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Inflam..tion and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C

World Journal of Gastroenterology 2020年第2期26卷 109-133页

作者： Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul m..rem..ing William.. Rosenberg UCL Institute for Liver and Digestive Health Division of MedicineUniversity College LondonRoyal Free CampusHampsteadLondon NW32PF United Kingdom Departm..t of Gastroenterology Whipps Cross University HospitalBarts Health NHS TrustLeytonstoneLondon E111NRUnited Kingdom

At present chronic liver disease(CLD),the third com..nest cause of prem..ure death in the United Kingdom..s detected late,when interventions are ineffective,resulting in considerable m..bidity and *** to the liver,the largest solid organ in the body,leads to a cascade of inflam..tory *** inflam..tion leads to the activation of hepatic stellate cells that undergo transdifferentiation to becom..m..fibroblasts,the m..n extra-cellular m..rix producing cells in the liver;over tim..increased extra-cellular m..rix production results in the form..ion of liver *** fibrogenesis m.. be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can becom..pathogenic culm..ating in CLD,cirrhosis and its associated *** the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated m..bidity,the diagnostic assessm..t of CLD by non-invasive testing is ***,in this review the m..hanism..by which liver inflam..tion and fibrosis develop in chronic liver diseases are explored to identify appropriate and m..ningful diagnostic targets for clinical *** to differing disease prevalence and treatm..t efficacy,disease specific diagnostic targets are required to optim..ly m..age individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C *** facilitate this,a review of the pathogenesis of both conditions is also ***,the evidence for hepatic fibrosis regression and the m..hanism..by which this occurs are discussed,including the current use of antifibrotic therapy.

关键词： Liver inflam..tion Fibrosis Cirrhosis Non-alcoholic fatty liver disease Chronic hepatitis C Chronic liver disease Anti-fibrotic Biom..ker

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Shaped Co^(2+) doped TiO_(2) nanocrystals synthesized from..anotubular precursor: Structure and ferrom..netic behavior

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Journal of Advanced Ceram..s 2017年第3期6卷 220-229页

作者： m..RANJES J.KULJANIN JAKOVLJEVIC Z.KONSTANTINOVIC A.POm.. m..TOILJKOVIC m..ITRIC T.RADETIC Z.SAPONJIC Vinca Institute of Nuclear Sciences University of BelgradeP.O.Box 52211001 BelgradeSerbia Center for Solid State Physics and New m..erials Institute of Physics BelgradeUniversity of BelgradePregrevica 11811080 BelgradeSerbia Institut de Ciència de m..erials de Barcelona CSICCampus UAB08193 BellaterraSpain Faculty of Technology and m..allurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia

Co2+ doped TiO2 nanocrystals were synthetized by a hydrotherm.. treatm..t procedure applied to precursor dispersion of titania nanotubes and Co2+ ions. m..ture of polygonal and prolate spheroid-like nanocrystals was obtained. The results of X-ray diffraction (XRD) analysis showed that resulted nanocrystals retain anatase crystal phase for both dopant concentrations (1.69 and 2.5 at%), but the crystal lattice param..ers were affected. Reflection spectra revealed altered optical properties com..red to bare TiO2. Room..em..rature ferrom..netic ordering with saturation m..netic m..ent in the range of 0.001–0.002 μB /Co was observed for both m..sured film..m..e of Co2+ doped TiO2 nanocrystals.

关键词： hydrotherm.. synthesis X-ray diffraction(XRD) transm..sion electron m..roscopy(TEm) doped TiO_(2) m..netic properties

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Textual research of Wudu earthquake in 186 B.C. in Gansu Province, China and discussion on its causative structure

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Acta Seism..ogica Sinica(English Edition) 2007年第6期20卷 696-707页

作者：袁道阳雷中生何文贵熊振葛伟鹏刘兴旺刘百篪 Lanzhou Institute of Seism..ogy China Earthquake Administration Earthquake Adm..istration of Jiangsu Province

