators are studied and talked about in *** include the forced damped rotating pendulum oscillator with gallows,the damped standard simple pendulum oscillator,and the damped rotating pendulum oscillator without *** mSm first-order approximations for all the cases mentioned are derived in *** obtained results are illustrated with concrete numerical *** first-order mSm approximations are compared to the fourth-order Runge-Kutta(RK4)numerical ***,the maximum error is estimated for the first-order approximations obtained through the mSm,compared to the numerical approximations obtained by the RK4 ***,we conducted a comparative analysis of the outcomes obtained by the used method(mSm)and He-mSm to ascertain their respective levels of *** proposed method can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales method approximate solution damped oscillations forced pendulum with gallows he-multiple scales method

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