On the basis of the textual research on the historical earthquake data and the field investigation of Wudu earthquake occurred in 186 B.C., we suggest that the earthquake param..ers drawn from..he present earthquake catalogs are not definite and am..dm..ts should be m..e. The heavily-dam..ed area of this earthquake should be located between Jugan township of Wudu County and Pingding township of Zhouqu County. Its epicenter should be in the vicinity of Lianghekou in Wudu County with a m..nitude of about 7-7 1/4 and an intensity of about IX-X. The m..or axis direction of the heavily-dam..ed area should be in the WNW direction that is approxim..ely consistent with the strike of the m..dle-east segm..t of Diebu-Bailongjiang active fault zone, and the origin tim..should m..ch up to that of the latest paleoearthquake event [before （83±46） B.C.] obtained by the trench investigation. Certain seism.. rupture evidences are still preserved on this fault segm..t. Therefore, we propose on the basis of com..ehensive analysis that the causative structure of the m..-7 1/4 Wudu earthquake in 186 B.C. should be in the m..dle-east segm..t of Diebu-Bailongjiang active fault zone.

关键词： Wudu earthquake in 186 B.C. textual research of historical earthquake causative structure Diebn-Bailongjiang fault zone

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Assessm..t of the ballistic response of honeycom..sandwich structures subjected to offset and norm.. im..ct

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Defence Technology（防务技术） 2023年第10期28卷 56-73页

作者： Nikhil Khaire Gaurav Tiwari Vivek Patel m...Iqbal Departm..t of m..hanical Engineering Indian Institute of Technology DelhiNew Delhi110016India Departm..t of m..hanical Engineering Visvesvaraya National Institute of TechnologyNagpur440026India School of m..hanical Engineering Dr.Vishwanath Karad MIT World Peace UniversityPune411038India Departm..t of Civil Engineering Indian Institute of Technology RoorkeeRoorkee247667India

In the present study,experim..tal and num..ical investigations were carried out to exam..e the behavior of sandwich panels with honeycom..*** high velocity im..ct tests were carried out using a com..essed air gun.A sharp conical nosed projectile was im..cted norm..ly and with som..offset distance(20 m..and 40 m...The deform..ion,failure m..e and energy dissipation characteristics were obtained for both kinds of ***,the explicit solver was run in Abaqus to create the finite elem..t *** num..ically obtained test results were com..red with the experim..tal to check the accuracy of the *** num..ical result was further em..oyed to obtain strain energy dissipation in each elem..t by externally running user-defined code in ***,the influence of inscribe circle diam..er and cell wall and face sheet thickness on the energy dissipation,deform..ion and failure m..e was *** result found that ballistic resistance and deform..ion were higher against offset im..ct com..red to the norm.. im..ct *** panel im..cted at 40 m..offset distance required 3 m.. and 1.9 m.. m..e velocity than 0 and 20 m..offset ***,increasing the face sheet and wall thickness had a positive im..ct on the ballistic resistance in term..of a higher ballistic lim.. and energy ***,inscribe circle diam..er had a negative influence on the ballistic ***,the geom..rical param..ers of the sandwich structure had a significant influence on the energy dissipation in the different deform..ion *** energy dissipation in plastic work was highest for circum..rential direction,regardless of im..ct condition followed by tangential,radial and axial directions.

关键词： Honeycom..sandwich structure Offset im..ct Energy dissipation characteristic Deform..ion and failure m..e Geom..ry effect

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Em..dding in Anisotropic Spheres

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Research in Astronom..and Astrophysics 2022年第4期22卷 62-70页

作者： Alberto K.m..hias Sunil D.m..araj Jefta m..unzu Jason m..kenyeleye Departm..t of m..hem..ics and Statistics The University of DodomaP.O.Box 338DodomaTanzania Astrophysics Research Centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalDurban 4000South Africa

Exact solutions to the Einstein field equations for class I spacetim..sym..try in relativistic stars are *** sym..try provides a relation between the gravitational potentials that lead to generalized solutions of the Einstein field *** choose one of the gravitational potentials on a physical basis,which allows us to obtain the other gravitational potential via an em..dding *** is therefore possible to generate a m..el with astrophysical *** m..el generated satisfies physical properties like stability,causality,regularity,equilibrium..nd energy conditions.

关键词： gravitation astroparticle physics relativistic processes

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Assessing the visualization of space and traffic volum..using GIS-based processing and visibility param..ers of space syntax

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Geo-Spatial Inform..ion Science 2020年第3期23卷 209-221,I0002页

作者： Fazzam..Othm.. Zaharah m..usoff Siti Aekbal Salleh Centre of Studies for Surveying Sciences and Geom..ics Faculty of ArchitecturePlanning and SurveyingUniversiti Teknologi MARAShah AlamSelangorMalaysia

Streets and physical layouts can be inherent in a sustainable city by em..asizing the use of space with planned strategies by prom..ing the m..em..t of people and social behaviors for enhancing an econom.. *** analysis of the space layout is beneficial for defining the urban areas that can affect street behavior.A GIS incorporated with a space syntax can help to propagate the effectiveness of a spatial analysis in a study on urban *** integration of the com..tational pieces of both a GIS analytical tool and space syntax param..ers will stim..ate research oriented urban system..and spatial m..phologies com..ned with a spatial ***,the developm..t of livability can be affected by a set of param..ers that define the used ***,this paper was aim.. at exam..ing the space syntax param..ers for space visualization to evaluate street behavior using the GIS processing and space syntax *** this study,a spatial analysis was used to generate spatial inform..ion on traffic volum..while a space syntax was used to test the street ***,a predictive analysis was conducted to identify the correlation between traffic behavior and a set of *** results showed that integration and direct visibility were significant to the traffic *** of the streets that were linked to the com..rcial area showed high integration and direct visibility,which increased by m..e than half,com..red with the unlinked *** on the statistical analysis,both param..ers recorded aprobability of less than 5%.The results showed that any space designed with a continuous,direct and clear traffic volum..will lead to increased integration and direct visibility,thus influencing a natural vehicle m..em..t.

关键词： Space behavior traffic volume space syntax isovist visibility analysis

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An Efficient Tide-Surge Interaction m..el for the Coast of Bangladesh

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China Ocean Engineering 2020年第1期34卷 56-68页

作者： m..izanur RAHm.. Gour Chandra PAUL Ashabul HOQUE Departm..t of m..hem..ics Shahjalal University of Science&TechnologySylhet 3114Bangladesh Departm..t of m..hem..ics University of RajshahiRajshahi-6205Bangladesh

The num..ical m..hod of lines(m..s)in coordination with the classical fourth-order Runge Kutta(RK(4,4))m..hod is used to solve shallow water equations(SWEs)for foreseeing water levels owing to the nonlinear interaction of tide and surge accom..nying with a storm..long the coast of *** SWEs are developed by extending the body forces with tide generating forces(TGFs).Spatial variables of the SWEs along with the boundary conditions are approxim..ed by m..ns of finite difference technique on an Arakawa C-grid to attain a system..f ordinary differential equations(ODEs)of initial valued in tim..which are being solved with the aid of the RK(4,4)*** grid technique is adopted to solve coastal com..exities closely with least com..tational cost.A stable tidal solution in the region of our choice is produced by applying the tidal forcing with the m..or tidal constituent m..lunar sem..diurnal)along the southern open-sea boundary of the outer *** experim..tations are carried out to sim..ate water levels generated by the cyclonic storm..ILA along the coast of *** m..el sim..ated results are found to be in a reasonable agreem..t with the lim..ed available reported data and observations.

关键词： Bangladesh coast shallow water equations m..hod of lines tide-surge interaction islands tide generating forces inverse barom..er

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Concurrent m..erial Selection of Natural Fibre Filam..t for Fused Deposition m..eling Using Integration of Analytic Hierarchy Process/Analytic Network Process

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Journal of Renewable m..erials 2022年第5期10卷 1221-1238页

作者： m...m..tura R.Nadlene R.Jum..din S.I.Abdul Kudus m...m..sor H.m...Firdaus Fakulti Teknologi Kejuruteraan m..anikal dan Pem..atan Universiti Teknikal Malaysia MelakaMelaka76100Malaysia Fakulti Kejuruteraan m..anikal Universiti Teknikal Malaysia MelakaMelaka76100Malaysia

The em..oym..t of natural fibres in fused deposition m..eling has raised m..h attention from..esearchers in finding a suitable form..ation for the natural fibre com..site ***,selection of suitable natural fibres for fused deposition m..eling should be perform.. before the developm..t of the *** could not be perform.. without identifying selection criteria that com..ehend both m..erials and fused deposition m..eling process ***,in this study,integration of the Analytic Hierarchy Process(AHP)/Analytic Network Process(ANP)has been introduced in selecting the natural fibres based in different clusters of selection *** selection process has been perform.. based on the interdependency am..g the selection *** com..rison m..rices are constructed based on AHP’s hierarchical m..el and super m..rices are constructed based on the ANP’s network *** a result,flax fibre has ranked at the top of the selection by scored 19.5%from..he overall *** fibre has excellent m..erial properties and been found in various natural fibre com..site *** investigation is needed to study the com..tibility of this fibre to be reinforced with a therm..lastic polym.. m..rix to develop a resultant natural fibre com..site filam..t for fused deposition m..eling.

关键词： m..erial selection natural fibre com..sites fused deposition m..eling analytic hierarchy process analytic network process

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An Insight into the Structural, Electronic and Transport Characteristics of XIn_(2)S_(4) (X = Zn, Hg) Thiospinels using a Highly Accurate All-Electron FP-LAPW+Lo m..hod

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Chinese Physics Letters 2013年第7期30卷 205-209页

作者： m..ood Yousaf m...Saeed Ahm.. Radzi m.. Isa H.A.Rahnam..e Aliabad m...Sahar Departm..t of Physics Faculty of ScienceUniversiti Teknologi MalaysiaSkudai-81310JohorMalaysia Departm..t of Physics Hakim Sabzevari UniversityIran

The highly accurate full-potential linearized augm..ted plane wave plus local orbital m..hod is em..oyed to calculate the structural,electronic and transport properties of HgIn_(2)S_(4) and ZnIn_(2)S_(4).For ZnIn_(2)S_(4),the calculated In–S bond length is in good agreem..t with the experim..tal *** m..uli results suggest that ZnIn_(2)S_(4) can afford m..e com..essional effects than HgIn_(2)S_(4).The present study confirm..that both HgIn_(2)S_(4) and ZnIn_(2)S_(4) are indirect band gap m..erials with band gap values of 0.705 eV and 1.533 eV *** localized region existing in the m..t bottom..alance band of both m..erials splits into states by 1 eV energy difference under the spin orbital coupling *** plots of charge density predict that chem..al bonding in these com..unds is a m..ture of ionic and covalent *** m..s results reveal that m..ility of charge carriers in ZnIn_(2)S_(4) is greater than that in HgIn_(2)S_(4).

关键词： effect. orbital charge

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Post-endoscopic retrograde cholangiopancreatography pancreatitis

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Gastroenterology Report 2015年第1期3卷 32-40页

作者： Adarsh m..haker Jeffrey D.m..ko Tyler m..erzin Center for Advanced Endoscopy Division of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Acute pancreatitis rem..ns the m..t com..n com..ication of endoscopic retrograde cholangiopancreatography(ERCP).It is reported to occur in 2–10%of unselected patient sam..es and up to 40%of high-risk *** purpose of this article is to review the evidence behind the known risk factors for post-ERCP pancreatitis,as well as the technical and m..ical approaches developed to prevent *** have been m..y advances in identifying the causes of this *** on this knowledge,a variety of preventive strategies have been developed and *** approach to prevention begins with careful patient selection and perform..g ERCP for specific indications,while considering alternative diagnostic m..alities when *** should also be classified by high-risk factors such as young age,fem..e sex,suspected sphincter of Oddi dysfunction,a history of post-ERCP pancreatitis,and norm.. serum..ilirubin,all of which have been identified in num..ous research *** pathways of injury that are believed to cause post-ERCP pancreatitis eventually lead to the com..n endpoint of inflam..tion,and these individual steps can be targeted for preventive therapies through procedural techniques and m..ical *** includes the use of a guide wire for cannulation,m..im..ing the num..r of cannulation attem..s,avoiding contrast injections or traum..to the pancreatic duct,and placem..t of a tem..rary pancreatic duct stent in high-risk *** of rectal non-steroidal anti-inflam..tory agents(NSAIDs)in high-risk patients is the proven pharm..ological m..sure for prevention of post-ERCP *** evidence for or against num..ous other attem..ed therapies is still unclear,and ongoing investigation is required.

关键词： endoscopic retrograde cholangiopancreatography pancreatitis prevention com..ications

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